期刊
DRUG DESIGN DEVELOPMENT AND THERAPY
卷 14, 期 -, 页码 157-165出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/DDDT.S213968
关键词
ezetimibe; rosuvastatin; lipid-lowering treatment; cost-effectiveness analysis; Markov model; secondary prevention of cardiovascular diseases
资金
- Cholesterol Fund by China Cardiovascular Foundation
- Cholesterol Fund by China Heart House
- International Visiting Program for Excellent Young Scholars of Sichuan University
- Sichuan Science and Technology Program [2019YFH0150]
- National Natural Science Foundation of China [81400811, 21534008]
- 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University [ZYGD18022]
Background: For patients with inadequate control of cholesterol using moderate-dose statins in the secondary prevention of cardiovascular diseases (CVD), either doubling the dose of statins or adding ezetimibe should be considered. The cost-effectiveness of them is unknown in the Chinese context. The aim of this study is to compare the cost and effectiveness of the two regimens, and estimate the incremental cost-effectiveness ratio (ICER). Methods: A Markov model of five health statuses were used to estimate long-term costs and quality-adjusted life-years (QALYs) of the two treatment regimens from the healthcare perspective. The effectiveness data used to calculate the transition probability was based on a previously published randomized trial. The utility data was gathered from literature and the costs were gathered from the electronic medical record system of West China Hospital in Chinese Yuan (CNY) in 2017 price. One-way sensitivity analysis and probabilistic sensitivity analysis were conducted. Results: The ICER for ezetimibe plus moderate-dose rosuvastatin was 47,102.99 CNY per QALY for 20 years simulation, which did not reach the threshold of per capita gross domestic product (GDP) of 59,660 CNY per QALY in 2017 in China. Non-CVD-related mortality and CVD-related mortality contributed most to the ICER. Conclusion: Adding ezetimibe to the moderate-dose statin in secondary prevention for CVD is cost-effective, compared with the high-dose statin in the Chinese context whose low-density lipoprotein cholesterol (LDL-c) was not inadequately controlled by moderate-dose statin alone.
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