期刊
JOURNAL OF FUNCTIONAL FOODS
卷 65, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2019.103716
关键词
Fisetin nanoparticle; PM2.5; Astrocyte; NF-kappa B
资金
- National Natural Science Foundation of China (NSFC) [81703527]
- Chongqing Research Program of Basic Research and Frontier Technology [cstc2017jcyjAX0356, cstc2018jcyjA3686, cstc2018jcyjAX0784, cstc2018jcyjA1472, cstc2018jcyjAX0811, cstc2018jcyjA3533, KJZD-M201801601]
- School-level Research Program of Chongqing University of Education [KY201710B, 17GZKP01]
- Advanced Programs of Post-doctor of Chongqing [2017LY39]
- Science and Technology Research Program of Chongqing Education Commission of China [KJQN201901608, KJQN201901615, KJ1601402]
- Children's Research Institute of National Center for Schooling Development Programme
- Chongqing University of Education [CSDP19FS01108]
Astrocytes activation related NF-kappa B signaling and oxidative stress were treated as key target associated with PM2.5 threating nerve injury. Unfortunately, the underlying molecular mechanisms of interaction between NF-kappa B signaling, glial cells activation in neuroinflammation are still not absolutely explained. Fisetin, a natural flavonoid was found to be promote health, partly due to its ability in antioxidant and anti-inflammation. In this regard, we constructed fisetin nanoparticles (FN) to investigate the anti-inflammatory effect in PM2.5-induced mice. Accordingly, qPCR and western blot analysis indicated that astrocytes activation related NF-kappa B signaling and oxidative stress contributed to PM2.5-induced neuroinflammation, which were significantly suppressed by increasing concentration of FN treatment. Also, FN may directly enhance anti-oxidative stress and anti-inflammatory way to perform inhibitory effects on NF-kappa B related glial cells activation. Overall, here we identified a new mechanism of action of FN as potential anti-inflammatory product against PM2.5-induced neuroinflammation via regulation of astrocytes activation related NF-kappa B.
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