Review
Cell Biology
Ilona M. Gora, Anna Ciechanowska, Piotr Ladyzynski
Summary: Type 2 diabetes mellitus is characterized by chronic inflammation, and the activation of the NLRP3 inflammasome plays a significant role in this condition. Endothelial dysfunction is identified as a key step in inflammasome activation, suggesting that targeting the NLRP3 inflammasome could offer new therapeutic approaches.
Review
Immunology
Yaxuan Xing, Longmei Yan, Xiaoya Li, Zhijie Xu, Xianyu Wu, Huirong Gao, Yiduo Chen, Xiaojuan Ma, Jiangang Liu, Jingchun Zhang
Summary: This review discusses the interconnection between NLRP3 inflammasomes and gut microbiota in the development of atrial fibrillation, and explores the potential value of pharmacological and dietary induction in managing AF through the association between NLRP3 inflammasomes and gut microbiota.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yuhua Shi, Qian Lv, Mengjie Zheng, Hongxiang Sun, Fushan Shi
Summary: INF39 is a specific inhibitor for NLRP3 inflammasome activation, without affecting other inflammasomes. It exerts its anti-inflammatory effect by inhibiting the interaction of NEK7-NLRP3 and other downstream events.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Physiology
Yajun Yao, Mei Yang, Dishiwen Liu, Qingyan Zhao
Summary: Immune remodeling is a new direction for research and therapeutic strategies for atrial fibrillation (AF) as it has complex relationships with atrial electrical, structural, and neural remodeling. It may provide effective therapies for AF.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kun Zuo, Chen Fang, Zheng Liu, Yuan Fu, Ye Liu, Lifeng Liu, Yuxing Wang, Xiandong Yin, Xiaoqing Liu, Jing Li, Jiuchang Zhong, Mulei Chen, Li Xu, Xinchun Yang
Summary: This study found that short-chain fatty acids (SCFA) produced from gut microbiota fermentation of dietary fiber can alleviate atrial remodeling mediated by NLRP3 signaling and protect against atrial fibrillation (AF) development. The results showed that supplementation of SCFA can restore atrial remodeling and reduce AF symptoms in mice fed a low-fiber diet, and the protective effect of SCFA on AF was mediated by GPR43-mediated deactivation of NLRP3 inflammasome.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Amir Ajoolabady, Stanley Nattel, Gregory Y. H. Lip, Jun Ren
Summary: Atrial fibrillation, the most prevalent form of arrhythmia, increases the risk of heart failure, thromboembolism, and stroke. Activation of the NLRP3 inflammasome is associated with the onset and progression of atrial fibrillation.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Mitchel R. Stacy, Ben A. Lin, Stephanie L. Thorn, David C. Lobb, Mark W. Max, Craig Novack, Kia N. Zellars, Lisa Freeburg, Joseph G. Akar, Albert J. Sinusas, Francis G. Spinale
Summary: Left ventricular remodeling post-myocardial infarction can lead to new-onset atrial fibrillation, and increased susceptibility to atrial fibrillation is associated with remodeling of the atrial extracellular matrix.
Article
Biochemistry & Molecular Biology
Yueke Lin, Xiaoting Lv, Caiyu Sun, Yanlin Sun, Min Yang, Dapeng Ma, Weiqiang Jing, Yunxue Zhao, Yeping Cheng, Haocheng Xuan, Lihui Han
Summary: This study reveals a novel regulatory mechanism of NLRP3 via TRIM50 and suggests that modulating TRIM50 might represent a therapeutic strategy for NLRP3-dependent pathologies.
Article
Biotechnology & Applied Microbiology
Yanzhao Wei, Wei Li, Shuang Yang, Peng Zhong, Yingying Bi, Yanhong Tang
Summary: In recent years, it has been found that high-decibel noise is a risk factor for ischemic heart disease. This study explored the association between noise exposure and postinfarction cardiac remodeling, focusing on the activation of the NLRP3 inflammasome. The results showed a higher activation of the NLRP3 inflammasome in the noisy environment group, highlighting the importance of effective noise prevention in improving postinfarction prognosis.
Article
Cardiac & Cardiovascular Systems
Yun Zhang, Song Zhang, Bolin Li, Yingchun Luo, Yongtai Gong, Xuexin Jin, Jiawei Zhang, Yun Zhou, Xiaozhen Zhuo, Zixi Wang, Xinbo Zhao, Xuejie Han, Yunlong Gao, Hui Yu, Desen Liang, Shiqi Zhao, Danghui Sun, Dingyu Wang, Wei Xu, Guangjin Qu, Wanlan Bo, Dan Li, Yue Wu, Yue Li
Summary: By using a faecal microbiota transplantation (FMT) rat model, it was demonstrated that the high AF susceptibility of aged rats could be transmitted to a young host. Inhibition of inflammasome by a potent and selective inhibitor of the NLRP3 inflammasome resulted in a lower atrial fibrosis and AF susceptibility. Clinical studies showed that serum LPS and glucose levels were progressively increased in elderly patients compared to young individuals, with similar results confirmed in clinical AF patients.
CARDIOVASCULAR RESEARCH
(2022)
Review
Immunology
Wanyi Huang, Ziqi Zhang, Yueyang Qiu, Yuan Gao, Yongqiang Fan, Qiang Wang, Qing Zhou
Summary: Implant surgery triggers inflammatory reactions that impact postoperative outcomes. The inflammasome has a crucial role in inflammation, inducing pyroptosis and producing interleukin-1 beta. The activation of the inflammasome in bone healing after implant surgery needs to be studied. Research has focused on metal-induced NLRP3 inflammasome activation due to the prominence of metals as implant materials. This review consolidates knowledge on NLRP3 inflammasome structures, activation mechanisms, and metal-induced NLRP3 inflammasome activation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yoshiko Murakata, Fumi Yamagami, Nobuyuki Murakoshi, DongZhu Xu, Zhonghu Song, Siqi Li, Yuta Okabe, Kazuhiro Aonuma, ZiXun Yuan, Haruka Mori, Kazutaka Aonuma, Kazuko Tajiri, Masaki Ieda
Summary: Inflammatory atrial cardiomyopathy can lead to atrial fibrillation, characterized by enlarged atria, infiltration of inflammatory cells, and fibrosis. These changes increase susceptibility to arrhythmias by affecting electrical conduction, genetic factors, and autonomic regulation. Therefore, reducing inflammation is important in preventing atrial fibrillation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Ling-ling Qian, Xiao-yu Liu, Xiao-yan Li, Fan Yang, Ru-Xing Wang
Summary: Atrial fibrillation is a common arrhythmia, and diabetes mellitus is an independent risk factor for atrial fibrillation. The increased risk of atrial fibrillation in diabetic patients is related to structural and electrical changes in the atrium. This article focuses on the electrical remodeling of atrial cardiomyocytes in diabetes mellitus, including changes in sodium channels, calcium channels, potassium channels, and other channels, providing the basis for the clinical management of antiarrhythmic drugs in diabetic patients with atrial fibrillation.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Yuwen Wu, Haohua Deng, Jiazhong Sun, Yancheng Xu
Summary: This study investigates the potential role of Nlr family member X1 (NLRX1) in diabetic nephropathy (DN) and the underlying mechanisms. The results show that NLRX1 can attenuate inflammation and prevent kidney injury by inhibiting NOD-like Receptor Family Pyrin Domain Containing 3 (NLRP3) inflammasome in both in vivo and in vitro models. Therefore, NLRX1 may serve as a potent target for preventing the progression of DN through inhibition of NLRP3 inflammasome-dependent inflammation.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Chemistry, Medicinal
Roberta Mancuso, Lorenzo Agostino Citterio, Simone Agostini, Ivana Marventano, Francesca La Rosa, Francesca Re, Pierfausto Seneci, Marina Saresella, Mario Clerici, Leonidas A. Phylactou
Summary: The anti-hyperglycemic drug glibenclamide and bi-functionalized liposomes are capable of inhibiting NLRP3 inflammasome activation and reducing the release of inflammatory cytokines. They also have the ability to modulate the expression of certain miRNAs. These findings suggest a potential new strategy for treating neurodegenerative diseases using glibenclamide and liposomes.
