期刊
ACS MEDICINAL CHEMISTRY LETTERS
卷 11, 期 10, 页码 1785-1788出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.9b00687
关键词
Bioisosteres; structural alerts; reactive metabolites; anilines; aminonorbornanes
资金
- NIH NIGMS [R01-GM127774]
Many promising drug candidates and pharmaceutical compounds fail due to idiosyncratic adverse drug reactions (IADRs), often arising from the formation of reactive metabolites. Among the structural alerts responsible, anilines are well-known to undergo deleterious metabolic processing, yet isosteric replacement strategies remain limited. Herein we discuss current art and potential new avenues of saturated isosteres to mitigate aniline-related toxicities.
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