A genome-wide association study in mice reveals a role for Rhbdf2 in skeletal homeostasis

Determinants of QTL Mapping Power in the Realized Collaborative Cross

(2019) Gregory R. Keele et al.   G3-Genes Genomes Genetics

An atlas of genetic influences on osteoporosis in humans and mice

(2018) John A. Morris et al.   NATURE GENETICS

Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis

(2017) John P Kemp et al.   NATURE GENETICS

Statistical correction of the Winner’s Curse explains replication variability in quantitative trait genome-wide association studies

(2017) Cameron Palmer et al.   PLoS Genetics

High-fat-diet induced development of increased fasting glucose levels and impaired response to intraperitoneal glucose challenge in the collaborative cross mouse genetic reference population

(2016) Hanifa J. Abu-Toamih Atamni et al.   BMC GENETICS

iRhom2 regulates CSF1R cell surface expression and non-steady state myelopoiesis in mice

(2016) Xiaoping Qing et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Heritability and Genetic Correlations for Bone Microarchitecture: The Framingham Study Families

(2016) David Karasik et al.   JOURNAL OF BONE AND MINERAL RESEARCH

iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING

(2016) Wei-Wei Luo et al.   NATURE IMMUNOLOGY

Collaborative cross mice in a genetic association study reveal new candidate genes for bone microarchitecture

(2015) Roei Levy et al.   BMC GENOMICS

Erythropoietin directly stimulates osteoclast precursors and induces bone loss

(2015) Sahar Hiram-Bab et al.   FASEB JOURNAL

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

(2015) Xue Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut Melatonin in Vertebrates: Chronobiology and Physiology

(2015) Sourav Mukherjee et al.   Frontiers in Endocrinology

The Recent Prevalence of Osteoporosis and Low Bone Mass in the United States Based on Bone Mineral Density at the Femoral Neck or Lumbar Spine

(2014) Nicole C Wright et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Colony-stimulating factor 1 potentiates lung cancer bone metastasis

(2014) Jaclyn Y Hung et al.   LABORATORY INVESTIGATION

Heritability and coefficient of genetic variation analyses of phenotypic traits provide strong basis for high-resolution QTL mapping in the Collaborative Cross mouse genetic reference population

(2014) Fuad A. Iraqi et al.   MAMMALIAN GENOME

The Osteoblast to Osteocyte Transition: Epigenetic Changes and Response to the Vitamin D3Hormone

(2014) Hillary C. St. John et al.   MOLECULAR ENDOCRINOLOGY

Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin

(2014) V. Hosur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice

(2014) O. M. Siggs et al.   Biology Open

Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6

(2013) Xiaofei Zhang et al.   EMBO JOURNAL

Fibroblast Growth Factor 23, Bone Mineral Density, and Risk of Hip Fracture Among Older Adults: The Cardiovascular Health Study

(2013) Anna Jovanovich et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits

(2013) Unnur Styrkarsdottir et al.   NATURE

Genetic Determinants of Trabecular and Cortical Volumetric Bone Mineral Densities and Bone Microstructure

(2013) Lavinia Paternoster et al.   PLoS Genetics

RHBDF2 Mutations Are Associated with Tylosis, a Familial Esophageal Cancer Syndrome

(2012) Diana C. Blaydon et al.   AMERICAN JOURNAL OF HUMAN GENETICS

iRhom2 is required for the secretion of mouse TNF 

(2012) O. M. Siggs et al.   BLOOD

The Genome Architecture of the Collaborative Cross Mouse Genetic Reference Population

(2012)   GENETICS

Genome-Wide Association Studies of Skeletal Phenotypes: What We Have Learned and Where We Are Headed

(2012) Yi-Hsiang Hsu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

(2012) Karol Estrada et al.   NATURE GENETICS

Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

(2012) C. Adrain et al.   SCIENCE

iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

(2012) D. R. McIlwain et al.   SCIENCE

Collaborative Cross mice and their power to map host susceptibility toAspergillus fumigatusinfection

(2011) Caroline Durrant et al.   GENOME RESEARCH

Smad6 is essential to limit BMP signaling during cartilage development

(2011) Kristine D Estrada et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mouse genomic variation and its effect on phenotypes and gene regulation

(2011) Thomas M. Keane et al.   NATURE

Epidemiology of hip fracture: Worldwide geographic variation

(2010) DineshK Dhanwal et al.   Indian Journal of Orthopaedics

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

(2010) Mary L Bouxsein et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Genome-Wide Association Meta-Analysis of Cortical Bone Mineral Density Unravels Allelic Heterogeneity at the RANKL Locus and Potential Pleiotropic Effects on Bone

(2010) Lavinia Paternoster et al.   PLoS Genetics

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

PrimerBank: a resource of human and mouse PCR primer pairs for gene expression detection and quantification

(2009) Athanasia Spandidos et al.   NUCLEIC ACIDS RESEARCH

Cytoglobin:A Novel Potential Gene Medicine for Fibrosis and Cancer Therapy

(2008) Yinghui Lv et al.   CURRENT GENE THERAPY

Epidermal growth factor receptor regulates osteoclast differentiation and survival through cross-talking with RANK signaling

(2008) TacGhee Yi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study

(2008) JB Richards et al.   LANCET

Multiple Genetic Loci for Bone Mineral Density and Fractures

(2008) Unnur Styrkarsdottir et al.   NEW ENGLAND JOURNAL OF MEDICINE