Article
Medicine, General & Internal
Yulei Ji, Qiaolin Zhang, Yang Song, Qiuli Hu, Gusztav Fekete, Julien S. Baker, Yaodong Gu
Summary: This study used finite element analysis to explore the biomechanical characteristics of two posterior bilateral pedicle screw fixation methods. The results showed that a smaller number of pedicle screw fixation can achieve similar stability as a larger number of fixation, and effectively reduce the stress on the screws and rods, reducing the risk of fracture. The 3D finite element model established in this study can serve as a reference for further studies on spinal column biomechanics.
Article
Clinical Neurology
Khalid Odeh, Alexander Rosinski, Jeremi Leasure, Dimitriy Kondrashov
Summary: This controlled laboratory study aimed to measure the total BMD, cortical volume, and cortical thickness in seven different anatomical regions of the lumbar spine using CT images. The results showed that the lamina and inferior articular process contained the highest total BMD and largest volumes of cortical bone.
GLOBAL SPINE JOURNAL
(2021)
Article
Medicine, General & Internal
Mateusz Bielecki, Przemyslaw Kunert, Artur Balasa, Slawomir Kujawski, Andrzej Marchel
Summary: The study evaluated the long-term follow-up results of patients with lumbar degenerative disease treated with CBTT, showing that over 90% of patients achieved clinical improvement at a mean follow-up of 4.4 years.
Review
Clinical Neurology
Min Cheol Chang, Yoo Jin Choo, Gun Woo Lee
Summary: Comparing traditional pedicle screws with cortical bone trajectory-pedicle screws in posterior lumbar fusion surgery, it was found that the cortical screw group had less blood loss and shorter operative time, with a lower total complication rate. However, these findings were based on limited, bias-prone retrospective studies.
Article
Orthopedics
Tzu-Tsao Chung, Chen-Lun Chu, Dueng-Yuan Hueng, Shang-Chih Lin
Summary: This study investigated how screw parameters affect the biomechanical properties and efficacy of traditional trajectory (TT) and cortical bone trajectory (CBT) screws. The results showed that the trajectory and diameter of the screws had a greater impact on the responses from the implant and tissues, with CBT having a larger contact length and supporting area within the cortical bone. TT and CBT were equally effective at stabilizing the instrumented segment, but CBT experienced less adjacent segment compensations.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Dermatology
Hanze Mao, Zhigang Wang, Qiang Li
Summary: A meta-analysis was conducted to compare the effects of cortical bone trajectory screw fixation (CBTSF) and traditional pedicle screw fixation (TPSF) on surgical site wound infection (SSWI) in posterior lumbar fusion (PLF). The analysis found no significant difference in SSWI between individuals using CBTSF and TPSF in PLF.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Orthopedics
Robert K. Eastlack, Pierce D. Nunley, Kornelis A. Poelstra, Alexander R. Vaccaro, Marcus Stone, Larry E. Miller, Pierre Legay, Julien Clin, Aakash Agarwal
Summary: This study used finite element analysis to compare the biomechanical properties of a novel posterior fixation device with a conventional pedicle screw system in lumbar fusion surgery. The results showed that the new device can effectively reduce the range of motion of the spine and provide comparable stability to the traditional screw system when used with different interbody devices.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Surgery
Alafate Kahaer, Xieraili Maimaiti, Julaiti Maitirouzi, Shuiquan Wang, Wenjie Shi, Nueraihemaiti Abuduwaili, Zhihao Zhou, Dongshan Liu, Abulikemu Maimaiti, Paerhati Rexiti
Summary: This study evaluated and compared the biomechanical properties of different hybrid fixation techniques at the L4-L5 segment using finite element models. The results showed that the hybrid MCBT-TT and TT-MCBT techniques had superior biomechanical performance in reducing ROM of L4-L5 segment, ROM of posterior fixation, intervertebral disc stress, and posterior fixation stress compared to stability-based MCBT-MCBT and TT-TT techniques.
FRONTIERS IN SURGERY
(2022)
Article
Surgery
Yiqi Zhang, Yue Li, Yong Hai, Li Guan, Xinuo Zhang, Aixing Pan, Hongyi Lu, Bingchao Wu, Yuzeng Liu
Summary: This study investigated the risk factors for screw loosening after single-level PLIF using CBT screw and established a nomogram for predicting screw loosening. The results identified fixed to S1, the coronal angle of the screw, and cortical bone contacted layers as significant risk factors for screw loosening. The nomogram showed good predictive accuracy and calibration, and can guide treatment decisions.
FRONTIERS IN SURGERY
(2022)
Article
Surgery
Xi-Nuo Zhang, Li-Jin Zhou, Qing-Jun Su, Li Guan, Dong-Yue Li, Bao-Qing Pei, Ai-Xing Pan, Hong-Hao Yang, Hong-Tao Ding, Yu-Zeng Liu, Yong Hai
Summary: This study evaluated the accuracy of cortical bone trajectory screw placement guided by spinous process clamp. Using 8 lumbar specimens, a total of 96 screws were implanted. The results showed that the SPC guide group had higher clinically acceptable placement and reduced severe deviations in important directions. Therefore, implanting CBT screws guided by SPC can improve surgical accuracy.
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2023)
Article
Surgery
Xi-nuo Zhang, Yi-qi Zhang, Yu-zeng Liu, Qing-jun Su, Li Guan, Dong-yue Li, Bao-qing Pei, Ai-xing Pan, Hong-hao Yang, Hong-tao Ding, Yong Hai, Li-jin Zhou
Summary: This study explores the accuracy of cortical screw placement with the use of an implanted spinous process clip guide. The results show that the SPC guide can achieve reliable execution for cortical screw placement compared to preoperative planning and actual inserted screws.
Article
Orthopedics
Ying Huang, Abulikemu Maimaiti, Yiming Tian, Zhengrong Li, Alafate Kahaer, Paerhati Rexiti
Summary: This study compared the biomechanical performance of the hybrid lumbar fixation technique with the traditional and cortical bone trajectory techniques using the finite element method. The results showed that the hybrid CBT-TT and TT-CBT techniques increased the biomechanical stability of the internal fixation structure of the lumbar fusion segment and provided a theoretical basis for further clinical development.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Orthopedics
Yongqiang Zeng, Zhiping Huang, Zucheng Huang, Yongquan Cheng, Qing'an Zhu, Wei Ji, Hui Jiang
Summary: UPS + CLS + LM technique is a reliable internal fixation method to provide sufficient immediate stability and promote postoperative bone fusion after resection of a dumbbell tumor in the cervical spine.
ORTHOPAEDIC SURGERY
(2023)
Article
Clinical Neurology
Gregory M. Mundis Jr, Eric C. Olsson, Robert A. Hart, Seth K. Williams, Ryan Martyn, Douglas G. Orndorff, Anastasia L. Berg, Nicholas A. Russell, Frank Vizesi
Summary: The study assesses the safety and accuracy of lateral mass screw placement using a new lateral mass drill guide instrument (LM Guide) compared to standard freehand technique. The LM Guide significantly reduces the rate of screw malpositioning and improves screw trajectory accuracy, regardless of surgeon experience level.
Article
Engineering, Biomedical
Marzieh Ovesy, Juan Diego Silva-Henao, James W. A. Fletcher, Boyko Gueorguiev, Philippe K. Zysset, Peter Varga
Summary: This study compared different methods in predicting the pullout force of 3.5 mm screws in human cadaveric tibial cortical bone, with results showing that the non-linear micro-FE models were more accurate in predicting the experimental outcomes.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Endocrinology & Metabolism
Alessandro Maria Berton, Filippo Gatti, Federica Penner, Emanuele Varaldo, Nunzia Prencipe, Francesca Rumbolo, Fabio Settanni, Valentina Gasco, Ezio Ghigo, Francesco Zenga, Silvia Grottoli
NEUROENDOCRINOLOGY
(2020)
Review
Clinical Neurology
Apurva Pande, Nayan Lamba, Marco Mammi, Paulos Gebrehiwet, Alyssa Trenary, Joanne Doucette, Stefania Papatheodorou, Adomas Bunevicius, Timothy R. Smith, Rania A. Mekary
Summary: There was no significant difference in failure rate between ETV and VPS in patients with hydrocephalus, but ETV had lower complication rates in prospective cohort studies. Further research is needed to identify which specific patient populations may benefit more from one intervention over the other.
NEUROSURGICAL REVIEW
(2021)
Article
Endocrinology & Metabolism
F. Penner, S. Grottoli, M. M. R. Lanotte, D. Garbossa, F. Zenga
Summary: This paper illustrates the feasibility of pituitary region surgery during the SARS-CoV-2 pandemic. The results showed that neither healthcare providers nor patients developed Covid symptoms, indicating that the described method is effective and safe for this high-risk non-urgent surgery.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Review
Biochemistry & Molecular Biology
Andrea Lavorato, Stefania Raimondo, Marina Boido, Luisa Muratori, Giorgia Durante, Fabio Cofano, Francesca Vincitorio, Salvatore Petrone, Paolo Titolo, Fulvio Tartara, Alessandro Vercelli, Diego Garbossa
Summary: The study discusses the features and applications of different types of mesenchymal stem cells in peripheral nerve regeneration after nerve injury. ADSCs are considered the most suitable MSCs for recovery from peripheral nerve lesions due to their excellent support and stimulation of axonal growth, remarkable paracrine activity, differentiation potential, low immunogenicity, and high survival rate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Alessandra Costanza, Francesco Zenga, Roberta Ruda, Andrea Amerio, Andrea Aguglia, Gianluca Serafini, Mario Amore, Guido Bondolfi, Isabella Berardelli, Khoa Dinh Nguyen
MEDICINA-LITHUANIA
(2020)
Article
Environmental Sciences
Alessandra Costanza, Michalina Radomska, Francesco Zenga, Andrea Amerio, Andrea Aguglia, Gianluca Serafini, Mario Amore, Isabella Berardelli, Yasutaka Ojio, Khoa D. Nguyen
Summary: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease caused by repetitive brain injuries, often seen in contact sports, which can lead to suicidal behavior. Two cases of retired professional athletes in high contact sports with similar clinical trajectories and severe suicidal behavior were reported. The findings can help improve the identification of CTE patients and provide mechanistic insights for the prevention of potential severe suicidal behavior.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Neurosciences
Daniele Bongetta, Fulvio Tartara, Fabio Pagella, Teresa Somma, Marilou Cavaliere, Giuseppe Di Perna, Francesco Zenga, Fabio Cofano, Diego Garbossa, Cesare Zoia
Summary: The use of fluorescent agents in pituitary surgery has the potential to improve surgical outcomes, with ICG and fluorescein showing the most promising results in differentiating pathological tissue. However, further studies are needed to optimize their use.
Letter
Clinical Neurology
Fabio Colano, Giuseppe Di Perna, Fulvio Tartara, Nicola Marengo, Marco Ajello, Marco Bozzaro, Francesco Zenga, Diego Garbossa
WORLD NEUROSURGERY
(2021)
Article
Neurosciences
Francesco Maria Calamo Specchia, Matteo Monticelli, Pietro Zeppa, Andrea Bianconi, Francesco Zenga, Roberto Altieri, Beatrice Pugliese, Giuseppe Di Perna, Fabio Cofano, Fulvio Tartara, Luca Bertero, Paola Cassoni, Antonio Melcarne, Michele Maria Lanotte, Diego Garbossa
Summary: Despite aggressive multimodal treatment, glioblastoma (GBM) remains a challenge for neurosurgeons. Surgical approach is crucial for GBM therapeutic management, and the use of photodynamic molecules may improve resection extent. Study shows different molecular assets of GBM may result in varied fluorescence expression, implying further research is needed to understand GBM cell metabolic activity better.
Review
Clinical Neurology
Fabio Cofano, Giuseppe Di Perna, Daria Bongiovanni, Vittoria Roscigno, Bianca Maria Baldassarre, Salvatore Petrone, Fulvio Tartara, Diego Garbossa, Marco Bozzaro
Summary: This review analyzed the impact of obesity on outcomes after spine surgery, finding that although obese patients may experience more peri-operative complications, the use of MIS techniques can reduce surgical risks and improve surgical satisfaction.
GLOBAL SPINE JOURNAL
(2022)
Article
Clinical Neurology
Fabio Cofano, Francesco Langella, Salvatore Petrone, Alice Baroncini, Riccardo Cecchinato, Andrea Redaelli, Diego Garbossa, Pedro Berjano
Summary: This study evaluated the clinical and mechanical performance of indirect decompression with ALIF in L5-S1 foraminal stenosis. The results showed that ALIF significantly increased foraminal height and posterior disc height, improved radicular pain, and these increases were directly associated with pain improvement.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Clinical Neurology
Vittorio Sancipriano, Federica Penner, Fabio Cofano, Marco Ajello, Nicola Marengo, Salvatore Petrone, Francesco Zenga, Manuela Crobeddu, Andrea Bianco, Christian Cossandi, Diego Garbossa
Summary: This study investigates the impact of intraoperative computed tomography (iCT) on the accuracy of C1-C2 screw positioning and proposes a multiparametric scoring system. The results show that the introduction of iCT is associated with a significant improvement in screw placement accuracy.
WORLD NEUROSURGERY
(2022)
Article
Surgery
Salvatore Petrone, Fabio Cofano, Federico Nicolosi, Giannantonio Spena, Marco Moschino, Giuseppe Di Perna, Andrea Lavorato, Michele Maria Lanotte, Diego Garbossa
Summary: This study validates a hybrid neurosurgical simulator that combines virtual and physical components, and uses an intermediate step to provide a hybrid solution. Practical experience on the anatomical 3D-printed model confirms the practicality and usability of the simulator.
FRONTIERS IN SURGERY
(2022)
Article
Clinical Neurology
Giuseppe Di Perna, Nicola Marengo, Keitaro Matsukawa, Geert Mahieu, Bianca Maria Baldassarre, Salvatore Petrone, Raffaele De Marco, Pietro Zeppa, Marco Ajello, Alessandro Fiumefreddo, Francesco Zenga, Diego Garbossa, Fabio Cofano
Summary: This study aimed to compare the differences between free-hand three-dimensional (3D) planning-guided cortical bone trajectory (CBT) screw placement and 3D-printed template-guided CBT screw positioning in terms of accuracy, size of screws, and potential complications. Data from patients who underwent CBT screws for lumbar degenerative pathologies were analyzed and compared between the free-hand and template-guided groups. The template-guided group showed larger screws size and significant differences in accuracy parameters.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Guilu He, Jianhao Lin, Jing Ye, Fobao Huang, Changzhi Yan, Zesi Liu, Xiuming Zhou, Qiao Li, Liang Zhang
Summary: This article introduces long tunneled external ventricular drain (LTEVD), which effectively avoids multiple surgeries by connecting an external shunt valve. It allows visual control of drainage flow, prolongs catheter indwelling time, and eliminates the need for multiple surgeries.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Vinay Suresh, H. S. Suresh, Bharath Raju, Himanshu Jindal, Ahmad Ozair
Summary: This study investigated the outcomes of postoperative discitis treated with debridement and a novel technique focused on reducing outpatient antibiotic requirement in a low- and middle-income country (LMIC) setting. The results showed that patients with medically refractory postoperative discitis potentially have good outcomes after debridement plus 2-week local antibiotic instillation in LMICs.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Beatrice C. Bono, Davide Milani, Fabio Ferreli, Simone Olei, Luca Raspagliesi, Maria Pia Tropeano, Giovanni B. Lasio, Federico Pessina
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Avi A. Gajjar, Shrey Patel, Raj Swaroop Lavadi, Rida Mitha, Rohit Prem Kumar, Tavis Taylor, Galal A. Elsayed, D. Kojo Hamilton, Nitin Agarwal
Summary: Art in neurosurgery has played a crucial role in the discipline for centuries. Medical illustrations help visualize anatomy and surgical procedures, contributing to education, surgical planning, and navigation.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Joaquin Perez Zabala, Yamila Basilotta Marquez, Romina Arganaraz, Beatriz Mantese
Summary: We present a low-cost and easily accessible adaptation system for stereotactic procedures in infants. By using a headband cast technique, a stereotactic biopsy was successfully performed in a 5-month-old patient, achieving precise targeting, histopathological diagnosis, and no associated complications.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Muhammad Kusdiansah, Arnau Benet, Yosuke Suzuki, Kenichi Haraguchi, Nakao Ota, Kosumo Noda, Rokuya Tanikawa
Summary: Fusiform vertebral artery aneurysms are difficult to treat, and endovascular and open microsurgical treatments are used for different situations. This report presents a case with complex anatomy and branch involvement and describes the treatment strategy used.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Victor M. Lu
Summary: This review emphasizes four essential domains that should be considered when interpreting pediatric neurosurgical SRMAs and provides examples to ensure accurate and effective interpretation of findings in this niche.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Lapo Bonosi, Angelo Torrente, Filippo Brighina, Cateno Concetto Tito Petralia, Pietro Merlino, Chiara Avallone, Vincenzo Gulino, Roberta Costanzo, Lara Brunasso, Domenico Gerardo Iacopino, Rosario Maugeri
Summary: Corticocortical evoked potentials (CCEPs) have emerged as a valuable intraoperative monitoring technique in eloquent brain tumor surgery, aiding in preserving critical functional areas. Current research shows the potential of CCEPs in guiding surgical decision making, reducing the risk of postoperative neurological deficits, and mapping functional connectivity, but further research and standardization are needed.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Yuchen Duan, Dagang Feng, Min Zhu, Heng Qiu, Tong Li, Zhen Chen, Leiming Jiang, Yong Huang
Summary: This study aimed to compare the effect of different Modic changes (MC) grades on the cage subsidence rate after spinal interbody fusion surgery. A meta-analysis was conducted on relevant randomized controlled trials and cohort studies. The results showed that MC may be associated with a higher cage subsidence rate. With the increase in MC grades, the incidence of subsidence decreased gradually, but it was always higher than that in the non-Modic changes (NMC). Oblique lumbar interbody fusion may be a better treatment choice for lumbar degenerative disease with MC.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Brian F. Saway, Conor M. Cunningham, Mustafa Ismail, Alejandro M. Spiotta
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Joanna M. Roy, Michael M. Covell, Carmelo Venero Jr, Christian A. Bowers
Summary: Early exposure to neurosurgery during medical school is critical for improving recruitment into the specialty. However, about 30% of medical schools in the U.S. lack a neurosurgery program, limiting students' exposure to the field. Virtual education, facilitated by webinars during the pandemic, has advantages such as global outreach and accessibility for international medical students. This review identifies and describes 16 educational resources, serving as a guide for medical students interested in neurosurgery.
WORLD NEUROSURGERY
(2024)