Review
Biochemistry & Molecular Biology
Aleksandra Goralczyk-Binkowska, Dagmara Szmajda-Krygier, Elzbieta Kozlowska
Summary: This article highlights the link between the intestinal microbiome and the brain, as well as the host response involving different pathways between the intestinal microbiota and the nervous system. It discusses microbiota alterations and their role in the development of psychiatric disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychiatry
Dara E. Babinski, Erika F. H. Saunders, Fan He, Duanping Liao, Amanda M. Pearl, Daniel A. Waschbusch
Summary: This study examined the diagnostic indicators, clinical characteristics, and functional impairment associated with adult ADHD using electronic medical records and self-report measures. The results showed a significant difference in prevalence of ADHD between self-report screening and medical records. ADHD was found to contribute to functional impairment even when controlling for other psychiatric comorbidities.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
Kai Yao, Tracey van der Veen, Johan Thygesen, Nick Bass, Andrew Mcquillin
Summary: This study explores the interaction between adverse childhood experiences and genetic risk for bipolar disorder and its impact on symptom outcomes. The findings emphasize the importance of considering multiple psychiatric polygenic risk scores in predicting symptom outcomes among bipolar disorder patients.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Multidisciplinary Sciences
Won-Seok Choi, Young Sup Woo, Sheng-Min Wang, Hyun Kook Lim, Won-Myong Bahk
Summary: The prevalence of comorbid psychiatric disorders in adults with ADHD varies depending on the diagnostic tools used and the characteristics of the population. Standardization of ADHD diagnostic tools is necessary.
Article
Neurosciences
Azadeh Kushki, Robyn E. Cardy, Sina Panahandeh, Mahan Malihi, Christopher Hammill, Jessica Brian, Alana Iaboni, Margot J. Taylor, Russell Schachar, Jennifer Crosbie, Paul Arnold, Elizabeth Kelley, Muhammad Ayub, Robert Nicolson, Stelios Georgiades, Jason P. Lerch, Evdokia Anagnostou
Summary: The study discovered associations between social communication abilities and distributed cortical and subcortical networks implicated in social behaviors, language, attention, memory, and executive functions, as well as three data-driven, diagnosis-agnostic subgroups based on the patterns of association in these networks.
Article
Neurosciences
Jose Ramon Gutierrez-Casares, Cristina Segu-Verges, Juncal Sabate Chueca, Tamara Pozo-Rubio, Mireia Coma, Carmen Montoto, Javier Quintero
Summary: Attention-deficit/hyperactivity disorder (ADHD) is a psychiatric condition that can continue into adulthood and is often accompanied by other psychiatric comorbidities. Lisdexamfetamine (LDX) is a stimulant prodrug approved for treating ADHD and binge eating disorder (BED). Through a computational model, we evaluated the efficacy of a virtual model of LDX (vLDX) as ADHD treatment in improving five common ADHD psychiatric comorbidities in adults and children, and explored the molecular mechanisms underlying the predicted efficacy of LDX.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Helena Pelin, Marcus Ising, Frederike Stein, Susanne Meinert, Tina Meller, Katharina Brosch, Nils R. Winter, Axel Krug, Ramona Leenings, Hannah Lemke, Igor Nenadic, Stefanie Heilmann-Heimbach, Andreas J. Forstner, Markus M. Noethen, Nils Opel, Jonathan Repple, Julia Pfarr, Kai Ringwald, Simon Schmitt, Katharina Thiel, Lena Waltemate, Alexandra Winter, Fabian Streit, Stephanie Witt, Marcella Rietschel, Udo Dannlowski, Tilo Kircher, Tim Hahn, Bertram Mueller-Myhsok, Till F. M. Andlauer
Summary: Psychiatric disorders display diverse symptoms and progression patterns, with the current classification system failing to accurately represent their molecular causes and symptomatic variations. By utilizing high-dimensional data clustering, we identified five clusters of psychiatric patients with shared clinical and genetic characteristics, aiding in the understanding of the heterogeneity of psychiatric disorders and potentially facilitating personalized treatment approaches.
NEUROPSYCHOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Wu Jeong Hwang, Tae Young Lee, Nahrie Suk Kim, Jun Soo Kwon
Summary: This review highlights the role of estrogen and estrogen signaling in psychiatric disorders, emphasizing their impact on brain functions and neuroprotection. The potential therapeutic use of estrogen in treating psychiatric disorders is explored, along with disruptions in estrogen signaling and their implications for pathophysiologies in these disorders. Insights from this review suggest potential novel treatment strategies involving estrogen and its signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Che-Sheng Chu, Shih-Jen Tsai, Ju-Wei Hsu, Kai-Lin Huang, Chih-Ming Cheng, Tung-Ping Su, Tzeng-Ji Chen, Ya-Mei Bai, Chih-Sung Liang, Mu-Hong Chen
Summary: The study found that the progression rate from ADHD to BD is 5.12% among adolescents and young adults. Risk factors for progression include older age, comorbidity with other mental disorders, and alcohol use. Protective factors identified were male sex and certain personality disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Endocrinology & Metabolism
Mu-Hong Chen, Shih-Jen Tsai, Ya-Mei Bai, Kai-Lin Huang, Tung-Ping Su, Tzeng-Ji Chen, Ju-Wei Hsu
Summary: This study found that patients with type 1 diabetes mellitus (T1DM) have an increased risk of major psychiatric disorders such as schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorder (ASD), and attention-deficit hyperactivity disorder (ADHD). These findings highlight the importance of closely monitoring the mental health of individuals with T1DM and conducting further research to elucidate the underlying mechanisms of comorbidities between T1DM and major psychiatric disorders.
DIABETES & METABOLISM
(2022)
Review
Neurosciences
Tomasz Kozlowski, Weronika Bargiel, Maksymilian Grabarczyk, Maria Skibinska
Summary: This systematic review compares studies on peripheral S100B levels in five major psychiatric disorders with shared genetic backgrounds, and the results suggest that alterations in S100B levels are not disease-specific.
Article
Psychology, Clinical
E. Martin, C. T. Dourish, R. Hook, S. R. Chamberlain, S. Higgs
Summary: The study found that symptoms of ADHD and impulsivity are associated with disordered eating, and depression plays a mediating role in this relationship.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychiatry
Judit Cabana-Dominguez, Barbara Torrico, Andreas Reif, Noelia Fernandez-Castillo, Bru Cormand
Summary: Psychiatric disorders exhibit clinical and genetic overlap, with dopaminergic and serotonergic neurotransmission playing important roles. This study assessed the genetic contribution of these systems to eight psychiatric disorders using GWAS analyses, identifying several associated genes and gene sets.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychiatry
Mariah K. Evans, Jeremy L. Grove, Tapan A. Patel, Molly Gromatsky, Patrick S. Calhoun, Jean C. Beckham, Nathan A. Kimbrel
Summary: This study aimed to explore the association between attention-deficit/hyperactivity disorder (ADHD) symptoms and nonsuicidal self-injury (NSSI) in veterans. Contrary to hypotheses, adult ADHD symptoms were not associated with NSSI history or disorder. Instead, disorders characterized by negative affect may have greater utility for predicting NSSI.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
Simone Pisano, Gianluca Sesso, Vincenzo Paolo Senese, Gennaro Catone, Annarita Milone, Gabriele Masi
Summary: The study confirmed the two-correlated factor structure of CHT and found its correlations with different clinical symptoms. CHTQ total scores can discriminate patients from healthy controls, while the differences in CHTQ subscale scores among clinical groups are relatively small.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Engineering, Biomedical
Jun Cao, Kacper Grajcar, Xiaocai Shan, Yifan Zhao, Jiaru Zou, Liangyu Chen, Zhiqing Li, Richard Grunewald, Panagiotis Zis, Matteo De Marco, Zoe Unwin, Daniel Blackburn, Ptolemaios G. Sarrigiannis
Summary: This study introduces a multivariate method to characterize sensor level brain functional connectivity from interictal EEG data to identify patients with generalized epilepsy.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Review
Clinical Neurology
Artemios Artemiadis, Andreas Liampas, Loizos Hadjigeorgiou, Panagiotis Zis
Summary: This study reviewed 18 papers and found that COVID-19 related myelopathy can affect patients of all ages, with a predilection for middle-aged individuals. The majority of cases met the criteria for postinfectious transverse myelitis, and treatment with corticosteroids, intravenous immunoglobulin or plasma exchange often led to significant improvement of symptoms within a few weeks.
NEUROLOGICAL RESEARCH
(2021)
Correction
Clinical Neurology
Andreas Liampas, Antonios Nteveros, Konstantinos Parperis, Mohammed Akil, Efthymios Dardiotis, Elizabeth Andreadou, Marios Hadjivassiliou, Panagiotis Zis
ACTA NEUROLOGICA BELGICA
(2023)
Review
Clinical Neurology
Liampas Andreas, Nteveros Antonios, Parperis Konstantinos, Akil Mohammed, Dardiotis Efthymios, Andreadou Elizabeth, Hadjivassiliou Marios, Zis Panagiotis
Summary: Primary Sjogren's syndrome (pSS) is a chronic autoimmune disorder characterized by lymphocytic infiltrates of the exocrine glands, particularly the salivary and lacrimal glands, resulting in oral and ocular dryness. Cerebellar ataxia in pSS patients is estimated to be 1.5%, with a female-to-male ratio of 6:1. The diagnostic approach to a patient with cerebellar ataxia of unknown etiology should include evaluation for an underlying pSS, such as antibody testing and brain MRI imaging.
ACTA NEUROLOGICA BELGICA
(2022)
Article
Clinical Neurology
Panagiotis Zis, Faiza Shafique, Ptolemaios G. Sarrigiannis, Artemios Artemiadis, Dasappaiah G. Rao, David S. Sanders, Marios Hadjivassiliou
Summary: The study found that two-thirds of patients with GN have sudomotor dysfunction, and the lack of correlation between pain and sudomotor dysfunction suggests different patterns of small fiber involvement in patients with GN.
NEUROLOGICAL SCIENCES
(2022)
Review
Medicine, General & Internal
Andreas Liampas, Loizos Hadjigeorgiou, Antonios Nteveros, Christiana Ioannou, Giustino Varrassi, Panagiotis Zis
Summary: The study evaluates the effectiveness of physical exercise as an adjuvant for managing PNP, with higher intensity interval training programs showing promise for future studies.
POSTGRADUATE MEDICINE
(2022)
Review
Clinical Neurology
Panagiotis Zis, Andreas Liampas, Artemios Artemiadis, Gabriela Tsalamandris, Panagiota Neophytou, Zoe Unwin, Vasilios K. Kimiskidis, Georgios M. Hadjigeorgiou, Giustino Varrassi, Yifan Zhao, Ptolemaios Georgios Sarrigiannis
Summary: Pain is a universal and complex sensation, and the development of a non-invasive tool for objectively measuring pain is crucial for clinical and research purposes. Electroencephalography (EEG) has emerged as an important non-invasive clinical tool for understanding brain network complexities and identifying areas of dysfunction. This review examines the potential role of EEG recordings as biomarkers for pain perception.
Review
Clinical Neurology
Panagiotis Zis, Andreas Liampas, Theodora Pozotou, Konstantinos Parperis, Artemios Artemiadis, Georgios Hadjigeorgiou
Summary: Immunoglobulin therapy for painful peripheral neuropathy shows potential therapeutic benefits, with 65% of patients reporting pain relief following treatment. The likelihood of achieving pain relief with immunoglobulin treatment is higher compared to placebo.
Article
Medicine, General & Internal
Panagiotis Zis, Christiana Ioannou, Artemios Artemiadis, Katerina Christodoulou, Stefania Kalampokini, Georgios M. Hadjigeorgiou
Summary: This study found that chronic pain, especially neuropathic pain, is widely prevalent in COVID-19 survivors. The most common sites of pain are the low back and joints. Age and gender are predictors of chronic pain, while headache during COVID-19 is associated with neuropathic pain.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Stefano Coaccioli, Piercarlo Sarzi-Puttini, Panagiotis Zis, Giuseppe Rinonapoli, Giustino Varrassi
Summary: In recent years, there have been interesting advancements in the understanding of the basis of osteoarthritis (OA). Research suggests that cartilage degeneration is preceded by subchondral bone lesions, indicating a key role of this mechanism in the pathogenesis and progression of OA. Chronic low-grade inflammation of the synovial lining, along with immunological and metabolic factors, is now considered crucial in driving inflammation and tissue destruction in OA. Additionally, the role of neuroinflammation and central sensitization mechanisms as underlying causes of chronic pain has been characterized.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Nutrition & Dietetics
Andreas Liampas, Panagiotis Zis, Georgios Hadjigeorgiou, George D. Vavougios
Summary: Stroke is the second most common cause of death worldwide and can cause long-term morbidity. Selenium, a trace element, has various effects on human health. Lower selenium levels are associated with increased stroke risk and poorer outcomes. However, higher selenium levels are associated with glucose metabolism disturbances and high blood pressure, both of which are also risk factors for stroke. In addition, selenium deficiency can impair immune fitness and contribute to inflammation and infection, which can further worsen stroke outcomes. This complex interrelationship between selenium, stroke, and infection has important implications for human health and disease.
Review
Nutrition & Dietetics
Raman Muhamad, Alexandra Akrivaki, Georgia Papagiannopoulou, Periklis Zavridis, Panagiotis Zis
Summary: Vitamin B6 is a water-soluble vitamin that can be obtained from food and dietary supplements. Both deficiency and high intake of B6 have been associated with the development of peripheral neuropathy. Higher levels of B6 may lead to sensory neuropathy, while the relationship between low B6 levels and neuropathy is still uncertain.
Review
Medicine, General & Internal
Laura Dawn Williams, Panagiotis Zis
Summary: This systematic review aimed to investigate the prevalence and determinants of neuropathic pain among individuals infected with COVID-19. The results showed that the prevalence of COVID-19-related neuropathic pain was 6.7% for hospitalized patients during the acute phase and 34.3% for long COVID patients. Risk factors for COVID-19-related neuropathic pain development included depression, COVID-19 severity, and azithromycin use.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Clinical Neurology
Laura D. Williams, Panagiotis Zis
Summary: This systematic review and meta-analysis aimed to establish the prevalence of COVID-19-related burning eye syndrome (BES) and burning mouth syndrome (BMS) and describe their phenomenology. The results showed that the pooled prevalence of COVID-19-related BES was 9.9%, while the frequency of COVID-19-related BMS has not been thoroughly investigated but female patients are more susceptible. Both BES and BMS are associated with the severity of COVID-19. Further research is needed on the manifestations of these syndromes in long COVID syndrome.
Review
Clinical Neurology
Panayiota Neophytou, Artemios Artemiadis, Georgios M. Hadjigeorgiou, Panagiotis Zis
Summary: This study systematically reviewed Miller Fisher syndrome (MFS) cases in the context of COVID-19 infection or vaccination. It found that MFS can occur after both COVID-19 infection and vaccination, with a higher prevalence in male and middle-aged patients. The prognosis is excellent with treatment or even without treatment.
ACTA NEUROLOGICA BELGICA
(2023)
