Article
Oncology
Zhile Wang, Yijun Wu, Li Wang, Liang Gong, Chang Han, Naixin Liang, Shanqing Li
Summary: This study aimed to establish a prediction model for occult lymph node metastasis (OLNM) in patients with lung adenocarcinoma <= 2 cm. Through retrospective analysis, risk factors for OLNM were identified and a predictive model was developed, showing effectiveness in preoperative prediction.
Article
Radiology, Nuclear Medicine & Medical Imaging
Chengzhou Zhang, Liping Wang, Xiaoting Cai, Mengfei Li, Dandan Sun, Ping Wang
Summary: The relationship between tumor and pleura is a risk factor for occult lymph node metastasis (OLNM) in peripheral clinical stage IA solid adenocarcinoma. Patients with type 3 or 4 tumor-pleura relationship are more likely to have visceral pleural invasion and predict OLNM.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Kun Wang, Mengchao Xue, Jianhao Qiu, Ling Liu, Yueyao Wang, Rongyang Li, Chenghao Qu, Weiming Yue, Hui Tian
Summary: This study aimed to explore the genetic features and risk factors of lymph node metastasis in patients with a non-predominant micropapillary component (NP-MPC) in surgically resected lung adenocarcinoma. The study found that EGFR exon 19 deletion was the most common genetic alteration in NP-MPC patients and was significantly associated with the risk of occult lymph node metastasis (OLNM).
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Chengxin Zhang, Siqi Fu, He Liu, Shuai Xue
Summary: This study found that age, PTMC location, and liquefaction or microcalcification were independent risk factors for suspicious small lymph node metastasis in PTMC patients. The use of the number of risk factors can help evaluate the malignant potential of these lymph nodes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Jing-Sheng Cai, Fan Yang, Xun Wang
Summary: This study compared the clinical presentations and survivals of NSCLC patients with occult lymph node metastasis (OLNM) and those with evident lymph node metastasis (ELNM), and analyzed the predictive factors for OLNM. The results showed that OLNM was not rare and was not a favorable prognosis factor for resected NSCLC patients with lymph node metastasis. Positive lymph nodes (PLN) was the only prognostic factor for patients with OLNM, and clinical tumor size was a strong predictive factor for OLNM.
Article
Surgery
Cheng Fang, Yangwei Xiang, Weili Han
Summary: This study retrospectively reviewed clinical N0 lung adenocarcinoma patients and found that preoperative CEA level, tumor size, and consolidation/tumor ratio were independent risk factors for lymph node metastasis. It has been suggested that the lymph node metastasis rate is extremely low in clinical N0 lung adenocarcinoma patients with tumor size ≤ 3 cm, and lymph node dissection should be avoided in patients without risk factors to reduce surgical trauma.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiao-Qun He, Tian-You Luo, Xian Li, Ji-Wen Huo, Jun-Wei Gong, Qi Li
Summary: The study showed that combining clinicopathological characteristics with the CT morphological features of tumours is more accurate in predicting OLNM in PS-NSCLC patients compared to relying solely on CT findings in lymph nodes. Independent predicting factors included carcinoembryonic antigen level, pathological type, vascular convergence, and pleural involvement.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Simone E. S. Faustino, Kellen C. Tjioe, Agnes Assao, Michele C. Pereira, Andre L. Carvalho, Luiz P. Kowalski, Denise T. Oliveira
Summary: ILVD and PLVD showed no significant association with occult lymph node metastasis or clinical follow-up, but ILVD was significantly associated with regional recurrence. PLVD was related to perineural invasion and had significant associations with disease-specific and disease-free survivals.
Article
Surgery
Min -Long Chen, Dong Xu, Xing-Qiang Yan, Bo-Jian Xie
Summary: This study investigated the necessity of total thyroidectomy for unilateral PTC patients with benign nodules in the contralateral lobe and the predictive value of DLN metastasis. It was found that 44.6% of patients had occult contralateral carcinoma, and multifocality of primary carcinoma, DLN metastasis, capsular invasion, and male patients were independent predictors.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Oncology
Yu Heng, Duo Zhang, Liang Zhou, Ming Zhang, Chunping Wu, Lei Tao
Summary: This study aims to quantitatively predict the risk of occult contralateral lymph node metastasis in HSCC patients with ipsilateral lymph node metastasis, and construct two nomograms to guide treatment selection. Multivariate analyses identified several factors as independent risk factors for contralateral lymph node metastasis, and the nomograms provide guidance on the necessity of contralateral lymph node dissection and therapeutic radiation targeting. High-risk patients should receive contralateral lymph node dissection, while moderate-risk and low-risk patients require varying levels of follow-up and treatment.
Review
Oncology
Danyu Ma, Ying Zhang, Xiaoliang Shao, Chen Wu, Jun Wu
Summary: This paper explores the feasibility and predicting effectiveness of using PET/CT to detect occult lymph node metastasis (OLNM) in gastric cancer patients. The current landscape and future trends of primary metabolic parameters and new imaging agents of PET are reviewed. Non-invasive detection of OLNM can assist surgeons in choosing appropriate lymph node dissection areas, reducing unnecessary dissections and providing more rational, personalized, and comprehensive treatments for gastric cancer patients.
Article
Biochemistry & Molecular Biology
Bo Zhou, Yue Zhou, Ying Liu, Hailin Zhang, Huangxing Mao, Mingjing Peng, Anji Xu, Zan Li, Hui Wang, Haolei Tan, Huayi Ren, Xiao Zhou, Ying Long
Summary: A novel CASC18/miR-20a-3p/TGFB2 ceRNA axis was identified in OLNM of TSCC. Higher CASC18 expression was positively correlated with the presence of OLNM and worse outcome of TSCC patients, while knockdown of CASC18 inhibited cell migration and invasion.
MOLECULAR MEDICINE
(2021)
Article
Otorhinolaryngology
Xiaohui Yuan, Chi-Yao Hsueh, Ming Zhang, Lei Tao, Liang Zhou
Summary: This study identified age, history of drinking, histological differentiation of tumor, and depth of tumor invasion as independent risk factors for occult lymph node metastasis in early cN0 hypopharyngeal squamous cell carcinoma. A nomogram model was successfully developed to predict the risk of OLNM in these patients. The model showed good discrimination and calibration performance.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jaeseong Lee, Sungtaek Kang, Hyeseon Park, Jeong Gil Sun, Eun Chae Kim, Gayong Shim
Summary: Lymph nodes are important organs that control immune cells and provide a pathway for tumors to spread. Nanoparticles offer several advantages for effective lymphatic delivery, including tailored size for migration and targeting of specific cells. Existing contrast agents are not able to selectively target metastatic lymph nodes, but nanoparticles can achieve this goal. Additionally, functionalized nanoparticles can deliver anticancer drugs to metastatic lymph nodes. This review discusses the use of nanoparticles for lymphatic mapping and highlights design considerations for detecting metastatic lymph nodes. Future directions for lymph node-targeting nanoparticles are also suggested.
Article
Multidisciplinary Sciences
Xiaodong Wang, Ying Chen, Yunshu Gao, Huiqing Zhang, Zehui Guan, Zhou Dong, Yuxuan Zheng, Jiarui Jiang, Haoqing Yang, Liming Wang, Xianming Huang, Lirong Ai, Wenlong Yu, Hongwei Li, Changsheng Dong, Zhou Zhou, Xiyang Liu, Guanzhen Yu
Summary: The study proposes a deep-learning framework to analyze lymph node whole-slide images, identifying lymph nodes and tumor regions, and revealing the importance of the tumor-area-to-MLN-area ratio (T/MLN) in predicting the prognosis of gastric cancer patients.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Si Young Choi, Youngkyu Moon
Summary: The study found that uniportal VATS is not inferior to multiportal VATS in surgical outcomes or short-term prognosis for the treatment of lung cancer with whole pleural adhesion. There were no significant differences in perioperative and postoperative outcomes between the two groups.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Chemistry, Physical
Mohsen Saeidi, Minjong Lee, Odongo Francis Ngome Okello, Si-Young Choi, Seung Soo Oh, Abdolreza Simchi
Summary: The study investigates the graphitization mechanism of graphitic oxide under ultrafast thermal reduction induced by electromagnetic radiation and Ar+ cation collisions. The prepared spongy graphene structure shows excellent charge storage performance, high electrical conductivity, and stability in multiple applications.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Critical Care Medicine
Jin Yong Jeong, Ah Young Shin, Jick Hwan Ha, Jong Hui Suh, Si Young Choi, Ju Sang Kim, Chan Beom Park
Summary: This study investigated whether contralateral bullae/blebs should be resected simultaneously during ipsilateral VATS bullectomy. The presence of contralateral bullae/blebs was found to be associated with a higher risk of contralateral pneumothorax, but the annual rate of pneumothorax decreased over time. Therefore, a conservative approach is recommended for unruptured contralateral bullae/blebs.
Article
Chemistry, Multidisciplinary
Yu-Rim Hong, Soumen Dutta, Sun Woo Jang, Odongo Francis Ngome Okello, Hyeonae Im, Si-Young Choi, Jeong Woo Han, In Su Lee
Summary: This study addresses the inefficient interfacial contact effect in Pt-catalyzed alkaline hydrogen evolution reaction (HER) by producing atomically flat two-dimensional Pt nanodendrites (2D-PtNDs) and realizing a maximized and firmly bound lateral heterointerface with NiFe-layered double hydroxide (LDH). This work demonstrates the importance of shape and facet of Pt in creating heterointerfaces that provide catalytic synergy for efficient hydrogen production.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Physical
Liguo Zhang, Litao Yu, Oi Lun Li, Si-Young Choi, Ghuzanfar Saeed, Damin Lee, Kwang Ho Kim
Summary: Uniform amorphous FePO4 nanospheres with a diameter of 220 nm are successfully synthesized by a simple hydrothermal process, showing good sodium-ion storage performances. The necessity of an amorphous structure for the sodium-ion battery system is highlighted, as it enables the transformation between amorphous and microcrystalline structures and contributes to the overall performance improvement.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Chemistry, Physical
Junghun Han, Kyoung-June Go, Jinhyuk Jang, Sejung Yang, Si-Young Choi
Summary: This study demonstrates the possibility of achieving structural analysis with sub-pixel accuracy by segmenting atomic signals from background and applying denoising techniques. The elimination of Poisson noise and residual noise greatly increases the peak signal-to-noise ratio. Extracting centroids of atomic columns using K-means clustering allows for a deeper understanding of the local structural dynamics.
NPJ COMPUTATIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yunkyu Park, Hyeji Sim, Kyung-Yeon Doh, Minguk Jo, Donghwa Lee, Si -Young Choi, Junwoo Son
Summary: This study demonstrates the importance of electron supply in controlling charged ionic flow and proposes a strategy for ion-defect-induced emergent properties at interfaces.
Article
Chemistry, Multidisciplinary
Youngki Yeo, Soo-Yoon Hwang, Jinwook Yeo, Jihun Kim, Jinhyuk Jang, Heung-Sik Park, Yong-Jin Kim, Duc Duy Le, Kyung Song, Moonhong Kim, Seunghwa Ryu, Si-Young Choi, Chan-Ho Yang
Summary: We report a technique for the spontaneous gathering of oxygen vacancies at strain-relaxed crack walls using flexoelectricity. Enhanced electronic conductance and a switchable diode-like feature were observed at the crack walls. The diffusivity of mobile defects in crack walls was determined to be 1.4 x 10-16 cm2/s, consistent with oxygen vacancy kinetics.
Article
Chemistry, Physical
Jiye Kim, Kyung-Yeon Doh, Seokho Moon, Chang-Won Choi, Hokyeong Jeong, Jaewon Kim, Wonseok Yoo, Kyungwook Park, Kyeongock Chong, Chunhyng Chung, Hanmei Choi, Si-Young Choi, Donghwa Lee, Jong Kyu Kim
Summary: We have achieved the conformal growth of sp2-hybridized few-layer h-BN on an array of Si-based nanotrenches using pulsed-mode MOCVD method. X-ray absorption fine structure spectroscopy and density functional theory calculations reveal that B-O bonds formed on the noncatalytic SiO2 surface serve as nucleation sites for the subsequent formation of mixed sp2- and sp3-hybridized BON2 and BN3. This allows for the conformal growth of few-layer sp2-hybridized h-BN with excellent step coverage, which can be used for advanced three-dimensional Si-based nanoscale architectures.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yong-Jun Kwon, Youngki Yeo, Min-Su Kim, Yong-Jin Kim, Heung-Sik Park, Jaegyu Kim, Si-Young Choi, Chan-Ho Yang
Summary: Topological textures of ferroelectric polarizations have potential applications in future information technology. However, energy losses and deviations from stability can affect the symmetry and shape of these textures. In this study, we investigated the domain structure of bismuth tungsten oxide thin films grown on SrTiO3 substrates using advanced microscopy techniques. We discovered a hidden phase with a different polarization orientation that promotes the formation of flux closure domains, bringing us one step closer to an isotropic two-dimensional polar material.
Article
Chemistry, Multidisciplinary
Min-Yeong Choi, Chang-Won Choi, Dong-Yeong Kim, Moon-Ho Jo, Yong-Sung Kim, Si-Young Choi, Cheol-Joo Kim
Summary: We propose a method using sodium molybdate liquid alloys to control atomic defects at grain boundaries of monolayer MoS2. The Mo-rich environment in the alloys leads to the formation of Mo-polar 5|7 defects with a yield exceeding 95%. The photoluminescence (PL) intensity of VLS-grown polycrystalline MoS(2) films is enhanced due to the suppression of nonradiative recombination of charged excitons with donor-type defects of adsorbed Na elements.
Article
Chemistry, Multidisciplinary
Un Yang, Byunghwa Kang, Moon-Jung Yong, Dong-Hwan Yang, Si-Young Choi, Jung Ho Je, Seung Soo Oh
Summary: Through nanoscale confinement, evaporation, and solidification, the direct 3D printing of intact biopolymers is demonstrated, allowing precise control of molecular-scale structures and shapes. Different biopolymers can be patterned with desired size and geometry by controlling concentrations and molecular weights, and their 3D architectures are biologically active in various solvents.
Article
Chemistry, Multidisciplinary
Soo-Yoon Hwang, Gyoung-Ja Lee, Yuzhao Qi, Michael Abraham Listyawan, Kyung Song, Youngho Kang, Jungho Ryu, Xiaoyan Lu, Min-Ku Lee, Si-Young Choi
Summary: In this study, a method to achieve outstanding thermal stability of converse piezoelectric constant in lead-free potassium sodium niobate (KNN)-based ceramics is proposed. The relationship between grain size and polar configuration is demonstrated, and improved thermal stability in fine grains is suggested. The thermal stability is realized in a device by successfully demonstrating the temperature dependence of piezoelectricity, making it possible to apply the lead-free piezoelectric ceramics as piezoelectric devices with high thermal stability.
MATERIALS HORIZONS
(2023)
Correction
Chemistry, Multidisciplinary
Ji-Sang An, Hae-Seung Lee, Pilgyu Byeon, Dongho Kim, Hyung Bin Bae, Si-Young Choi, Jungho Ryu, Sung-Yoon Chung
Summary: The study corrects the interstice-occupying dopant segregation at grain boundaries in perovskite oxide dielectrics and proposes a new class of ceramic capacitors.
ENERGY & ENVIRONMENTAL SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Ji-Sang An, Hae-Seung Lee, Pilgyu Byeon, Dongho Kim, Hyung Bin Bae, Si-Young Choi, Jungho Ryu, Sung-Yoon Chung
Summary: When foreign cations are doped into ABO(3)-type perovskite oxides, they usually replace A or B sites depending on their ionic size. This study uncovers the presence of indium dopants occupying square-planar interstices and charge-compensating Ba vacancies at grain boundaries in polycrystalline BaTiO3. This chemical heterogeneity inhibits grain-boundary migration and enables the attainment of fine-grain microstructures with unprecedented dielectric properties.
ENERGY & ENVIRONMENTAL SCIENCE
(2023)
