Article
Environmental Sciences
Huiyun Zou, Bjorn Berglund, Shuang Wang, Ziyu Zhou, Congcong Gu, Ling Zhao, Chen Meng, Xuewen Li
Summary: This study investigated the distribution and resistance mechanisms of carbapenem-resistant Raoultella spp. (CRR) in a wastewater treatment plant (WWTP) in eastern China. The results showed that CRR were mainly found in the water inlet and mud cake stacking area of the WWTP, with a higher detection rate in the water inlet. All CRR isolates were resistant to multiple antibiotics and various carbapenemase genes were identified. Interestingly, R. ornithinolytica isolates from the WWTP were closely related to those from human samples in China. Plasmid analysis revealed the transmission routes and core structures of carbapenemase genes in the environment.
ENVIRONMENTAL POLLUTION
(2022)
Article
Microbiology
Qian Yuan, Peiyuan Xia, Lirong Xiong, Linli Xie, Shan Lv, Fengjun Sun, Wei Feng
Summary: This study reported a carbapenem-resistant Enterobacter hormaechei isolate carrying three resistance plasmids with mcr-9, bla(KPC-2), and bla(NDM-1) genes. These plasmids carry a large number of resistance genes and contribute to high resistance to most antibiotics tested. Monitoring the prevalence and genetic features of these coexisting plasmids is essential for effective control strategies.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Infectious Diseases
Qingyang Sun, Yuzhu Dai, Jian Chen, Kexin Yu, Yue Wang, Yingqiang Zhang, Yingying Kong, Jun Cheng
Summary: This study reported the complete genome sequence of a carbapenem-resistant Klebsiella pneumoniae (CRKP) strain KP46 isolated from a cerebrospinal fluid specimen in China. The strain carried one bla(NDM-1) gene and two copies of bla(KPC-2) gene, and showed resistance to most antimicrobial agents. KP46 belongs to sequence type 15 (ST15) and is closely related to other ST15 strains found in China.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Infectious Diseases
Camila Maria dos Santos Boralli, Julian Andres Paganini, Rodrigo Silva Meneses, Camila Pacheco Silveira Martins da Mata, Edna Marilea Meireles Leite, Anita C. Schurch, Fernanda L. Paganelli, Rob J. L. Willems, Ilana Lopes Baratella Cunha Camargo
Summary: The study characterized four Klebsiella pneumoniae isolates from a Brazilian hospital outbreak during the COVID-19 pandemic, which harbored bla(KPC) and bla(NDM) genes and exhibited high levels of drug resistance. The bla(KPC) gene was located on an IncN plasmid of approximately 56 Kbp, while the bla(NDM) gene was carried by an IncC plasmid of approximately 102 Kbp. These plasmids had a high copy number and the bla(KPC) gene showed a high transferability to Escherichia coli. Therefore, these findings are of great significance for understanding the transmission mechanism and emergence of carbapenem-resistant strains.
Article
Microbiology
Mohamed Abd El-Gawad El-Sayed Ahmed, Yanxian Yang, Yongqiang Yang, Bin Yan, Guanping Chen, Reem Mostafa Hassan, Lan-Lan Zhong, Yuan Chen, Adam P. Roberts, Yiping Wu, Ruowen He, Xiaoxue Liang, Mingyang Qin, Min Dai, Liyan Zhang, Hongyu Li, Fan Yang, Lingqing Xu, Guo-Bao Tian
Summary: The study presents the genetic basis and plasmid analysis of carbapenem-resistant hypervirulent K. pneumoniae (CR-HvKP) in Egyptian hospitals. The main findings include the identification of different sequence types of CRKP isolates, the presence of high-risk clone ST11 KL47 serotype, and the coexistence of carbapenemase-encoding and virulence plasmids in a CR-HvKP strain. This research aims to alert clinicians to the hypervirulence of CRKP isolates and the evolving virulence and multidrug resistance in K. pneumoniae.
Article
Microbiology
Ekaterina S. Kuzina, Angelina A. Kislichkina, Angelika A. Sizova, Yury P. Skryabin, Tatiana S. Novikova, Olga N. Ershova, Ivan A. Savin, Olga E. Khokhlova, Alexander G. Bogun, Nadezhda K. Fursova
Summary: Klebsiella pneumoniae strains carrying multiple plasmids, including carbapenemase genes, have been found in patients from a neuro-intensive care unit in Moscow. These strains show resistance to multiple antibiotics, posing a significant clinical challenge.
Article
Immunology
Yulan Huang, Xiaobo Ma, Shihan Zeng, Liang Fu, Heping Xu, Xiaoyan Li
Summary: This study reports the first identification of a Salmonella strain carrying bla(NDM-13). The strain is multidrug-resistant and carries multiple virulence genes. The bla(NDM-13) gene is located in a transmissible plasmid and exhibits genetic stability. This finding highlights the importance of monitoring and controlling the dissemination of bla(NDM-13).
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Gregory A. Ballash, Amy L. Albers, Dixie F. Mollenkopf, Emily Sechrist, Rachael J. Adams, Thomas E. Wittum
Summary: Fresh retail meat products, including processed ones, are important sources of zoonotic foodborne pathogens and antimicrobial resistant bacteria. A high proportion of these products were found to be contaminated with MRSA, Salmonella, and various types of antibiotic resistant bacteria, with some even harboring epidemic carbapenemase-producing genotypes.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Xinmiao Jia, Peiyao Jia, Ying Zhu, Wei Yu, Xue Li, Jingyuan Xi, Xiaoyu Liu, Kang Liao, Yingchun Xu, Bin Cheng, Qiwen Yang
Summary: We identified a novel hybrid plasmid carrying both bla(NDM-1) and bla(IMP-4) genes, and characterized its genetic and phenotypic features. The plasmid showed potential for horizontal transfer and high stability, without exerting significant growth pressure on bacteria.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Infectious Diseases
Min Yuan, Hongxia Guan, Dan Sha, Wenting Cao, Xiaofeng Song, Jie Che, Biao Kan, Juan Li
Summary: This study characterized a 29-kb bla(KPC-2)-carrying plasmid, pR31-KPC, from a multidrug resistant strain of Pseudomonas aeruginosa isolated in China. The plasmid was found to have a close relationship with four other bla(KPC-2)-carrying plasmids and contained unique accessory modules. Comparative analysis revealed genetic differences and potential mechanisms for the transfer of bla(KPC-2) among these plasmids, contributing to a deeper understanding of bla(KPC-2) carrying plasmids in Pseudomonas.
Article
Microbiology
Shihan Zeng, Yulan Huang, Xiwei Zhang, Liang Fu, Zhaohui Sun, Xiaoyan Li
Summary: This study isolated two carbapenem-resistant Salmonella enterica serovar Typhimurium strains from a clinical outpatient, and found that they had the same genetic relationship and resistance genes. A transferable conjugative plasmid carrying the bla(NDM-5) gene was detected in one of the strains, posing a significant threat to clinical treatment.
Article
Microbiology
Yali Gong, Yifei Lu, Dongdong Xue, Yu Wei, Qimeng Li, Gang Li, Shuguang Lu, Jing Wang, Yunying Wang, Yizhi Peng, Yan Zhao
Summary: This study describes the emergence of a carbapenem-resistant Klebsiella pneumoniae (CRKP) strain, KP2e, in a Chinese hospital. The strain, recovered from a fatal septic shock case, carried the NDM-6 gene and exhibited resistance to almost all beta-lactams except for monobactam. It belonged to sequence type 4024 and had a genome composed of one chromosome and three plasmids. Coexistence of bla(NDM-6) on two self-transmissible plasmids, belonging to types IncFIB and IncN, was observed. The study highlights the importance of monitoring and detecting bla(NDM)-harbouring plasmids.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Jie Qiao, Yingying Chen, Haoyu Ge, Hao Xu, Xiaobing Guo, Ruishan Liu, Chenyu Li, Ruyan Chen, Jianjun Gou, Mantao Chen, Beiwen Zheng
Summary: This study identified a Citrobacter freundii isolate carrying IMP-4, NDM-1, OXA-1, and KPC-2 genes and conducted comprehensive research on its drug resistance mechanism, molecular transfer mechanism, and epidemiology. It revealed that these four resistance genes coexist on a novel transferable hybrid plasmid that carries multiple drug resistance genes and insertion sequences.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Infectious Diseases
Weiqiang Xiao, Xiaokun Wang, Yuanye Qu, Mingyue Sun, Yanmin Chang, Wenjiao Li, Yong Shen, Xiufang Shi, Min Jing, Qingxia Xu
Summary: In a affiliated cancer hospital in Henan, China, 27 CRKP strains were randomly selected from January 2019 to January 2021. Among them, one strain named K9 was found to co-harboring KPC-2 and NDM-5 carbapenemases. K9 strain showed resistance to multiple antibiotics and carried two different plasmids, highlighting the urgent need to control the spread of CRKP strains co-producing KPC and NDM carbapenemases.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Infectious Diseases
Xinhua Luo, Fang Dong, Piaopiao Dai, Mengqiao Xu, Lianhua Yu, Dakang Hu, Jiao Feng, Jin Zhang, Ying Jing
Summary: This study reported the discovery of an IncHI5 plasmid pK254-KPC_NDM carrying two different class carbapenemase genes blaKPC-2 and blaNDM-1 in Klebsiella michiganensis K254. The plasmid displayed the conserve IncHI5 backbone and carried a resistant accessory region. The study also found that pK254-KPC_NDM could be transferred intercellularly and keep stable vertical inheritance.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2023)
Article
Chemistry, Physical
Qixing Zhou, Shuanglong Ma, Sihui Zhan
APPLIED CATALYSIS B-ENVIRONMENTAL
(2018)
Article
Chemistry, Applied
Shuanglong Ma, Sihui Zhan, Yuguo Xia, Pengfei Wang, Qianlei Hou, Qixing Zhou
Article
Engineering, Environmental
Haichao Fu, Shuanglong Ma, Peng Zhao, Shengjun Xu, Sihui Zhan
CHEMICAL ENGINEERING JOURNAL
(2019)
Article
Chemistry, Physical
Zhuoqian Li, Shuanglong Ma, Shengjun Xu, Haichao Fu, Yi Li, Peng Zhao, Qingxiang Meng
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2019)
Article
Chemistry, Physical
Jinge Du, Shuanglong Ma, Yunhui Yan, Kai Li, Fengying Zhao, Jianguo Zhou
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2019)
Article
Engineering, Environmental
Haichao Fu, Peng Zhao, Shengjun Xu, Gong Cheng, Zhuoqian Li, Yi Li, Kai Li, Shuanglong Ma
CHEMICAL ENGINEERING JOURNAL
(2019)
Article
Chemistry, Physical
Jinge Du, Shuanglong Ma, Haiping Liu, Haichao Fu, Li Li, Zhuoqian Li, Yi Li, Jianguo Zhou
APPLIED CATALYSIS B-ENVIRONMENTAL
(2019)
Article
Chemistry, Physical
Haiping Liu, Shuanglong Ma, Li Shao, Haitao Liu, Qiancheng Gao, Baojun Li, Haichao Fu, Shuai Fu, Honggang Ye, Fengying Zhao, Jianguo Zhou
APPLIED CATALYSIS B-ENVIRONMENTAL
(2020)
Article
Engineering, Environmental
Yi Li, Shuanglong Ma, Shengjun Xu, Haichao Fu, Zhuoqian Li, Kai Li, Kai Sheng, Jinge Du, Xin Lu, Xianghua Li, Shiliang Liu
CHEMICAL ENGINEERING JOURNAL
(2020)
Article
Chemistry, Physical
Zhuoqian Li, Kai Li, Shuanglong Ma, Bingjun Dang, Yi Li, Haichao Fu, Jinge Du, Qingxiang Meng
Summary: A convenient and efficient method for fabricating isolated Fe single-atom catalysts (ISA-Fe/MC) on Myriophyllum aquaticum-based biochar was reported for peroxymonosulfate-based organics degradation. Compared to Fe nanoparticles anchored on biochar, ISA-Fe/MC demonstrated better catalytic performance for phenol degradation, attributed to its unique structure and atomically dispersed Fe species facilitating electron transfer for activation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Analytical
Kai Sheng, Lantao Li, Qian Zhang, Shuanglong Ma, YiLun Wang
MICROCHEMICAL JOURNAL
(2020)
Article
Chemistry, Physical
Jinge Du, Zhe Xu, Hui Li, Haijun Yang, Shengjun Xu, Jun Wang, Yanan Jia, Shuanglong Ma, Sihui Zhan
Summary: A novel Z-scheme Ag3PO4/g-C3N4 heterostructure was successfully constructed for efficient photocatalytic inactivation of Escherichia coli and degradation of organic pollutants. The improved photocatalytic efficiency can be attributed to the formation of a Z-scheme heterostructure, rapid separation of photo-induced carriers, enhanced electronic transport capacity, and prolonged carrier lifetime. The Ag3PO4/g-C3N4 heterostructure exhibited significantly boosted visible-light-driven photocatalytic performance for various pollutants degradation.
APPLIED SURFACE SCIENCE
(2021)
Article
Engineering, Environmental
Kai Li, Shuanglong Ma, Shengjun Xu, Haichao Fu, Zhuoqian Li, Yi Li, Shiliang Liu, Jinge Du
Summary: Three magnetic biochar nanocomposites were prepared with different catalytic performances for bisphenol A degradation, where C800-3 showed the best performance. The dominant role of electron transfer pathway was gradually replaced by the SO4 center dot- pathway with the increase of iron amount and the destruction of graphitized carbon layers.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Sihui Zhan, Qianlei Hou, Yi Li, Shuanglong Ma, Pengfei Wang, Yanan Li, Haitao Wang