Article
Chemistry, Multidisciplinary
Sharafaldin Al-Musawi, Salim Albukhaty, Hassan Al-Karagoly, Faizah Almalki
Summary: A dual-targeting nanomedicine composed of pH-sensitive superparamagnetic iron oxide core-gold shell SPION@Au, chitosan (CS), and folate (FA) was developed for doxorubicin (DOX) antitumor medication. The nanocomposite exhibited elevated drug loading behavior and sustained drug release capacity, with long-term anti-cancer efficacy shown in SkBr3 cell lines. In vivo results demonstrated significant tumor size reduction in treated mice, indicating the potential of this formulation for clinical breast cancer treatment.
Article
Materials Science, Biomaterials
Cristina de la Encarnacion, Felix Jungwirth, David Vila-Liarte, Carlos Renero-Lecuna, Safiyye Kavak, Inaki Orue, Claire Wilhelm, Sara Bals, Malou Henriksen-Lacey, Dorleta Jimenez de Aberasturi, Luis M. Liz-Marzan
Summary: Hyperthermia has been shown to be an effective and selective cancer therapy strategy by heating malignant cells above 42 degrees C to trigger cell death. Magnetic and photothermal hyperthermia can benefit from the use of nanomaterials. This hybrid colloidal nanostructure, consisting of plasmonic gold nanorods covered by a silica shell and subsequently grown with iron oxide nanoparticles, is responsive to both external magnetic fields and near-infrared irradiation, enabling targeted magnetic separation and photothermal heating.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Chemistry, Multidisciplinary
Juan Esteban Montoya Cardona, Dounia Louaguef, Eric Gaffet, Nureddin Ashammakhi, Halima Alem
Summary: Despite some delays in clinical implementation, functionalized magnetic and photothermal nanostructures remain the most promising way to target hyperthermia treatment of cancer towards local tumor regions. The synthesis method and parameters play a crucial role in optimizing the physicochemical properties for efficient energy transduction into locally released heat. This review aims to provide the latest applications and prospects of nanomaterials for hyperthermia properties.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Physical
Fatima Abla, Sofian M. Kanan, Yeji Park, Changseok Han, Maria Omastova, Mohamed M. Chehimi, Ahmed A. Mohamed
Summary: Core-shell nanostructures of Au@SnO2 were successfully synthesized in a green one-step reaction at room temperature. XPS results confirmed gold in metallic state and tin in oxidized state as SnO2 compound. Higher temperatures led to increased size of both AuNPs and SnO2 shell with decreased coverage.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Materials Science, Biomaterials
Fatima Fernandez-Alvarez, Carlos Caro, Gracia Garcia-Garcia, Maria Luisa Garcia-Martin, Jose L. Arias
Summary: The study has successfully developed a biocompatible and long-circulating nanoplatform with promising therapeutic applications in biomedical imaging and hyperthermia against cancer. The nanoparticles showed satisfactory embedment of iron oxide nanocores within a solid polymer matrix and the formation of an external shell of chitosan, demonstrating adequate magnetic responsiveness and heating properties for potential clinical use.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Roman Buchheit, Bjoern Kuttich, Lola Gonzalez-Garcia, Tobias Kraus
Summary: A new type of hybrid core-shell nanoparticle dielectric suitable for inkjet printing is introduced, with gold cores covalently grafted with polystyrene to create dielectric layers with metal volume fractions of 5 to 21%. The materials show high dielectric constants without the risk of breakdown at high metal fractions, making them ideal for capacitor applications.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Haotian Yang, Claron J. Ridge, Kyle Overdeep, C. Michael Lindsay, Xiao Tong, Alexander Orlov
Summary: In this study, the thermal stability of Au-Al2O3 core-shell and Au nanowires was investigated. The nanowires were synthesized using the helium droplets method and deposited on various substrates. The in situ characterization showed that the Au-Al2O3 system had significantly enhanced stability compared to pure Au nanowires, indicating its potential as a durable Au-based nanocatalyst. Moreover, strong metal-support bonding was observed in the Au/Al2O3 system.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Giovanni Marco Saladino, Ronak Kakadiya, Shaquib Rahman Ansari, Alexandra Teleki, Muhammet Sadaka Toprak
Summary: Superparamagnetic iron oxide nanoparticles (SPIONs) play a dominant role in various biomedical applications, including magnetic separation, drug delivery, diagnostics, and hyperthermia treatments. In this study, superparamagnetic nanoclusters (SP-NCs) with high unit magnetization and diameters up to 400 nm were synthesized using conventional or microwave-assisted solvothermal methods. The choice of synthesis route and capping agent significantly influenced the particle size, SP-NC size, surface chemistry, and magnetic properties. The SP-NCs were then coated with a silica shell doped with a fluorophore to provide fluorescence properties and high stability. The heating efficiency studies demonstrated the potential of these synthesized SP-NCs in hyperthermia treatment. The enhanced magnetically-active content, fluorescence, magnetic property, and heating efficiency of SP-NCs offer promising opportunities for biomedical applications.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Yujie Liu, Haijun Zhou, Jinling Wang, Ding Yu, Zhaolei Li, Rui Liu
Summary: Core-shell nanoparticles (Fe3O4@PDA) wrapped with Ag were prepared using a simple and green synthesis method. The obtained nanoparticles showed excellent catalytic activity and selectivity, indicating their potential applications in various fields.
Article
Chemistry, Multidisciplinary
Yang Cao, Ziqun Chen, Haitao Ran
Summary: Near-infrared laser triggered theranostic platforms have been successfully developed for guided photothermal therapy and real-time temperature monitoring in cancer treatment. The platform exhibits excellent optical absorption, photothermal conversion, and photoacoustic signal generation.
Article
Chemistry, Multidisciplinary
Eman A. Bakr, Marwa N. El-Nahass, Wafaa M. Hamada, Tarek A. Fayed
Summary: This study developed a facile synthetic route for reusable nanocatalysts based on the combination of magnetite's supermagnetic properties with the unique optical and catalytic properties of noble metal hybrid nanomaterials. Compared two synthetic methods, thermal decomposition and hydrothermal, for Fe3O4 and Fe3O4@M (M = Ag or Au) core-shell hybrid nanostructures synthesis. The hydrothermal method showed better crystalline structure and particle dispersion, as well as better catalytic performance for Fe3O4@Ag and Fe3O4@Au.
Article
Chemistry, Physical
Daniel Boas, Sergei Remennik, Meital Reches
Summary: We have developed a short peptide consisting of only six amino acids that can simultaneously reduce Au3+ or Ag+ ions and stabilize the resulting nanoparticles. The peptide-capped nanoparticles demonstrated a fast, selective, and pH-dependent detection system for Hg2+, Mn2+, and Fe2+ ions. In addition, the peptide-mediated photoreduction process successfully enveloped gold nanoparticles with a silver shell, resulting in bimetallic Au@Ag core/shell nanoparticles.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Ke Luo, Kaiqiang Wang, Min-Cheol Lim, Ki-Baek Jeong, Young-Rok Kim
Summary: This study reports a simple and green approach for fabricating gold-shelled starch microbeads that exhibit significant broadband absorption. By controlling the concentration of gold seeds, the diameter of the resulting particles can be adjusted, allowing for size-controllable core-shell plasmonic particles with excellent SERS activity. The method offers an effective means of large-scale production and can be applied to various highly sensitive analytical systems.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Zixin Wang, Hui Wang
Summary: This study synthesized Au@C/Pt core@shell/satellite supra-nanostructures and demonstrated the modulation of catalytic reaction kinetics through plasmonic antenna effects and photothermal transduction. The interplay between plasmonic and catalytic effects in these antenna-reactor nanohybrids was investigated using a specific model reaction.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Physical
Francisco J. Garza, Ramis Arbi, Muhammad Munir, Jong-Hyun Lim, Ayse Turak
Summary: In this study, the shell thickness of core-shell nanoparticles (CSNP) was analyzed using Shard's methodology, which allowed for the conversion of XPS peak intensities into shell thickness. By simulating XPS spectra, extracting parameters using Shard's methodology, and comparing with experimental spectra to quantify the shell thickness, insights into the morphology and composition of CSNP were obtained. The results demonstrate that simulation software can serve as a complementary tool to multitechnique analysis for a detailed understanding of CSNP.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Nanoscience & Nanotechnology
Christian D. Ahrberg, Ji Wook Choi, Bong Geun Chung
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
(2018)
Article
Nanoscience & Nanotechnology
Jong Min Lee, Ji Wook Choi, Christian D. Ahrberg, Hyung Woo Choi, Jang Ho Ha, Seok Gyu Mun, Sung Joon Mo, Bong Geun Chung
MICROSYSTEMS & NANOENGINEERING
(2020)
Article
Biochemical Research Methods
Ji Wook Choi, Young Jae Kim, Jong Min Lee, Jin-Ha Choi, Jeong-Woo Choi, Bong Geun Chung
Article
Polymer Science
Hwan Gyun Jeon, Ji Wook Choi, Hee Uk Lee, Bong Geun Chung
Summary: Polymerase chain reaction is commonly used for diagnosing infectious diseases, but traditional thermal cyclers are not suitable for point-of-care testing. Therefore, there is an urgent need for a low-cost and efficient portable thermal cycler.
Article
Polymer Science
Sang Ik Lee, Yoon Young Choi, Seong Goo Kang, Tae Hyeon Kim, Ji Wook Choi, Young Jae Kim, Tae-Hyung Kim, Taewook Kang, Bong Geun Chung
Summary: A microfluidic-based droplet system was developed to generate uniform 3D tumor spheroids for drug screening applications. The system allowed high-throughput generation of spheroids with various cellular ratios, providing a potentially powerful tool for anti-cancer drug analysis.
Article
Biochemical Research Methods
Ji Wook Choi, Won Ho Seo, Taejoon Kang, Taewook Kang, Bong Geun Chung
Summary: Since the outbreak of COVID-19, detection technologies in molecular diagnosis applications, particularly droplet digital PCR (ddPCR), have gained significant attention. The combination of isothermal amplification strategies with ddPCR has made it a popular method for on-site testing. However, non-specific amplification still poses a challenge. In this study, a multiplexed droplet digital recombinase polymerase amplification (MddRPA) assay was developed, offering rapid detection, precise quantification, and multiplexing capability for viral infections.
Article
Biochemical Research Methods
Ji Wook Choi, Won Ho Seo, Young Suh Lee, So Young Kim, Bong Suk Kim, Kyoung G. Lee, Seok Jae Lee, Bong Geun Chung
Summary: This study presents an IoT-integrated multiplexed dPCR (IM-dPCR) system for rapid detection of COVID-19 infection and other infectious diseases. The system demonstrates high sensitivity, multiplexing capabilities, and automated processing.
Article
Biochemical Research Methods
Christian D. Ahrberg, Ji Wook Choi, Jong Min Lee, Kyoung G. Lee, Seok Jae Lee, Andreas Manz, Bong Geun Chung
Article
Nanoscience & Nanotechnology
Ji Wook Choi, Jong Min Lee, Tae Hyun Kim, Jang Ho Ha, Christian D. Ahrberg, Bong Geun Chung