☆ 4.6 Editorial Material

Emerging Viruses without Borders: The Wuhan Coronavirus

VIRUSES-BASEL (2020)

期刊

VIRUSES-BASEL

卷 12, 期 2, 页码 -

出版社

MDPI

DOI: 10.3390/v12020130

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类别

Virology

资金

NIAID NIH HHS [R01 AI150473] Funding Source: Medline

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Reagent

摘要

The recently emerged coronavirus in Wuhan, China has claimed at least 6 lives as of January 22 and infected hundreds if not thousands of individuals. The situation has drawn international attention, including from the virology community. We applaud the rapid release to the public of the genome sequence of the new virus by Chinese virologists, but we also believe that increased transparency on disease reporting and data sharing with international colleagues are crucial for curbing the spread of this newly emerging virus to other parts of the world.

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Article Immunology

Increased COVID-19 Mortality and Deficient SARS-CoV-2 Immune Response Are Not Associated with Higher Levels of Endemic Coronavirus Antibodies

Bindu Adhikari, Eugene M. Oltz, Joseph S. Bednash, Jeffrey C. Horowitz, Joshua O. Amimo, Sergei A. Raev, Soledad Fernandez, Mirela Anghelina, Shan-Lu Liu, Mark P. Rubinstein, Daniel M. Jones, Linda J. Saif, Anastasia N. Vlasova

Summary: This study evaluated the impact of pre-existing common cold coronavirus antibodies on SARS-CoV-2 immune responses and disease severity in hospitalized COVID-19 patients. The results showed a positive correlation between levels of common cold coronavirus antibodies and SARS-CoV-2 antibodies. Higher levels of common cold coronavirus antibodies were associated with better clinical outcomes in COVID-19 patients. Age, cancer, and immunosuppression were found to be associated with higher mortality and reduced levels of SARS-CoV-2 and common cold coronavirus antibodies.

IMMUNO (2023)

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