Article
Neurosciences
Sara Isernia, Alice Pirastru, Davide Massaro, Marco Rovaris, Antonella Marchetti, Francesca Baglio
Summary: The neural mechanisms underlying theory of mind deficit in multiple sclerosis (MS) appear to involve abnormal intrinsic and extrinsic connectivity, particularly the disconnection between the limbic-paralimbic network and prefrontal execution loops, as well as aberrant intrinsic connectivity within the anterior cingulate cortex (ACC).
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2022)
Review
Neurosciences
Danka Jandric, Anisha Doshi, Richelle Scott, David Paling, David Rog, Jeremy Chataway, Menno M. Schoonheim, Geoff Parker, Nils Muhlert
Summary: There is an association between cognitive impairment in multiple sclerosis (MS) and functional connectivity (FC) abnormalities measured by resting-state functional MRI (rs-fMRI), with both high and low FC being linked to cognitive dysfunction. The choice of methodology may influence the observed findings.
BRAIN CONNECTIVITY
(2022)
Article
Medicine, General & Internal
Amir Hosein Riazi, Hossein Rabbani, Rahele Kafieh
Summary: This article introduces a new framework that uses spectral ICA method to measure the differences in brain connectivity between multiple sclerosis patients and healthy controls. The results show that, in both static and dynamic connectivity, multiple sclerosis patients have significantly decreased connectivity in the anterior cingulate cortex, while the connectivity in the core region of the posterior cingulate cortex is significantly weaker but stronger in the periphery.
Article
Neurosciences
Sepehr Shirani, Maryam Mohebbi
Summary: This study investigates the effects of MS on the brain's functional connectivity network using EEG resting-state signals and graph theory approach. The results indicate lower cortical activity in the alpha frequency bands and higher activity in the gamma frequency bands for patients with RRMS. Additionally, the functional brain network in RRMS cases shows a higher diameter, global efficiency, and transitivity in certain frequency bands.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Ersin Ersoezlue, Robert Perneczky, Maia Tato, Julia Utecht, Carolin Kurz, Jan Hackert, Selim Guersel, Lena Burow, Gabriele Koller, Sophia Stoecklein, Daniel Keeser, Boris Papazov, Marie Totzke, Tommaso Ballarini, Frederic Brosseron, Katharina Buerger, Peter Dechent, Laura Dobisch, Michael Ewers, Klaus Fliessbach, Wenzel Glanz, John Dylan Haynes, Michael T. Heneka, Daniel Janowitz, Ingo Kilimann, Luca Kleineidam, Christoph Laske, Franziska Maier, Matthias H. Munk, Oliver Peters, Josef Priller, Alfredo Ramirez, Sandra Roeske, Nina Roy, Klaus Scheffler, Anja Schneider, Bjorn H. Schott, Annika Spottke, Eike J. Spruth, Stefan Teipel, Chantal Unterfeld, Michael Wagner, Xiao Wang, Jens Wiltfang, Steffen Wolfsgruber, Renat Yakupov, Emrah Duezel, Frank Jessen, Boris-Stephan Rauchmann
Summary: Cognitive reserve (CR) explains inter-individual differences in the impact of neurodegenerative burden on cognitive functioning. This study explored the associations between residual CR markers (CRM) and intrinsic network connectivity (INC) in Alzheimer's disease neuropathological continuum. The results showed that INC was positively associated with CRM in the default mode network (DMN), and CRM was positively associated with the anti-correlation between memory-related regions in the frontoparietal network (FPN) and DMN in ADN and A+T/N+.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Alessandro Pasquale De Rosa, Fabrizio Esposito, Paola Valsasina, Alessandro D'Ambrosio, Alvino Bisecco, Maria A. Rocca, Silvia Tommasin, Chiara Marzi, Nicola De Stefano, Marco Battaglini, Patrizia Pantano, Mario Cirillo, Gioacchino Tedeschi, Massimo Filippi, Antonio Gallo
Summary: The Italian Neuroimaging Network Initiative (INNI) is an expanding database of brain MRI data from multiple sclerosis (MS) patients, with a focus on the quality of the data and functional connectivity (FC) features after preprocessing. The study found that FC features showed inter-site and site-specific inter-group effects, and significant reductions were observed in somatomotor and limbic networks in MS patients. The implemented procedures provide technical information and reference for future RS-fMRI studies within INNI.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Sean L. Carter, Ronak Patel, John D. Fisk, Chase R. Figley, Ruth Ann Marrie, Erin L. Mazerolle, Md Nasir Uddin, Kaihim Wong, Lesley A. Graff, James M. Bolton, James J. Marriott, Charles N. Bernstein, Jennifer Kornelsen
Summary: This study aimed to assess functional connectivity differences between individuals with multiple sclerosis (MS) and healthy controls (HC), and identified brain regions associated with cognitive impairment.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Eirini Messaritaki, Sonya Foley, Simona Schiavi, Lorenzo Magazzini, Bethany Routley, Derek K. Jones, Krish D. Singh
Summary: The study investigates the relationship between brain structure and function using microstructural MRI and resting-state MEG data. The shortest-path-length algorithm is found to be better at predicting functional connectivity patterns, with streamline count and myelination leading to the highest correlations between predicted and observed functional connectivity.
NETWORK NEUROSCIENCE
(2021)
Article
Neurosciences
Min Zhang, Shuang Liu, Shicong Wang, Yan Xu, Longmao Chen, Ziqiang Shao, Xinwen Wen, Wenhan Yang, Jun Liu, Kai Yuan
Summary: In this study, the authors investigated the differences in volume and resting-state functional connectivity of the thalamus between acute abstinent heroin users and healthy controls. They found decreased RSFC in specific thalamic subregions in the heroin users, which were negatively correlated with cognitive function deficits measured by TMT-A scores. Additionally, craving and withdrawal symptoms were also found to be correlated with specific thalamic RSFC patterns.
HUMAN BRAIN MAPPING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haiying Lyu, Xue Zhu, Naying He, Qing Li, Qianyi Yin, Yufei Huang, Fuhua Yan, Jun Liu, Yong Lu
Summary: The study aimed to investigate the functional connectivity (FC) changes of the central autonomic network (CAN) in patients with multiple system atrophy (MSA). Using core modulatory regions of CAN as seeds, significant FC aberrances were found between CAN and brain areas related to sensorimotor control, limbic network, putamen, and cerebellum in MSA patients. The FC changes of CAN were correlated with disease severity and were more significant in severe MSA group compared to moderate MSA group. Conclusion: MSA demonstrates widespread FC changes of CAN, suggesting abnormal functional integration of CAN may be involved in disease pathogenesis of MSA.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Neurosciences
Sebastian C. Schneider, Stephan Kaczmarz, Jens Goettler, Jan Kufer, Benedikt Zott, Josef Priller, Michael Kallmayer, Claus Zimmer, Christian Sorg, Christine Preibisch
Summary: This study investigates and compares different hemodynamic-vascular processes and their impact on BOLD-FC in healthy controls and patients with ICAS. The results suggest that systemic perfusion delays have a stronger influence on BOLD-FC than impairments in local neurovascular coupling.
Article
Biochemistry & Molecular Biology
Nguyen Thanh Nhu, David Yen-Ting Chen, Jiunn-Horng Kang
Summary: This study compared the accuracy of network rs-FC and brain structural features in identifying FM using a machine learning approach. The results showed that the rs-FC ML model outperformed the structural ML model in distinguishing FM patients from pain-free controls, and the combined rs-FC and structural ML model performed the best. Several rs-FC features in the final ML model were found to correlate with FM's clinical data.
Article
Clinical Neurology
Lorenzo Conti, Paolo Preziosa, Alessandro Meani, Elisabetta Pagani, Paola Valsasina, Olga Marchesi, Carmen Vizzino, Maria A. Rocca, Massimo Filippi
Summary: Cognitive impairment in multiple sclerosis patients is associated with specific white matter lesions, FA abnormalities, and gray matter atrophy. The relevance of these MRI measures was confirmed in a cross-validation analysis.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
John C. Williams, Philip N. Tubiolo, Jacob R. Luceno, Jared X. Van Snellenberg
Summary: Simultaneous multi-slice (multiband) accelerated functional magnetic resonance imaging (fMRI) provides improved temporal and spatial resolution for studying the brain. However, motion artifacts pose challenges for denoising, which affects the reliability and reproducibility of the results. This study evaluates different methods for motion denoising and proposes new quantitative metrics for benchmarking. The authors also develop a method for determining optimal parameters for denoising and provide recommendations for researchers to apply this approach to their own datasets.
Article
Biology
Daniel Vereb, Mite Mijalkov, Anna Canal-Garcia, Yu-Wei Chang, Emiliano Gomez-Ruiz, Blanca Zufiria Gerboles, Miia Kivipelto, Per Svenningsson, Henrik Zetterberg, Giovanni Volpe, Matthew Betts, Heidi I. L. Jacobs, Joana B. Pereira
Summary: This study investigates the functional heterogeneity of the locus coeruleus (LC) in different age groups using brain imaging techniques, and finds that it is associated with age, emotional memory, and emotion regulation. The study also reveals that the spatial features of the LC's functional heterogeneity are relevant markers of behavioral measures and psychopathology.
Review
Psychology, Clinical
Simona Raimo, Mariachiara Gaita, Maria Cropano, Giusi Mautone, Alfonsina D'Iorio, Luigi Trojano, Gabriella Santangelo
Summary: Atypical Parkinsonism (AP) is characterized by a variety of non-motor symptoms, including attention and executive deficits. This study found significant cognitive impairment in patients with AP compared to healthy controls. Different types of AP showed varying degrees of cognitive decline, and widespread cognitive impairment could be an important clinical indicator to distinguish AP from other movement disorders.
NEUROPSYCHOLOGY REVIEW
(2023)
Review
Psychology, Multidisciplinary
Francesco Panico, Laura Sagliano, Alfonso Magliacano, Gabriella Santangelo, Luigi Trojano
Summary: This review explores the relationship between Cognitive Reserve (CR) and cognition in adulthood. The results suggest a positive association between CR and almost all cognitive domains. However, limited studies on constructional abilities prevent a clear conclusion in this area.
CURRENT PSYCHOLOGY
(2023)
Article
Neurosciences
Chiara Marzi, Alessandro d'Ambrosio, Stefano Diciotti, Alvino Bisecco, Manuela Altieri, Massimo Filippi, Maria Assunta Rocca, Loredana Storelli, Patrizia Pantano, Silvia Tommasin, Rosa Cortese, Nicola De Stefano, Gioacchino Tedeschi, Antonio Gallo
Summary: This study used machine learning techniques to assess the relationship between brain MRI structural volumes and cognitive deficits in MS patients, and found that damage to gray matter structures is most closely related to cognitive performance.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Alessandro Pasquale De Rosa, Fabrizio Esposito, Paola Valsasina, Alessandro D'Ambrosio, Alvino Bisecco, Maria A. Rocca, Silvia Tommasin, Chiara Marzi, Nicola De Stefano, Marco Battaglini, Patrizia Pantano, Mario Cirillo, Gioacchino Tedeschi, Massimo Filippi, Antonio Gallo
Summary: The Italian Neuroimaging Network Initiative (INNI) is an expanding database of brain MRI data from multiple sclerosis (MS) patients, with a focus on the quality of the data and functional connectivity (FC) features after preprocessing. The study found that FC features showed inter-site and site-specific inter-group effects, and significant reductions were observed in somatomotor and limbic networks in MS patients. The implemented procedures provide technical information and reference for future RS-fMRI studies within INNI.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Gianmarco Abbadessa, Giuseppina Miele, Elisabetta Maida, Emanuele Vanore, Lorenzo Cipriano, Cinzia Coppola, Luigi Lavorgna, Simona Bonavita
Summary: Ocrelizumab is a monoclonal antibody that targets the CD20 molecule and depletes B-cells. However, it also affects other lymphocyte subpopulations. This review summarizes the effects of ocrelizumab on circulating lymphocytes and identifies potential biomarkers for treatment response monitoring.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Simona Raimo, Roberto Giorgini, Mariachiara Gaita, Antonio Costanzo, Daniele Spitaleri, Liana Palermo, Marco Tullio Liuzza, Gabriella Santangelo
Summary: Cognitive impairment is common in Multiple Sclerosis (MS) and greatly impacts patients' quality of life. This study aims to assess the sensitivity of cognitive tests included in three widely used batteries for MS-associated CI. The results show that executive functioning tests are the most sensitive in differentiating cognitive functioning between MS patients and healthy controls.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Giovanni Cirillo, Roberta Pepe, Mattia Siciliano, Domenico Ippolito, Dario Ricciardi, Manuela de Stefano, Daniela Buonanno, Danilo Atripaldi, Salvatore Abbadessa, Brunella Perfetto, Minoo Sharbafshaaer, Giovanna Sepe, Simona Bonavita, Alessandro Iavarone, Vincenzo Todisco, Michele Papa, Gioacchino Tedeschi, Sabrina Esposito, Francesca Trojsi
Summary: This study evaluated the effects of bilateral rTMS on plasmatic levels of MMPs and TIMPs, as well as cognitive performances, in MCI patients. The results showed that rTMS treatment reduced MMP1, -9, and -10 levels, increased TIMP1 and TIMP2 levels, and improved visuospatial performances in MCI patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Gianmarco Abbadessa, Giuseppina Miele, Paola Cavalla, Paola Valentino, Girolama Alessandra Marfia, Marco Vercellino, Antonio De Martino, Vittorio Simeon, Luigi Lavorgna, Simona Bonavita
Summary: This study aimed to evaluate the impact of previous DMTs on the lymphocyte subset kinetics in MS patients switching to OCR. The results showed that previous DMTs influence the lymphocyte dynamics in MS patients switching to OCR, which is important for optimizing treatment strategies.
JOURNAL OF NEUROIMMUNOLOGY
(2023)
Correction
Clinical Neurology
Alessandro Pasquale De Rosa, Fabrizio Esposito, Paola Valsasina, Alessandro d'Ambrosio, Alvino Bisecco, Maria A. Rocca, Silvia Tommasin, Chiara Marzi, Nicola De Stefano, Marco Battaglini, Patrizia Pantano, Mario Cirillo, Gioacchino Tedeschi, Massimo Filippi, Antonio Gallo, INNI Network
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Giuseppina Miele, Gianmarco Abbadessa, Elisabetta Maida, Simona Bonavita
Summary: We report a case of pericarditis in an RRMS patient treated with ocrelizumab, characterized by chest pain, high body temperature, and systemic inflammation, with a favorable clinical outcome.
NEUROLOGICAL SCIENCES
(2023)
Review
Clinical Neurology
Lorenzo Cipriano, Giuseppina Miele, Lorenzo Ugga, Gianmarco Abbadessa, Ferdinando Caranci, Simona Bonavita
Summary: Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) is a rare but potentially reversible autoimmune encephalopathy. MRI findings often show normal brain or non-specific white matter hyperintensities. Less than 30% of cases may show focal neuroanatomical correlates, with temporal hyperintensities being the most frequent.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Teresa Costabile, Elisabetta Signoriello, Francesca Lauro, Manuela Altieri, Antonio Rosario Ziello, Alessandro 'Ambrosio, Alvino Bisecco, Giorgia Maniscalco, Simona Bonavita, Antonio Gallo, Vincenzo Brescia Morra, Giacomo Lus, Francesco Sacca, Cinzia Valeria Russo
Summary: This study aims to develop a tablet version of BICAMS (iBICAMS) and evaluate its reliability compared to the paper version. We tested 139 MS patients and found differences between the paper and tablet versions for all three sub-tests of BICAMS. However, the reliability between BICAMS and iBICAMS was high, suggesting that iBICAMS could become a standard in clinical practice.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Neurosciences
Gianpaolo Maggi, Carmine Vitale, Alessia Delle Curti, Marianna Amboni, Gabriella Santangelo
Summary: Altered self-awareness or anosognosia may affect everyday life and independent functioning of PD patients. The present study aimed to explore the awareness of apathy in PD patients through comparing self-reported evaluations with caregivers' ratings. The study found that there was fair agreement between patients' self-reports and caregivers' ratings on apathy scores. Patients reported less severe apathetic symptoms compared to their caregivers' reports, especially those related to executive and auto-activation processing. Executive functioning mediated the relationship between disease stage and awareness of apathy. Awareness of executive apathy impacted patients' self-reported quality of life. Anosognosia for apathy in PD patients may affect their quality of life perception and delays diagnosis and treatment.
Article
Pediatrics
Nicola Davide Cavallo, Gianpaolo Maggi, Francesco Ferraiuolo, Anna Sorrentino, Silverio Perrotta, Marco Carotenuto, Gabriella Santangelo, Claudia Santoro
Summary: This study examined the prevalence of bullying/cyberbullying behaviors and victimization behaviors in children and adolescents with NF1. The findings show that victimization behaviors were more common than bullying/cyberbullying ones. Participants also reported depressive and anxiety symptoms, reduced self-esteem, and low psychosocial quality of life, with females experiencing more severe effects. Reduced self-esteem was associated with more visible NF1 symptoms, and victimization behaviors mediated the relationship between anxiety and psychosocial quality of life. These results highlight the importance of a multidisciplinary approach in the diagnosis and treatment of NF1.
Article
Clinical Neurology
Gianmarco Abbadessa, Marta Ponzano, Floriana Bile, Giuseppina Miele, Alessio Signori, Simone Cepparulo, Maddalena Sparaco, Elisabetta Signoriello, Giorgia Teresa Maniscalco, Roberta Lanzillo, Vincenzo Brescia Morra, Giacomo Lus, Maria Pia Sormani, Luigi Lavorgna, Simona Bonavita
Summary: This study aimed to assess whether the scores of Patient Reported Outcomes Measures (PROMs) can predict the occurrence of disease progression in Multiple Sclerosis (MS) within three years. The study found that patients with scores higher than 77.5 in SF36-Physical Functioning subscale have a higher likelihood to experience disability progression within the next three years.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)