Review
Genetics & Heredity
Mengyu Lim, Alessandro Carollo, Dagmara Dimitriou, Gianluca Esposito
Summary: This study used document co-citation analysis to systematically review literature on ASD genetic research from 2018 to 2022 and identified 12 major clusters representing different sub-topics in the field.
Review
Biochemistry & Molecular Biology
Andrea Stoccoro, Eugenia Conti, Elena Scaffei, Sara Calderoni, Fabio Coppede, Lucia Migliore, Roberta Battini
Summary: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with unknown causes. Epigenetic mechanisms, specifically DNA methylation, may play a role in ASD pathogenesis. This systematic review aimed to investigate the clinical application of DNA methylation in children with ASD, with potential as a biomarker. The results suggest that peripheral DNA methylation could be a promising methodology in ASD research, but further studies are needed to develop clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Computer Science, Hardware & Architecture
Fangyu Shi, Wei Sun, Huiyu Duan, Xiaotian Liu, Menghan Hu, Wei Wang, Guangtao Zhai
Summary: This study established an ASD painting database, analyzed the unique characteristics of paintings by children with ASD, and trained a classifier using extracted features as a potential screening tool for autism spectrum disorder.
Article
Medicine, General & Internal
Giordano D'Urso, Elena Toscano, Veronica Sanges, Anne Sauvaget, Christine E. Sheffer, Maria Pia Riccio, Roberta Ferrucci, Felice Iasevoli, Alberto Priori, Carmela Bravaccio, Andrea de Bartolomeis
Summary: Transcranial direct current stimulation (tDCS) applied to the cerebellar lobe shows potential in reducing the severity of symptoms in patients with autism spectrum disorder (ASD). In this pilot study, 20 sessions of cathodal stimulation resulted in a 25% reduction in global severity of symptoms, with improvements in multiple subscales. The treatment was well-tolerated without serious adverse events.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Yushan Zhang, Rena Maimaiti, Shan Lou, Reyila Abula, Adila Abulaiti, Asimuguli Kelimu
Summary: This study established an accurate personalized predictive model for ASD behaviors in children based on blood element detection index. The model identified gender and concentrations of lead, calcium, and zinc in children's blood as independent risk factors for ASD behaviors.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Pediatrics
Stefano Berloffa, Claudia Dosi, Benedetta Tascini, Beatrice Fossati, Ilaria Lupetti, Gabriele Masi
Summary: Although little is known about the occurrence and characteristics of NMS in pediatric patients with autism spectrum disorder (ASD), current research suggests that the clinical features of NMS in this population appear to be similar to those in non-ASD populations. Further studies are needed to confirm these findings.
Article
Nutrition & Dietetics
Beata Kazek, Anna Brzoska, Justyna Paprocka, Tomasz Iwanicki, Karolina Koziol, Agnieszka Kapinos-Gorczyca, Wirginia Likus, Malgorzata Ferlewicz, Agnieszka Babraj, Agata Buczek, Irena Krupka-Matuszczyk, Ewa Emich-Widera
Summary: Children with ASD often exhibit difficulties during mealtimes, requiring entertainment and diverting of attention, being fed by parents, and consuming meals away from the table. Significant differences in utensil usage and food selectivity were found, working to the disadvantage of the study group. More focus should be placed on feeding and eating problems in children with ASD, with a need for multidisciplinary team cooperation and parental involvement in their care.
Article
Psychology, Developmental
Eynat Gal, Rotem Gal-Mishael, Roni Enten Vissoker, Darren Hedley, Simon M. Bury, Orit Stolar
Summary: The Aut-Eat Questionnaire (AEQ) was used to assess eating problems in children with ASD and typically developing children, showing high internal consistency and significant differences between the two groups in all domains.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2022)
Review
Genetics & Heredity
Christine F. Stafford, Pedro A. Sanchez-Lara
Summary: Genetics play a key role in the development of autism spectrum disorder (ASD), and genetic testing can guide clinical management and medical interventions, making it important for all ASD patients to have access to genetic evaluation.
Article
Engineering, Electrical & Electronic
Shuning Xu, Junbing Yan, Menghan Hu
Summary: This study introduces a new bio-inspired metric for classifying ASD and TD children, improving the accuracy of traditional models by screening stimulus materials and calculating SSIM values for different eye movement distributions. Experimental results demonstrate that the new model performs well in terms of classification accuracy.
SIGNAL PROCESSING-IMAGE COMMUNICATION
(2021)
Article
Biochemistry & Molecular Biology
Irena Voinsky, Yazeed Zoabi, Noam Shomron, Moria Harel, Hanoch Cassuto, Joseph Tam, Shannon Rose, Adrienne C. Scheck, Mohammad A. Karim, Richard E. Frye, Adi Aran, David Gurwitz
Summary: Mutations in over 100 genes are found to be associated with autism spectrum disorder (ASD). This study revealed differential expression of certain genes in ASD children, suggesting their potential involvement in ASD pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Nurkhaniza Kaman, Azlina Ishak, Juliawati Muhammad
Summary: This study aimed to determine the knowledge, attitudes, and associated factors among caregivers toward children with ASD. It found that the majority of caregivers had good knowledge and attitudes toward ASD. When managing children with ASD, the age and sex of the caregiver, the position of the ASD child among siblings, and the presence of other learning disorders in the family should be taken into consideration.
Review
Psychology, Developmental
Claire Blennerhassett, Michael Richards, Stephen Clayton
Summary: This systematic review examines the significance of caregiver-led interventions in improving food selectivity in autistic children and their acceptability. A search of four key academic databases yielded 36 studies. All studies reported improvements in food outcomes, although the meaningfulness in terms of the child's nutritional status remained unclear. Additionally, it was challenging to draw meaningful conclusions about the acceptability of interventions in the family environment. Future parent-led interventions should use standardized measures for food outcomes and consider the child's nutritional status, as well as thoroughly explore intervention acceptability.
REVIEW JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Education, Special
Yen-Wenn Liu, Jia-En Wang, Fang-Ju Sun, Yu-Hsin Huang, Hui-Ju Chen
Summary: This study supports the beneficial effects of PS128 on behavioral and emotional problems in children with ASD.
RESEARCH IN AUTISM SPECTRUM DISORDERS
(2023)
Editorial Material
Psychology, Developmental
Tobias Banaschewski, Oliviero Bruni, Joaquin Fuentes, Catherine Mary Hill, Allan Hvolby, Maj-Britt Posserud, Carmen Schroder
Summary: Between 50-80% of children with ASD experience insomnia, and experts recommend screening for insomnia and seeking specialist help when comorbid sleep disorders are suspected. The expert panel has developed tools for screening and monitoring to standardize practices, improve care, and enhance the well-being of children with ASD and their families.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2022)
Article
Neurosciences
George A. Buzzell, Hannah R. Thomas, Yeo Bi Choi, So Hyun Kim
Summary: Children with ASD exhibit deficits in error-related mediofrontal theta power, particularly during a late time window, which predicts poorer academic and social outcomes. Early intervention targeting these cognitive control processes may lead to more successful functional outcomes for children with ASD.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Article
Psychology, Clinical
Elizabeth P. McKernan, So Hyun Kim
Summary: The study compared language abilities of children with ASD and typically developing children at kindergarten entry, finding that children with ASD showed more impairments. It was also found that pragmatic language abilities at kindergarten entry predicted concurrent math and reading achievement for children with ASD. Furthermore, pragmatic language significantly predicted various functional skills at kindergarten exit for children with ASD.
CLINICAL NEUROPSYCHOLOGIST
(2022)
Article
Psychology, Clinical
Ericka L. Wodka, Julia Parish-Morris, Robert D. Annett, Laura Carpenter, Emily Dillon, Jacob Michaelson, So Hyun Kim, Rebecca Landa, Stephen Kanne
Summary: The study found significant differences in symptom presentation between females and males, school-age and adolescent individuals, and by co-occurring conditions (ASD/ADHD/Anxiety), with the impact of co-occurring conditions differing by age and sex.
CLINICAL NEUROPSYCHOLOGIST
(2022)
Review
Otorhinolaryngology
Do Hyun Kim, Sung Won Kim, Soo Ah Son, Jaehoon Jung, So-Hyun Kim, Se Hwan Hwang
Summary: The endoscopic prelacrimal recess approach (EPLRA) has a lower recurrence rate for maxillary sinus inverted papilloma removal compared to conventional surgeries, and it can preserve the lacrimal system, contributing to a successful surgery.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2022)
Article
Clinical Neurology
Rebecca Shaffer, Angela John Thurman, Lucienne Ronco, Diego Cadavid, Shane Raines, So Hyun Kim
Summary: This study examined the suitability of a social communication outcome measure called BOSCC-MV for individuals with FXS. The results showed that BOSCC-MV demonstrated strong inter-rater and test-retest reliability in FXS, and had strong convergent validity with standard clinical measures. This suggests that BOSCC-MV has the potential to be an effective outcome measure for social communication in FXS.
JOURNAL OF NEURODEVELOPMENTAL DISORDERS
(2022)
Article
Psychology, Developmental
Emily F. Dillon, Stephen Kanne, Rebecca J. Landa, Robert Annett, Raphael Bernier, Catherine Bradley, Laura Carpenter, So Hyun Kim, Julia Parish-Morris, Robert Schultz, Ericka L. Wodka
Summary: This study utilized a large dataset (SPARK) to examine sex differences in ASD symptoms. The findings revealed small but consistent differences between males and females, with different markers for each gender. Language concerns were more apparent in males, aiding in the diagnosis of ASD, while early motor concerns in females may hinder diagnosis as they are not captured within traditional ASD diagnostic criteria.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Audiology & Speech-Language Pathology
Elysha Clark-Whitney, Claire Brito Klein, Pamela A. Hadley, Catherine Lord, So Hyun Kim
Summary: This study aimed to investigate the change in sentence diversity of children with autism spectrum disorder (ASD) over 6 months of treatment with Naturalistic Developmental Behavioral Intervention (NDBI), as well as explore potential predictors of this change. The results showed that changes in caregiver NDBI strategy use and caregiver baseline Toy Talk were significant predictors of changes in sentence diversity.
JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
(2022)
Article
Multidisciplinary Sciences
Elizabeth P. McKernan, Manoj Kumar, Adriana Di Martino, Lisa Shulman, Alexander Kolevzon, Catherine Lord, Shrikanth Narayanan, So Hyun Kim
Summary: This study aimed to identify an automated behavioral marker of treatment response in social communication in children with ASD. Using an automated computational method, the study successfully derived the latency of response between children with ASD and adult social partners. The results indicate that the automated measure of latency is a scalable and objective method for quantifying treatment response in children with ASD.
SCIENTIFIC REPORTS
(2022)
Article
Psychology, Developmental
Rebecca Grzadzinski, Alapika Jatkar, Kevin Donovan, Kinh Truong, Alison Holbrook, Catherine Lord, So Hyun Kim
Summary: The evaluation of overlap between ADOS BOSCC and Standard BOSCC, as well as exploring child characteristics that can predict change, are important steps in consolidating data-driven definitions of improvement. Initial characteristics can guide tailoring of early intervention to maximize treatment outcomes and help determine which outcome measures to use.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Behavioral Sciences
Katherine Byrne, Shuting Zheng, Somer Bishop, Juliana Boucher, Sheila Ghods, So Hyun Kim, Catherine Lord
Summary: The study shows that children with ASD exhibit more severe worsening of behaviors during fever compared to TD children, though there may be rare cases of behavioral improvements among ASD children. Further research is needed to elucidate the nature of this phenomenon.
Article
Chemistry, Multidisciplinary
Tae Gwang Yun, Jiyoung Lee, Han Seul Kim, Jun Young Cheong, So Hyun Kim, Younghan Kim, Seonghun Lee, Il-Doo Kim
Summary: A novel smart and flexible zinc-ion battery is proposed in this study, which utilizes a p-bridge spacer-embedded polymer cathode to improve ion accessibility and charge transfer, resulting in high electrochemical performance and color change efficiency.
ADVANCED MATERIALS
(2023)
Article
Neurosciences
Amanda M. M. Buch, E. E. Vertes, Jakob Seidlitz, So Hyun Kim, Logan Grosenick, Conor Liston
Summary: Using a large neuroimaging dataset, this study identified three latent dimensions of functional brain network connectivity that predicted individual differences in autism spectrum disorder (ASD) behaviors. Four reproducible ASD subgroups were discovered with distinct functional connectivity alterations and clinical symptom profiles, which were validated in an independent sample. Integrating neuroimaging data with gene expression data revealed that ASD-related functional connectivity could be explained by regional differences in the expression of distinct ASD-related gene sets, implicating different molecular signaling pathways.
NATURE NEUROSCIENCE
(2023)
Article
Genetics & Heredity
Bethany Vibert, Patricia Segura, Louise Gallagher, Stelios Georgiades, Panagiota Pervanidou, Audrey Thurm, Lindsay Alexander, Evdokia Anagnostou, Yuta Aoki, Catherine S. Birken, Somer L. Bishop, Jessica Boi, Carmela Bravaccio, Helena Brentani, Paola Canevini, Alessandra Carta, Alice Charach, Antonella Costantino, Katherine T. Cost, Elaine A. Cravo, Jennifer Crosbie, Chiara Davico, Federica Donno, Junya Fujino, Alessandra Gabellone, Cristiane T. Geyer, Tomoya Hirota, Stephen Kanne, Makiko Kawashima, Elizabeth Kelley, Hosanna Kim, Young Shin Kim, So Hyun Kim, Daphne J. Korczak, Meng-Chuan Lai, Lucia Margari, Lucia Marzulli, Gabriele Masi, Luigi Mazzone, Jane McGrath, Suneeta Monga, Paola Morosini, Shinichiro Nakajima, Antonio Narzisi, Rob Nicolson, Aki Nikolaidis, Yoshihiro Noda, Kerri Nowell, Miriam Polizzi, Joana Portolese, Maria Pia Riccio, Manabu Saito, Ida Schwartz, Anish K. Simhal, Martina Siracusano, Stefano Sotgiu, Jacob Stroud, Fernando Sumiya, Yoshiyuki Tachibana, Nicole Takahashi, Riina Takahashi, Hiroki Tamon, Raffaella Tancredi, Benedetto Vitiello, Alessandro Zuddas, Bennett Leventhal, Kathleen Merikangas, Michael P. Milham, Adriana Di Martino
Summary: The study examined the impact of the COVID-19 pandemic on youth with autism spectrum disorder and related neurodevelopmental disorders, revealing heterogeneity in symptoms and access to services. The findings can inform recovery efforts and emphasize the importance of international data-sharing and collaborations in addressing the needs of vulnerable populations during crises.
Article
Acoustics
Rimita Lahiri, Md Nasir, Manoj Kumar, So Hyun Kim, Somer Bishop, Catherine Lord, Shrikanth Narayanan
Summary: This study evaluates three different objective measures of behavioral synchrony using vocal and linguistic communication modalities. Quantifying behavioral synchrony is crucial for clinical diagnosis and interventions in neuro-developmental disorders.
JASA EXPRESS LETTERS
(2022)
Article
Psychology, Developmental
Denisse Janvier, Yeo Bi Choi, Claire Klein, Catherine Lord, So Hyun Kim
Summary: This study investigated the test-retest reliability of the Calibrated Severity Score (CSS) of the Autism Diagnostic Observation Schedule-2 (ADOS-2) across different modules and found strong reliability for quantifying autism symptom severity. The results support the use of ADOS CSS as a reliable tool for assessing autism symptom severity across development.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2022)
