mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis

Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females

(2019) Sully Fernandez et al.   Cell Reports

Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

(2019) Su Myung Jung et al.   MOLECULAR CELL

The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase

(2018) Phillip J. White et al.   Cell Metabolism

Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis

(2018) Joan Sanchez-Gurmaches et al.   Cell Metabolism

DHHC7 Palmitoylates Glucose Transporter 4 (Glut4) and Regulates Glut4 Membrane Translocation

(2017) Keyong Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin action and resistance in obesity and type 2 diabetes

(2017) Michael P Czech   NATURE MEDICINE

The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond

(2017) Peter L. Lee et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism

(2017) James R. Krycer et al.   Cell Reports

LC-quadrupole/Orbitrap high-resolution mass spectrometry enables stable isotope-resolved simultaneous quantification and 13C-isotopic labeling of acyl-coenzyme A thioesters

(2016) Alexander J. Frey et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

FluxFix: automatic isotopologue normalization for metabolic tracer analysis

(2016) Sophie Trefely et al.   BMC BIOINFORMATICS

mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue

(2016) V. Albert et al.   EMBO Molecular Medicine

Plug-and-play analysis of the human phosphoproteome by targeted high-resolution mass spectrometry

(2016) Robert T Lawrence et al.   NATURE METHODS

TORC2 Structure and Function

(2016) Christl Gaubitz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism

(2016) Yuefeng Tang et al.   Nature Communications

ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch

(2016) Steven Zhao et al.   Cell Reports

Production of stable isotope-labeled acyl-coenzyme A thioesters by yeast stable isotope labeling by essential nutrients in cell culture

(2015) Nathaniel W. Snyder et al.   ANALYTICAL BIOCHEMISTRY

Glut4 palmitoylation at Cys223 plays a critical role in Glut4 membrane trafficking

(2015) Wenying Ren et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Selective Insulin Resistance in Adipocytes

(2015) Shi-Xiong Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation

(2015) Guang Yang et al.   Cell Reports

Histone H3 K27 acetylation marks a potent enhancer element on the adipogenic master regulator gene Pparg2

(2014) Muhammad Khairul Ramlee et al.   CELL CYCLE

Rictor/mTORC2 Loss in the Myf5 Lineage Reprograms Brown Fat Metabolism and Protects Mice against Obesity and Metabolic Disease

(2014) Chien-Min Hung et al.   Cell Reports

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

(2013) N. Turner et al.   DIABETOLOGIA

Akt-dependent Activation of the Heart 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase (PFKFB2) Isoenzyme by Amino Acids

(2013) Laura Novellasdemunt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology

(2013) C. Betz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

(2013) S. A. Kang et al.   SCIENCE

Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors

(2012) Ayaz Najafov et al.   BIOCHEMICAL JOURNAL

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism

(2012) Mark A. Herman et al.   NATURE

Comet: An open-source MS/MS sequence database search tool

(2012) Jimmy K. Eng et al.   PROTEOMICS

Mammalian TOR signaling to the AGC kinases

(2011) Bing Su et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

O-GlcNAcylation Increases ChREBP Protein Content and Transcriptional Activity in the Liver

(2011) C. Guinez et al.   DIABETES

Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor

(2011) E. Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

(2010) Brendan MacLean et al.   BIOINFORMATICS

Fat Cell-Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism

(2010) A. Kumar et al.   DIABETES

Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice

(2010) Julien Bricambert et al.   JOURNAL OF CLINICAL INVESTIGATION

RAD18 transmits DNA damage signalling to elicit homologous recombination repair

(2009) Jun Huang et al.   NATURE CELL BIOLOGY

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Isoform-specific regulation of adipocyte differentiation by Akt/protein kinase Bα

(2008) Sung-Ji Yun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL