Review
Cell & Tissue Engineering
Wen-zhao Liu, Zhan-jun Ma, Jie-ru Li, Xue-wen Kang
Summary: SCI often leads to serious motor and sensory dysfunction of the limbs below the injured segment, causing physical, psychological harm and economic burden. MSC therapy for SCI has shown promise but faces challenges like low survival rate and immune rejection, while exosomes derived from MSCs have great potential in the treatment of SCI.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Medicine, Research & Experimental
Sheng-Ping Fu, Xiang-Chong Wu, Rui-Lin Yang, De-Zhi Zhao, Jie Cheng, Hu Qian, Jun Ao, Qian Zhang, Tao Zhang
Summary: Spinal Cord Injury (SCI) is a devastating neurological disorder with no effective treatment. Secondary inflammatory responses contribute to the difficulties in neurological recovery. Mesenchymal Stem Cells (MSCs) have shown therapeutic potential by regulating macrophage balance and facilitating tissue repair and regeneration.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Rodrigo Montoto-Meijide, Rosa Meijide-Failde, Silvia Maria Diaz-Prado, Antonio Montoto-Marques
Summary: A systematic review shows that mesenchymal stem cell (MSC)-based cell therapy has significant efficacy and safety in the treatment of traumatic spinal cord injury (TSCI), leading to improvements in AIS grades, sensory scores, and to a lesser extent, motor scores. However, further research is needed to address the long-term safety and clinical implications due to limited scientific evidence available.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Soo-Eun Sung, Min-Soo Seo, Young-In Kim, Kyung-Ku Kang, Joo-Hee Choi, Sijoon Lee, Minkyoung Sung, Sang-Gu Yim, Ju-Hyeon Lim, Hyun-Gyu Seok, Seung-Yun Yang, Gun-Woo Lee
Summary: This study demonstrated that exosomes isolated from human epidural adipose tissue-derived MSCs can help restore locomotor function in rats with SCI by reducing inflammatory response.
Review
Biochemistry & Molecular Biology
Giovanni Schepici, Serena Silvestro, Emanuela Mazzon
Summary: Spinal cord injury (SCI) is a devastating condition that causes permanent motor and sensory deficits. Researchers have been studying potential therapeutic strategies to mitigate the neuro-inflammatory response following injury. Recent studies have shown that exosomes-derived MSCs (MSC-EXOs) have promising effects as an innovative therapy for SCI patients.
Article
Cell & Tissue Engineering
Liem Thanh Nguyen, Nghia Trung Tran, Uyen Thi Trang Than, Minh Quang Nguyen, Anh Minh Tran, Phuong Thi Xuan Do, Thao Thi Chu, Tu Dac Nguyen, Anh Viet Bui, Tien Anh Ngo, Van Thanh Hoang, Nhung Thi My Hoang
Summary: This study evaluated the efficiency of UCB-MSC isolation and expansion using different commercially available media kits and found that StemMACS(TM) MSC Expansion Media is more appropriate. Autologous serum coating and plasma supplement enhanced cell proliferation. UCB-MSCs exhibited functions in promoting angiogenesis and inhibiting cancer cell growth.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Medicine, Research & Experimental
Qi-Ming Pang, Kua-Qian Deng, Meng Zhang, Xiang-Chong Wu, Rui-Lin Yang, Sheng-Ping Fu, Feng-Qin Lin, Qian Zhang, Jun Ao, Tao Zhang
Summary: Spinal cord injury (SCI) is a serious complication that affects the central nervous system (CNS) after spine injury, resulting in sensory, motor, and autonomic dysfunction. Stem cell therapy, specifically the use of mesenchymal stem cells (MSCs), has shown promise in SCI treatment due to their immunomodulatory, neuroprotective, and angiogenic properties. However, the complex pathophysiological environment following SCI limits the therapeutic effect of MSCs. This review discusses the specific mechanisms of MSCs in promoting SCI repair and explores the use of pluripotent stem cells in combination with other therapeutic approaches for anatomical and functional recovery post-SCI.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Jinsu Hwang, Sujeong Jang, Choonghyo Kim, Sungjoon Lee, Han-Seong Jeong
Summary: Neurological disorders pose a global health problem, and current pharmacological treatments have side effects. Mesenchymal stem cells (MSCs) have anti-inflammatory, anti-apoptotic, and immunomodulatory properties, and their secreted paracrine factors play a therapeutic role. Exosomes and MSC-derived miRNAs also regulate genes and alleviate neuropathological changes in neurological diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Lila Teixeira de Araujo, Carolina The Macedo, Patricia Kauanna Fonseca Damasceno, Italo Gabriel Costa das Neves, Carla Souza de Lima, Girlaine Cafe Santos, Thais Alves de Santana, Gabriela Louise de Almeida Sampaio, Daniela Nascimento Silva, Cristiane Flora Villarreal, Alessandra Casemiro de Campos Chaguri, Crislaine Gomes da Silva, Augusto Cesar de Andrade Mota, Roberto Badaro, Ricardo Ribeiro dos Santos, Milena Botelho Pereira Soares
Summary: Spinal cord injury (SCI) is an important public health problem with no effective treatments available. Stem cell therapy, particularly mesenchymal stem/stromal cells (MSCs), has been investigated as a potential approach for SCI treatment. However, there is heterogeneity in the design of clinical trials and a lack of standardized protocols and recommendations for the therapeutic use of stem cells in SCI.
Article
Cell & Tissue Engineering
Desheng Kong, Baofeng Feng, Asiamah Ernest Amponsah, Jingjing He, Ruiyun Guo, Boxin Liu, Xiaofeng Du, Xin Liu, Shuhan Zhang, Fei Lv, Jun Ma, Huixian Cui
Summary: The study shows that using human iPSC-derived neural stem cells can promote neural functional recovery in mice with acute SCI, while also reducing fibrosis, glial scar formation, and inflammation.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Ilya Shulman, Tatyana Ageeva, Alexander Kostennikov, Sergei Ogurcov, Leysan Tazetdinova, Ilyas Kabdesh, Alexander Rogozhin, Ilnur Ganiev, Albert Rizvanov, Yana Mukhamedshina
Summary: Spinal cord injury (SCI) is a current medical and social problem that causes severe disability. The use of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) is a strategy to promote the recovery of spinal cord structure and function after trauma. This study evaluated the therapeutic potential of repeated intrathecal injection of autologous MSC-derived EVs in a pig model of subacute contused SCI. The results showed partial restoration of locomotor activity through remyelination of axons and timely reperfusion of nervous tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Gang-Un Kim, Soo-Eun Sung, Kyung-Ku Kang, Joo-Hee Choi, Sijoon Lee, Minkyoung Sung, Seung Yun Yang, Seul-Ki Kim, Young In Kim, Ju-Hyeon Lim, Min-Soo Seo, Gun Woo Lee
Summary: Spinal cord injury (SCI) is a serious condition that leads to permanent disability. Research on SCI treatment focuses on reducing neuroinflammation, with Mesenchymal stem cells (MSCs) and MSC-derived extracellular vesicles (EVs) showing potential therapeutic effects but inconsistent results in animal models. Development of novel agents for regenerative medicine is necessary.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Liming Li, Jiafu Mu, Yu Zhang, Chenyang Zhang, Teng Ma, Lu Chen, Tianchen Huang, Jiahe Wu, Jian Cao, Shiqing Feng, Youzhi Cai, Min Han, Jianqing Gao
Summary: This study found that exosomes derived from hypoxic preconditioned human umbilical vein endothelial cells can stimulate angiogenic MSCs, showing great potential in the treatment of traumatic spinal cord injury.
Article
Chemistry, Multidisciplinary
Min Han, Hongru Yang, Xiangdong Lu, Yuming Li, Zihao Liu, Feng Li, Zehan Shang, Xiaofeng Wang, Xuze Li, Junliang Li, Hong Liu, Tao Xin
Summary: Exosomes derived from three-dimensional culture of MSCs have shown great potential in spinal cord injury therapy, compared to exosomes from conventional two-dimensional culture. It is urgent to develop a reliable, convenient, and effective exosome delivery method for constant in situ release.
Article
Cell Biology
Jun Ochiai, Larakaye Villanueva, Hope Niihara, Yutaka Niihara, Joan Oliva
Summary: This study developed a method to engineer multilayer adipose stem cell cell sheets (ASCCSs) using chemically defined/serum-free culture media, which can differentiate into osteoblasts and chondrocytes. The number of cells per cell sheet was estimated using cell sheet transmittance, providing important non-invasive information.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)