Article
Dentistry, Oral Surgery & Medicine
Masato Kaku, Jin Izumino, Taeko Yamamoto, Yuka Yashima, Saiji Shimoe, Kotaro Tanimoto
Summary: The study demonstrated that hyperbaric oxygen accelerates bone formation by increasing ATP levels in osteoblasts, and bFGF can serve as a substitute for VEGF in vascularization during HBO application.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tracy L. Smith, Malika Oubaha, Gael Cagnone, Cecile Boscher, Jin Sung Kim, Yassine El Bakkouri, Ying Zhang, Rony Chidiac, Jeanne Corriveau, Chantal Delisle, Gregor U. Andelfinger, Przemyslaw Sapieha, Jean-Sebastien Joyal, Jean-Philippe Gratton
Summary: The study indicates that inhibition of eNOS alters the polarity program of endothelial cells, leading to increased cell polarization, regulated sprouting angiogenesis, and normalized pathological neovascularization during retinopathy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jong-Eun Won, Won Jong Kim, Ji Suk Shim, Jae Jun Ryu
Summary: Synthetic scaffolds as bone grafts play an important role in bone tissue regeneration, but the lack of angio- and osteo-induction limits their usefulness. In this study, a polymer capable of controlled nitric oxide (NO) release is developed to promote the osteogenic capacity of artificial scaffolds. The compound enhances pre-osteoblast activity and mineralization and modulates macrophages to adopt a pro-regenerative phenotype. In a critical-sized defect model, the scaffold with NO compound promotes neovascularization and bone formation. This NO-releasing system is valuable for guiding bone regeneration in critical-sized defects.
MACROMOLECULAR BIOSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
J. Lindenmann, L. Kamolz, W. Graier, J. Smolle, F. -m. Smolle-Juettner
Summary: Hyperbaric oxygen therapy (HBO) enhances tissue repair and healing by modulating various biological mechanisms and restoring physiological balance.
Review
Oncology
Fatema Tuz Zahra, Md. Sanaullah Sajib, Constantinos M. Mikelis
Summary: Anti-angiogenic therapies targeting VEGF signaling have shown temporary benefits in cancer treatment, with resistance often developing due to the upregulation of other growth factors like bFGF. Recent efforts have focused on developing multi-target anti-angiogenic drugs to overcome resistance mechanisms and improve outcomes in clinical practice.
Article
Multidisciplinary Sciences
Magdalena Zmudzka, Jerzy A. Zoladz, Joanna Majerczak
Summary: The study aims to present the current state of knowledge on the key signaling molecules implicated in the regulation of skeletal muscle and bone angiogenesis during aging and physical training.
Article
Engineering, Biomedical
Zhangzhe Zhou, Yang Liu, Wenjing Li, Zhijian Zhao, Xiaowei Xia, Junlin Liu, Yaoge Deng, Yubin Wu, Xiangqiang Pan, Fan He, Huilin Yang, Weihong Lu, Yong Xu, Xuesong Zhu
Summary: A self-adaptive biomimetic periosteum strategy using interpenetrating double network hydrogel has been proposed for repairing critical-size bone defects, showing promising potential in solving clinical problems.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Jun Chen, Dandan Sheng, Ting Ying, Haojun Zhao, Jian Zhang, Yunxia Li, He Xu, Shiyi Chen
Summary: The study introduces a NO-loaded metal-organic frameworks (MOFs) therapeutic system, NMPGA, which can promote tendon regeneration through angiogenesis, improve tubular formation capability of endothelial cells, and accelerate blood perfusion near the injured tendon, leading to faster collagen maturation and biomechanical strength recovery of regenerated tendon tissue.
NANO-MICRO LETTERS
(2021)
Article
Multidisciplinary Sciences
Nevin Witman, Chikai Zhou, Timm Haeneke, Yao Xiao, Xiaoting Huang, Eduarde Rohner, Jesper Sohlmer, Niels Grote Beverborg, Kenneth R. Chien, Makoto Sahara
Summary: Cardiogenic growth factors, such as PLGF, play crucial roles in heart development. PLGF exhibits both autocrine and paracrine functions during cardiomyogenesis and vasculogenesis, and it may have potential therapeutic applications for heart disease. Further studies have revealed the previously unrecognized transcriptional networks related to PLGF, driven by EOMES and SOX17.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Mamta P. Sumi, Blair Tupta, Sanjoy Roychowdhury, Suzy Comhair, Kewal Asosingh, Dennis J. Stuehr, Serpil C. Erzurum, Arnab Ghosh
Summary: This study discovered that hemoglobin in lung epithelial cells can protect soluble guanylyl cyclase in smooth muscles from excessive nitric oxide. However, in patients with asthma or chronic obstructive pulmonary disease, lung epithelial hemoglobin may be unable to scavenge nitric oxide due to a lack of heme.
Article
Biochemistry & Molecular Biology
Oliver Baum, Felicitas A. M. Huber-Abel, Martin Fluck
Summary: This study investigated the relationship between nNOS expression and capillarity in the TA muscle of mice undergoing treadmill training. The results showed that both mRNA and protein levels of nNOS were up-regulated after 28 days of treadmill training. Additionally, ZsGreen1-positive fibers in the nNOS-transfected TA muscle of trained mice exhibited higher immunofluorescence for nNOS and more capillary contacts around MHC-IIb fibers compared to ZsGreen1-negative fibers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Bo Zhang, Yumei Qin, Li Yang, Huining Wan, Lu Yuan, Yunbing Wang
Summary: This study developed a new stent that combines the biological functions of nitric oxide gas and VEGF to promote the proliferation and migration of endothelial cells while suppressing smooth muscle cells. The functionalized stent showed enhanced vascular healing and reduced inflammation and vessel wall injury.
Article
Multidisciplinary Sciences
Monica Zocchi, Marco Bartolini, Jeanette A. Maier, Sara Castiglioni
Summary: Magnesium plays a pivotal role in maintaining skeletal muscle health and optimizing performance. Deficiency in magnesium can decrease muscle strength and affect muscle behavior and metabolism. Nitric oxide appears to be a key player in these effects. Understanding these mechanisms can help improve muscle conditions associated with magnesium deficiency.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Silke D. De Wolde, Rick H. Hulskes, Robert P. Weenink, Markus W. Hollmann, Robert A. Van Hulst
Summary: HBOT has potential new treatment applications in preconditioning for surgery, reducing complications rates and hospital stay by reducing inflammation and promoting angiogenesis through oxidative stress modulation. Further research is needed to determine the implications of these findings for clinical practice.
Article
Biochemistry & Molecular Biology
William Lory, Bridgette Wellslager, Chao Sun, Ozlem Yilmaz, Hong Yu
Summary: S1PR2 antagonist JTE013 enhances expression of VEGFA, PDGFA, and GDF15 genes, activates TGFβ/Smad and Akt signaling, and promotes angiogenesis and alveolar bone regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)