Review
Chemistry, Multidisciplinary
Nuria Lafuente-Gomez, Ana Latorre, Paula Milan-Rois, Ciro Rodriguez Diaz, Alvaro Somoza
Summary: Nanoparticles loaded with anti-cancer drugs have advantages in terms of solubility, biodistribution, controlled release, and reducing exposure of healthy tissues to chemotherapeutics, thus improving treatment effectiveness. Their properties, potential clinical translation, and limitations for cancer treatment are highlighted in this review.
CHEMICAL COMMUNICATIONS
(2021)
Review
Chemistry, Physical
Justyna Milan, Klaudia Niemczyk, Malgorzata Kus-Liskiewicz
Summary: Recent advances in the synthesis of metal nanoparticles, particularly gold nanoparticles, have led to their promising applications in biomedical field, such as imaging, treatment, and drug delivery. The unique properties and functionality of gold nanoparticles make them ideal for specific biomedical applications.
Article
Nanoscience & Nanotechnology
Mohzibudin Z. Quazi, Ukjae Lee, Sanghak Park, Seonhye Shin, Eunseop Sim, Hyungbin Son, Nokyoung Park
Summary: Stimuli-responsive nanoparticles, specifically reversibly pH-responsive gold nanoparticles, have been developed and demonstrated as an effective theranostic reagent for cancer treatment, showing highly enhanced Raman imaging and therapeutic efficiency in cancer cells.
ACS APPLIED BIO MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Xing-Qun Pu, Xiao-Jie Ju, Lei Zhang, Quan-Wei Cai, Yu-Qiong Liu, Han-Yu Peng, Rui Xie, Wei Wang, Zhuang Liu, Liang-Yin Chu
Summary: A novel class of multifunctional responsive nanoparticles was designed and fabricated as drug nanocarriers for synergetic chemo-photothermal therapy of tumors. These nanoparticles demonstrated good biocompatibility and outstanding photothermal conversion efficiency, with controlled drug release under low pH and high temperature conditions. Experimental results showed that the nanoparticles were phagocytosed by tumor cells and released drugs in acidic environments, with higher efficacy in combined chemo and photothermal therapy compared to individual treatments.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
X. Hai, M. Ji, K. Yu, T. Tian, Z. Cui, S. Bi, X. Zhang
Summary: DNA nanotechnology has been utilized to construct a DNA-Au nanomachine with active/passive dual-targeting capacity for lysosomal acidic microenvironment-activated combinational chemo-photothermal therapy of cervical carcinoma. The nanomachine consists of three-dimensional DNA nanoflowers and BSA-modified gold nanoparticles, allowing for targeted chemotherapy and photothermal therapy. In vitro and in vivo studies demonstrate the potential of this nanomachine for targeted combinational therapy of cancer.
MATERIALS TODAY NANO
(2023)
Article
Chemistry, Multidisciplinary
Shichuan Zhong, Lifeng Hang, Lulu Wen, Tao Zhang, An Cao, Pan Zeng, Hanlin Zhang, Dilong Liu, Weiping Cai, Yue Li
Summary: We developed a tunable, ultrafast (5 seconds), and mass-producible seed-mediated synthesis method to prepare branched Au superparticles consisting of multiple small Au island-like nanoparticles by a wet chemical route. We revealed and confirmed the toggling formation mechanism of Au superparticles between the Frank-van der Merwe (FM) growth mode and the Volmer-Weber (VW) growth mode. These Au superparticles demonstrate broadband absorption from visible to near-infrared regions due to their multiple plasmonic coupling, making them suitable for applications in sensors, photothermal conversion, and therapy.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Kishwor Poudel, Asmita Banstola, Milan Gautam, Zar Chi Soe, Le Minh Pham, Jee-Heon Jeong, Han-Gon Choi, Sae Kwang Ku, Chul Soon Yong, Tuan Hiep Tran, Jong Oh Kim
Summary: The study successfully constructed redox- and laser-responsive nanourchins capable of releasing MTX and ICG upon GSH induction and laser irradiation, leading to tumor growth inhibition. The combination of Bi2S3 and ICG generated heat and reactive oxygen species, further enhancing the anticancer activity of MTX against cancer cells. This targeted nanocarrier system showed promising results in in vitro and in vivo studies, with tumor-selective attributes and effective tumor ablation without affecting vital organs.
Article
Nanoscience & Nanotechnology
Maryam Deinavizadeh, Alireza Kiasat, Nasrin Hooshmand, Mohammad Shafiei, Mohammad Sabaeian, Roya Mirzajani, Seyed Mohammadsaleh Zahraei, Hagar Labouta, Mostafa A. El-Sayed
Summary: A novel biocompatible nanocomposite, consisting of gold nanorods coated with rod-like mesoporous silica particles, has been designed for synergistic thermal and chemotherapeutic delivery in eradicating cancer cells. The nanocomposite demonstrated high potential therapeutic efficacy in ablation of lung cancer cells through a combination of photothermal and chemotherapy treatments.
Article
Biophysics
Xiaowei Wang, Yaxuan Gu, Qi Li, Yapeng Xu, Yifan Shi, Zheran Wang, Mingyu Xia, Ji Li, Dongkai Wang
Summary: The study introduces an intelligent polymer drug carrier based on pH-responsive charge-reversal, which delivers drugs for chemo-photothermal combination therapy, leading to enhanced efficacy in tumor treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Pharmacology & Pharmacy
Weirong Kang, Yuwei Liu, Weiping Wang
Summary: Immunotherapy has revolutionized cancer treatments by activating the immune system to effectively inhibit cancer progression. Recent advances in cancer immunotherapy, such as checkpoint blockades and adoptive cellular therapy, have shown remarkable clinical outcomes. However, low response rates and side effects limit the widespread use of immunotherapy. Nanomedicine, specifically light-responsive nanoplatforms, show promise in enhancing immunotherapy by precise drug delivery and modulation of the tumor microenvironment.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Nanoscience & Nanotechnology
Yan Yang, Xi Zheng, Lu Chen, Xuefeng Gong, Hao Yang, Xingmei Duan, Yuxuan Zhu
Summary: Cancer is the second leading cause of death in the world and poses a serious threat to human health. Nanomedicine, particularly gold nanoparticles (AuNPs), has emerged as a promising technology for overcoming the limitations of conventional cancer therapies. This review discusses the current achievements and clinical trials of AuNPs in anticancer applications, as well as the challenges in translating basic findings into the clinic, providing a reference for future research.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Grazia M. L. Consoli, Giuseppe Forte, Ludovica Maugeri, Valeria Consoli, Valeria Sorrenti, Luca Vanella, Gianpiero Buscarino, Simonpietro Agnello, Massimo Camarda, Giuseppe Granata, Loredana Ferreri, Salvatore Petralia
Summary: This study presents a novel method to prepare water-dispersible gold nanostructures with near-infrared localized surface plasmon resonance (LSPR) properties. These nanostructures were synthesized using NADH as a reducing agent and an amphiphilic choline-calix[4]arene derivative (CholCalix) forming micelles as a template. Characterization of the CholCalix-Au nanostructures was performed using UV-visible spectrophotometry, Raman spectroscopy, and atomic force microscopy. The agglomeration of the nanostructures due to multiple crosslinking interactions was observed and supported by modeling simulation. The CholCalix-AuNPs demonstrated effective anticancer photothermal-induced effect on human breast cancer cells irradiated with biofriendly light at 808 nm.
ACS APPLIED NANO MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Rui Sun, Huajian Chen, Linawati Sutrisno, Naoki Kawazoe, Guoping Chen
Summary: Photothermal therapy is a promising method for cancer treatment with less severe side effects. The use of photothermal agents and composite scaffolds can enhance treatment efficacy while minimizing adverse effects, promoting the reconstruction and regeneration of tissues and organs.
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Subin Son, Jungryun Kim, Jaewon Kim, Byungkook Kim, Jieun Lee, Yuri Kim, Mingle Li, Heemin Kang, Jong Seung Kim
Summary: Light-based phototherapy has limitations in cancer treatment due to its limited penetration depth. To overcome these limitations, various energy sources such as ultrasound, chemiluminescence, radiation, microwave, electricity, and magnetic field have been developed. Combining these energy sources with other strategies or therapies can improve the effectiveness of cancer treatment.
CHEMICAL SOCIETY REVIEWS
(2022)
Review
Chemistry, Multidisciplinary
Song Shen, Jichuan Qiu, Da Huo, Younan Xia
Summary: Photothermal therapy shows great potential in killing cancer cells through hyperthermia. The efficacy is affected by various parameters, including the laser, photothermal transducers, spatial distribution of the transducers, bioeffect of the tissue (heat-sink effect, thermal conductivity), and real-time temperature monitoring.
