Article
Food Science & Technology
Jaff Ribeiro da Silva, Mariana Barros de Cerqueira e Silva, Biane Oliveira Philadelpho, Victoria Cruz de Souza, Johnnie Elton Machado dos Santos, Marcelo Santos Castilho, Ederlan de Souza Ferreira, Eduardo Maffud Cilli
Summary: The newly designed peptides Pyr-GF and GSTLN enhance the inhibitory effect of pravastatin on HMGCoAR, with the combination showing more significant inhibition compared to pravastatin alone. The peptides demonstrate a cholesterol-lowering effect and act as adjuvants when combined with pravastatin, with Pyr-GF mainly targeting the catalytic site and GSTLN targeting the NADPH site of HMGCoAR.
Article
Biology
Muhammad Bilal Azmi, Saleha Sultana, Sadaf Naeem, Shamim Akhtar Qureshi
Summary: The study investigated the in silico activity of alkaloids from Rauwolfia serpentina roots as inhibitors of HMGCR. Five alkaloids were identified as potential inhibitors of HMGCR, showing promising results for suppressing cholesterol biosynthesis pathway.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Medicine, General & Internal
Yixiong Yuan, Ruilin Xiong, Yi Wu, Jason Ha, Wei Wang, Xiaotong Han, Mingguang He
Summary: This study found that the use of statins is associated with a slightly lower risk of onset of open-angle glaucoma (OAG) based on existing evidence, but the relationship between statin use and progression of OAG remains inconclusive. The analysis included 515,788 participants from ten studies for OAG onset and 26,347 OAG patients from seven studies for OAG progression.
Review
Food Science & Technology
A. M. Api, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. A. Cancellieri, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, A. D. Fryer, L. Jones, K. Joshi, M. Kumar, A. Lapczynski, M. Lavelle, I Lee, D. C. Liebler, H. Moustakas, M. Na, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, T. W. Schultz, D. Selechnik, F. Siddiqi, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
Summary: The material was found to be non-genotoxic and non-irritating in various toxicological tests, meeting environmental safety standards.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ahmed Aboelmagd, Samir M. El Rayes, Mohamed S. Gomaa, Walid Fathalla, Ibrahim A. I. Ali, Mohamed S. Nafie, Faheem H. Pottoo, Firdos Alam Khan, Mohamed M. Ibrahim
Summary: A series of new metal complexes were synthesized and tested for their anti-tumor activities on colorectal carcinoma cells and normal cells. Most of the compounds showed significant inhibitory effects on cancer cells while having no impact on normal cells.
Article
Chemistry, Physical
Xiucan Jia, Yutian Ma, Xiaopo Wang
Summary: In this study, the vapor-liquid equilibrium of 3, 3, 3-Trifluoropropene (R1243zf) with [Emim][BF4] and [Bmim][BF4] ionic liquids was measured, and the experimental results were correlated using the NRTL model. The effects of different anions and cations on the liquid phase molar fraction of R1243zf were studied. In addition, thermodynamic properties and phase behavior of different HFO refrigerants with [Emim][BF4] were compared and analyzed.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Rheumatology
Kothapalli Nagamounika, Josna Joseph, R. Hemanth Kumar, John Mathew
Summary: Statin-naive immune-mediated necrotizing myopathy (IMNM) is a rare disease with a complicated diagnosis in the absence of a reliable biomarker. This case, the first reported in South India, is unique as it highlights the significance of hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) antibody in diagnosing IMNM, particularly when myositis-specific antibodies are absent. A comprehensive diagnostic approach, including testing for HMGCR antibody, is recommended for IMNM.
INDIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Clinical Neurology
Kam-Ho Lee, Yuan Gao, Vince Lau
Summary: Statin-associated anti-HMGCR myopathy manifests as bilateral symmetrical pan-compartmental edema on thigh muscle MRI, with anterolateral predilection in the anterior compartment and greater involvement of the semimembranosus with relative sparing of the short head of the biceps femoris in the posterior compartment. These observations can aid in the diagnosis of statin-associated anti-HMGCR myopathy.
Article
Medicine, Research & Experimental
N. Radyukhina, N. Yu Ruleva, A. Yu Filatova, T. Aref'eva
Summary: Statins have an impact on the functional activity of CD4(+) T lymphocytes, including inhibiting cell proliferation and regulating the expression of active caspase-3. Lipophilic atorvastatin shows cellular effects at lower concentrations compared to hydrophilic rosuvastatin.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Review
Microbiology
Aleksei Gendron, Kylie D. Allen
Summary: Methyl-coenzyme M reductase (MCR) is an enzyme involved in methane metabolism, playing a crucial role in methane production and the conversion of alkanes. It is a dimer composed of heterotrimers and requires unique post-translational modifications and a specific coenzyme for its catalytic activity. Understanding the catalysis of MCR and its production in heterologous hosts is important for optimizing biocatalytic systems.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Patrick A. Twohig, Enrique De-Madaria, Shyam Thakkar, Parambir Dulai, Timothy B. Gardner, Gursimran Kochhar, Dalbir S. Sandhu
Summary: The study found that ACE inhibitors and statins increase the risk of drug-induced pancreatitis (DIP), with men and patients over 65 years of age being more susceptible.
Article
Endocrinology & Metabolism
Si Jin Kwon, Kyung-Won Hong, Silvia Choi, Ji Su Hong, Jung Won Kim, Ju Whi Kim, Hye-Ja Lee, Han Byul Jang, Keun-Sang Yum
Summary: The study found that obesity in children and adolescents with ASD is associated with the cholesterol synthesis pathway. By examining the HMGCR gene polymorphisms, the study identified associations between certain allele subgroups and metabolic traits. Further research is needed to elucidate the molecular mechanisms by which the HMGCR gene influences metabolic traits.
METABOLIC BRAIN DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Hong-Ru Zhao, Bing-Mei Su, Yi-Bing Shi, Juan Lin
Summary: The present study developed two robust and efficient bio-catalysts, Mu-S2 and Mu-R4, for the synthesis of (S)-EHPP and (R)-EHPP respectively. Through rational design of alcohol dehydrogenase PcSDR from Pedobacter chitinilyticus based on molecular dynamics simulation analysis, these catalysts exhibited high synthesis efficiency and selectivity under high EBA loading conditions. This work provides potential biocatalysts for the industrial production of (R)-EHPP and (S)-EHPP and enriches the constructure-function relationship of alcohol dehydrogenases.
ENZYME AND MICROBIAL TECHNOLOGY
(2022)
Article
Microbiology
Damian A. Madrigal-Aguilar, Adilene Gonzalez-Silva, Blanca Rosales-Acosta, Celia Bautista-Crescencio, Jossue Ortiz-Alvarez, Carlos H. Escalante, Jaime Sanchez-Navarrete, Cesar Hernandez-Rodriguez, German Chamorro-Cevallos, Joaquin Tamariz, Lourdes Villa-Tanaca
Summary: Due to the emergence of multidrug-resistant strains of yeasts, discovering antifungal agents that target alternative molecular targets is urgently needed. This study evaluated the capacity of three different series of synthetic compounds to inhibit a specific enzyme in Candida glabrata, leading to the disruption of ergosterol synthesis and yeast viability. Two compounds, 1c and 5b, were identified as the best antifungal candidates among the compounds studied. They effectively inhibited the growth of fluconazole-resistant and fluconazole-susceptible C. glabrata strains. The compounds act by inhibiting the mevalonate synthesis pathway, resulting in a decrease in ergosterol concentration. The docking analysis suggested that their inhibitory effect may be mediated by their interaction with the enzyme's catalytic site. Further research and modifications to increase their specificity and potency are needed.
MICROBIOLOGY SPECTRUM
(2022)
Article
Rheumatology
Latika Gupta, Arvind Nune, R. Naveen, Ritu Verma, Pallavi Prasad, Rajat Kharbanda, Upendra Rathore, Mohit Kumar Rai, Mantabya Kumar Singh, Anamika Kumari Anuja, Vikas Agarwal
Summary: This study investigated the prevalence and clinical characteristics of anti-HMGCR antibodies in idiopathic inflammatory myositis (IIM) in northern India. The results showed a low positivity rate of anti-HMGCR antibodies in both adult and pediatric patients, with higher muscle enzyme levels and fewer systemic symptoms. One case of chronic Limb-girdle muscular dystrophy (LGMD) pattern was also identified in a young girl.
RHEUMATOLOGY INTERNATIONAL
(2022)
Review
Endocrinology & Metabolism
Richard Ofori-Asenso, Berhe W. Sahle, Ken Lee Chin, Mohsen Mazidi, Zanfina Ademi, Marie Louise De Bruin, Danny Liew
Summary: The study found that real-world adherence and persistence to SGLT2 inhibitors is poor, with approximately 60% of patients adherent at six months and 50% at one year, while persistence data showed even lower proportions. Targets for improving treatment adherence and persistence need to be identified and appropriate interventions implemented.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2021)
Article
Cardiac & Cardiovascular Systems
Michael Lim, Diem T. Dinh, Angela Brennan, Danny Liew, Christopher Reid, Jeffrey Lefkovits, Stephen J. Duffy, Nick Andrianopoulos, Dion Stub
Summary: This study investigated contemporary outcomes of older patients with NSTEACS undergoing PCI and found that those with left ventricular systolic dysfunction or renal impairment are at increased risk of MACCE post PCI. Randomised studies are needed to determine if invasive management remains beneficial for these patients compared with medical therapy.
HEART LUNG AND CIRCULATION
(2021)
Article
Cardiac & Cardiovascular Systems
Feby Savira, Bing H. Wang, Andrew R. Kompa, Zanfina Ademi, Alice J. Owen, Sophia Zoungas, Andrew Tonkin, Danny Liew, Ella Zomer
Summary: The study found that adding dapagliflozin as an adjunct therapy to standard care for patients with chronic heart failure and reduced ejection fraction can prevent acute heart failure hospitalizations, increase years of life and quality-adjusted life-years, at a cost-effective ratio well below the Australian willingness-to-pay threshold.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Clara Marquina, Stella Talic, Sandra Vargas-Torres, Marjana Petrova, Dina Abushanab, Alice Owen, Sean Lybrand, David Thomson, Danny Liew, Ella Zomer, Zanfina Ademi
Summary: The study estimated the health and economic burden of cardiovascular disease in Australia from 2020 to 2029, finding a significant impact in terms of morbidity, mortality, healthcare costs, and productivity losses. The model projected a high number of fatal and non-fatal cardiovascular events, with a substantial number of Australians expected to have prevalent cardiovascular disease by 2029. The total cost of cardiovascular disease, including healthcare costs and productivity losses, was projected to exceed a significant amount in Australian dollars.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Dina Abushanab, Daoud Al-Badriyeh, Danny Liew, Zanfina Ademi
Summary: This study evaluated the cost-effectiveness of first-line empagliflozin plus standard care for patients with newly diagnosed type 2 diabetes and existing cardiovascular disease. The results indicate that adding empagliflozin to standard care can provide additional years of life and quality-adjusted life years for patients at a reasonable cost.
CURRENT PROBLEMS IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jennifer Y. Zhou, Danny Liew, Stephen J. Duffy, Antony Walton, Nay Htun, Dion Stub
Summary: Recent studies suggest that balloon-expandable and self-expanding TAVI may offer cost-effective options compared to SAVR for low-risk patients with severe aortic stenosis. While balloon-expandable TAVI showed higher quality-adjusted survival years but higher costs, self-expanding TAVI was found to be economically dominant with lower costs and slightly lower increase in quality-adjusted survival years.
HEART LUNG AND CIRCULATION
(2021)
Article
Biochemistry & Molecular Biology
Ruth R. Magaye, Feby Savira, Yue Hua, Xin Xiong, Li Huang, Christopher Reid, Bernard L. Flynn, David Kaye, Danny Liew, Bing H. Wang
Summary: Our study reveals a relationship between the PI3K/Akt-mTOR signaling cascade and collagen synthesis and myocyte hypertrophy induced by exogenous dhS1P in primary neonatal cardiac cells. In addition, PI3K inhibition also affects the gene expression related to S1P receptors and enzymes.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Jedidiah I. Morton, Stephen P. McDonald, Agus Salim, Danny Liew, Jonathan E. Shaw, Dianna J. Magliano
Summary: The study projected an increase in the incidence of ESKD-D over the coming decades, but widespread use of SGLT2is may help limit this increase. Diabetes prevention will be crucial in preventing the ever-increasing burden of diabetes complications.
Article
Economics
Ella Zomer, YongJoo Rhee, Danny Liew, Zanfina Ademi
Summary: Major depression in South Korea affects over 500,000 individuals aged 15-54, leading to significant premature deaths, years of life lost, and productivity-adjusted life-years lost. The total economic impact of depression in terms of lost GDP is substantial, highlighting the need for improved prevention and treatment strategies to enhance long-term economic gains.
APPLIED HEALTH ECONOMICS AND HEALTH POLICY
(2021)
Article
Cardiac & Cardiovascular Systems
Thara Govindaraju, Tracy A. McCaffrey, John J. McNeil, Christopher M. Reid, Ben J. Smith, Duncan J. Campbell, Danny Liew, Alice J. Owen
Summary: This cross-sectional study examined the association between cardiovascular disease risk factors and quality of life in older adults. The study found that smoking was negatively associated with mental component score of quality of life, while physical activity was positively associated with mental component score. Alcohol consumption was positively associated with physical component score, and saturated fat intake showed a negative association with the physical functioning domain of quality of life.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Review
Oncology
Abdallah Y. Naser, Richard Ofori-Asenso, Safaa Al Awawdeh, Sami Qadus, Hassan Alwafi, Danny Liew
Summary: In this study, a systematic review and meta-analysis were conducted to summarize the adherence and persistence rate among patients prescribed oral therapy for multiple myeloma. The analysis suggested that about 68% of patients were adherent and 36% discontinued treatment. These findings emphasize the need for interventions to improve treatment adherence in order to achieve desired clinical outcomes.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2022)
Review
Cardiac & Cardiovascular Systems
Benjamen Wang, Justin Verrocchi, Danny Liew, Dominica Zentner
Summary: This study aims to compare the long-term outcomes after cardiac surgery in adults with and without Down syndrome (DS). The meta-analysis showed that DS does not affect long-term survival after congenital cardiac surgery in adulthood, but individuals with DS have a lower risk of cardiac reoperation. The study is limited by limited sample sizes and clinical heterogeneity.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Endocrinology & Metabolism
Jedidiah Morton, Clara Marquina, Jonathan E. Shaw, Danny Liew, Kevan R. Polkinghorne, Zanfina Ademi, Dianna J. Magliano
Summary: The use of SGLT2i is cost-effective based on cardiovascular and kidney benefits for people with type 2 diabetes, while the use of GLP-1 RA is not.
Article
Endocrinology & Metabolism
Anthony Pease, Emily Callander, Ella Zomer, Mary B. Abraham, Elizabeth A. Davis, Timothy W. Jones, Danny Liew, Sophia Zoungas
Summary: The study found that HCL therapy was more cost-effective than current care for young people with type 1 diabetes in Australia. The incremental cost-effectiveness ratio was AUD $32,789 per QALY gained, with the majority of simulations falling below the willingness-to-pay threshold of AUD $50,000 per QALY gained. Sensitivity analyses indicated that the results were robust.
Article
Health Care Sciences & Services
Peter Hudson, Afaf Girgis, Kristina Thomas, Jennifer Philip, David C. Currow, Geoffrey Mitchell, Deborah Parker, Danny Liew, Caroline Brand, Brian Le, Juli Moran
Summary: Family meetings can help reduce psychological distress and enhance preparedness of family caregivers for their role. The study results suggest that these meetings may be conducted without increasing hospital health utilization impacts. Further health economic examination is recommended to fully understand the cost-benefit implications.
PALLIATIVE MEDICINE
(2021)
