Review
Environmental Sciences
Esteban Manuel Villena-Martinez, Paola Andrea Alvizuri-Tintaya, Jaime Lora-Garcia, Juan Ignacio Torregrosa-Lopez, Vanesa Gladys Lo-Iacono-Ferreira
Summary: Reverse osmosis (RO) is an effective alternative for water purification. The use of laboratory-scale RO modeling allows the evaluation of system behavior and identification of optimal operating variables for industrial scale-ups. Statistical and mathematical models provide useful information for predicting plant operation and efficiency in RO plants, particularly for developing countries with water contamination issues.
Article
Biochemistry & Molecular Biology
Tania Sousa, Marcos Gouveia, Rui D. M. Travasso, Armindo Salvador
Summary: This study estimated the concentrations, half-lives and transport ranges of O2 center dot- and H2O2 in the human capillary system, revealing their characteristics and mechanisms in this environment.
Article
Engineering, Mechanical
Pudi Wang, Qing Zhang, Xu Fang, Feng Lin, Jianyong Huang
Summary: This passage discusses the mechanical mechanisms of cell volume regulation in a 3D microenvironment, revealing a competitive relationship between intracellular cortices and 3D ECM, as well as the joint regulation of cell growth and volume adaption by factors such as initial cell size and ECM stiffness. It also highlights the critical role of prestresses on cell-ECM interfaces in constraining 3D cell growth, and the geometric size-dependent sensitivity of cell volume variation to external stimuli.
EXTREME MECHANICS LETTERS
(2021)
Article
Engineering, Chemical
Xianhui Li, Ying Mei, Junwei Zhang, Yang Yang, Lu Elfa Peng, Weihua Qing, Di He, Anthony G. Fane, Chuyang Y. Tang
Summary: The Osmotically Enhanced Reverse Osmosis (OERO) process effectively increases water recovery by reducing transmembrane osmotic pressure. Using a model based on mass-transfer principles, the study shows that water recovery is significantly enhanced by increasing water permeance and decreasing the structure parameter of hollow fiber membranes. Longer fibers are more suitable for low-salinity water reuse, while larger-diameter fibers are more efficient for seawater desalination.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Article
Biology
J. R. Reoch, Y. M. Stokes, J. E. F. Green
Summary: This paper presents a mathematical model that investigates the mechanical behavior of biological gels by taking into account cell-gel interactions and osmotic pressure. The results show that the composition of the gel and the strength of cell traction forces can lead to different behaviors, including oscillations between gel swelling and contraction. The study also considers the effects of physical parameters such as drag and viscosity on gel evolution.
JOURNAL OF MATHEMATICAL BIOLOGY
(2022)
Article
Engineering, Environmental
Paula Jungwon Choi, Jia-Yong Lao, Paul Kwan Sing Lam, Sung-Ju Im, Am Jang, Alicia Kyoungjin An
Summary: Pressure-assisted volume-retarded osmosis (PA-VRO) is an energy-efficient process for recovering high-quality water from secondary wastewater treatment, with the ability to remove harmful substances while producing potable water. The well-optimized PA-VRO process can be utilized for treating wastewater and producing water suitable for drinking.
Editorial Material
Immunology
Gennady Bocharov, Dmitry Grebennikov, Jordi Argilaguet, Andreas Meyerhans
Summary: Researchers have proposed a new perspective on the cooperative interaction between neutralizing antibodies and CD8(+) T cells in virus infections, and suggested how this cooperation could be utilized to enhance vaccine-induced protective immunity.
TRENDS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kristi E. Miller, Cesar Vargas-Garcia, Abhyudai Singh, James B. Moseley
Summary: Eukaryotic cells tightly regulate their size, but the mechanisms underlying size control are not well understood. Fission yeast cells divide at a threshold surface area, which is influenced by the protein kinase Cdr2. However, mutants that divide at a larger size switch to volume-based divisions. Diploid cells divide at a larger size than haploid cells, but still maintain surface area-based divisions, indicating that the size threshold for transitioning from surface-area-based to volume-based control is determined by ploidy. The mitotic activator Cdc25 accumulates as a volume-based sizer molecule, while the mitotic cyclin Cdc13 acts as a timer in the nucleus. A proposed integrated model for cell size control incorporates multiple signaling pathways that report on different aspects of cell size and growth, including surface area (Cdr2), volume (Cdc25), and time (Cdc13). Computational modeling and experimental findings demonstrate how this system can exhibit both size-based regulation and size-addition properties.
Article
Electrochemistry
Jake Christensen, Somani Patnaik, David Cook, Paul Albertus
Summary: The electrical design of a lithium-ion battery has a significant impact on its performance and aging behavior. This study presents a coupled electrochemical + electrical network model to investigate the effect of current collector resistance on battery performance and internal state heterogeneity. The research reveals that current collector resistance can cause nonuniformity in current and electrochemical states, leading to enhanced and nonuniform lithium plating and other aging processes.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Cell Biology
John Devany, Martin J. Falk, Liam J. Holt, Arvind Murugan, Margaret L. Gardel
Summary: Cell proliferation, which is essential in tissue development, homeostasis, and disease, is poorly understood in the tissue context. In this study, a quantitative framework was introduced to investigate how tissue growth dynamics regulate cell proliferation. The research demonstrated that tissue expansion at a limited rate suppresses cell growth, leading to an uncoupling between cell growth and division rates in epithelia, resulting in reduced cell volume. Overall, these findings highlight the interplay between tissue confinement and cell-volume regulation in the regulation of epithelial proliferation.
DEVELOPMENTAL CELL
(2023)
Article
Engineering, Chemical
Mohd Muzammil Zubair, Haleema Saleem, Syed Javaid Zaidi
Summary: This article provides a comprehensive assessment of the modeling of reverse osmosis (RO) processes, including basic theories and mathematical models based on different membrane configurations. The study shows that these models can optimize the design and operation of RO systems, improving efficiency, reducing energy consumption, and enhancing water quality.
Article
Engineering, Chemical
Esteban Manuel Villena-Martinez, Paola Andrea Alvizuri-Tintaya, Jaime Lora-Garcia, Juan Ignacio Torregrosa-Lopez, Vanesa Gladys Lo-Iacono-Ferreira
Summary: An investigation in Bolivia found heavy metals exceeding permissible limits for drinking water in two basins. The study developed a mathematical model based on the Spiegler-Kedem concentration polarization model to design efficient facilities for removing these metals using reverse osmosis technology. The model showed high accuracy in predicting the process performance.
Article
Multidisciplinary Sciences
Tahereh Tekieh, P. A. Robinson, Svetlana Postnova
Summary: This study presents a new model that incorporates higher void volume and clearance in sleep, multiple waste compounds, and clearance obstruction by waste. The model successfully reproduces normal sleep-wake cycles, sleep deprivation effects, and performance decreases under chronic sleep restriction. The results indicate a central role for waste products with lifetimes similar to tau protein and predict tau accumulation consistent with the development of Alzheimer's disease.
SCIENTIFIC REPORTS
(2022)
Article
Mathematics, Applied
Syed Abbas, Swati Tyagi, Pushpendra Kumar, Vedat Suat Erturk, Shaher Momani
Summary: This manuscript introduces fractional order onto a time-delay differential equation model of cell-to-cell spread of HIV-1. The local stability and conditions for Hopf bifurcation of the resulting system are investigated. Explicit expressions for determining stability of critical surfaces are also provided. Numerical results are presented using an Adams-type predictor-corrector technique. The main objective of this study is to describe the structure of HIV-1 using a fractional-order mathematical model, motivated by the ability of fractional derivatives to capture memory effects in the system.
MATHEMATICAL METHODS IN THE APPLIED SCIENCES
(2022)
Article
Endocrinology & Metabolism
Rudolf Hoermann, Mark J. Pekker, John E. M. Midgley, Rolf Larisch, Johannes W. Dietrich
Summary: This paper presents a new mathematical model to study the regulation principles of the HPT axis. The model uncovers mechanisms for both maintaining the homeostasis of hormone FT3 and adapting to new levels. Additionally, the model accounts for essential properties of endocrine regulation, such as sensitivity, anticipation, robustness, and adaptation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemical Research Methods
Andre Scholich, Simon Syga, Hernan Morales-Navarrete, Fabian Segovia-Miranda, Hidenori Nonaka, Kirstin Meyer, Walter de Back, Lutz Brusch, Yannis Kalaidzidis, Marino Zerial, Frank Juelicher, Benjamin M. Friedrich
PLOS COMPUTATIONAL BIOLOGY
(2020)
Article
Biochemical Research Methods
T. J. Sego, Josua O. Aponte-Serrano, Juliano Ferrari Gianlupi, Samuel R. Heaps, Kira Breithaupt, Lutz Brusch, Jessica Crawshaw, James M. Osborne, Ellen M. Quardokus, Richard K. Plemper, James A. Glazier
PLOS COMPUTATIONAL BIOLOGY
(2020)
Article
Biology
Emanuel Cura Costa, Leo Otsuki, Aida Rodrigo Albors, Elly M. Tanaka, Osvaldo Chara
Summary: Through a combination of modeling and experimental data, it was found that the regenerative response in Axolotls is associated with a specific signal that guides ependymal cell proliferation around the injury site; visualization of cell cycles using FUCCI technology revealed synchrony between cells, contributing to a better understanding of spinal cord regeneration.
Article
Anatomy & Morphology
Camilo Riquelme-Guzman, Maritta Schuez, Alexander Boehm, Dunja Knapp, Sandra Edwards-Jorquera, Alberto S. Ceccarelli, Osvaldo Chara, Martina Rauner, Tatiana Sandoval-Guzman
Summary: The axolotl is a key model for studying appendicular regeneration. Bone maturation in axolotls is a continuous process that extends throughout their life, with ossification of the appendicular bones being slow and continuing until complete.
DEVELOPMENTAL DYNAMICS
(2022)
Article
Dermatology
Nicole Berndt, Christine Wolf, Kristina Fischer, Emanuel Cura Costa, Peter Knuschke, Nick Zimmermann, Franziska Schmidt, Martin Merkel, Osvaldo Chara, Min Ae Lee-Kirsch, Claudia Gunther
Summary: The exonuclease TREX1 plays a protective role in preventing DNA accumulation and innate immune activation. TREX1 mutations lead to chronic DNA damage, IFN-1 response, and associated diseases such as Aicardi-Goutières syndrome, familial chilblain lupus, and systemic lupus erythematosus. Patients with lupus and TREX1 mutation show enhanced photosensitivity and increased levels of DNA damage in response to UV radiation, which can trigger disease flares.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Alberto S. Ceccarelli, Augusto Borges, Osvaldo Chara
Summary: The study investigates the effect of finite tissue size on model-predicted spatio-temporal morphogen distributions using an analytical approach. The results reveal a crossover tissue size, below which the infinite-domain model fails but the finite-domain model accurately describes the morphogen distribution. Additionally, the study finds that the infinite-domain model overestimates diffusion coefficients when fitting to finite spatial profiles.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Cell Biology
Arthur Boutillon, Sophie Escot, Amelie Elouin, Diego Jahn, Sebastian Gonzalez-Tirado, Joern Starruss, Lutz Brusch, Nicolas B. David
Summary: During zebrafish gastrulation, the migration of polster cells guides the extension of the embryonic axis, and each cell is oriented by its followers through mechanotransduction.
DEVELOPMENTAL CELL
(2022)
Article
Biochemistry & Molecular Biology
Bilal Shaikh, Lucian P. Smith, Dan Vasilescu, Gnaneswara Marupilla, Michael Wilson, Eran Agmon, Henry Agnew, Steven S. Andrews, Azraf Anwar, Moritz E. Beber, Frank T. Bergmann, David Brooks, Lutz Brusch, Laurence Calzone, Kiri Choi, Joshua Cooper, John Detloff, Brian Drawert, Michel Dumontier, G. Bard Ermentrout, James R. Faeder, Andrew P. Freiburger, Fabian Frohlich, Akira Funahashi, Alan Garny, John H. Gennari, Padraig Gleeson, Anne Goelzer, Zachary Haiman, Jan Hasenauer, Joseph L. Hellerstein, Henning Hermjakob, Stefan Hoops, Jon C. Ison, Diego Jahn, Henry Jakubowski, Ryann Jordan, Matus Kalas, Matthias Koenig, Wolfram Liebermeister, Rahuman S. Malik Sheriff, Synchon Mandal, Robert McDougal, J. Kyle Medley, Pedro Mendes, Robert Mueller, Chris J. Myers, Aurelien Naldi, Tung V. N. Nguyen, David P. Nickerson, Brett G. Olivier, Drashti Patoliya, Loic Pauleve, Linda R. Petzold, Ankita Priya, Anand K. Rampadarath, Johann M. Rohwer, Ali S. Saglam, Dilawar Singh, Ankur Sinha, Jacky Snoep, Hugh Sorby, Ryan Spangler, Joern Starruss, Payton J. Thomas, David van Niekerk, Daniel Weindl, Fengkai Zhang, Anna Zhukova, Arthur P. Goldberg, James C. Schaff, Michael L. Blinov, Herbert M. Sauro, Ion I. Moraru, Jonathan R. Karr
Summary: Computational models have great potential in accelerating bioscience, bioengineering, and medicine. However, reproducing and reusing simulations is still challenging due to the different formats and methods used by different software tools. To address this issue, we developed BioSimulators, a central registry that provides consistent interfaces and recommendations for simulation tools, using standards and validation tools to ensure consistency. We anticipate that BioSimulators will facilitate the exchange, reproduction, and combination of simulations by modelers.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Catarina R. Oliveira, Dunja Knapp, Ahmed Elewa, Tobias Gerber, Sandra G. Gonzalez Malagon, Phillip B. Gates, Hannah E. Walters, Andreas Petzold, Hernan Arce, Rodrigo C. Cordoba, Elaiyaraja Subramanian, Osvaldo Chara, Elly M. Tanaka, Andras Simon, Maximina H. Yun
Summary: Through single-cell RNAseq analysis, Tig1 has been identified as a central cell surface determinant of proximal identity in salamander limb regeneration. Its overexpression leads to regeneration defects in the distal elements and elicits proximal displacement of blastema cells, while its neutralisation blocks proximo-distal cell surface interactions.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Sebastian S. Roeder, Petra Burkardt, Fabian Rost, Julian Rode, Lutz Brusch, Roland Coras, Elisabet Englund, Karl Hakansson, Goran Possnert, Mehran Salehpour, Daniel Primetzhofer, Laszlo Csiba, Sarolta Molnar, Gabor Mehes, Anton B. Tonchev, Stefan Schwab, Olaf Bergmann, Hagen B. Huttner
Summary: Using a combination of methods, evidence for postnatal neurogenesis in the human amygdala was found. This discovery provides new insight into neuronal exchange and cell renewal.
COMMUNICATIONS BIOLOGY
(2022)
Correction
Multidisciplinary Sciences
Catarina R. Oliveira, Dunja Knapp, Ahmed Elewa, Tobias Gerber, Sandra G. Gonzalez Malagon, Phillip B. Gates, Hannah E. Walters, Andreas Petzold, Hernan Arce, Rodrigo C. Cordoba, Elaiyaraja Subramanian, Osvaldo Chara, Elly M. Tanaka, Andras Simon, Maximina H. Yun
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Juan M. F. Fernandez, Damian N. Spagnuolo, Maria T. Politi, Ivan A. Tello Santacruz, Miguel Schiavone, Cesar Caceres Monie, Horacio A. Avaca, Osvaldo Chara
Summary: Alteration of muscle activation sequence is a key mechanism in heart failure, and the lack of precise dyssynchrony quantification limits the success of cardiac resynchronization therapy (CRT). In this study, a computational pipeline was implemented to assess ventricular dyssynchrony by reconstructing vectorcardiograms from electrocardiograms. The dyssynchrony index showed significant differences between healthy controls and patients with left bundle branch block or pacemakers. Additionally, high dyssynchrony indexes were associated with mechanical dyssynchrony. This index shows promise in enhancing the selection and optimization of candidates for CRT.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Paula Heinke, Fabian Rost, Julian Rode, Palina Trus, Irina Simonova, Eniko Lazar, Joshua Feddema, Thilo Welsch, Kanar Alkass, Mehran Salehpour, Andrea Zimmermann, Daniel Seehofer, Goran Possnert, Georg Damm, Henrik Druid, Lutz Brusch, Olaf Bergmann
Summary: This study used retrospective radiocarbon birth dating to investigate the turnover of human liver cells. The results showed that human hepatocytes undergo continuous and lifelong renewal, which keeps the liver young. Diploid hepatocytes have a higher birth rate than polyploid hepatocytes, and the transition between diploid and polyploid cells is limited under homeostatic conditions.
Article
Biochemistry & Molecular Biology
Carlotta Mayer, Sophie Nehring, Michael Kuecken, Urska Repnik, Sarah Seifert, Aleksandra Sljukic, Julien Delpierre, Hernan Morales-Navarrete, Sebastian Hinz, Mario Brosch, Brian Chung, Tom Karlsen, Meritxell Huch, Yannis Kalaidzidis, Lutz Brusch, Jochen Hampe, Clemens Schafmayer, Marino Zerial
Summary: Hepatocytes dynamically respond to bile acids and bile flow, but little is known about their response to intraluminal pressure. This study reveals that hepatocytes form apical bulkheads in response to obstructed bile flow, which protect bile canaliculi against elevated pressure. The loss of apical bulkheads leads to abnormally dilated canaliculi, highlighting the importance of canalicular pressure in liver diseases.
Article
Mathematics, Interdisciplinary Applications
Robert Mueller, Arthur Boutillon, Diego Jahn, Joern Starruss, Nicolas B. David, Lutz Brusch
Summary: Collective cell migration is a crucial process in biological development and tissue repair, but it can become malignant during tumor invasion. Mathematical and computational models are essential for understanding the self-organization mechanisms that drive collective migration from individual cell interactions. This study explores how guidance stimuli are integrated when multiple cells interact simultaneously, using an individual-based model. The results show that collective cell migration remains robust and qualitatively the same regardless of the variant of stimulus integration considered. This study highlights the importance of individual-based modeling for understanding collective phenomena arising from cell-cell interactions.
FRONTIERS IN APPLIED MATHEMATICS AND STATISTICS
(2023)
Article
Biology
Theodoros Kyriazos, Mary Poga
Summary: This paper explores the innovative intersection of quantum mechanics and psychology, examining the potential impact of quantum principles on human emotions, cognition, and consciousness. By drawing parallels between quantum phenomena and psychological counterparts, a quantum-psychological model is proposed, reimagining the characteristics of emotional states, cognitive breakthroughs, interpersonal relationships, and the nature of consciousness. Computational models and simulations are used to explore the implications and applications of this interdisciplinary fusion, highlighting its potential benefits and inherent challenges. Approaching this emerging framework with both enthusiasm and skepticism is crucial, and rigorous empirical validation is necessary to fully realize its potential in research and therapeutic contexts.
Article
Biology
Abir U. Igamberdiev
Summary: Biological systems strive to maximize self-maintenance and adaptability by establishing stable non-equilibrium states that organize the fluxes of matter and energy and control metabolic processes. These states are realized in autopoietic structures that operate based on biological codes. The principle of thermodynamic buffering optimizes metabolic fluxes, and in developing systems, the principle transforms into increasing external work. Bauer's concept of the stable non-equilibrium state places thermodynamics within the framework of internal biological causality, providing a relational theory of biological thermodynamics.
Article
Biology
Oleg Gaidai, Vladimir Yakimov, Yuhao Niu, Zirui Liu
Summary: This study presents a new methodology for assessing pandemic risks in a national health system. The suggested approach addresses the highdimensionality and complex cross-correlations between regional observations, enabling accurate epidemiological risk forecasts for multi-regional biological and health systems.
Article
Biology
Amirreza Khalili Golmankhaneh, Suemeyye Tunc, Agnieszka Matylda Schlichtinger, Dachel Martinez Asanza, Alireza Khalili Golmankhaneh
Summary: This article introduces important concepts such as fractal calculus and fractal analysis, the calculation of squared residuals, and the determination of Aikaike's information criterion for fitting cancer-related data. The study also investigates the double-size cancer in the fractal temporal dimension with respect to various mathematical models.