期刊
JOURNAL OF FUNCTIONAL FOODS
卷 65, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2019.103738
关键词
Chlamydomonas reinhardtii; Gastrointestinal symptoms; American Gut; Microbiome; Dextran sodium sulfate; Bioactive
资金
- Triton Algae Innovations
- US Department of Energy [DE-EE0008246]
The effects of consuming whole-cell biomass of the green algae Chlamydomonas reinhardtii on gastrointestinal health in mice and humans was examined. A 14-day murine model of acute colitis revealed significantly less weight loss in mice that received C. reinhardtii biomass by oral gavage. Based on this result, human volunteers with varying gastrointestinal symptoms were asked to consume 1 or 3 g of C. reinhardtii daily for 30 days. Participants reported changes in their gastrointestinal health through a questionnaire and provided stool samples to analyze the composition of their gut microbiome. Those who typically experience frequent gastrointestinal symptoms reported significantly less bowel discomfort or diarrhea, significantly less gas or bloating, more regular bowel movements, and better stool consistency when regularly consuming C. reinhardtii. Analysis of participant stool samples suggested the gut microbiome composition in all groups remained complex, and no signs of dysbiosis or adverse effect on microbial composition were observed.
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