Article
Chemistry, Multidisciplinary
Ruizhi Hu, Chen Dai, Chunmei Wang, Jie Lin, Hui Hu, Zhifang Li, Han Lin, Li Ding, Yu Chen, Bo Zhang
Summary: By developing 2D arsenic-phosphorus (AsP) nanosheets, toxic arsenic is confined into AsP crystals, improving the biosafety and biocompatibility of arsenic-based chemotherapeutic drugs. AsP nanosheets exhibit high light absorption and strong photothermal-conversion efficiency in the second near infrared biowindow (NIR-II), enabling contrast-enhanced photoacoustic imaging and local tumor hyperthermia, leading to a synergistic arsenic-mediated antineoplastic effect.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Environmental
Hongshan Wang, Zhenzhen He, Qiangbin Yang, Guangyong Zeng, Zhaomei Yang, Shengyan Pu
Summary: In this study, MXene nanosheets were functionalized with sodium lignosulfonate (LS) and MoS2 nanosheets were intercalated between the functionalized MXene layers to fabricate a two-dimensional MXene membrane. This composite membrane exhibited high water permeation and excellent dye separation characteristics. It had a significantly higher pure water flux compared to the unfunctionalized MXene membrane and showed good rejection of dye molecules. The composite membrane also demonstrated low rejection of salts, leading to the mutual separation of dyes and salts. Additionally, the membrane displayed excellent stability and anti-fouling ability.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Marc Julian Kloberg, Haoyang Yu, Elisabeth Gross, Felix Eckmann, Tassilo M. F. Restle, Thomas F. Faessler, Jonathan G. C. Veinot, Bernhard Rieger
Summary: The study introduces a novel synthesis method for surface-anisotropic silicon quantum dots on a 2D silicon nanosheet, showing potential in self-assembly, microelectronics, and biology. By exposing only one side of the QDs and introducing two different functional groups, the unique optoelectronic properties of the SiQDs are retained. The anisotropic morphology is confirmed through the aggregation behavior of amphiphilic Janus SiQDs at the water-hexane interface, demonstrating the versatility of these nanoparticles.
ADVANCED MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Fei Wang, Zhao Zhang, Imran Shakir, Chengbing Yu, Yuxi Xu
Summary: This review explores the synthesis, membrane fabrication, and applications of 2D polymer nanosheets, highlighting their potential in membrane separation and suggesting future research directions.
Article
Chemistry, Physical
Selene Acosta, H. Joazet Ojeda-Galvan, Mildred Quintana
Summary: Hierarchically assembled 2D material membranes show great potential as platforms for energy conversion processes in nanofluidics. This perspective discusses recent advances in the production of smart 2D material membranes that mimic biological energy conversion processes, and their application in water purification systems, artificial photosynthesis, and solar energy conversion devices. By modulating the active sites, electron transport, mass transfer, and stability, these membranes aim to be cost-effective and highly efficient.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Mingcong Niu, Xiulian Gu, Jingyi Yang, Haoyu Cui, Xinyi Hou, Yue Ma, Chunhua Wang, Guangcheng Wei
Summary: Bacterial drug resistance poses a serious threat, necessitating the development of effective antibacterial drugs. This study focused on the design and synthesis of glycolipidpeptides with excellent antibacterial and immunomodulatory activities, which exhibited sustained-release properties and combined sterilization effects. The results demonstrate the potential applications of this research.
Article
Chemistry, Multidisciplinary
Mingcong Niu, Xiulian Gu, Jingyi Yang, Haoyu Cui, Xinyi Hou, Yue Ma, Chunhua Wang, Guangcheng Wei
Summary: Bacterial drug resistance is a serious issue, and the development of effective antibacterial drugs is urgently needed. Antimicrobial peptides (AMPs) show great potential as candidates for fighting bacteria. In this study, a series of AMPs with specific biological characteristics were designed and synthesized. Among them, the glycolipidpeptide GLP6 demonstrated excellent antibacterial and immunomodulatory activity, stability, biocompatibility, biofilm eradication, and membrane penetrating activity.
Article
Chemistry, Multidisciplinary
Michalis Stavrou, Aristeidis Stathis, Ioannis Papadakis, Alina Lyuleeva-Husemann, Emmanouel Koudoumas, Stelios Couris
Summary: This study reports on the transient nonlinear optical responses of two different types of 2D silicon nanosheets. The results demonstrate the importance of chemical functionalization for the efficient enhancement and tailoring of the NLO properties of these Si-based materials, and reveal that the silicon nanosheets exhibit larger NLO responses compared to graphene nanosheets.
Article
Chemistry, Physical
Yujie Li, Yuanyuan Liu, Danning Xing, Jiajia Wang, Liren Zheng, Zeyan Wang, Peng Wang, Zhaoke Zheng, Hefeng Cheng, Ying Dai, Baibiao Huang
Summary: The research found that BiVO4 ultrathin nanosheets can simultaneously disintegrate pure water into hydrogen and oxygen under simulated solar light irradiation without sacrificial reagents. A novel 2D/2D BiVO4/Ti3C2 composite was successfully synthesized through electrostatic interaction, showing higher photoexcited carrier transfer and separation efficiency for remarkable photocatalytic overall water splitting activity.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2021)
Article
Engineering, Chemical
Han-zhuo Ding, Fei Xie, Zi-yin Wang, Wei Huang, Xiao-hua Ma, Zhen-liang Xu
Summary: Electrospray-assisted interfacial polymerization combined with 2D molybdenum disulfide nanosheets can improve the selectivity and performance of polyamide membranes. The optimized membrane shows high water permeance and Na2SO4 rejection, along with excellent stability and antifouling properties.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Engineering, Environmental
Gancheng Zuo, Yuting Wang, Wei Liang Teo, Aming Xie, Yang Guo, Yuxuan Dai, Weiqiang Zhou, Deblin Jana, Qiming Xian, Wei Dong, Yanli Zhao
Summary: In this study, hierarchical 2D-Bi2MoO6@2D-MXene nanohybrid was successfully fabricated by growing Bi2MoO6 nanosheets on the surface of MXene nanosheets, which suppressed the agglomeration of Bi2MoO6 and maximized the exposed activity sites. The Schottky heterojunction derived from MXene not only promoted photoinduced electron transport but also limited photoexcited electron-hole recombination, leading to enhanced visible-light photocatalytic water oxidation activity.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Chemical
Tao Liu, Jiashu Yuan, Yihan Zhen, Cuijuan Zhang, Yongdan Li
Summary: A new porous poly(vinylidene fluoride) (PVDF) membrane with 2D vermiculite nanosheets modification is proposed and prepared to improve the performance of non-aqueous redox flow batteries. The resultant battery constructed with the new porous membrane exhibits higher Coulombic efficiency and large average discharge capacity.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Engineering, Chemical
Biao Li, Juanjuan Peng, Menghan Li, Zeya Yang, Jun Lu, Jingbin Han
Summary: Researchers have developed a scalable method for synthesizing micro-sized nitrate ZnAl layered double hydroxide (LDH) and subsequent exfoliating to yield monolayer nanosheets for the construction of 2D membranes, overcoming the challenges posed by the negatively-charged and easily-swellable properties of 2D membranes in water for Li/Mg ion separation.
Review
Chemistry, Multidisciplinary
Lifang Ma, Xinran Song, Yongchun Yu, Yu Chen
Summary: Silicon-composed 2D silicene/silicon nanosheets with unique planar nanostructure, large surface area, and abundant surface chemistry are emerging for versatile biomedical applications, including tumor theranostics and antibacterial treatments. These nanosheets exhibit desirable photothermal-conversion performance and good biodegradability and biocompatibility, making them promising for clinical translations in the future.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yuvasri Genji Srinivasulu, Anbu Mozhi, Nirmal Goswami, Qiaofeng Yao, Jianping Xie
Summary: Nanomaterial-based antimicrobial photodynamic therapy shows promise in eradicating drug-resistant bacterial biofilms. This study presents a new nanocomposite design that generates higher levels of reactive oxygen species and effectively kills bacteria. Furthermore, the nanocomposite exhibits improved penetration and elimination of biofilms, demonstrating the efficacy of a synergistic killing mechanism.
MATERIALS CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Min Ge, Haiyan Guo, Ming Zong, Zhixin Chen, Zhuang Liu, Han Lin, Jianlin Shi
Summary: This study demonstrates the potential of surface chemical engineering to broaden the band gap of 2D germanene, enabling it to be used as a novel inorganic photosensitizer for singlet oxygen photodynamic therapy. The H-germanene nanosheets show a substantially enlarged band gap and favorable biodegradability, indicating their potential in cancer treatment.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Biomedical
Ni Ni, Min Ge, Rui Huang, Dandan Zhang, Han Lin, Yahan Ju, Zhimin Tang, Huiqin Gao, Huifang Zhou, Yu Chen, Ping Gu
Summary: Bone healing is a complex process involving the recruitment of cells, revascularization, and osteogenic differentiation. Insufficient osteoblast cells, poor blood supply, and limited bone induction at the site of critical-sized bone defect hinder bone repair. To address this issue, SiO2-silicene@AIPH nanoparticles were designed to efficiently promote bone repair through controlled near-infrared irradiation. These nanoparticles stimulated cellular activities, including proliferation and angiogenesis, and promoted osteogenic differentiation. In a rat cranial defect model, the engineered nanoparticles demonstrated remarkable bone repair efficiency. This bionic-oriented strategy offers a new perspective for the application of cell-instructive biomaterials in bone tissue engineering.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Oncology
Chen Shen, Xin Jiang, Mei Li, Yao Luo
Summary: Hepatocellular carcinoma (HCC) is a global health challenge caused by hepatitis virus infection. Hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis D virus (HDV) are major risk factors for HCC development. This review discusses the mechanisms by which these viruses induce HCC and presents new diagnostic and therapeutic approaches. The potential relationship between hepatitis E virus (HEV) and HCC is also considered.
Article
Chemistry, Multidisciplinary
Yanling You, Ya-Xuan Zhu, Junjie Jiang, Zhixin Chen, Chenyao Wu, Zhimin Zhang, Han Lin, Jianlin Shi
Summary: In this study, a new two-dimensional iodine nanomaterial called iodinene was proposed for the treatment of infectious diseases in vivo. Iodinene demonstrated enhanced antibacterial efficacy against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa by in situ production of active HIO and I2 molecules via allotropic transformation. The in vivo results further confirmed the desirable antibacterial efficacy of iodinene in treating bacterial wound infection and pneumonia.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Ya-Xuan Zhu, Yanling You, Zhixin Chen, Deliang Xu, Wenwen Yue, Xinxin Ma, Junjie Jiang, Wencheng Wu, Han Lin, Jianlin Shi
Summary: In this study, a copolymer-modified two-dimensional H-silicene nanomaterial was developed to help probiotics adapt to different gastrointestinal microenvironments. The material can resist acidic destruction in the stomach and generate anti-inflammatory hydrogen gas in the intestine, thus alleviating colitis. This strategy holds great significance for the development of intelligent self-adaptive materials.
Article
Chemistry, Multidisciplinary
Yao Luo, Xin Jiang, Rong Zhang, Chen Shen, Mei Li, Zhenzhen Zhao, Mengyuan Lv, Shengjun Sun, Xuping Sun, Binwu Ying
Summary: Aptamer-functionalized MXene nanosheet is used as a novel bionanosensor for the sensitive and rapid detection of COVID-19. The sensor can detect SARS-CoV-2 spike protein and pseudovirus within 30 minutes, with high sensitivity and specificity. Its successful application for clinical sample analysis is also demonstrated.
Article
Immunology
Lanyang Gao, Lei Zhu, Chen Shen, Xiaoming Hou, Youyou Chen, Linglin Zou, Huiyan Qiang, Alexander T. Teichmann, Wenguang Fu, Yao Luo
Summary: 4-OHA cream can effectively inhibit the growth of breast cancer, with similar anti-tumor effects as its injection formulation. It can also enhance immune cell infiltration in mammary tumor tissues, suggesting its potential value in neoadjuvant treatment of ER+ breast cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Chen Shen, Mei Li, Yujuan Duan, Xin Jiang, Xiaoming Hou, Fulai Xue, Yinan Zhang, Yao Luo
Summary: Hepatocellular carcinoma (HCC) is a common liver cancer with poor prognosis and increasing incidence globally. Immunotherapy has been considered as an ideal approach for HCC treatment and is changing patient management. However, immunotherapy resistance hinders the effectiveness of current therapies for some HCC patients. Recent studies have shown that histone deacetylase inhibitors (HDACis) can enhance the efficacy of immunotherapy in various tumors, including HCC. This review discusses the current understanding and recent advances in immunotherapy-based and HDACi-based treatments for HCC, highlighting the synergistic effects of these therapies and efforts to translate this knowledge into clinical benefits. Additionally, the potential of nano-based drug delivery systems (NDDS) as a novel strategy to enhance HCC treatment is explored.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Deliang Xu, Min Ge, Ming Zong, Chenyao Wu, Zhixin Chen, Zhimin Zhang, Ya-Xuan Zhu, Xiangyu Lu, Han Lin, Jianlin Shi
Summary: By controllably synthesizing and properly decorating mesoporous silica nanoparticles, the destruction to the vascular system can be minimized and the effects on tumor metastasis can be reduced. The synthesized nanoparticles effectively prevent cancer cell migration upon intracellular endocytosis, demonstrating high biocompatibility and safety for nanomedicine use.
Article
Biochemistry & Molecular Biology
Yalan Zhu, He Zhang, Pengjun Jiang, Chengxia Xie, Yao Luo, Jie Chen
Summary: Non-alcoholic fatty liver disease (NAFLD) includes a range of conditions from simple steatosis (non-alcoholic fatty liver (NAFL)) to non-alcoholic steatohepatitis (NASH), and its global prevalence is increasing. A diagnostic model was developed based on the transcriptome and epigenome to differentiate NASH from NAFL. The logistic regression (LR) model, consisting of ApoF, THOP1, and BICC1, performed the best with high accuracy and sensitivity. This study provides potential mechanisms for NAFLD progression and a useful tool for patient stratification.
Article
Engineering, Biomedical
Mingqi Chen, Yucui Shen, Yinying Pu, Bangguo Zhou, Jinhong Bing, Min Ge, Yaxuan Zhu, Shuang Gao, Wencheng Wu, Min Zhou, Jianlin Shi
Summary: This study reports a novel biomimetic ferroptosis inducer capable of regulating the immunosuppressive tumor microenvironment for enhanced cancer ferroptosis immunotherapy. The inducer triggers both cancer cell and TAMs ferroptosis, activating the anticancer immune response and favoring the normalization of the tumor microenvironment.
Article
Food Science & Technology
Shiyao Huang, Ziming Wu, Youyou Chen, Han Li, Linglin Zou, Alexander T. Teichmann, Yao Luo, Lifeng Zhang, Lanyang Gao
Summary: Formestane (4-OHA) has been proven effective in treating ER+ breast cancer, but its intramuscular administration and associated side effects make it unsuitable for adjuvant treatment. Formestane cream may offer a convenient solution with retained tumor-shrinking effects, suggesting its promising clinical applications.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Wenqiang Li, Mei Li, Qian Huang, Xiaoyu He, Chen Shen, Xiaoming Hou, Fulai Xue, Zhiping Deng, Yao Luo
Summary: Lung cancer is a leading cause of cancer-associated death worldwide, with non-small cell lung cancer being the most common type. The mechanisms of non-small cell lung cancer evolution involve complex alterations of multiple signaling pathways. Despite advances in understanding and treatment, there are still many challenges in treating non-small cell lung cancer. Nanoparticles have shown great potential in the diagnosis and treatment of tumors, delivering drugs to regulate specific molecular signaling pathways. This review summarizes the recent advances in therapeutic targets and nanoparticle-based drug delivery systems in non-small cell lung cancer, and presents future prospects and challenges.
FRONTIERS IN CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Huan Xu, Yingying Liu, Yinan Zhang, Xinhua Dai, Xueqiao Wang, Haojun Chen, Lin Yan, Xingxin Gong, Jiaxi Yue, Zhengli Wan, Jiwen Fan, Yangjuan Bai, Yao Luo, Yi Li
Summary: The study developed a method to quantify the concentrations of Tacrolimus and Mycophenolic acid in peripheral blood mononuclear cells (PBMCs) using liquid chromatography tandem mass spectrometry. The concentrations were measured in renal transplant recipients and were found to have a weak correlation with whole blood concentrations. The proposed method provides clinically reliable information on drug concentration at an active site, but further research is needed to study its application in adverse outcomes of renal transplant.
Article
Chemistry, Multidisciplinary
Yao Luo, Min Yin, Chunlan Mu, Xingjie Hu, Hui Xie, Jingyi Li, Tingting Cao, Nan Chen, Ji Wu, Chunhai Fan
Summary: This study developed a nanocomplex, Pdot-siRNA, based on semiconductor polymer dots for effective gene knockdown in female germline stem cells (FGSCs). The high fluorescence brightness of Pdots was utilized for comprehensive investigation of their cellular uptake, intracellular trafficking, and exocytosis in FGSCs. Furthermore, Pdots demonstrated excellent biocompatibility and minimal disturbance to FGSCs differentiation. The intracellular Pdots could escape from lysosomes and undergo active exocytosis, making them ideal nanocarriers for bioactive cargos. Additionally, Pdot-siRNA could penetrate into 3D ovarian organoids derived from FGSCs and down-regulate the expression levels of target genes. This study sheds light on the manipulation and medical application of FGSCs and explores the interface between theranostic nanoparticles and FGSCs for the first time.
ADVANCED MATERIALS
(2023)