期刊
EPIGENOMICS
卷 12, 期 3, 页码 183-197出版社
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2019-0277
关键词
AGO; ectopic endometrium; endometriosis; eutopic endometrium; noncoding RNAs; small RNA sequencing; tiRNAs; transfer RNA-derived fragments; tRFs; tRNA
资金
- National Natural Science Foundation of China [81801426]
- Hunan Provincial Natural Science Foundation of China [2018JJ3855]
Aim: Transfer RNA-derived fragments have been reported to play a vital role in disease progression, but their role in the pathogenesis of endometriosis remains unknown. Materials & methods: Small RNA sequencing was conducted in three paired ovarian endometriomas and eutopic endometria. The data from 22 paired samples were validated by quantitative real-time polymerase chain reaction (qPCR) and bioinformatic analysis was performed to establish the roles of these fragments in endometriosis pathogenesis. Results: We identified 19 upregulated and five downregulated tRNA-derived fragments, of which tiRNA-5 was the most common. Gene Ontology and pathway analyses revealed that these molecules could have roles in the pathogenesis of endometriosis. Conclusion: tRNA-derived fragments are dysregulated and could be involved in the pathogenesis and progression of ovarian endometriosis.
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