Article
Immunology
Hui Liang, Nathanael Matei, Devin W. McBride, Yang Xu, Zhenhua Zhou, Jiping Tang, Benyan Luo, John H. Zhang
Summary: Activation of TGR5 mitigates brain injury by inhibiting neuroinflammation after MCAO, potentially mediated by Pellino3 inhibition of caspase-8/NLRP3.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Konstantinos M. Themistoklis, Themistoklis I. Papasilekas, Konstantinos S. Melanis, Konstantinos A. Boviatsis, Stefanos I. Korfias, Konstaninos Vekrellis, Damianos E. Sakas
Summary: The tifMCAO stroke model in rats is widely used and has been proven to reliably mimic human stroke. The surgical technique has been detailed with stepwise instructions and visual aids provided.
WORLD NEUROSURGERY
(2022)
Article
Immunology
Shuqi Jiang, Huifang Wang, Qiuping Zhou, Qian Li, Nan Liu, Zhenggong Li, Chunbo Chen, Yiyu Deng
Summary: The study showed that Melatonin (MEL) can shift A1 astrocytes towards A2, increase myelin protein expression, reduce axonal hypomyelination, and improve neurological function in septic neonatal rats.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Cell Biology
Kitti Thiankhaw, Nipon Chattipakorn, Siripron C. Chattipakorn
Summary: MCAO and cerebral I/R injury can lead to microvascular injury, blood-brain barrier dysfunction, inflammation, oxidative stress, and neuronal death, resulting in brain infarction. HBOT has shown positive effects on neurological outcomes after these injuries, but conflicting data exists on its impact on functional recovery. Studies have been conducted to evaluate the potential benefits of HBOT, both in vivo and clinically, in the context of stroke outcomes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Chemistry, Medicinal
Tae-Hoon Park, Han-Gyul Lee, Seung-Yeon Cho, Seong-Uk Park, Woo-Sang Jung, Jung-Mi Park, Chang-Nam Ko, Ki-Ho Cho, Seungwon Kwon, Sang-Kwan Moon
Summary: This study investigated the effects of Geopung-Chunghyuldan (GCD) and its component Chunghyuldan (CD) on ischemic brain damage. The results showed that GCD significantly reduced cell death in an in vitro ischemia model, while CD did not show a significant protective effect. In an in vivo ischemia mice model, GCD and CD both reduced the infarct volume, with GCD showing a more significant effect. This suggests that GCD may have a synergistic neuroprotective effect and could be a potential alternative for the prevention and treatment of ischemic stroke.
Article
Neurosciences
Maria Santos-Galdiano, Paloma Gonzalez-Rodriguez, Enrique Font-Belmonte, Irene F. Ugidos, Berta Anuncibay-Soto, Diego Perez-Rodriguez, Arsenio Fernandez-Lopez
Summary: The study suggests that Celecoxib may exert neuroprotection by reducing ER stress, enhancing the IRE1-UPR pathway and UPS degradation, providing a potential new therapeutic target for stroke treatment.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Cell Biology
Geun-Hyoung Ha, Eun Ji Kim, Jee Soo Park, Ji Eun Kim, Hyun Nam, Je Young Yeon, Sun-Ho Lee, Kyunghoon Lee, Chung Kwon Kim, Kyeung Min Joo
Summary: This study demonstrated the neuroprotective and pro-angiogenic effects of adult human neural stem cells (ahNSCs) in the treatment of ischemic stroke. Tissue analysis showed that ahNSCs reduced brain tissue atrophy and functional loss, and preserved neurons by decreasing reactive astrogliosis and microglial activation. Furthermore, these effects were mediated by paracrine factors and reversed when the JAK2/STAT3 signaling pathway was inhibited. This preclinical study provides important insights for the development of stem cell therapeutics for ischemic stroke.
Article
Neurosciences
Sijie Li, Wenbo Zhao, Guiyou Liu, Changhong Ren, Ran Meng, Yuan Wang, Haiqing Song, Qingfeng Ma, Yuchuan Ding, Xunming Ji
Summary: Chronic remote ischemic conditioning (RIC) appears to be well-tolerated and associated with a low annual risk of ischemic stroke and cardio-cerebrovascular events in patients with symptomatic internal carotid artery or middle cerebral artery occlusion with impaired hemodynamics.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Neurosciences
Marloes Verkerke, Amber Berdenis van Berlekom, Vanessa Donega, Danielle Vonk, Jacqueline A. Sluijs, Nayab F. Butt, Lois Kistemaker, Lot D. de Witte, R. Jeroen Pasterkamp, Jinte Middeldorp, Elly M. Hol
Summary: This study investigates the development and maturation of astrocytes in cerebral organoids derived from human induced pluripotent stem cells. Based on morphological and transcriptomic analysis, it is found that the optimal time to study matured astrocytes is after 19 weeks in culture.
Article
Biochemistry & Molecular Biology
Chun-Wei Wu, Jia-Jin Chen, Chou-Ching K. Lin, Chien-An Chen, Chun-Ie Wu, Ing-Shiou Hwang, Tsung-Hsun Hsieh, Bor-Shing Lin, Chih-Wei Peng
Summary: This study investigated the changes in brain tissue optical properties using frequency-domain near-infrared spectroscopy (FD-NIRS) and established the relationship between cerebral hemodynamics and infarct variation in a middle cerebral artery occlusion (MCAO) model. The results suggest that FD-NIRS parameters may be associated with the severity of the infarction and subsequent pathologies in MCAO.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuelin Zhao, Xiaohua Shi, Jiaoqi Wang, Jing Mang, Zhongxin Xu
Summary: The study found that betulinic acid can reduce cerebral injury by decreasing oxidative stress, as well as activate the SIRT1/FoxO1 pathway to suppress autophagy and improve cerebral injury.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Clinical Neurology
Andrea Naldi, Alessandra Di Liberto, Enrica Duc, Alessandro Rapellino, Giacomo Paolo Vaudano, Roberto Cavallo, Andrea Boghi
Summary: Bilateral simultaneous middle cerebral artery occlusion is a rare condition that requires rapid intervention for restoring brain perfusion. Perfusion-computed tomography is essential for selecting stroke patients for mechanical thrombectomy, but its role in guiding the optimal treatment strategy for concomitant multivessel cerebral occlusion has not been reported before. This case study highlights the importance of perfusion-computed tomography in both guiding endovascular procedures and planning the sequence of mechanical thrombectomies for bilateral middle cerebral artery occlusion.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Jingsi Xu, Zheyu Zhang, Bo Jin, Yu Geng, Longting Lin, Sheng Zhang
Summary: This study aimed to determine whether baseline delayed filling of the superficial middle cerebral vein (SMCV) was an independent cause of stroke prognosis in patients with acute anterior large vessel occlusion (LVO). The results showed a significant association between baseline delayed SMCV and a 3-month poor outcome, while SMCV reversal did not significantly change the stroke prognosis.
FRONTIERS IN NEUROLOGY
(2022)
Review
Neurosciences
Lang Zeng, Shengqi Hu, Lingcheng Zeng, Rudong Chen, Hua Li, Jiasheng Yu, Hongkuan Yang
Summary: Ischemic stroke is a common type of stroke that has a significant impact on human well-being and quality of life. To better understand the pathophysiology of ischemic stroke and develop new treatment strategies, controllable and consistent animal models are urgently needed. The middle cerebral artery occlusion (MCAO) model is currently the most widely used model for studying ischemic stroke. This review discusses different methods for constructing the MCAO model and compares their advantages and disadvantages, aiming to provide better approaches for studying ischemic stroke.
Review
Clinical Neurology
Jennifer D. Sokolowski, Sauson Soldozy, Khadijeh A. Sharifi, Pedro Norat, Kathryn N. Kearns, Lei Liu, Ashley M. Williams, Kaan Yagmurlu, Panagiotis Mastorakos, G. Wilson Miller, M. Yashar S. Kalani, Min S. Park, Ryan T. Kellogg, Petr Tvrdik
Summary: Stroke is a major burden, and despite advances in prevention and treatment, it still negatively affects patients, families, and healthcare professionals. Preclinical basic research, particularly using mouse models, can help to understand stroke pathology and discover effective interventions. This article reviews the middle cerebral artery occlusion technique and introduces various imaging approaches to enhance preclinical stroke evaluation.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Michael Fleischer, Bayram Coskun, Benjamin Stolte, Adela Della-Marina, Heike Koelbel, Hildegard Lax, Michael Nonnemacher, Christoph Kleinschnitz, Ulrike Schara-Schmidt, Tim Hagenacker
Summary: The Essen transition model aims to improve healthcare and quality of life in young adults with neuromuscular diseases. It combines the therapeutic effort of different specialist disciplines through standardized procedures, joint consultations, interdisciplinary conferences, and a transitional database, providing complex care for patients.
Article
Clinical Neurology
Ahmet Burak Caglayan, Mustafa Caglar Beker, Elif Sertel Evren, Berrak Caglayan, Ulkan Kilic, Nilay Ates, Aysun Caglayan, Muhammed Furkan Dasdelen, Thorsten Roland Doeppner, Mart Saarma, Dirk Matthias Hermann, Ertugrul Kilic
Summary: CDNF and MANF, when administered after stroke, can promote neurological recovery and increase neuronal survival. They also reduce brain atrophy and glial scar formation. CDNF has the additional effect of increasing endogenous neurogenesis and promoting axonal growth.
TRANSLATIONAL STROKE RESEARCH
(2023)
Review
Geriatrics & Gerontology
Leonard Radu Pinosanu, Bogdan Capitanescu, Daniela Glavan, Sanziana Godeanu, Israel Fernaundez Cadenas, Thorsten R. Doeppner, Dirk M. Hermann, Adrian-Tudor Balseanu, Catalin Bogdan, Aurel Popa-Wagner
Summary: The functions and activities of astroglia cells in brain development, aging, and neurodegenerative diseases differ. Comparing the transcriptomic activity of astroglia cells in these processes may provide new therapeutic strategies to protect the aging brain and improve clinical outcomes.
Article
Neurosciences
Mina Borbor, Dongpei Yin, Ulf Brockmeier, Chen Wang, Marius Doeckel, Matthias Pillath-Eilers, Britta Kaltwasser, Dirk M. Hermann, Egor Dzyubenko
Summary: This study reveals that astrocytes play a crucial role in the maintenance of neuronal networks and their dysfunction can contribute to neurodegeneration. The researchers found that ischemia-reperfusion induces metabolic reprogramming in astrocytes, resulting in mitochondrial dysfunction and synaptic degeneration. Inhibiting STAT3 signaling pathway and increasing glycogen content in astrocytes can prevent synaptic degeneration.
Editorial Material
Neurosciences
Egor Dzyubenko, Maryam Sardari, Dirk M. Hermann
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Editorial Material
Neurosciences
Zongjian Liu, Dirk M. Hermann, Egor Dzyubenko, Guodong Cao, Xiang Cao
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Cell Biology
Leoni Rolfes, Steffen Pfeuffer, Jelena Skuljec, Xia He, Chuanxin Su, Sinem-Hilal Oezalp, Marc Pawlitzki, Tobias Ruck, Melanie Korsen, Konstanze Kleinschnitz, Derya Aslan, Tim Hagenacker, Christoph Kleinschnitz, Sven G. Meuth, Refik Pul
Summary: Cladribine-treated MS patients can mount an adequate immune response to influenza independently of treatment duration and time interval to the last cladribine administration. The antibody response against influenza A was comparable between cladribine-treated patients and controls, while the response against influenza B was lower in the cladribine cohort. The increase in geometric mean titers was also lower in the cladribine group compared to controls, but titers increased in both groups for all strains.
Article
Microbiology
Hedda Luise Verhasselt, Elakiya Ramakrishnan, Melina Schlag, Julian R. Marchesi, Jan Buer, Christoph Kleinschnitz, Tim Hagenacker, Andreas Totzeck
Summary: The fungal microbiome in the intestines of patients with myasthenia gravis (MG) was found to be similar to that of patients with non-inflammatory neurological disorders (NIND), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), and healthy volunteers. However, due to incomplete data, further analysis and conclusions are limited.
Article
Biochemistry & Molecular Biology
Michael K. Schuhmann, Friederike Langhauser, Lena Zimmermann, Maximilian Bellut, Christoph Kleinschnitz, Felix Fluri
Summary: The study found that DMF treatment can reduce infarct volume and brain edema after stroke, and attenuate lymphocyte infiltration, thus mitigating immune cell-driven damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Jonas Feldheim, Teresa Schmidt, Christoph Oster, Julia Feldheim, Martin Stuschke, Walter Stummer, Oliver Grauer, Bjoern Scheffler, Carsten Hagemann, Ulrich Sure, Christoph Kleinschnitz, Lazaros Lazaridis, Sied Kebir, Martin Glas
Summary: To minimize the risk of infections during the COVID-19 pandemic, remote video consultations have become popular in medical fields. However, telemedicine in neuro-oncology presents unique challenges and opportunities. This study analyzed over 3700 neuro-oncological consultations, including more than 300 video consultations, to understand the differences between patient groups and evaluate the benefits and drawbacks of video consultations. Patients who opted for video consultations had worse clinical conditions, higher malignancy grades, were diagnosed more frequently with glioblastoma, and traveled longer distances.
Article
Cell Biology
Markus Leo, Linda-Isabell Schmitt, Fabian Mairinger, Andreas Roos, Christina Hansmann, Stefanie Hezel, Jelena Skuljec, Refik Pul, Ulrike Schara-Schmidt, Christoph Kleinschnitz, Tim Hagenacker
Summary: This study analyzed serum samples of late-onset SMA patients before and after treatment with nusinersen using high-throughput nCounter NanoString technology. Four genes were found to have significantly altered transcript counts in the serum of patients, and these alterations were associated with SMA subtype and treatment response.
Article
Cell Biology
Egor Dzyubenko, Katrin I. Willig, Dongpei Yin, Maryam Sardari, Erdin Tokmak, Patrick Labus, Ben Schmermund, Dirk M. Hermann
Summary: The study found that perineuronal nets (PNNs) undergo structural changes after ischemic stroke and these changes are associated with the recovery of motor coordination. The study also revealed that activated microglia/macrophages preferentially contact neurons coated with PNNs. These findings provide new insights into the mechanisms underlying neuroplasticity after stroke.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Jordi Kuehne Escola, Bessime Bozkurt, Bastian Brune, Woon Hyung Chae, Lennart Steffen Milles, Doreen Pommeranz, Lena Brune, Philipp Dammann, Ulrich Sure, Cornelius Deuschl, Michael Forsting, Clemens Kill, Christoph Kleinschnitz, Martin Koehrmann, Benedikt Frank
Summary: Stroke mimics are common in the emergency department, and early detection is crucial for initiating appropriate treatment. This study compared the frequency, clinical characteristics, and predictors of non-neurological and neurological stroke mimics in patients with suspected stroke. The results highlighted the importance of awareness of underlying etiologies and differences in clinical characteristics for optimal care.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Christoph Oster, Teresa Schmidt, Sarina Agkatsev, Lazaros Lazaridis, Christoph Kleinschnitz, Ulrich Sure, Bjorn Scheffler, Sied Kebir, Martin Glas
Summary: This study analyzed phase III clinical trials for glioblastoma conducted since 2005, revealing that the majority of trials did not result in significant improvement in overall survival. Only the EORTC/NCIC, EF-14, and CeTeG studies showed positive outcomes in terms of overall survival in the younger cohort.
NEURO-ONCOLOGY ADVANCES
(2023)