期刊
EPIGENOMICS
卷 11, 期 16, 页码 1827-1837出版社
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2019-0135
关键词
aneuploidy; chromosome; dosage compensation; gene expression
资金
- NIH [R01GM126223]
- ICTAS Center for Engineered Health at Virginia Tech
- National Science Foundation [MCB-1517506]
- Virginia Tech College of Science
Aneuploidy (i.e., abnormal chromosome number) is the leading cause of miscarriage and congenital defects in humans. Moreover, aneuploidy is ubiquitous in cancer. The deleterious phenotypes associated with aneuploidy are likely a result of the imbalance in the levels of gene products derived from the additional chromosome(s). Here, we summarize the current knowledge on how the presence of extra chromosomes impacts gene expression. We describe studies that have found a strict correlation between gene dosage and transcript levels as wells as studies that have found a less stringent correlation, hinting at the possible existence of dosage compensation mechanisms. We conclude by peering into the epigenetic changes found in aneuploid cells and outlining current knowledge gaps and potential areas of future investigation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据