Article
Rheumatology
Joshua Craig, Brian M. Feldman, Lynn Spiegel, Saunya Dover
Summary: The study compared the Childhood Health Assessment Questionnaire (CHAQ) and PROMIS measures in pediatric rheumatology patients, finding that PROMIS tools show improvements in areas where CHAQ is weak, with no ceiling effects and preferred by patients. Further research is needed to determine the correlation and responsiveness of PROMIS tools to changes in disease activity for wider clinical use.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Medicine, General & Internal
William Tillett, Julie Birt, Cristi Cavanaugh, Yoojin Jung, Aisha Vadhariya, Sarah Ross, Jessica Paulus, Ennio Lubrano
Summary: This study investigated the clinical effectiveness of ixekizumab for the treatment of psoriatic arthritis in a real-world setting. The results showed that treatment with ixekizumab improved musculoskeletal disease activity and patient-reported outcomes over 6- and 12-month follow-up periods. Rating: 9 out of 10.
FRONTIERS IN MEDICINE
(2023)
Review
Multidisciplinary Sciences
Jaclyn Shelton, Sierra Casey, Nathan Puhl, Jeanette Buckingham, Elaine Yacyshyn
Summary: The scoping review aimed to characterize the current literature on electronic patient-reported outcome measures (ePROMs) in rheumatology and assess the feasibility and utility of ePROMs and mobile health technology in the management of rheumatic disease. Research shows that ePROMs in rheumatology have significant utility in clinical practice, particularly in inflammatory arthritis, and further research is needed to better understand their feasibility and impact on patient outcomes.
Review
Medicine, General & Internal
Alba Nicolas-Boluda, Anne Oppenheimer, Jerome Bouaziz, Arnaud Fauconnier
Summary: Patient Reported Outcome Measures (PROM) allow capturing patients' perspectives on their condition in the context of endometriosis care. Despite their extensive use in research and clinical trials, PROMs are rarely used in clinical practice. The development of digital tools can help facilitate the integration of PROMs into routine endometriosis care, improving patient-centered communication and quality of life.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Marta Valero-Exposito, Maria Martin-Lopez, Carlos Guillen-Astete, Beatriz Joven, Carolina Merino-Argumanez, Valentina Emperiale, Jose Campos, Ana Perez, Javier Bachiller-Corral
Summary: This study investigated the retention rate of Secukinumab in real-world scenario and identified factors that influence the retention rate, including the presence of peripheral arthritis and longer disease duration.
Article
Rheumatology
Paras Karmacharya, Courtney Stull, Alisa Stephens-Shields, M. Elaine Husni, Jose U. Scher, Ethan Craig, Robert Fitzsimmons, Soumya M. Reddy, Marina N. Magrey, Alexis Ogdie, Jessica A. Walsh
Summary: This study aimed to determine the responsiveness to therapy and minimum clinically important improvement (MCII) for patient-reported outcome measures in psoriatic arthritis (PsA) and to examine the impact of baseline disease activity on the ability to demonstrate change. Results showed that the standardized response means (SRMs) and MCII were relatively small in this real-world population, particularly among those with lower disease activity at baseline. BASDAI, cDAPSA, and PsAID12 were found to have good sensitivity to change, but selection for use in trials should consider the baseline disease activity of patients to be enrolled.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Soumya D. Chakravarty, Jill Abell, Megan Leone-Perkins, Ana-Maria Orbai
Summary: The study aimed to collect feedback on commonly used PROMs for SpA through group discussions with PsA or AS patients. Participants identified concepts like fatigue, isolation, and depression that reflected their experiences living with the diseases. Both individualized and small group reviews were conducted to understand patient preferences for PROMs.
RHEUMATOLOGY AND THERAPY
(2021)
Review
Ophthalmology
Mallika Prem Senthil, Sumu Simon, Paul A. Constable
Summary: We reviewed the use of patient-reported outcome measures (PROMs) in evaluating the quality of life in uveitis patients and assessed the psychometric properties of the PROMs to aid in selecting the most appropriate questionnaire. Our review encompassed 158 articles, revealing 98 PROMs employed for measuring quality of life in uveitis, with the National Eye Institute Visual Function Questionnaire 25 (NEI VFQ-25) being the most commonly used. Although there are uveitis-specific PROMs available, they are tailored for specific subtypes of uveitis, lacking options for common types such as anterior uveitis, intermediate uveitis, panuveitis, and chronic uveitis. Uveitis-specific PROMs showed better performance based on our quality assessment criteria, but they were developed using traditional methods and have not been evaluated using modern psychometric assessment approaches like Rasch analysis.
SURVEY OF OPHTHALMOLOGY
(2023)
Article
Oncology
Andrew Blauvelt, Craig L. Leonardi, Norman Gaylis, Julia Jauch-Lembach, Alison Balfour, Lena Lemke, Sohaib Hachaichi, Ines Brueckmann, Teodora Festini, Piotr Wiland
Summary: The biosimilar SDZ-ADL showed comparable improvements in quality of life and patient-reported outcomes for patients with PsO, PsA, and RA compared to reference adalimumab (ref-ADL), with no negative impact on PROs during treatment switches.
Editorial Material
Dermatology
C. C. Zouboulis, P. V. Chernyshov
Summary: The study by R. Sommer et al. published in the Journal of the European Academy of Dermatology and Venereology in 2021 focused on a specific topic in the field of dermatology.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Biochemical Research Methods
Martin Howell, Noa Amir, Chandana Guha, Karine Manera, Allison Tong
Summary: Randomised controlled clinical trials are essential for clinical guidelines and patient care. Valid and reliable PROMs are necessary to measure patient outcomes. Mixed methods research is critical for developing PROMs.
Article
Rheumatology
Rebecca Heijke, Mathilda Bjork, Ingrid Thyberg, Alf Kastbom, Laura McDonald, Christopher Sjowall
Summary: The study investigated the relationship between patient-reported outcome measure (PROM) scores and organ damage in patients with recent-onset systemic lupus erythematosus (SLE) and early rheumatoid arthritis (RA). The results showed that RA patients had worse PROMs than SLE patients, which improved by month 6 after diagnosis, while SLE patients' PROMs remained stable. The incidence of organ damage in SLE was 13.6 per 100 patient-years.
CLINICAL RHEUMATOLOGY
(2022)
Review
Rheumatology
Anna Antony, Richard Holland, Maria-Antonietta D'Agostino, Walter P. Maksymowych, Heidi Bertheussen, Lori Schick, Niti Goel, Alexis Ogdie, Ana-Maria Orbai, P. Hojgaard, Laura C. Coates, Vibeke Strand, Dafna D. Gladman, Robin Christensen, Ying Ying Leung, Philip Mease, William Tillett
Summary: This systematic review focused on the measurement properties of radiographic outcome instruments for structural damage in Psoriatic Arthritis, identifying significant knowledge gaps in the responsiveness of peripheral radiographic instruments and the need for further validation of axial instruments. The peripheral instruments Ratingen and modified Sharp van der Heijde scores showed some evidence of reliability and validity while the evidence for axial instruments was limited.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Article
Health Care Sciences & Services
Conrad Harrison, Ryan Trickett, Justin Wormald, Thomas Dobbs, Przemyslaw Lis, Vesselin Popov, David J. Beard, Jeremy Rodrigues
Summary: This paper introduces a method called Ecological Momentary Computerized Adaptive Testing (EMCAT) that captures high-frequency data via a smartphone app. The study found that EMCAT significantly reduces the length and completion time of PROM assessments while obtaining similar scores to full-length PROM assessments. EMCAT has potential applications in both research and clinical practice.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Review
Rheumatology
Tim Pickles, Rhiannon Macefield, Olalekan Lee Aiyegbusi, Claire Beecher, Mike Horton, Karl Bang Christensen, Rhiannon Phillips, David Gillespie, Ernest Choy
Summary: The current standard of care for rheumatoid arthritis (RA) requires assessment of disease activity (DA) through joint counts and blood tests, but the frequency of assessment is often limited by healthcare providers. Patient Reported Outcome Measures (PROMs) could provide an efficient and informative way to assess RA DA.
Letter
Rheumatology
Kimme L. Hyrich, Martin Schaefer, Anja Strangfeld, Loreto Carmona, Laure Gossec, Elsa F. Mateus, Saskia Lawson-Tovey, Milena Gianfrancesco, Philip C. Robinson, Jinoos Yazdany, Pedro M. Machado
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Lihi Eder, Ruth Croxford, Aaron M. Drucker, Arielle Mendel, Bindee Kuriya, Zahi Touma, Sindhu R. Johnson, Richard Cook, Sasha Bernatsky, Nigil Haroon, Jessica Widdifield
Summary: Compared with the general population, patients with immune-mediated inflammatory diseases (IMIDs) were more likely to be tested for SARS-CoV-2, but the infection rate was similar. The odds of SARS-CoV-2 infection varied across different IMID subgroups.
ARTHRITIS CARE & RESEARCH
(2023)
Letter
Rheumatology
Ricardo J. O. Ferreira, Paco M. J. Welsing, Johannes W. G. Jacobs, Laure Gossec, Mwidimi Ndosi, Pedro M. Machado, Desiree van der Heijde, Jose A. P. Da Silva
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Ana-Maria Orbai, William Tillett, Suzanne Grieb, Steve Peterson, Elizabeth A. Holdsworth, Nicola Booth, Soumya D. Chakravarty, Laure Gossec
Summary: This study described the flares of psoriatic arthritis (PsA) and their impact on patient-reported outcomes (PROs). Results showed that flare status was associated with worse quality of life, work impairment, and disability. The study suggests that PsA flares should be regularly assessed and managed in clinical care.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Laura C. Coates, Christopher T. Ritchlin, Laure Gossec, Philip S. Helliwell, Proton Rahman, Alexa P. Kollmeier, Xie L. Xu, May Shawi, Chetan S. Karyekar, Christine Contre, Wim Noel, Shihong Sheng, Yanli Wang, Stephen Xu, Philip J. Mease
Summary: The study evaluated the efficacy of guselkumab for treating active psoriatic arthritis. The results showed that guselkumab provided sustained benefits over 1 year and was found to be an effective therapy for diverse manifestations of psoriatic arthritis.
Review
Rheumatology
Ying-Ying Leung, Tatiana V. Korotaeva, Liliana Candia, Susanne Juhl Pedersen, Wilson Bautista Molano, Eric M. Ruderman, Radjesh Bisoendial, Rodolfo Perez-Alamino, Wendy Olsder, Burkhard Moeller, Simeon Grazio, Tania Gudu, Girish M. Mody, Carlos Pineda, Helena Raffayova, Sherry Rohekar, Claudia Goldenstein-Schainberg, Sergio R. Gutierrez Urena, Julio Cesar Casasola Vargas, Bhowmik Meghnathi, Roopa Prasad, Pascal Richette, Jose Roberto S. Miranda, Nikolas Malliotis, Ulla Lindqvist, David Simon, Amara Ezeonyeli, Enrique R. Soriano, Oliver FitzGerald
Summary: The objective of this study was to provide evidence for the efficacy and safety of therapeutic options for the peripheral arthritis domain of PsA for the revised 2021 GRAPPA treatment recommendations. Evidence was derived from new RCTs and recommendations were made for different patient groups based on their treatment history and response. Different classes of therapeutic options were strongly recommended for different patient groups.
JOURNAL OF RHEUMATOLOGY
(2023)
Editorial Material
Rheumatology
Laura Coates, Laure Gossec
Article
Rheumatology
Jessica A. Walsh, Alexis Ogdie, Kaleb Michaud, Steven Peterson, Elizabeth A. Holdsworth, Chetan S. Karyekar, Nicola Booth, Chloe Middleton-Dalby, Soumya D. Chakravarty, Natalie Dennis, Laure Gossec
Summary: This study found that key manifestations of psoriatic arthritis (PsA) have varying impacts on quality of life, physical function, and work disability. These manifestations include peripheral arthritis, psoriasis, axial involvement, enthesitis, and dactylitis. The results show that these symptoms are associated with poorer general and disease-specific quality of life, physical function, and work disability.
Review
Rheumatology
Deepak R. Jadon, Nadia Corp, Danielle A. van der Windt, Laura C. Coates, Enrique R. Soriano, Arthur Kavanaugh, Tim Raine, Florian Rieder, Stefan Siebert, Michel Zummer, Sergio Schwartzman, James T. Rosenbaum, Brigitte Michelsen, Ramasharan Laxminarayan, Dongze Wu, Latika Gupta, Beverly Ng, Hannah Jethwa, Nick De Windt, Tania Gudu, Joseph Hutton, Denis O'Sullivan, Michele M. Luchetti, Matthew Stoll, Jasvinder A. Singh, Rosario Peluso, Judith Rademacher, M. Elaine Husni
Summary: This study summarizes the efficacy and safety of advanced therapies for psoriatic arthritis in patients with related conditions, including Crohn's disease, ulcerative colitis, and noninfectious uveitis. The tumor necrosis factor inhibitor (TNFi) class appears to be effective and safe, while interleukin 12/23 inhibitors (IL-12/23i) show efficacy in Crohn's disease and ulcerative colitis. However, caution should be exercised when using interleukin 17 inhibitors (IL-17i) in patients with psoriatic arthritis at high risk of inflammatory bowel disease.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Marlene Sousa, Ennio Lubrano, Josef S. Smolen, Clemence Gorlier, Maarten de Wit, Laura C. Coates, Umut Kalyoncu, Adeline Ruyssen-Witrand, Ying-Ying Leung, Rossana Scrivo, Juan D. Canete, Penelope Palominos, Sandra Meisalu, Andra Balanescu, Uta Kiltz, Sibel Zehra Aydin, Inna Gaydukova, Emmanuelle Dernis, Bruno Fautrel, Ana-Maria Orbai, Laure Gossec
Summary: This study aimed to explore patient-defined flares in psoriatic arthritis (PsA) and compare them to an increase in disease activity in psoriatic arthritis (DAPSA). The validity of a patient-reported flare question was also analyzed. The results showed that patient-reported flares were associated with disease activity and symptoms, and there was moderate agreement between patient and physician definitions of worsening.
Article
Rheumatology
Ling Xiang, Sungwon Yoon, Andrea H. L. Low, Ying Ying Leung, Warren Fong, Tang Ching Lau, Dow Rhoon Koh, Julian Thumboo
Summary: This study explores the applicability of social cognitive theory (SCT) in improving symptom appraisal and help-seeking among patients with autoimmune rheumatic diseases (ARDs). Semi-structured interviews were conducted with 33 ARD patients and the transcripts were coded using SCT as the framework. The study found that behavioral capacity and self-efficacy were lacking in symptom interpretation, leading to delayed help-seeking. Possible approaches to address this include education to improve behavioral capacity and self-efficacy and enhance expectations, observational learning, reinforcements, and reciprocal determinism.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Medicine, General & Internal
Alexander Ooms, Hussein Al-Mossawi, Louise Bennett, Mimi Bogale, Paul Bowness, Anne Francis, Carl Goodyear, Bruce W. Kirkham, Sylvine Lalnunhlimi, Iain B. Mcinnes, Duncan Richards, Stefan Siebert, Leonie S. Taams, Aysin Tulunay Virlan, Nicole Yager, Laura C. Coates
Summary: Psoriatic arthritis (PsA) affects a significant number of people in the UK and requires treatment with biologics. This study aims to investigate whether baseline Th17 levels can predict response to IL-17A or TNF inhibitors in PsA patients, and whether additional factors can refine the prediction model. The findings from this study may have implications for treatment guidelines in PsA.
Review
Rheumatology
Oliver FitzGerald, Frank Behrens, Anne Barton, Heidi Bertheussen, Bruno Boutouyrie-Dumont, Laura Coates, Owen Davies, Maarten de Wit, Filippo Fagni, Carl S. Goodyear, Robert Gurke, Lisa Hahnefeld, Christine Huppertz, Vassilios Ioannidis, Mark Ibberson, Arnon Katz, Maximilian Klippstein, Michaela Koehm, Shimon Korish, Sina Mackay, David A. Martin, Denis O'Sullivan, Khadijah Patel, Stefan Rueping, Georg Schett, Klaus Scholich, Jochen M. Schwenk, Stefan Siebert, David Simon, Arani Vivekanantham, Stephen R. Pennington, HIPPOCRATES Consortium
Summary: Achieving good outcomes for Psoriatic Arthritis (PsA) patients is challenging due to late diagnosis, diverse clinical presentation, and failure to control inflammatory features. To address these unmet needs, the HIPPOCRATES program, a collaboration between academic centers, pharmaceutical industry partners, and patient-representative organizations, aims to improve the diagnosis, management, and treatment of PsA in a five-year Innovative Medicines Initiative (IMI) initiative. The program's ambitious work and challenges are outlined, with the goal of ultimately improving short-term and long-term outcomes for PsA patients.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Article
Rheumatology
Magnus B. Petersen, Rebekka L. Hansen, Alexander Egeberg, Tanja S. Jorgensen, Joseph Frank Merola, Laura C. Coates, Lars Erik Kristensen
Summary: Comorbidities did not affect treatment persistence or clinical response rates in patients with PsA treated with first-line IL-17i. However, comorbidities were associated with increased baseline disease activity and frequency of depression and/or anxiety.
RHEUMATOLOGY ADVANCES IN PRACTICE
(2023)
Correction
Rheumatology
Georg Schett, Warner Chen, Sheng Gao, Soumya D. Chakravarty, May Shawi, Frederic Lavie, Miriam Zimmermann, Mohamed Sharaf, Laura C. Coates, Stefan Siebert
ARTHRITIS RESEARCH & THERAPY
(2023)