Article
Engineering, Environmental
Daifeng Li, Chi Zhang, Xiaoyan Tai, Denghui Xu, Jianzhong Xu, Pengfei Sun, Quli Fan, Zhen Cheng, Yi Zhang
Summary: This study developed a novel nanoplatform, P2NPs, with strong photothermal therapy and dual-modal optical tracking capabilities. In vitro and in vivo experiments demonstrated the potential of this platform in the treatment of osteosarcoma.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Physical
Siyu Lu, Liru Xue, Meng Yang, Jingjing Wang, Yang Li, Yuxin Jiang, Xuechuan Hong, Mingfu Wu, Yuling Xiao
Summary: Ovarian cancer is often diagnosed in the middle or late stages due to the lack of specific initial diagnostic methods. Dual-modal near-infrared II fluorescence/photoacoustic imaging shows great potential in early ovarian cancer diagnosis and image-guided surgery. A novel organic NIR-II dye and water-soluble nanoparticles were developed for targeted imaging and surgery, improving the early detection and prognosis of ovarian cancer.
Article
Engineering, Biomedical
Yaxi Li, Dehong Hu, Zonghai Sheng, Tianliang Min, Menglei Zha, Jen-Shyang Ni, Hairong Zheng, Kai Li
Summary: In recent decades, research on fluorogens with aggregation-induced emission (AIEgens) has been intensively conducted with a focus on biomedical applications. One efficient strategy involves designing amphiphilic AIEgens that can self-assemble into uniform nanoparticles for high-resolution intravital vascular fluorescence imaging with a significant penetration depth.
Article
Chemistry, Applied
Guangzhao Yang, Yi Wang, Shan Zhou, Lu Chen, Yang Chen, Yu Liu, Xin Liang, Chao Yin, Hui Zhou, Quli Fan
Summary: Fluorescence imaging in the second near-infrared (NIR-II) window is a promising method for cancer diagnosis due to its deep penetration depth and high signal to background ratio. The integration of NIR-II imaging and NIR-II photothermal therapy (PTT) has great potential in biomedical research and preclinical practice. Semiconducting polymers with easily tunable optical properties, high photostability, and reliable biocompatibility have advantages, but most formed using nanoprecipitation have high accumulation in reticulum endoplasmic system (RES) and maximum absorption in the first near-infrared (NIR-I) window. Developing new NIR-II emissive semiconducting polymer nanoparticles (SPNs) that can be triggered by NIR-II light for deep tissue PTT is required.
Article
Pharmacology & Pharmacy
Xiaodong Zeng, Yuqin Liao, Xue Qiao, Ke Liang, Qiusi Luo, Mingbo Deng, Yishen Liu, Weijing Zhang, Xuechuan Hong, Yuling Xiao
Summary: Biliary atresia is a rare infant disease with challenging early diagnosis. A novel NIR-II fluorescence probe has been developed for efficient early diagnosis using simple fecal samples.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Chemistry, Multidisciplinary
Sara F. F. Almeida, Alexandra Fonseca, Jose Sereno, Hugo R. S. Ferreira, Mariana Lapo-Pais, Tania Martins-Marques, Teresa Rodrigues, Rui C. Oliveira, Catarina Miranda, Luis P. Almeida, Henrique Girao, Amilcar Falcao, Antero J. Abrunhosa, Celia M. Gomes
Summary: This study develops an imaging tool using exosomes derived from osteosarcoma cells as natural nanocarriers for the noninvasive detection of lung micrometastasis. The results demonstrate that these exosomes accumulate specifically in metastatic lesions and primary tumors in vivo, showing excellent targeting ability. Optical imaging using exosomes is also able to detect lung metastasis. These findings suggest that tumor-derived exosomes have great potential as targeted imaging agents for the noninvasive detection of small lung metastasis using PET.
Article
Chemistry, Multidisciplinary
Keng-Fang Hsu, Shih-Po Su, Hsiu-Feng Lu, Ming-Ho Liu, Yuan Jay Chang, Yi-Jang Lee, Huihua Kenny Chiang, Chao-Ping Hsu, Chin-Wei Lu, Yang-Hsiang Chan
Summary: The study presents the design of NIR-II emissive semiconducting polymer dots (Pdots) incorporated with thermally activated delayed fluorescence (TADF) moieties, which exhibit emission maxima of 1064-1100 nm and fluorescence quantum yields of 0.40-1.58% in aqueous solutions. By conducting density-functional theory calculations, the researchers gain a better understanding of how the TADF units affect the molecular packing and resulting optical properties of Pdots. In vivo 3D bone imaging in mice demonstrates the promising applications of these Pdots.
Article
Materials Science, Biomaterials
Yan Chen, Bo Sun, Xinyue Jiang, Zhangyu Yuan, Shangyu Chen, Pengfei Sun, Quli Fan, Wei Huang
Summary: This study successfully designed and developed three double-acceptor conjugated polymers, fabricated corresponding nanoparticles, and ultimately selected P1 NPs as nanoparticles with high NIR-II fluorescence intensity and superior NIR-II photothermal efficiency, which were effectively applied for tumor diagnosis and treatment.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Dandan Chen, Ye Liu, Zhe Zhang, Zhihe Liu, Xiaofeng Fang, Shuqing He, Changfeng Wu
Summary: The study found that nanoparticles not only accumulate in organs such as the liver, spleen, and kidney, but also in the bone as an important storage organ. The distribution of nanoparticles in bone is closely related to their size, with small nanoparticles around 15 nm diameter accumulating and being retained in bone, while larger nanoparticles over 25 nm are mainly distributed in the liver.
Article
Chemistry, Multidisciplinary
Diankai Liu, Zixu He, Yanyan Zhao, Yuantao Yang, Wen Shi, Xiaohua Li, Huimin Ma
Summary: This study introduces a series of xanthene-based NIR-II dyes, named VIXs, with VIX-4 showing the best performance in terms of fluorescence emission at 1210 nm and high brightness. The dye has been successfully used for dynamically imaging the blood flow of mice, allowing for direct differentiation between arteries and veins and measurement of blood flow volume through videos. The study not only provides an effective tool for high spatial and temporal resolution bioimaging, but also presents a new promising conjugated skeleton for NIR-II dyes.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Deling Li, Hui Shi, Qingrong Qi, Baisong Chang, Yuanwen Jiang, Kun Qian, Xiudong Guan, Peng Kang, Ning Ma, Yuan Zhang, Zeyu Zhang, Xiaojing Shi, Chunrong Qu, Yilei Wu, Weiyu Chen, Hao Chen, Baowang Li, Liangpeng Chen, Ziyang Li, Shunchang Ma, Lingyun Xu, Yanrong Zhang, Jie Tian, Zhenhua Hu, Wang Jia, Zhen Cheng
Summary: Benzyl Violet 4B (BV-4B) is discovered as a novel solid-state dye in the NIR-II window and can be used for non-invasively monitoring the fate of medical devices in the human body. It can diagnose the rupture of BV-4B-coated silicone catheter and guide fluorescence-guided surgery for arteriovenous malformation with embolization glue.
Article
Engineering, Environmental
Xiaoding Cheng, Chong Zhang, Kun Shen, Huifan Liu, Caihong Bai, Qihang Ding, Mengting Guan, Junzhu Wu, Zhiquan Tian, Deliang Chen, Lin Cai, Xuechuan Hong, Yuling Xiao
Summary: This study evaluates a unique strategy using a NIR-II fluorescent photosensitizer in combination with a DDR inhibitor to improve the therapeutic efficacy of osteosarcoma treatment. The results demonstrate that this strategy significantly enhances anti-tumor effects and has good bioavailability with low toxicity.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Multidisciplinary Sciences
Kang Li, Xingchen Duan, Zhiyong Jiang, Dan Ding, Yuncong Chen, Guo-Qiang Zhang, Zhipeng Liu
Summary: J-aggregation has been shown to be an effective strategy for developing fluorescent imaging agents in the NIR-II spectral region. However, designing suitable J-aggregates remains challenging. This study demonstrates the J-aggregation of a BODIPY dye with NIR-II emission and its application in lymph node imaging for fluorescence-guided surgery.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Qi Wang, Xinmin Zhang, Youguang Tang, Yanwei Xiong, Xu Wang, Chunlai Li, Tangxin Xiao, Feng Lu, Mengze Xu
Summary: By designing and synthesizing carboxyl-functionalized organic photothermal molecules and multi-layered rare-earth-doped nanoparticles, a high-performance hybrid phototheranostic nanoagent was constructed. This nanoagent exhibited high absorption at 1064 nm, large photothermal conversion efficiency, good NIR-IIb emission, and great photostability. It can efficiently kill tumor cells and realize in vivo angiography and tumor detection.
Article
Polymer Science
Yaojun Li, Jingtao Ye, Yang Li, Minling Jiang, Tingyu Shi, Huayu Qiu, Shouchun Yin
Summary: In this study, a nitrilation strategy is proposed to design photothermal agents with high fluorescence quantum yield and good photothermal conversion ability. Experimental results show that after nitrilation, the photothermal conversion efficiency and fluorescence quantum yield of nanoparticles are significantly enhanced, and both biological safety and cellular internalization ability are improved. These characteristics enable the nanoparticles to support high-resolution near-infrared second window fluorescence imaging/photoacoustic imaging-guided photothermal therapy in vivo.
Article
Chemistry, Multidisciplinary
Lu Zhang, Xian-meng Li, Xu-he Shi, Kai Ye, Xue-li Fu, Xue Wang, Shi-man Guo, Jia-qi Ma, Fei-fei Xu, Hui-min Sun, Qian-qian Li, Wei-ying Zhang, Li-hong Ye
Summary: HBXIP prevents sorafenib-induced cell death in hepatocellular carcinoma and attenuates ferroptosis.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Rheumatology
Jun Li, Suli Wang, Jiayi Zheng, Qianqian Li, Jia Li, Liangjing Lu
Summary: This study investigated the risk of PJP in newly diagnosed MDA5 + DM patients within 6 months and found a high incidence and mortality rate in these patients, with certain treatment methods being associated with a higher risk.
CLINICAL RHEUMATOLOGY
(2023)
Letter
Rheumatology
Hanlin Yin, Bei Liu, Qianqian Li, Qingran Yan, Liangjing Lu
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Chemistry, Applied
Yu Huang, Chunyuan Liang, Yueling Cai, Yi Zhou, Bingkun Guo, Jipeng Cheng, Heguang Liu, Peng Wang, Qianqian Li, Anmin Nie, Hongtao Wang, Jinsong Wu, Tongyi Zhang
Summary: The fundamental reaction behaviors of nickel sulfide (NixSy) as lithium-ion battery anodes were investigated using in-situ TEM. Ni3S2 was found to be the electrochemically stable phase. During lithiation, NixSy nanoparticles evolved into a mixture of Ni nanocrystals embedded in Li2S matrix, forming a porous structure. In delithiation, the Ni3S2 phase recrystallized to form a compact and interconnected network. Carbon substrate improved the tolerance for size-dependent pulverization of NixSy nanoparticles. This work enhances the understanding of electrochemical reaction behavior and aids in the rational design of high-energy density battery anodes.
JOURNAL OF ENERGY CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Wenkang Miao, Ronghui Hao, Jingzhou Wang, Zihan Wang, Wenxin Lin, Heguang Liu, Zhenjie Feng, Yingchun Lyu, Qianqian Li, Dongling Jia, Runhai Ouyang, Jipeng Cheng, Anmin Nie, Jinsong Wu
Summary: Non-noble metal catalysts have been successfully designed for the hydrogenation of CO2, with high conversion activity and stability. The reversible regeneration mechanism of catalytic activity has been revealed. This study is of great significance for rational structure design and improving catalyst performance.
Review
Chemistry, Multidisciplinary
Yang Zhou, Qianqian Li, Ye Wu, Xinyu Li, Ya Zhou, Zhu Wang, Hui Liang, Feiqing Ding, Sheng Hong, Nicole F. Steinmetz, Hui Cai
Summary: Self-assembly is a widely used method for constructing biomaterials, and peptides have been extensively investigated due to their desirable properties. Stimuli-responsive peptide nanoparticles, capable of conformational and chemical changes in response to stimuli, have emerged as a promising class of materials with diverse biomedical applications.
Article
Chemistry, Physical
Ronghui Hao, Wenkang Miao, Qiling Xiao, Zihan Wang, Wanyin Xu, Tianzhong Wang, Qianqian Li, Peng Wang, Anmin Nie, Hongtao Wang
Summary: This study reports the oxidation pathways of TiN with different grain sizes through careful atomic structure characterization. Nano-sized TiN single crystal undergoes a two-step phase transformation, while micron-sized TiN single crystal or polycrystals directly convert to rutile TiO2 upon oxidation. N2 nanobubbles are generated in the micron-sized TiN oxidation process, which preferentially embed inside of rutile TiO2 grain boundaries for single crystals and the oxide/nitride interface for polycrystals. The oxidation induces great volume expansion in all types of TiN, but only micron-sized single crystals are fractured and pulverized dramatically, impairing the mechanical properties.
APPLIED SURFACE SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Yu-Ting Xiong, Jian-Fei Wang, Xiao-Xia Niu, Yi-Ming Fu, Ke-Xin Wang, Chun-Yan Wang, Qian-Qian Li, Jian-Jun Wang, Jun Zhao, Dong Ji
Summary: Clinical characteristics and risk factors associated with the severity of drug-induced liver injury (DILI) in elderly patients were identified. The presence of autoimmunity was found to be associated with a more serious state of DILI.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Qianqian Li, Wenyi He, Weiran Li, Shulu Luo, Minghong Zhou, Dingcai Wu, Yan Li, Shuyi Wu
Summary: In guided bone regeneration surgery, a new class of local double-layered adhesive barrier membranes (ABMs) has been developed to immobilize bone graft materials. These ABMs have suction-adhesion properties and can firmly adhere to wet bone surfaces, effectively preventing displacement and leakage. This versatile strategy may open up new avenues for designing next-generation barrier membranes.
Article
Immunology
Ruixin Song, Chao Yang, Qianqian Li, Jiayin Wang, Jing Chen, Kai Sun, Hongmin Lv, Yankai Yang, Jing Liang, Qing Ye, YanYing Gao, Jun Li, Ying Li, Junqing Yan, Ying Liu, Tao Wang, Changen Liu, Ping Zhu, Fei Wang, Weili Yin, Huiling Xiang
Summary: The aim of this study was to evaluate the durability of immune response after basic and booster immunization with SARS-CoV-2 vaccines in patients with chronic liver disease (CLD). The results showed that the positive rates of antibodies decreased rapidly with the extension of vaccination time after basic immunization, while the positive rates increased rapidly and remained high after booster immunization. Thus, booster immunization improved the immune response and significantly prolonged the durability of SARS-CoV-2 antibodies in patients with CLD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Qingran Yan, Mei Zhang, Fang Du, Yuening Kang, Ping Ye, Qianqian Li, Bei Liu, Min Dai, Chunde Bao
Summary: This prospective study evaluated the efficacy and safety of IGU as an add-on therapy for patients with refractory lupus nephritis. The results showed that IGU, as a component of combination therapy, can effectively reduce urine protein and is well tolerated.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Agricultural Engineering
Qianqian Li, Chaoyang Zhang, Huawei Wang, Shengfan Chen, Wei Liu, Yi Li, Jianxun Li
Summary: It is important to evaluate vine tea comprehensively by considering both high content quality-related compounds and trace-level volatile compounds. NIR and GC-MS technologies were used for grade discrimination, and machine learning methods of random forest and PLS-DA were employed to construct a tea grade discrimination platform. The results showed that the mid-level fusion combined with random forest achieved impressive performance in terms of balanced matrix, efficient features, and discriminant ability.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Chemistry, Multidisciplinary
Shuoshuo Li, Wenyu Hu, Shenghui Gong, Ping Zhang, Jinbo Cheng, Shukun Wang, Yingyi Wang, Wenjun Shi, Qianqian Li, Fengchao Wang, Zengqiang Yuan
Summary: High altitude exposure leads to cognitive impairments by affecting the cerebral vasculature system and reducing oxygen and nutrition supply to the brain. The study investigates the molecular mechanism of vascular system remodeling under acute hypoxia and identifies a novel m6A reader protein, PRRC2B, in endothelial cells. Knockdown of PRRC2B promotes hypoxia-induced endothelial cell migration and vascular remodeling, alleviating hypoxia-induced cognitive decline. These findings provide a new potential therapeutic target for hypoxia-induced cognitive impairments.
Article
Computer Science, Interdisciplinary Applications
Qianqian Li, Jingqi Zeng, Lijuan Ma, Jinyuan Zhu, Fangyu Zhang, Yunan Wei, Mingshuang Li, Lu Yao, Jing Du, Zhisheng Wu
Summary: In this study, an industrial information integrated strategy was proposed to address the OQC evaluation issue of Chinese meteria medica (CMM) from multi-batch in the complex system of big honeyed pill. The strategy consisted of a two-step digital process control and an OQC diagnosis strategy. The two-step digital control utilized online near infrared (NIR) monitoring to acquire critical quality attributes (CQAs) and control consistency from honey refining to He-Tuo procedure. The OQC diagnosis strategy utilized data fusion approach to determine multi-batch OQC from different perspectives. The information integrated strategy successfully identified three abnormal samples out of 30 batches with weights of 27.82%, 44.60%, and 27.58% for NIR, mid-infrared (MIR), and texture technologies, respectively. The diagnosed samples were also tested using zebrafish efficacy as an in vivo test, which demonstrated the effectiveness of the OQC diagnosis strategy. Overall, the proposed information integrated strategy provides important theoretical and practical foundations for ensuring the overall quality of multi-batch CMM, especially for digital and intelligent industrialization.
JOURNAL OF INDUSTRIAL INFORMATION INTEGRATION
(2023)
Article
Chemistry, Physical
Hailin Shen, Yueling Cai, Zhongtao Ma, Peng Wang, Bingkun Guo, Jipeng Cheng, Qianqian Li, Hongtao Wang, Zhongyuan Liu, Anmin Nie, Jinsong Wu
Summary: The researchers report a metal phosphorous trichalcogenide of MnPS3 as a reliable and high-capacity anode material for lithium-ion batteries. It has a unique layered van der Waals structure and can enable fast insertion/extraction of ions.
