期刊
ONCOTARGETS AND THERAPY
卷 13, 期 -, 页码 1797-1807出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S239336
关键词
gastric cancer; chemotherapy; resistance
资金
- NSFC [81600401]
- Hubei Provincial Natural Science Foundation of China [2017CFB474]
- Health Commission of Hubei Province [WJ2019Q035]
Gastric cancer is one of the most common malignant tumors, and it is also one of the leading causes of cancer death worldwide. Because of its insidious symptoms and lack of early dictation screening, many cases of gastric cancer are at late stages which make it more complicated to cure. For these advanced-stage gastric cancers, combination therapy of surgery, chemotherapy, radiotherapy and target therapy would bring more benefit to the patients. However, the drug-resistance to the chemotherapy restricts its effect and might lead to treatment failure. In this review article, we discuss the mechanisms which have been found in recent years of drug resistance in gastric cancer. And we also want to find new approaches to counteract chemotherapy resistance and bring more benefits to the patients.
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