Article
Oncology
Xin Yu, Xueyan Fu, Xia Zhang, Changcai Bai, Yang Wang
Summary: The study found that circ_0001658 promotes the malignant phenotype and gefitinib resistance of NSCLC cells by regulating the miR-409-3p/TWIST1 axis.
Article
Biochemistry & Molecular Biology
Jinghan Hua, Xiaolin Wang, Liying Ma, Jingxin Li, Guozhen Cao, Shaobo Zhang, Wenchu Lin
Summary: circVAPA promotes the progression of small cell lung cancer through the miR-377-3p and miR-494-3p/IGF1R/AKT axis.
Article
Oncology
Xuan Lu, Ningning Kang, Xinxin Ling, Ming Pan, Wenjing Du, Shan Gao
Summary: The study investigated the biological activity of SLC7A11 in NSCLC cells through various methods, revealing that miR-27a-3p modulates ferroptosis by targeting SLC7A11 in NSCLC cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaomin Liu, Xianyi Wang, Binshu Chai, Zong Wu, Zhitao Gu, Heng Zou, Hui Zhang, Yanli li, Qiangling Sun, Wentao Fang, Zhongliang Ma
Summary: This study found that miR-199a-3p/5p is down-regulated in non-small cell lung cancer (NSCLC), and overexpression of miR-199a-3p/5p can inhibit cell proliferation, migration, and promote apoptosis. Rheb is identified as a common target of miR-199a-3p and miR-199a-5p, participating in the regulation of the mTOR signaling pathway. Additionally, miR-199a significantly inhibits tumor growth and metastasis in NSCLC and enhances the sensitivity of gefitinib in EGFR-T790M mutation. MiR-199a-3p/5p has the potential to serve as an early diagnostic marker or therapeutic target for NSCLC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Ming Li, Wulin Shan, Yan Hua, Fengmei Chao, Yayun Cui, Lei Lv, Xiaoyan Dou, Xing Bian, Jinglu Zou, Hong Li, Wenchu Lin
Summary: The study revealed that miR-92b-3p expression was increased in SCLC patients and correlated with chemoresistance. By affecting the PTEN/AKT regulatory network, miR-92b-3p mediated cell migration and chemoresistance in SCLC. Additionally, miR-92b-3p was identified as a potential dynamic biomarker for monitoring chemoresistance in SCLC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Fengmei Chao, Yang Zhang, Lei Lv, Yaqin Wei, Xiaoyan Dou, Na Chang, Qiyi Yi, Ming Li
Summary: By transcriptome sequencing, differentially expressed circRNAs were screened in chemoresistant and chemosensitive small cell lung cancer (SCLC) cells, and circSH3PXD2A was identified as significantly downregulated. In vivo and in vitro experiments demonstrated that circSH3PXD2A inhibits chemoresistance in SCLC through the miR-375-3p/YAP1 axis. Additionally, EVs-derived circSH3PXD2A may serve as a predictive biomarker for DDP-resistant SCLC patients.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Oncology
Sachin Kumar, Jyoutishman Saikia, Surender K. Sharawat, Prabhat S. Malik, Sunil Kumar, Anant Mohan
Summary: The overexpression of miR-375-3p and miR-197-3p may contribute to lung carcinogenesis, and the expression of miR-375-3p may assist in predicting therapeutic response.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Anatomy & Morphology
Minglei Yang, Enkuo Zheng, Junjun Ni, Xiang Xu, Xu Jiang, Guofang Zhao
Summary: This study reveals that circFOXO3 promotes the proliferation, migration, and invasion of NSCLC cells and regulates the expression of HMGB3 mRNA by binding to miR-545-3p/miR-506-3p. These findings suggest circFOXO3 as a potential therapeutic target for NSCLC.
Article
Cell Biology
Hongbo Su, Guanzhi Fan, Jin Huang, Xueshan Qiu
Summary: YBX1 is upregulated in NSCLC, while miR-148a-3p and Runx3 levels are reduced. YBX1 silencing inhibits NSCLC progression, while Runx3 upregulation restrains it. Runx3 interacts with miR-148a-3p to regulate NSCLC development.
CELLULAR SIGNALLING
(2021)
Article
Cell Biology
Chenlong Li, Hongshan Zheng, Jinsheng Xiong, Yuxin Huang, Haoyang Li, Hua Jin, Siqi Ai, Yingjie Wang, Tianqi Su, Guiyin Sun, Xu Xiao, Tianjiao Fu, Yujie Wang, Xin Gao, Peng Liang
Summary: This study investigates the role of miR-596-3p in brain metastasis of NSCLC. The results reveal that miR-596-3p inhibits the invasion of cancer cells and permeability of the blood brain barrier by modulating the YAP1-IL8 network. The findings suggest that miR-596-3p may serve as a potential therapeutic target for brain metastasis in NSCLC.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Hongliang Liao, Yaqin Liang, Lin Kang, Yun Xiao, Tao Yu, Renping Wan
Summary: Accumulating studies have suggested the significant role of microRNAs (miRs) in the development and progression of lung cancer, particularly in non-small cell lung cancer (NSCLC). This study investigated the association between miR-454-3p and NSCLC progression and found that miR-454-3p suppressed NSCLC cell proliferation and metastasis by targeting TGFB2, suggesting it as a promising strategy for treating NSCLC.
Article
Oncology
Kelin She, Shaoqi Yu, Shushuai He, Wen Wang, Biao Chen
Summary: This study found that circ_0009043 is upregulated in NSCLC cells and tissues, and lower expression of circ_0009043 is associated with poorer overall survival in NSCLC patients. Mechanistically, circ_0009043 acts as a molecular sponge, sequestering miR-148a-3p and promoting the expression of DNAJB4, thereby acting as a tumor suppressor in NSCLC.
BIOMARKER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Liurong Liu, Huihui Yao, Xin Zhou, Junjie Chen, Guoliang Chen, Xinyu Shi, Guanting Wu, Guoqiang Zhou, Songbing He
Summary: miR-15a-3p positively regulates ferroptosis in CRC by targeting GPX4, leading to increased levels of reactive oxygen species and malondialdehyde accumulation with overexpression, while reducing sensitivity to erastin and GPX4 with suppression.
MOLECULAR CARCINOGENESIS
(2022)
Article
Biochemistry & Molecular Biology
Ming Li, Yannan Liu, Xinglin Jiang, Yuanxin Hang, Haiying Wang, Hang Liu, Zhuo Chen, Yubo Xiao
Summary: miR-144-3p inhibits CEP55 expression in non-small cell lung cancer cells, leading to suppression of cell proliferation and migration, and promotion of apoptosis.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Yanli Li, Hui Zhang, Jing Guo, Wanqiu Li, Xianyi Wang, Caiyan Zhang, Qiangling Sun, Zhongliang Ma
Summary: The study revealed the crucial role of LINC01296 in NSCLC, promoting lung cancer development through regulation of the miR-143-3p/ATG2B axis, and affecting the sensitivity of NSCLC to paclitaxel.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Materials Science, Multidisciplinary
Wenyu Wu, Bin Guo, Xiaojing Liu, Huaxin Ma, Zhao Zhang, Zhi Zhang, Minghao Cui, Yu Gu, Ruijun Zhang
Summary: Boron nitride nanosheets (BNNSs) have great potential in many fields due to their excellent physical and chemical properties. However, the scalable preparation of large-size BNNSs is still a challenge. In this study, a simple and efficient microwave-assisted chemical exfoliation strategy using perchloric acid as the edge modifier and intercalation agent was proposed. The prepared BNNSs exhibited a thin-layered structure with a high yield and ultra-large size, leading to significantly improved thermal conductivity of polymer materials.
FRONTIERS OF MATERIALS SCIENCE
(2022)
Article
Agricultural Engineering
Jihua Zhao, Hongzhi Ma, Wenyu Wu, Mohammed Ali Bacar, Qunhui Wang, Ming Gao, Chuanfu Wu, Changlei Xia, Dayi Qian, William Woei Fong Chong, Su Shiung Lam
Summary: Two fermentation modes, electro-fermentation (EF) and traditional fermentation (TF), were used to produce medium-chain fatty acids (MCFAs) from different concentrations of liquor fermentation waste. EF mode at 40% substrate concentration resulted in the highest caproate (4.04 g/L) and butyrate (13.96 g/L) concentrations. TF experiments showed inhibition of ethanol oxidation and products formation above 40% substrate concentration. Compared to TF mode, EF mode significantly increased total substrates consumption by 2.6%-43.5% and product yields by 54.0%-83.0%. EF effectively alleviated substrate toxicity and enriched chain elongation bacteria, promoting ethanol oxidation and products formation. This study offers a new approach for producing MCFAs from high concentration wastewater.
BIORESOURCE TECHNOLOGY
(2023)
Review
Chemistry, Inorganic & Nuclear
Ruikai Wu, Wenyu Klingler Wu, Lucas Stieglitz, Sabyasachi Gaan, Bernhard Rieger, Manfred Heuberger
Summary: This review discusses the application and recent progress in the development of oc-diimine Ni and Pd complexes in catalyzed ethylene (co)polymerization. The effect of structural modifications on the catalytic behaviors and polymer properties is highlighted, as well as the heterogenization study on solid supports. The review provides valuable insights into the coordination-insertion chemistry and potential applications of these complexes.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Energy & Fuels
Jihua Zhao, Hongzhi Ma, Wenyu Wu, Mohammed Ali Bacar, Qunhui Wang, Ming Gao, Chuanfu Wu, Changlei Xia, Dayi Qian
Summary: Chinese liquor brewing wastewater (CLBW) can be upgraded to biofuels, specifically medium chain fatty acids (MCFAs), using microbial electrosynthesis (MES). The study found that under-1.0 V/CO2 condition, CLBW had the highest concentration and selectivity of caproate, which was 32.6% and 31.9% higher than the control group. The pH and electrochemical analysis supported the superiority of-1.0 V/CO2 condition. This study provides a new pathway for MCFAs production.
Article
Environmental Sciences
Qiang Yang, Yan Feng, Li Guan, Wenyu Wu, Sichen Wang, Qiangyu Li
Summary: X-band weather radar provides high-resolution data for precipitation observation and prediction, but it is susceptible to precipitation attenuation. This paper presents and validates an X-band attenuation correction method based on the LightGBM algorithm (the XACL method). The XACL method shows a significant correction effect and reduces the anomalous correction phenomenon compared to other methods. It achieves a 39.88% reduction in average error in precipitation estimation over 1204 meteorological stations.
Article
Plant Sciences
Xin Song, Baiquan Song, Jialu Huo, Huajun Liu, Muhammad Faheem Adil, Qiue Jia, Wenyu Wu, Abudukadier Kuerban, Yan Wang, Wengong Huang
Summary: Boron deficiency affects sugar beet production, and the use of nutrient-efficient varieties is an important solution. This study aimed to determine the effects of B deficiency on leaf phenotype and photosynthetic functions in B-efficient and B-inefficient sugar beet cultivars. The results showed that B-efficient cultivar had better adaptability to morphological changes and photosynthetic functions under B deficiency, providing theoretical basis for the selection of efficient sugar beet cultivars.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Multidisciplinary Sciences
Lulu Zhang, Siqi Zhang, Wenyu Wu, Xingkai Wang, Jieting Shen, Dongyuan Wang, Kuan Hu, Ming-Rong Zhang, Feng Wang, Rui Wang
Summary: The development of immune checkpoint blockade therapy has revolutionized cancer therapies, but the heterogeneous expression of PD-L1 in tumor cells hinders its effectiveness. To enhance treatment efficacy, there is a need for better methods to stratify patients and visualize PD-L1 expression. This study designed a new method using a radiolabeled tracer to detect PD-L1 expression in tumors through PET imaging.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Computer Science, Information Systems
Hanyu Xiang, Xianfeng Huang, Feng Lan, Chong Yang, Yunlong Gao, Wenyu Wu, Fan Zhang
Summary: This paper introduces a shape-preserving simplification method for urban building models, which improves real-time rendering and displaying of the models by considering both the overall shapes and local geometric features in the simplification process.
ISPRS INTERNATIONAL JOURNAL OF GEO-INFORMATION
(2022)
Article
Chemistry, Physical
Shuo Li, Wenyu Wu, Huaxin Ma, Zhao Zhang, Yu Gu, Jingjie Zhang, Ruijun Zhang
Summary: A newly-developed strategy for preparing layer-tunable graphene has overcome the poor service life issue of graphene oxide (GO)-based membranes in water purification. The assembled graphene membrane with an average layer number of 3 exhibits a high rejection rate of 99.9% for Rhodamine B and a water flux of up to 3452.6 L m-2 h-1 bar-1, thanks to its unique hierarchically nanochannel structure. The membrane also demonstrates superior service performance with the rejection rate of RB maintained at 99.9% even after 24 cycles of filtrations.
APPLIED SURFACE SCIENCE
(2023)
Article
Engineering, Environmental
Wenyu Wu Klingler, Valentin Rougier, Zhenyu Huang, Dambarudhar Parida, Sandro Lehner, Andri Casutt, Daniel Rentsch, Karin Brandli Hedlund, Gion Andrea Barandun, Veronique Michaud, Sabyasachi Gaan
Summary: The development of reusable fire-safe polymers with a prolonged lifetime is important for transitioning towards a circular economy. A novel phosphonated thermoset was synthesized using a two-step methodology, showing good flame retardancy and reprocessability at phosphorus concentrations above 5%. This thermoset exhibited high Tg, good thermal stability, and demonstrated its potential for application as a polymer matrix in composite materials.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Multidisciplinary
Wenyu Wu Klingler, Aurelio Bifulco, Carolina Polisi, Zhenyu Huang, Sabyasachi Gaan
Summary: This article introduces the difficulty of recycling thermosets and two major challenges in designing next-generation thermosets: embedded fire safety and reprocessability/recyclability. The research progress in designing fire-safe and thermomechanically reprocessable/recyclable thermosets is detailed in this review, including the categorization based on the chemistry of labile bonds and the use of bio-based raw materials.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Endocrinology & Metabolism
Fei Yu, Wenyu Wu, Liuting Zhang, Shaohua Li, Xiaochen Yao, Jun Wang, Yudan Ni, Qingle Meng, Rui Yang, Feng Wang, Liang Shi
Summary: This study aimed to develop a nomogram for predicting residual and recurrent cervical lymph node metastasis (CLNM) in postoperative papillary thyroid carcinoma (PTC) patients before I-131 therapy. Univariate and multivariate logistic regression analyses were performed to determine the risk factors of CLNM based on clinical and ultrasound features. Two nomograms were constructed based on models with high AUC, and their discrimination, calibration, and clinical usefulness were assessed through internal validation, calibration curves, and decision curves.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Automation & Control Systems
Renjie Zhu, Dongliang Fan, Wenyu Wu, Chongshan He, Guojie Xu, Jian S. Dai, Hongqiang Wang
Summary: By studying the combined softness-rigidity hybrid property of desert iguanas' skin, an anisotropic stiffness structure is developed, leading to the development of novel soft robots capable of various actions.
ADVANCED INTELLIGENT SYSTEMS
(2023)
Article
Biotechnology & Applied Microbiology
Ying-Ting Huang, Wen-Yu Wu, Fei-Yi Hung, Fa-Chuan Kuan, Kai-Lan Hsu, Wei-Ren Su, Chen-Wei Yen
Summary: Magnesium-matrix implants offer the advantage of being detected by X-ray for easier post-operative monitoring. Their similarity to human bones in terms of density and mechanical properties accelerates bone tissue recovery and regeneration while avoiding the stress-shielding effect. Furthermore, their biodegradability reduces the risk of infection and the financial burden of additional surgeries. However, the rapid degradation rate poses a challenge, which can be addressed through surface treatment. This study demonstrates that the adoption of a non-toxic and eco-friendly anodic oxidation method improves corrosion resistance and helps maintain mechanical properties.
BIOENGINEERING-BASEL
(2022)
Article
Chemistry, Physical
Wenyu Wu, Huaxin Ma, Zhao Zhang, Yu Gu, Jingjie Zhang, Shuo Li, Ruijun Zhang
Summary: This study presents the in-situ construction of porous carbon nanosheets with a unique polycrystalline-like micro-morphological feature. The carbon nanosheets exhibit a high specific surface area, excellent wettability to electrolytes, and a hierarchical micro- and meso-porous structure, providing abundant ion transport channels and accessible electrochemically active sites. The all-solid-state micro-supercapacitor built with these carbon nanosheets as the electrode material shows exceptional electrochemical performances, including an ultrahigh areal capacitance and energy density.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
