Review
Oncology
Shuangshuang Mei, Xing Chen, Kai Wang, Yuxin Chen
Summary: Ovarian cancer is a common gynecological malignancy with high morbidity and mortality. Peritoneal metastasis is common in ovarian cancer, involving large amounts of ascites. The mechanism behind this is still unclear.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Jung-A Choi, Hyosun Kim, Hyunja Kwon, Elizabeth Hyeji Lee, Hanbyoul Cho, Joon-Yong Chung, Jae-Hoon Kim
Summary: This study examined the clinical value and therapeutic potential of ascitic autotaxin (ATX) in epithelial ovarian cancer (EOC). The results showed that elevated levels of ascitic ATX were associated with advanced stage, high grade, and a short disease-free period in EOC patients. Combining ascitic ATX and serum CA-125 levels improved the diagnostic accuracy for EOC, and functional studies revealed that ascitic ATX played a role in maintaining cancer stem cell-like characteristics and invadopodia formation in EOC.
BRITISH JOURNAL OF CANCER
(2023)
Article
Medicine, Research & Experimental
Eun Ji Lee, Soo Jin Park, Aeran Seol, Hyunji Lim, Sumin Park, Ji Yeon Ahn, Jeong Mook Lim, Hee Seung Kim
Summary: This study confirms that piglets can serve as a model for peritoneal metastasis by inoculating ovarian cancer cell lines from humans. Using two cell lines, the rate of peritoneal metastasis is 75%.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mingxiang Wei, Yu Zhang, Cong Ding, Jianye Jia, Haimin Xu, Yao Dai, Guannan Feng, Cai Qin, Genji Bai, Shuangqing Chen, Hong Wang
Summary: This study investigates the performance of T2-weighted MRI-based deep learning and radiomics methods for evaluating peritoneal metastasis in epithelial ovarian cancer patients. The ensemble model outperforms the DL and clinical models, and can assist in clinical decision-making.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Reproductive Biology
Sigit Purbadi, Tricia Dewi Anggraeni, Angelina Vitria
Summary: This study evaluated the benefit of routine surgical staging for patients with clinical early-stage EOC. The results suggest that routine peritoneal biopsies may not be advantageous for these patients, as further research with a larger cohort is needed to obtain more information.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Tyvette S. Hilliard, Brooke Kowalski, Kyle Iwamoto, Elizabeth A. Agadi, Yueying Liu, Jing Yang, Marwa Asem, Yuliya Klymenko, Jeff Johnson, Zonggao Shi, Gifty Marfowaa, Madeleine G. Yemc, Phillip Petrasko, M. Sharon Stack
Summary: The glycoprotein mesothelin is overexpressed in ovarian cancer and may play a role in tumor progression by affecting the peritoneal ultrastructure and mesothelial cell surface architecture. Reduced expression of host mesothelin could result in smaller tumor aggregates and decreased peritoneal metastatic tumor burden in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Lingling Gao, Xin Nie, Rui Gou, Yuexin Hu, Hui Dong, Xiao Li, Bei Lin
Summary: This study found that ANXA2 from ovarian cancer cells can be transferred to HMrSV5 cells through exosomes. Exosomal ANXA2 not only promotes migration, invasion and apoptosis of HMrSV5 cells, but also regulates morphological changes and fibrosis of HMrSV5 cells.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Lucia Pascual-Anton, Beatriz Cardenes, Ricardo Sainz de la Cuesta, Lucia Gonzalez-Cortijo, Manuel Lopez-Cabrera, Carlos Cabanas, Pilar Sandoval
Summary: Most ovarian cancer patients have peritoneal disseminated disease at diagnosis, with peritoneal mesothelial cells being a key barrier. Exosomes and mesothelial-to-mesenchymal transition play crucial roles in peritoneal colonization of ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Ning Luo, Zubaidan Sulaiman, Chunyan Wang, Jinye Ding, Yingying Chen, Biting Liu, Zhongping Cheng, Shupeng Liu
Summary: The study identified circRNAs (hsa_circ_0000497 and hsa_circ_0000918) that promote metastasis of EOC via regulating epithelial-mesenchymal transition (EMT), suggesting their potential as therapeutic targets or prognostic biomarkers for EOC peritoneal metastasis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Kosuke Yoshida, Nobuhisa Yoshikawa, Kazuhisa Kitami, Satoshi Tamauchi, Yoshiki Ikeda, Akira Yokoi, Kimihiro Nishino, Kaoru Niimi, Hiroaki Kajiyama
Summary: The study investigated metabolomic differences in epithelial ovarian cancers, finding significant variations in metabolite profiles between metastatic and primary cancers. Urea concentration was notably decreased in omental metastatic cancers, and the pentose phosphate pathway was more dominant in these cancers. Additionally, amino acid levels, particularly the percentage of glutamine, were significantly enriched in serous carcinomas compared to nonserous carcinomas.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Jing Cai, Lanqing Gong, Guodong Li, Jing Guo, Xiaoqing Yi, Zehua Wang
Summary: Poor prognosis of ovarian cancer is mainly due to metastasis, with ascites-derived exosomes playing a role in promoting metastasis through epithelial-mesenchymal transition. The key microRNA miR-6780b-5p in ADEs facilitates cancer metastasis by promoting EMT in ovarian cancer cells, indicating a potential mechanism for ovarian cancer progression.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Hironari Akasaka, Honami Naora
Summary: This review article discusses the issues related to using normal saline for peritoneal washing during ovarian cancer surgery. The omentum has an absorptive ability, and the use of normal saline may increase the risk of colonization of preserved omental tissues by occult cancer cells. Therefore, using balanced crystalloid solutions for peritoneal washing may help to minimize the risk of colonization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Siyu Lu, Liru Xue, Meng Yang, Jingjing Wang, Yang Li, Yuxin Jiang, Xuechuan Hong, Mingfu Wu, Yuling Xiao
Summary: Ovarian cancer is often diagnosed in the middle or late stages due to the lack of specific initial diagnostic methods. Dual-modal near-infrared II fluorescence/photoacoustic imaging shows great potential in early ovarian cancer diagnosis and image-guided surgery. A novel organic NIR-II dye and water-soluble nanoparticles were developed for targeted imaging and surgery, improving the early detection and prognosis of ovarian cancer.
Review
Endocrinology & Metabolism
Sabrina J. Ritch, Carlos M. Telleria
Summary: Epithelial ovarian cancer is the deadliest gynecological disease, commonly diagnosed at late stages with metastasis. Understanding the unique microenvironments that promote EOC dissemination is crucial in improving patient outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yumei Zhang, Shunli Wang, Xiaofan Duan, Xiaoxiao Xu, Yuan Gao, Jiuli Zhou, Xiaolin Xu, Jin Li
Summary: This study developed an alternative, less toxic, and more effective docetaxel (DTX) formulation by preparing methoxy-poly(ethylene glycol)-block-poly(D,L-lactide) (mPEG-PDLLA) micelles loaded with DTX. Compared to traditional DTX, this new formulation showed improved pharmacokinetics and efficacy against ovarian cancer with peritoneal metastasis. The results suggest that DTX-mPEG-PDLLA has the potential to be used in the clinical treatment of peritoneal metastatic cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Yingying Lin, Keman Liao, Yifeng Miao, Zhongrun Qian, Zhaoyuan Fang, Xi Yang, Quanmin Nie, Gan Jiang, Jianhua Liu, Yiyi Yu, Jieqing Wan, Xiaohua Zhang, Yaomin Hu, Jiyao Jiang, Yongming Qiu
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2020)
Article
Oncology
Jun-jun Qiu, Ying-ying Lin, Xiao-yan Tang, Yan Ding, Xiao-fang Yi, Ke-qin Hua
EXPERIMENTAL CELL RESEARCH
(2020)
Article
Chemistry, Multidisciplinary
Gan Jiang, Huan Chen, Jialin Huang, Qingxiang Song, Yaoxing Chen, Xiao Gu, Zhenhuan Jiang, Yukun Huang, Yingying Lin, Junfeng Feng, Jiyao Jiang, Yinghui Bao, Gang Zheng, Jun Chen, Hongzhuan Chen, Xiaoling Gao
Article
Oncology
Keman Liao, Zhongrun Qian, Shuai Zhang, Binghong Chen, Zhiqiang Li, Renhua Huang, Lilin Cheng, Tianwei Wang, Renhao Yang, Jin Lan, Xiaojie Lu, Lin Kong, Xiwen Song, Yongming Qiu, Yingying Lin
Article
Oncology
Jun-Jun Qiu, Shu-Gen Sun, Xiao-Yan Tang, Ying-Ying Lin, Ke-Qin Hua
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Liemei Guo, Jing Cui, Herui Wang, Rogelio Medina, Shilei Zhang, Xiaohua Zhang, Zhengping Zhuang, Yingying Lin
Summary: The study found that metformin could enhance the inhibitory effect of cisplatin on meningioma cells by activating AMPK and inhibiting the mTOR signaling pathway. Additionally, the combined treatment of metformin and cisplatin showed significant anti-cancer effects on high-grade meningiomas.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Oncology
Xinjing Wang, Xiaoduan Li, Feikai Lin, Huizhen Sun, Yingying Lin, Ziliang Wang, Xipeng Wang
Summary: The study identified a novel pseudogene, lnc-CTSLP8, in ovarian cancer with significantly elevated expression in metastatic tumor tissues. Overexpression of lnc-CTSLP8 promoted ovarian cancer growth in vitro and in vivo, enhanced autophagy and EMT, and upregulated CTSL1 as a competitive endogenous RNA. Moreover, inhibition of CTSL1 and overexpression of miR-199a-5p reversed the effects of lnc-CTSLP8 overexpression, suggesting its potential as a therapeutic target for metastatic ovarian cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Cell Biology
Wenrui Zhang, Yingying Lin
Summary: Asparagine endopeptidase (AEP), also known as legumain, is a cysteine protease that specifically cleaves peptide bonds in asparaginyl residues in the mammalian genome, making it a potential therapeutic target in various carcinomas. Through intensive investigation on AEP substrates and mechanisms in tumors, researchers have identified several substrate proteins and elucidated the biochemical mechanism of AEP in carcinomas.
Article
Oncology
Lu Cao, Cheng Xu, Peiqiang Yi, Huan Li, Yingying Lin, Gang Cai, Shubei Wang, Dan Ou, Min Li, Jiayi Chen
Summary: Radiation-induced heart disease (RIHD) leads to myocardial dysfunction and metabolic abnormalities in patients treated with thoracic irradiation, affecting the long-term survival benefits of radiotherapy. Asparaginyl endopeptidase (AEP) plays a key role in cellular functions and increasing its expression can enhance cellular viability and DNA repair in cardiomyocytes exposed to radiation. These findings suggest a potential regulatory pathway involving AEP, P53, and NRF2 in maintaining redox homeostasis and heart function after radiation exposure.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Cell Biology
Guo Pin, Li Huanting, Zhu Chengzhan, Kong Xinjuan, Feng Yugong, Liu Wei, Li Shifang, Li Zhaojian, Han Kun, Yao Weicheng, Lin Yingying, Qiu Yongming, Yu Yanan
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Cell Biology
Haiwei Wang, Xinrui Wang, Liangpu Xu, Yingying Lin, Ji Zhang, Hua Cao
Article
Neurosciences
Zhi-Han Wang, Bing-Hong Chen, Ying-Ying Lin, Jin Xing, Zi-Long Wei, Li Ren
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Hongbin Wang, Binghong Chen, Yingying Lin, Yi Zhou, Xiaobo Li
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Xi Chen, Chen Wang, Keman Liao, Sunhai Zhou, Lu Cao, Jiayi Chen, Cheng Xu, Yingying Lin
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2019)