Article
Hematology
Manit Munshi, Xia Liu, Amanda Kofides, Nickolas Tsakmaklis, Maria Luisa Guerrera, Zachary R. Hunter, M. Lia Palomba, Kimon Argyropoulos, Christopher J. Patterson, Alexa G. Canning, Kirsten Meid, Joshua Gustine, Andrew R. Branagan, Catherine A. Flynn, Shayna Sarosiek, Jorge J. Castillo, Jinhua Wang, Sara J. Buhrlage, Nathanael S. Gray, Nikhil C. Munshi, Kenneth C. Anderson, Steven P. Treon, Guang Yang
Summary: The study found that HCK activates SYK in MYD88(Mut) B-cell lymphoma cells, expanding the prosurvival signaling. This has important implications for the treatment of MYD88(Mut) B-cell lymphomas.
Article
Hematology
Guang Yang, Jinhua Wang, Li Tan, Manit Munshi, Xia Liu, Amanda Kofides, Jiaji G. Chen, Nicholas Tsakmaklis, Maria G. Demos, Maria Luisa Guerrera, Lian Xu, Zachary R. Hunter, Jinwei Che, Christopher J. Patterson, Kirsten Meid, Jorge J. Castillo, Nikhil C. Munshi, Kenneth C. Anderson, Michael Cameron, Sara J. Buhrlage, Nathanael S. Gray, Steven P. Treon
Summary: The study identified KIN-8194 as a novel dual inhibitor of HCK and BTK, showing potent and selective killing of MYD88-mutated lymphoma cells, including ibrutinib-resistant ones. KIN-8194 demonstrated excellent bioavailability and pharmacokinetic parameters in rodent models and superior survival benefit over ibrutinib in both wild-type and mutant BTK-expressing DLBCL xenografted mice.
Article
Immunology
Young-Su Yi, Han Gyung Kim, Ji Hye Kim, Woo Seok Yang, Eunji Kim, Deok Jeong, Jae Gwang Park, Nur Aziz, Suk Kim, Narayanan Parameswaran, Jae Youl Cho
Summary: The MyD88-Syk axis plays a critical role in macrophage-mediated inflammatory responses, and its function is enhanced by an upstream Src kinase activated by Rac1-generated filamentous actin (F-actin).
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Allison M. Owen, Liming Luan, Katherine R. R. Burelbach, Margaret A. A. McBride, Cody L. L. Stothers, Olivia A. A. Boykin, Kalkena Sivanesam, Jessica F. F. Schaedel, Tazeen K. K. Patil, Jingbin Wang, Antonio Hernandez, Naeem K. K. Patil, Edward R. R. Sherwood, Julia K. K. Bohannon
Summary: Immunocompromised populations are at high risk of life-threatening infections, and strategies to protect these patients are urgently needed. This study explores the use of trained immunity, which enhances the immune response to subsequent infections, as a promising approach. The researchers demonstrate that the MyD88-dependent signaling pathway plays a critical role in TLR-mediated trained immunity, providing valuable insights into the mechanisms underlying this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Monika Avbelj, Iva Hafner-Bratkovic, Dusko Lainscek, Mateja Mancek-Keber, Tina Tinkara Peternelj, Gabriela Panter, Steven P. Treon, Boris Gole, Uros Potocnik, Roman Jerala
Summary: Coordination among multiple signaling pathways ensures an appropriate immune response, where a signaling pathway may impair or augment another signaling pathway. This study reveals a negative feedback regulation of MyD88 signaling by inflammasome-activated caspase-1, providing insight into another layer of innate immunity regulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Milton Pereira, Danielle F. Durso, Clare E. Bryant, Evelyn A. Kurt-Jones, Neal Silverman, Douglas T. Golenbock, Ricardo T. Gazzinelli
Summary: This study examines the importance of IRAK proteins in TLR4 activation and confirms the essential role of IRAK4 kinase activity in MYD88 signaling. It also reveals the crucial role of the IRAK4 scaffold in integrating MYD88 and TRIF in TLR4 signaling.
Article
Oncology
Kerri R. Thomas, Eric J. Allenspach, Nathan D. Camp, Michelle N. Wray-Dutra, Socheath Khim, Anna Zielinska-Kwiatkowska, Andrew E. Timms, Joseph P. Loftus, H. Denny Liggitt, Katia Georgopoulos, Sarah K. Tasian, Richard G. James, David J. Rawlings
Summary: Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a high-risk subtype of B-ALL often associated with genetic variants altering cytokine receptor signaling, such as mutations in the interleukin-7 receptor (IL7R). Mouse models expressing activated Il7r (aIL7R) demonstrated that Il7r activating mutations are sufficient for leukemogenesis, with additional mutations in associated adapter protein Lnk or transcription factor Ikaros increasing disease penetrance. Phosphoproteomic analyses revealed constitutive Stat5 and BCR-like signaling in aIL7R leukemic cells, and inhibition of Jak, mTOR, or Syk pathways blocked growth in vitro.
Article
Medicine, Research & Experimental
Sumio Hayakawa, Atsushi Tamura, Nikita Nikiforov, Hiroyuki Koike, Fujimi Kudo, Yinglan Cheng, Takuro Miyazaki, Marina Kubekina, Tatiana Kirichenko, Alexander N. Orekhov, Nobuhiko Yui, Ichiro Manabe, Yumiko Oishi
Summary: Recent studies have shown a close relationship between cellular metabolism and the regulation of immune cells. This study reveals that cholesterol metabolism plays an integral role in innate immune responses of macrophages. Cholesterol accumulation in endosomes and lysosomes is crucial for amplification of Myd88 signaling, which is involved in inflammatory macrophage activation. The supramolecular compound PRX is able to inhibit inflammatory macrophage activation by regulating cholesterol trafficking and efflux. These findings highlight the importance of cellular cholesterol metabolism in innate activation of macrophages and suggest its potential as a therapeutic target for inflammatory diseases.
Article
Biochemistry & Molecular Biology
Celeste Rizzello, Valeria Cancila, Sabina Sangaletti, Laura Botti, Chiara Ratti, Matteo Milani, Matteo Dugo, Francesco Bertoni, Claudio Tripodo, Claudia Chiodoni, Mario P. Colombo
Summary: This study found that in SLE-like syndrome, mice lacking OPN developed splenic lymphomas with higher incidence. Further experiments showed that OPN played an important inhibitory role in autoimmune-driven lymphomagenesis by suppressing the activation of the TLR9-MYD88-STAT3 signaling pathway.
Article
Immunology
Yamel Cardona Gloria, Stephan H. Bernhart, Sven Fillinger, Olaf-Oliver Wolz, Sabine Dickhoefer, Jakob Admard, Stephan Ossowski, Sven Nahnsen, Reiner Siebert, Alexander N. R. Weber
Summary: The study reveals the lack of a negative feedback loop in B cells that restricts TLR signaling, leading to sustained NF-kappa B activation and lymphomagenesis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Mandy Busse, Susanne Plenagl, Norina Kim Jutta Campe, Andreas J. Mueller, Kerry Tedford, Anne Schumacher, Ana Claudia Zenclussen
Summary: The loss of MyD88 signaling in maternal B cells may lead to intrauterine fetal death during pregnancy, while the activation of this signal could protect the mother from infection but potentially harm the fetus.
Article
Multidisciplinary Sciences
Franziska G. Thiel, Saeedeh Asgarbeik, Juliane Glaubitz, Anika Wilden, Markus M. Lerch, Frank Ulrich Weiss, Matthias Sendler
Summary: Acute pancreatitis is characterized by self-digestion of the pancreas, and this study investigates the role of the MYD88/IRAK signaling pathway in two animal models of mild and severe acute pancreatitis. The results suggest that moderate inflammation can promote tissue regeneration through better clearance of necrotic acinar cells, but excessive inflammation can lead to severe inflammatory response syndrome and increased disease severity.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Chao Xing, Laiben Gao, Xiaoqiu Dou, Kaikai Yang, Changli Zhao, Chuanliang Feng
Summary: This study constructs nanofibers based on chiral molecules to activate cellular autophagy extracellularly, protecting cells from hypoxic injury and alleviating scar formation and functional deterioration in a rat myocardial ischemia model.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biology
Carlos-Henrique D. Barbosa, Fabio B. Canto, Ariel Gomes, Layza M. Brandao, Jessica R. Lima, Guilherme A. Melo, Alessandra Granato, Eula G. A. Neves, Walderez O. Dutra, Ana-Carolina Oliveira, Alberto Nobrega, Maria Bellio
Summary: CD4CTLs play an important role in different pathologies, but the mechanisms controlling their generation are poorly understood. In this study, CD4CTLs were found to abundantly differentiate during mouse infection with Trypanosoma cruzi, exhibiting specific cytotoxicity and expressing immunoregulatory and exhaustion markers. The magnitude of the CD4CTL response was found to be controlled by T-cell intrinsic IL-18R/MyD88 signaling.
Article
Biochemistry & Molecular Biology
Alexander Schaefer, Benedicte Haenig, Julie Erupathil, Panja Strickner, Daniela Sabato, Richard W. D. Welford, Lheanna Klaeyle, Elise Simon, Clemens Krepler, Patricia Brafford, Min Xiao, Meenhard Herlyn, Matthias Gstaiger, Francois Lehembre, Imke Renz
Summary: The research demonstrates that the ETBR signaling pathway confers resistance to MAPK pathway inhibitors in BRAF mutated melanoma. However, a combination treatment of MAPK pathway inhibitors and ETBR antagonists can effectively suppress tumor growth and prolong survival in melanoma patients with hyperactivated MAPK signaling pathways.
Article
Computer Science, Hardware & Architecture
Zhang Long, Wang Jinsong
Summary: Network traffic classification is crucial for various network activities, and machine learning methods are increasingly used due to the rise of encryption. However, the application of machine learning methods for network traffic classification using sampled NetFlow data is underdeveloped. This study proposes a network traffic classification module that combines NetFlow data with a deep neural network, and demonstrates its superior performance compared to other classifiers using real-world datasets.
Article
Environmental Sciences
Lingsheng Wang, Weizhang Fu, Shujuan Sun, Huaihao Liu, Jinhua Wang, Wanzhen Zhong, Bin Ma
Summary: Due to rapid industrial and agricultural development, nitrate pollution in groundwater is increasing. In this study, a composite photocatalyst SiW11/TiO2/Cu was prepared using heteropoly silicotungstate K-8[alpha-SiW11O39] and Cu2+ as active components. The photocatalytic reduction of dissolved NO3-N using SiW11/TiO2/Cu showed significant advantages in terms of its photocatalytic activity. The mechanism of NO3-N reduction and the detection of free radicals were also investigated.
ENVIRONMENTAL TECHNOLOGY
(2023)
Article
Engineering, Marine
Jinlong Wang
Summary: This study proposes and develops a novel soft hang-off system to solve the low-efficiency and time limitation issues in retrieving risers during deepwater drilling operations. Sea trials are conducted to evaluate the load compensation effect of the system, and it is found to have high application value in deepwater drilling engineering.
SHIPS AND OFFSHORE STRUCTURES
(2023)
Article
Psychology, Multidisciplinary
Ning Yang, Hui Chen, Xue Li, Ming-Yue Yu, Xiao-Hua Frank Wang
Summary: Drawing on social influence theory, this study examines the relationship between leader status and team performance, and finds that leader popularity plays a mediating role in this relationship, which is moderated by leader narcissism.
CURRENT PSYCHOLOGY
(2023)
Review
Hematology
Jorge J. Castillo, Christian Buske, Judith Trotman, Shayna Sarosiek, Steven P. Treon
Summary: BTK inhibitors play a crucial role in the treatment of Waldenstrom macroglobulinemia, being the only FDA-approved agents for these patients. However, there are still unmet needs with BTK inhibitor therapy, such as indefinite duration therapy, high cost, scarcity of complete responses, and lower response rates in patients with CXCR4 mutations. This review focuses on the data supporting the use of covalent BTK inhibitors, management issues, clinical trials with covalent BTK inhibitor combination regimens, and upcoming non-covalent BTK inhibitors.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Materials Science, Composites
Jinhuo Wang, Yang Han, Xiaohong Ge, Zhengbing Qi, Jun Zhao, Rongwen Wang, Huawei Wu, Taiping Han, Shaoxun Sun, Hui Wang, Jia Lin, Yuejun Liu, Xiangsong Kong, Qiming Chen, Xiangxu Zeng
Summary: The optimization design of composite structures requires an accurate predictive model for forming behavior, considering the viscosity and micro-mechanisms of the composite materials, as well as the non-Newtonian effects, viscoelastic effects, and fiber rearrangement during fiber movement and shearing.
APPLIED COMPOSITE MATERIALS
(2023)
Article
Oncology
Shayna Sarosiek, Jorge J. Castillo
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2023)
Article
Computer Science, Information Systems
Dongsheng Han, Tao Liu, Feiyun Wu, Zhenyu Zhou, Yong Wei
Summary: This article presents a multi-BS heterogeneous network system model equipped with renewable energy production devices. A hybrid optimization algorithm is proposed to maximize the sum of SINR of users in the system through user scheduling and beam forming. Simulation results show that the proposed algorithm effectively increases system users' sum-SINR while ensuring system stability.
IEEE SYSTEMS JOURNAL
(2023)
Article
Environmental Sciences
Xiaojing Yan, Wenwen Liu, Shengfang Wen, Lanjun Wang, Lusheng Zhu, Jun Wang, Young Mo Kim, Jinhua Wang
Summary: Antibiotic resistance genes (ARGs) are a new type of environmental pollutant that pose a significant global health challenge. Horizontal gene transfer (HGT) is an important route for ARGs spread. The use of sulfamethazine (SM2) as a broad-spectrum bacteriostatic agent leads to high residual levels in the environment, increasing the spread of ARGs. This study found that SM2 at concentrations of 10 mg/L and 200 mg/L promoted the HGT of ARGs, but transfer frequency decreased at concentrations of 100 mg/L and 500 mg/L. The mechanism of SM2 improving conjugation transfer is through enhancement of conjugation gene and oxidative stress gene expression, inhibition of vertical transfer gene expression, up regulation of outer membrane protein gene expression, promotion of cell pore formation, and improvement of cell membrane permeability.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Letter
Oncology
Shayna Sarosiek, Steven P. Treon, Andrew R. Branagan, Jorge J. Castillo
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Feiping Nie, Xia Dong, Zhanxuan Hu, Rong Wang, Xuelong Li
Summary: This work proposes a parameter-free clustering model called discriminative projected clustering (DPC) for low-dimensional and discriminative projection learning and clustering. The connection between DPC and linear discriminant analysis (LDA) is theoretically analyzed, and experiments demonstrate the effectiveness and efficiency of DPC in real-world applications.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Article
Computer Science, Artificial Intelligence
Feiping Nie, Sisi Wang, Zheng Wang, Rong Wang, Xuelong Li
Summary: Principal component analysis (PCA) is unable to overcome the influence of outliers. Existing robust PCA methods have limitations and a new discrete robust PCA algorithm is proposed to eliminate the influence of outliers completely and improve anomaly detection capability.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Article
Computer Science, Artificial Intelligence
Wei Chang, Feiping Nie, Yijie Zhi, Rong Wang, Xuelong Li
Summary: Multitask learning is a joint learning paradigm that combines multiple related tasks to improve performance. It has been observed that different tasks share a low-dimensional common subspace. To approximate the rank minimization problem, two regularization-based models are proposed to minimize the k minimal singular values. Compared to the standard trace norm, these models provide tighter approximations and better capture the low-dimensional subspace among multiple tasks.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Article
Chemistry, Multidisciplinary
Xusheng Hui, Jianjun Luo, Rong Wang, Hao Sun
Summary: This study reports on an electrical/optical-actuated microactuator that can be used to develop ultrafast submillimeter robots. The robots exhibit flexible and precise movement under voltages and lasers, allowing for controllable and ultrafast inchworm-type movement. The robots also have the ability to maintain functionality even after being crashed or in a reversed state.
Article
Chemistry, Physical
Qianqian Fu, Hui Wang, Kunlun Nie, Xuyun Wang, Jianwei Ren, Rongfang Wang
Summary: In this study, P, S co-doped NiCoPxSy nanowire array catalysts were synthesized on a nickel foam substrate using a stepped preparation strategy. The prepared catalysts exhibited excellent electrocatalytic performance, enabling simultaneous hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) on both the anode and cathode. This research provides an effective method for designing innovative catalysts and producing clean energy.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2024)