期刊
NUTRIENTS
卷 12, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/nu12030670
关键词
dehydration; physical growth; cognitive development; brain transcriptome; hippocampus; brain-derived neurotrophic factor
资金
- Coway Co., Ltd.
- National Research Foundation of Korea [NRF-2015S1A5A2A03050006, NRF-2018R1D1A1B07048023]
- National Research Foundation of Korea [2015S1A5A2A03050006] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Infancy and childhood are periods of physical and cognitive development that are vulnerable to disruption by dehydration; however, the effects of dehydration on cognitive development during the periods have not yet been fully elucidated. Thus, the present study used a murine model to examine the effects of sustained dehydration on physical growth and cognitive development. Three-week-old C57BL/6J mice were provided either ad libitum (control group) or time-limited (15 min/day; dehydration group) access to water for 4 weeks. Physical growth was examined via a dual-energy X-ray absorptiometry whole-body scan, and cognitive development was assessed using the Barnes maze test. RNA-sequencing and qPCR analyses were carried out to assess the hippocampal transcriptome and the expression of key neurotrophic factors, respectively. These analyses showed that dehydrated mice exhibited a reduced body mass and tail length, and they spent four times longer completing the Barnes maze test than control mice. Moreover, dehydration significantly dysregulated long-term potentiation signaling and specifically decreased hippocampal brain-derived neurotrophic factor (Bdnf) expression. Collectively, these data confirm dehydration inhibits physical growth and suggest that it impairs cognitive development by altering the hippocampal transcriptional network in young mice; thus, they highlight the importance of water as a vital nutrient for optimal growth and development during infancy and childhood.
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