Article
Gastroenterology & Hepatology
Bridgette Wilson, Tokuwa Kanno, Rachael Slater, Megan Rossi, Peter M. Irving, Miranda C. Lomer, Chris Probert, A. James Mason, Kevin Whelan
Summary: Baseline faecal and urine metabolites can predict response to the low FODMAP diet in patients with irritable bowel syndrome.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Nutrition & Dietetics
Martyna Wiecek, Paulina Panufnik, Magdalena Kaniewska, Konrad Lewandowski, Grazyna Rydzewska
Summary: The study found that in patients in remission of IBD, a low-FODMAP diet intervention is effective in reducing IBS-like symptoms, regardless of the presence of bacterial overgrowth.
Article
Nutrition & Dietetics
Heidi M. Staudacher, Matthias Scholz, Miranda Ce Lomer, Frances S. Ralph, Peter M. Irving, James O. Lindsay, Francesca Fava, Kieran Tuohy, Kevin Whelan
Summary: This study aimed to investigate the relationship between diet and microbiota in IBS patients, as well as the impact of two nutritional interventions on the microbiota. The results showed that the low FODMAP diet and probiotic supplementation can alter the microbiota in IBS patients, but baseline microbiota cannot predict clinical response to interventions.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Samira Rastgoo, Nasser Ebrahimi-Daryani, Shahram Agah, Sara Karimi, Mohammad Taher, Bahram Rashidkhani, Ehsan Hejazi, Fatemeh Mohseni, Mina Ahmadzadeh, Amir Sadeghi, Azita Hekmatdoost
Summary: The study demonstrated the superiority of adding glutamine supplementation to a low FODMAP diet in alleviating IBS symptoms, while also confirming the beneficial effects of a low FODMAP diet in IBS management through a randomized controlled trial.
FRONTIERS IN NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Jie Wu, Imke Masuy, Jessica R. Biesiekierski, Heather E. Fitzke, Chinar Parikh, Laurel Schofield, Hafsa Shaikh, Anisha Bhagwanani, Qasim Aziz, Stuart A. Taylor, Jan Tack, Lukas Van Oudenhove
Summary: Fructans induce similar changes in small bowel motility and colon gas and volume in patients with irritable bowel syndrome (IBS) and healthy controls (HCs). Increased symptom responses to fructans in IBS are associated with altered brain responses in pain-related regions, indicating a dysregulation of the gut-brain axis in FODMAP-induced symptom generation in IBS.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Nutrition & Dietetics
Jongsung Hahn, Jeongwon Choi, Min Jung Chang
Summary: This meta-analysis revealed that a low fermentable oligo-, di-, monosaccharides, and polyols diet (LFD) has a moderate reduction effect on the symptom severity and a slight improvement effect on the quality of life of irritable bowel syndrome (IBS) patients, as well as a significant improvement in stool habits.
Article
Gastroenterology & Hepatology
Anupam Rej, David S. Sanders, Christian C. Shaw, Rachel Buckle, Nick Trott, Anurag Agrawal, Imran Aziz
Summary: This randomized trial compared the efficacy of traditional dietary advice (TDA) with low FODMAP diet (LFD) and gluten-free diet (GFD) in patients with non-constipated irritable bowel syndrome (IBS). The results showed that while all three diets were effective, TDA was the most suitable for patients in terms of cost and convenience.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Pediatrics
Elvira Ingrid Levy, Charlotte De Geyter, Abdelhalim Ouald Chaib, Berthold Albert Aman, Badriul Hegar, Yvan Vandenplas
Summary: There are limited randomized controlled trials on managing pediatric IBS, with most intervention trials targeting changes to the gastrointestinal microbiome. Heterogeneity in study designs and outcomes make it difficult to formulate recommendations. Insufficient evidence exists to recommend therapeutic interventions in pediatric IBS, despite the association with dysbiosis. More prospective trials are needed.
Review
Pharmacology & Pharmacy
Chao-Rong Xie, Bin Tang, Yun-Zhou Shi, Wen-Yan Peng, Kun Ye, Qing-Feng Tao, Shu-Guang Yu, Hui Zheng, Min Chen
Summary: This study evaluated the most effective approaches for managing irritable bowel syndrome (IBS) by analyzing different combinations and components of probiotics or a low FODMAP diet. The results showed that Lactobacillus was the most effective component for relieving IBS symptoms, while Bifidobacterium and Bacillus were potentially effective and require further verification.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Sofia D. Shaikh, Natalie Sun, Andrew Canakis, William Y. Park, Horst Christian Weber
Summary: Irritable Bowel Syndrome (IBS) is a functional disorder of the gastrointestinal tract characterized by abdominal pain and altered bowel habits. It has a high prevalence and disease burden, affecting the quality of life, work productivity and healthcare utilization and costs. IBS is associated with various conditions, including psychiatric comorbidities. The pathophysiology involves dysregulation of the brain-gut axis, leading to changes in intestinal motility, gut permeability, visceral hypersensitivity and gut microbiota composition. This article aims to explore the role of gut microbiota in the pathophysiology of IBS, factors influencing the gut microbiome, and the potential of microbiome as a treatment target.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Daniel So, Chu K. Yao, Zaid S. Ardalan, Phoebe A. Thwaites, Kourosh Kalantar-Zadeh, Peter R. Gibson, Jane G. Muir
Summary: Concomitant supplementation of fibers during a low FODMAP diet did not alter symptomatic response in patients with IBS but augmented stool bulk and normalized low stool water content and slow transit.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
William D. Chey, Jana G. Hashash, Laura Manning, Lin Chang
Summary: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder that affects quality of life. The latest clinical practice update recommends dietary modifications, such as the low-FODMAP diet, as the primary treatment for IBS symptoms. Best practice advice includes involving patients who are insightful and motivated in dietary changes, avoiding restrictive diets for patients who are poor candidates, highlighting the benefits of soluble fiber and the low-FODMAP diet, and following a three-phase approach for the low-FODMAP diet. The efficacy of a gluten-free diet for IBS is uncertain and there is limited evidence to support the routine use of biomarkers in clinical practice.
Review
Nutrition & Dietetics
Ionela-Daniela Morariu, Liliana Avasilcai, Madalina Vieriu, Vasile Valeriu Lupu, Branco-Adrian Morariu, Ancuta Lupu, Paula-Cristina Morariu, Oana-Lelia Pop, Iuliana Magalena Starcea, Laura Trandafir
Summary: Irritable bowel syndrome is a common gastrointestinal disease that causes various symptoms such as bloating, abdominal pain, and diarrhea. A low-FODMAP diet has been shown to effectively reduce these symptoms and improve the quality of life for patients with irritable bowel syndrome.
Article
Nutrition & Dietetics
Ameen Eetemadi, Ilias Tagkopoulos
Summary: This study identified two types of IBS patients based on gut microbiome data - those who respond well to a low-FODMAP diet and those who would benefit from dietary supplementation. Microbiome data can predict patient response to the low-FODMAP diet.
CLINICAL NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Hanna Fjeldheim Dale, Sissi Christiane Stove Lorentzen, Tonje Mellin-Olsen, Jorgen Valeur
Summary: Diet plays a crucial role in modulating the gut microbiota and is decisive for gut-microbiota-related diseases like IBS. While the LFD is commonly used to treat IBS, its long-term effects on microbiota, symptoms, and QoL are unclear. Therefore, alternative dietary strategies that promote beneficial gut microbiota and improve symptoms and QoL are of interest.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Mentore Ribolsi, Marzio Frazzoni, Nicola De Bortoli, Salvatore Tolone, Elena Arsie, Lucia Mariani, Giovanni De Carlo, Darla Maniero, Roberto Penagini, Michele Cicala, Edoardo Savarino
Summary: Acid, mixed, and proximal refluxes, as well as their duration, are key factors in eliciting PSPWs. PSPW represents a response to reflux directly related to the potential harmfulness of reflux contents.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Review
Gastroenterology & Hepatology
Brigida Barberio, Pierfrancesco Visaggi, Edoardo Savarino, Nicola de Bortoli, Christopher J. Black, Alexander C. Ford
Summary: This study conducted a network meta-analysis to evaluate the efficacy and safety of different medical therapies for endoscopy-negative reflux disease. The results showed that proton pump inhibitors (PPIs) are superior to other drugs in treating this condition. Future research should focus on better patient classification and investigating the efficacy of other drugs.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Editorial Material
Gastroenterology & Hepatology
Nicola de Bortoli, Federica Baiano Svizzero, Veronica Pardi, Pierfrancesco Visaggi
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Marzio Frazzoni, Leonardo Frazzoni, Mentore Ribolsi, Salvatore Russo, Rita Conigliaro, Nicola De Bortoli, Edoardo Savarino
Summary: This study defined on-PPI cut-offs of impedance-pH metrics to support the diagnosis and treatment of PPI-refractory GERD by evaluating real-time data of impedance-pH monitoring under PPI therapy. The results showed that comprehensive assessment of impedance-pH metrics, including PSPW index and MNBI, can improve the monitoring effectiveness for patients with PPI-refractory GERD.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Gastroenterology & Hepatology
Pierfrancesco Visaggi, Brigida Barberio, Giulio Del Corso, Nicola de Bortoli, Christopher J. Black, Alexander C. Ford, Edoardo Savarino
Summary: A network meta-analysis was conducted to compare the efficacy of different drugs for active eosinophilic esophagitis (EoE). The results showed that most available drugs were more effective than placebo in treating EoE. However, significant heterogeneity among the trials hindered the establishment of a solid therapeutic hierarchy.
Review
Biochemistry & Molecular Biology
Giovanni Marasco, Pierfrancesco Visaggi, Mariagiulia Vassallo, Miriam Fiocca, Cesare Cremon, Maria Raffaella Barbaro, Nicola De Bortoli, Massimo Bellini, Vincenzo Stanghellini, Edoardo Vincenzo Savarino, Giovanni Barbara
Summary: Eosinophilic gastrointestinal diseases (EGIDs) are a group of pathological conditions characterized by eosinophil infiltration in the gut. They can be classified into different types based on the specific tract involved. The epidemiology of EGIDs is evolving rapidly, and research on treatment options is ongoing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Analytical
Giorgia Spreafico, Marcello Chiurazzi, Davide Bagnoli, Sergio Emiliani, Nicola de Bortoli, Gastone Ciuti
Summary: Diseases of the esophageal tract represent a heterogeneous class of pathological conditions, and there are different diagnostic paradigms currently available. This review provides a comprehensive analysis of available endoluminal technologies and procedures to investigate esophagus health conditions.
Article
Medicine, General & Internal
Lorenzo Bertani, Claudia DAlessandro, Marco Fornili, Francesca Coppini, Federico Zanzi, Luca Carmisciano, Francesca Geri, Giovanni Baiano Svizzero, Emma Maria Rosi, Alice De Bernardi, Linda Ceccarelli, Maria Gloria Mumolo, Laura Baglietto, Massimo Bellini, Nicola De Bortoli, Francesco Costa
Summary: The study aimed to evaluate the impact of ustekinumab on body composition in patients with Crohn's disease. The results showed that ustekinumab treatment could modify body composition indicators in CD patients, with a significant improvement in nutritional status observed in responders.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Alessandro Massano, Luisa Bertin, Fabiana Zingone, Andrea Buda, Pierfrancesco Visaggi, Lorenzo Bertani, Nicola de Bortoli, Matteo Fassan, Marco Scarpa, Cesare Ruffolo, Imerio Angriman, Cristina Bezzio, Valentina Casini, Davide Giuseppe Ribaldone, Edoardo Vincenzo Savarino, Brigida Barberio
Summary: This review summarizes the evidence on the association between inflammatory bowel disease (IBD) and extraintestinal cancers (EICs), as well as the safety and management of immunomodulators and biologics for IBD patients with prior or current EICs.
Review
Medicine, General & Internal
Emanuele Tumino, Pierfrancesco Visaggi, Valeria Bolognesi, Linda Ceccarelli, Christian Lambiase, Sergio Coda, Purushothaman Premchand, Massimo Bellini, Nicola de Bortoli, Emanuele Marciano
Summary: Lower gastrointestinal endoscopy is the gold standard for diagnosing and removing colonic polyps. However, some patients refuse conventional colonoscopy due to fear of risks and discomfort. Robotic colonoscopy offers a promising alternative, allowing for a painless examination of the colon. Barium enema, computed tomographic colonography, and colon capsule endoscopy are also possible alternatives.
Review
Medicine, General & Internal
Pierfrancesco Visaggi, Irene Solinas, Federica Baiano Svizzero, Andrea Bottari, Brigida Barberio, Greta Lorenzon, Matteo Ghisa, Daria Maniero, Elisa Marabotto, Massimo Bellini, Nicola de Bortoli, Edoardo V. Savarino, Anastasios Koulaouzidis
Summary: This review summarizes the evidence on investigational non-invasive or minimally invasive biomarkers for the diagnosis and follow-up of EoE, and discusses the limitations that currently hinder their integration into clinical practice. Future studies should focus on validating the utility of these biomarkers using rigorous protocols and updated consensus criteria for EoE.
Article
Nutrition & Dietetics
Gianluca Rizzo, Luciana Baroni, Chiara Bonetto, Pierfrancesco Visaggi, Mattia Orazzini, Irene Solinas, Giada Guidi, Jessica Pugliese, Giulia Scaramuzza, Filippo Ovidi, Irene Buselli, Massimo Bellini, Edoardo V. Savarino, Nicola de Bortoli
Summary: This study investigated the association between diet and GERD, and found that individuals on a vegan diet had a significantly lower risk of developing GERD and reported a worse quality of life.