Article
Medicine, Research & Experimental
Xiaohong Chen, Hongliang Tang, Yingye Liang, Pingting Wu, Liuhong Xie, Yao Ding, Peng Yang, Bingcai Long, Jing Lin
Summary: Acupuncture can improve ovulation dysfunction and abnormal follicular development in patients with polycystic ovary syndrome by down-regulating LncMEG3 expression, inhibiting the PI3K/AKT/mTOR pathway, reducing granulosa cell autophagy, and ultimately normalizing their proliferation, suggesting its clinical potential as a safe treatment for PCOS ovulatory dysfunction.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Reza Salehi, Meshach Asare-Werehene, Brandon A. Wyse, Atefeh Abedini, Bo Pan, Alex Gutsol, Sahar Jahangiri, Peter Szaraz, Kevin D. Burns, Barbara Vanderhyden, Julang Li, Dylan Burger, Clifford L. Librach, Benjamin K. Tsang
Summary: Polycystic ovarian syndrome (PCOS) is associated with increased levels of androgen and arrested follicle growth. Previous studies have shown that androgen-induced release of miR-379-5p from follicle granulosa cells promotes cell proliferation through PDK1 upregulation. Androgen also affects macrophage polarization and increases the inflammatory M1 phenotype in rat follicles. However, the role of small extracellular vesicles (exosomes) in mediating the effects of miRNAs on receiving cells is not well understood. This study aimed to investigate the regulatory role of exosomal miR-379 from granulosa cells on macrophage polarization and ovarian inflammation, and its impact on granulosa cell proliferation in a stage-specific manner.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Qi Jiang, Ye Pan, Ping Li, Yanjun Zheng, Yuehong Bian, Wenqi Wang, Guihua Wu, Tian Song, Yuhua Shi
Summary: This study revealed higher expression of ANGPTL4 in ovarian granulosa cells of PCOS patients. Its association with glucose and lipid metabolism suggests that ANGPTL4 may play an important role in the metabolism and pathogenesis of PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Qi Xie, Wenli Hong, Yuan Li, Shuyi Ling, Ziqiong Zhou, Yuqing Dai, Wenbo Wu, Ruoxin Weng, Zhisheng Zhong, Jun Tan, Yuehui Zheng
Summary: Polycystic Ovary Syndrome (PCOS) is a common reproductive endocrine disorder that can cause infertility. This study investigated the impact of inflammation and oxidative stress on granulosa cells (GCs) in PCOS patients and found that chitosan oligosaccharide (COS) can improve GC function by reducing inflammation and oxidative stress.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Linyi Song, Jin Yu, Danying Zhang, Xi Li, Lu Chen, Zailong Cai, Chaoqin Yu
Summary: Excess androgen could damage the mitochondrial ultrastructure and function of ovarian granulosa cells in PCOS model rats by down-regulating the expression of NDUFB8 and ATP5j.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Liping Zou, Qiwen Feng, Wei Xia, Changhong Zhu
Summary: This study aimed to identify common targets of miR-223-3p, miR-122-5p, and miR-93-5p in PCOS and assess their transcript levels in PCOS rat ovaries. Transcriptome profiles of granulosa cells from PCOS patients were analyzed to identify DEGs, followed by miRNA target prediction and functional analysis. The study identified several potential genes, including JMJD1C, PLCG2, SMAD3, FOSL2, TGFB1, TRIB1, GAS7, TRIM25, NFYA, and CALCRL, which may play a role in the development of PCOS. These findings contribute to the identification of potential biomarkers for the prevention and treatment of PCOS in the future.
FRONTIERS IN GENETICS
(2023)
Article
Endocrinology & Metabolism
Xiao-lin Jiang, He Tai, Xuan-si Xiao, Shi-yu Zhang, Shi-chao Cui, Shu-bo Qi, Dan-dan Hu, Li-na Zhang, Jin-song Kuang, Xian-sheng Meng, Shun-min Li
Summary: This study found that CFDT can alleviate pathological damage and apoptosis in PCOS rat model. In addition, CFDT can improve ovarian function, reduce inflammatory response, inhibit apoptosis of granular cells, and inhibit the operation of ASK1/JNK pathway in PCOS rats.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Yiyin Gao, Yinggang Zou, Guijie Wu, Lianwen Zheng
Summary: Polycystic ovarian syndrome (PCOS) is a common cause of infertility in women, affecting 5%-15% of women of reproductive age globally. Clinical symptoms include menstrual disorders, excessive hair growth, and obesity. PCOS can lead to serious complications such as endometrial cancer, diabetes, and cardiovascular disease. Oxidative stress (OS) and mitochondrial dysfunction in granulosa cells (GCs) have been found to contribute to PCOS progression. This review aims to summarize and discuss the role of OS and mitochondrial dysfunction in impaired ovarian function and the development of PCOS.
FRONTIERS IN MEDICINE
(2023)
Article
Mathematical & Computational Biology
Beibei Dai, Jun Jiang
Summary: The study found that miR-188-3p may have a rare function of upregulating its targeted gene expression in PCOS, providing new insights into the pathology of the disease and new targets for treatment strategies.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2021)
Article
Endocrinology & Metabolism
Jun-Hui Zhang, Lei Zhan, Ming-Ye Zhao, Jin-Juan Wang, Fen-Fen Xie, Zu-Ying Xu, Qian Xu, Yun-Xia Cao, Qi-Wei Liu
Summary: Polycystic ovarian syndrome (PCOS) is a common endocrinological disorder, and the etiology is still unclear. This study demonstrated that EGFR may play a potential role in the pathogenesis of PCOS, and the selective inhibition of EGFR could improve the ovulatory function of ovaries in PCOS mice.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biology
Xiaohong Chen, Hengzhen He, Bingcai Long, Binli Wei, Peng Yang, Xiaoying Huang, Qian Wang, Jing Lin, Hongliang Tang
Summary: This study found that acupuncture can inhibit granulosa cell apoptosis and improve follicular development abnormalities in patients with PCOS by targeting and regulating miR-21-3p through LncMEG3. These findings highlight the clinical potential of acupuncture as a safe treatment for follicular developmental abnormalities in PCOS.
BIOLOGICAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Qinling Zhu, Yue Yao, Lizhen Xu, Hasiximuke Wu, Wangsheng Wang, Yaqiong He, Yuan Wang, Yao Lu, Jia Qi, Ying Ding, Xinyu Li, Jiaan Huang, Hanting Zhao, Yanzhi Du, Kang Sun, Yun Sun
Summary: In PCOS patients, ovarian granulosa cells are capable of producing SAA1, and excessive SAA1 reduces insulin sensitivity by activating the TLR2/4 and NF-kappa B pathways, inducing PTEN expression and inhibiting Akt phosphorylation, thereby promoting the development of IR.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Yun S. Kim, Ji H. Lee
Summary: Granulosa cell tumors (GCTs) are rare malignant ovarian tumors that should be differentiated from other benign ovarian tumors. This case highlights the importance of considering GCTs in female patients with PCOS and amenorrhea.
Article
Medicine, General & Internal
Jie Deng, Chanyu Li, Jianbo Luo, Jiaqiong Xie, Cong Peng, Xiaoyang Deng
Summary: This study revealed the important role of miR-125b in the pathogenesis of PCOS, as it controls the proliferation rate of granulosa cells in polycystic ovaries. The inhibition of miR-125b decreased cell viability by regulating cyclin B1 expression, suggesting that miR-125b could be a potential therapeutic target for PCOS patients.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Medicine, Research & Experimental
Jie Zhou, Xuejing Jin, Zhumei Sheng, Zhifen Zhang
Summary: The study revealed that miR-206 was downregulated in PCOS patients, and its target gene CCND2 was identified to modulate granulosa cell viability and apoptosis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)