Article
Endocrinology & Metabolism
Michaella Ben-Shachar, Tehila Daniel, Ayala Wollman, Sharmila Govindaraj, Sarit Aviel-Ronen, Albert Pinhasov, Tovit Rosenzweig
Summary: Chronic stress affects the development of obesity-related metabolic outcomes. In this study, researchers investigated the impact of stress response on metabolic health under obesity using a mouse model. The results showed that mice with stress vulnerability exhibited negative metabolic effects when fed a high-fat diet, while mice with stress resilience were protected. Furthermore, the study found a correlation between stress resiliency and inflammation in the development of healthy or unhealthy obesity.
Article
Medicine, Research & Experimental
Matheus Ajackson, Brenda A. Nagagata, Ilitch A. Marcondes-de-Castro, Carlos A. Mandarim-de-Lacerda, Marcia Barbosa Aguila
Summary: The aim of this study was to investigate the effects of melatonin supplementation in the liver of adult offspring from obese mothers during pregnancy and lactation. The results showed that supplementation of melatonin reduced body weight and liver lipid levels in offspring from high-fat diet-fed mothers. Additionally, melatonin supplementation improved lipid metabolism, inflammation, oxidative stress, and endoplasmic reticulum stress in the offspring's liver.
Article
Biochemistry & Molecular Biology
Jinchao Li, Ying Tang, Ting-Chun Lin, Huawei Zeng, Joel B. Mason, Zhenhua Liu
Summary: Strong evidence suggests an association between body fatness and the development of colorectal cancer (CRC), but there is still limited understanding of the causality between obesity and CRC. This study investigates the role of TNF-alpha in obesity-associated CRC development. The research shows that the deletion of TNF-alpha reduces inflammation and Wnt signaling, thereby attenuating obesity-induced intestinal tumorigenesis. Targeting TNF-alpha signaling may be a potential strategy for reducing the risk of CRC associated with obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Immunology
Hui Zhou, Xiyan Liao, Qin Zeng, Haowei Zhang, Jianfeng Song, Wanyu Hu, Xiaoxiao Sun, Yujin Ding, Dandan Wang, Yalun Xiao, Tuo Deng
Summary: Accumulation and activation of immunocytes in adipose tissues are important in obesity-induced inflammation and insulin resistance. Chemokines, especially CCL5, play a crucial role in recruiting immunocytes to adipose tissue during obesity. CCL5 deficiency exacerbates adipose inflammation and impairs insulin sensitivity in obese mice. This study provides insights into the role of CCL5 in obesity-induced adipose inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shumeng Hao, Sulin Zhang, Jialin Ye, Lifan Chen, Yan Wang, Siyu Pei, Qingchen Zhu, Jing Xu, Yongzhen Tao, Neng Zhou, Huiyong Yin, Cai-Wen Duan, Chaoming Mao, Mingyue Zheng, Yichuan Xiao
Summary: Obesity is associated with elevated fatty acid beta-oxidation (FAO) and CD4(+) T cell hyperactivation, leading to enhanced induction of inflammation. The FAO rate-limiting enzyme Cpt1a stabilizes mitochondrial E3 ubiquitin ligase Goliath, promoting glycolysis and hyperactivation of CD4(+) T cells in obesity. Inhibiting the FAO-glycolysis metabolic axis with the Goliath inhibitor DC-Gonib32 reduces inflammation in obese mice.
Article
Oncology
Fazlur Rahman Talukdar, David Israel Escobar Marcillo, Ruhina Shirin Laskar, Alexei Novoloaca, Cyrille Cuenin, Paolo Sbraccia, Lorenza Nistico, Valeria Guglielmi, Tarik Gheit, Massimo Tommasino, Eugenia Dogliotti, Paola Fortini, Zdenko Herceg
Summary: This study found that weight loss after bariatric surgery is associated with DNA methylation changes in immune and inflammatory gene pathways. These results were validated in an independent cohort of monozygotic twins. Additionally, bariatric surgery significantly decelerates epigenetic aging. The findings suggest that the effectiveness of weight loss through bariatric surgery may be mediated by epigenetic regulation of genes involved in endothelial and adipose tissue function.
CLINICAL EPIGENETICS
(2022)
Article
Gastroenterology & Hepatology
Sidharth P. Mishra, Bo Wang, Shalini Jain, Jingzhong Ding, Jared Rejeski, Cristina M. Furdui, Dalane W. Kitzman, Subhash Taraphder, Christian Brechot, Ambuj Kumar, Hariom Yadav
Summary: In this study, the causal role of gut microbiota in inducing gut permeability, inflammation, and glucose metabolic dysfunctions was demonstrated. It was found that obese microbiota has reduced capacity to metabolize ethanolamine, leading to its accumulation in the gut and subsequent induction of gut permeability, inflammation, and abnormalities in glucose metabolism. Restoring ethanolamine-metabolizing capacity by a novel probiotic therapy can reverse these abnormalities.
Article
Oncology
Megan Sedeman, Claudia Christowitz, Louis De Jager, Anna-Mart Engelbrecht
Summary: This study investigated the effects of DXR on hepatic tissue in an obese tumour-bearing mouse model and found that DXR caused significant liver damage in obese mice, highlighting the importance of understanding treatment outcomes and toxicity in breast cancer patients.
Article
Nutrition & Dietetics
Priscila G. G. Pereira, Luciana L. L. Alves, Bianca T. T. Ciambarella, Kissila Rabelo, Ana Lucia R. Nascimento, Alan Cesar N. Moraes, Andressa Bernardi, Fernanda V. V. Guimaraes, Gabriela M. M. Carvalho, Jemima F. R. da Silva, Jorge J. J. de Carvalho
Summary: In this study, treatment with capybara oil (CO) was found to improve lipid profile and reduce blood pressure levels in obese mice. It also showed positive effects on renal histopathology, reducing inflammation, oxidative stress, and fibrosis. However, improvement in renal function was not significant.
Article
Chemistry, Applied
Carlos M. Donado-Pestana, Erika V. M. Pessoa, Larissa Rodrigues, Rafaela Rossi, Marcio H. C. Moura, Priscila R. dos Santos-Donado, Erique Castro, William T. Festuccia, Maria Ines Genovese
Summary: Polyphenols from Cambuci have therapeutic actions in alleviating insulin resistance and hepatic steatosis in obese mice fed with a high-fat-sucrose diet. The effects include reductions in body weight gain, inflammation, hyperglycemia, and improvement in glucose intolerance and insulin resistance through the activation of Akt and AMPK.
Review
Immunology
Michael Karin, Shabnam Shalapour
Summary: Chronic inflammation promotes tumor development and treatment resistance, while the antagonism between inflammation and immunity, as well as cancer cells' ability to evade immune detection, affect cancer development and treatment outcomes.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Chiara Mando, Silvio Abati, Gaia Maria Anelli, Chiara Favero, Anais Serati, Laura Dioni, Marta Zambon, Benedetta Albetti, Valentina Bollati, Irene Cetin
Summary: This study found that the epigenetic profile in the saliva of obese pregnant women is markedly different from that of normal-weight pregnant women, suggesting the presence of impaired mechanisms and damaged pathways. The characterization of this profile can serve as a promising tool for the identification of obesity-related altered mechanisms and the development of biomarkers for early diagnosis and treatment of pregnancy-adverse conditions.
Article
Cell Biology
Marek Adamowski, Karolina Wolodko, Joana Oliveira, Juan Castillo-Fernandez, Daniel Murta, Gavin Kelsey, Antonio M. Galvao
Summary: The study characterized the activation levels of NLRP3 inflammasome in the ovaries and liver of mice during obesity progression, revealing a link between leptin signaling and NLRP3 inflammasome activation in the ovary throughout obesity progression. Both ovaries and liver showed differential expression of NLRP3 and IL-1 beta proteins in various experimental models, shedding light on the molecular mechanisms underlying ovarian failure in maternal obesity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Lingyan Ma, Yinhua Ni, Luting Hu, Yufeng Zhao, Liujie Zheng, Song Yang, Liyang Ni, Zhengwei Fu
Summary: Spermidine administration can reduce fat mass and plasma lipid profile in HFD-induced obese mice, improve hepatic steatosis, reduce adipose tissue inflammation, and enhance gut barrier function. Additionally, spermidine treatment also enhances thermogenic gene expression in brown adipose tissue.
Article
Food Science & Technology
Tariful Islam, Iurii Koboziev, Kembra Albracht-Schulte, Brandon Mistretta, Shane Scoggin, Mohammad Yosofvand, Hanna Moussa, Masoud Zabet-Moghaddam, Latha Ramalingam, Preethi H. Gunaratne, Naima Moustaid-Moussa
Summary: The research suggests that curcumin supplementation can significantly reduce fat accumulation and decrease total macrophage infiltration in WAT, as well as lower mRNA levels of M1 and M2 macrophage markers. Furthermore, curcumin supplementation can also reduce the expression of other key pro-inflammatory genes in WAT, and exert protective metabolic effects through alterations in gut microbiota composition.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Hematology
Rajesh K. Singh, Abigail S. Haka, Priya Bhardwaj, Xiaohui Zha, Frederick R. Maxfield
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2019)
Article
Oncology
Laura W. Bowers, Claire G. Lineberger, Nikki A. Ford, Emily L. Rossi, Arunima Punjala, Kristina K. Camp, Bruce K. Kimler, Carol J. Fabian, Stephen D. Hursting
BREAST CANCER RESEARCH AND TREATMENT
(2019)
Article
Oncology
Priya Bhardwaj, Takahiro Ikeda, Xi Kathy Zhou, Hanhan Wang, Xi Emily Zheng, Dilip D. Giri, Olivier Elemento, Akanksha Verma, Miki Miyazawa, Sushmita Mukherjee, Domenick J. Falcone, Nils K. Wendel, Douglas S. Scherr, Andrew J. Dannenberg
Article
Multidisciplinary Sciences
Khadijah A. Mitchell, Noah Nichols, Wei Tang, Jennifer Walling, Holly Stevenson, Marbin Pineda, Roxana Stefanescu, Daniel C. Edelman, Andrew T. Girvin, Adriana Zingone, Sanju Sinha, Elise Bowman, Emily L. Rossi, Rony F. Arauz, Yuelin Jack Zhu, Justin Lack, Elizabeth Weingartner, Josh Waterfall, Sharon R. Pine, John Simmons, Paul Meltzer, Brid M. Ryan
NATURE COMMUNICATIONS
(2019)
Correction
Multidisciplinary Sciences
Khadijah A. Mitchell, Noah Nichols, Wei Tang, Jennifer Walling, Holly Stevenson, Marbin Pineda, Roxana Stefanescu, Daniel C. Edelman, Andrew T. Girvin, Adriana Zingone, Sanju Sinha, Elise Bowman, Emily L. Rossi, Rony F. Arauz, Yuelin Jack Zhu, Justin Lack, Elizabeth Weingartner, Joshua J. Waterfall, Sharon R. Pine, John Simmons, Paul Meltzer, Brid M. Ryan
NATURE COMMUNICATIONS
(2020)
Review
Oncology
Priya Bhardwaj, Kristy A. Brown
Summary: This review examines the interaction between obesity and breast cancer, focusing on estrogen, inflammatory mediators, and adipokines derived from breast adipose tissue, and how they are linked to oxidative stress, DNA damage, and pro-oncogenic transcriptional programs. Strategies targeting these factors for decreasing the risk of obesity-induced breast epithelial cell transformation and breast cancer development are evaluated for feasibility and efficacy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Moritz Reiterer, Mangala Rajan, Nicolas Gomez-Banoy, Jennifer D. Lau, Luis G. Gomez-Escobar, Lunkun Ma, Ankit Gilani, Sergio Alvarez-Mulett, Evan T. Sholle, Vasuretha Chandar, Yaron Bram, Katherine Hoffman, Priya Bhardwaj, Phoebe Piloco, Alfonso Rubio-Navarro, Skyler Uhl, Lucia Carrau, Sean Houhgton, David Redmond, Alpana P. Shukla, Parag Goyal, Kristy A. Brown, Benjamin R. tenOever, Laura C. Alonso, Robert E. Schwartz, Edward J. Schenck, Monika M. Safford, James C. Lo
Summary: The study found that hyperglycemia is common among patients with ARDS, and in patients with both ARDS and COVID-19, insulin resistance is the main cause of hyperglycemia. COVID-19 patients have lower levels of adiponectin, and SARS-CoV-2 may infect adipocytes, leading to dysfunction of adipose tissue.
Correction
Cell Biology
Moritz Reiterer, Mangala Rajan, Nicolas Gomez-Banoy, Jennifer D. Lau, Luis G. Gomez-Escobar, Lunkun Ma, Ankit Gilani, Sergio Alvarez-Mulett, Evan T. Sholle, Vasuretha Chandar, Yaron Bram, Katherine Hoffman, Priya Bhardwaj, Phoebe Piloco, Alfonso Rubio-Navarro, Skyler Uhl, Lucia Carrau, Sean Houhgton, David Redmond, Alpana P. Shukla, Parag Goyal, Kristy A. Brown, Benjamin R. tenOever, Laura C. Alonso, Robert E. Schwartz, Edward J. Schenck, Monika M. Safford, James C. Lo
Retraction
Oncology
Kotha Subbaramaiah, Erika Sue, Priya Bhardwaj, Baoheng Du, Clifford A. Hudis, Dilip Giri, Levy Kopelovich, Xi Kathy Zhou, Andrew J. Dannenberg
Summary: This article has been retracted due to evidence of data falsification or fabrication found in four figures. Suspicious duplications of band images were found in Figs. 1D, 2D, 3D, and 6C. The retraction notice was sent to the authors, but seven authors and two authors did not respond. The authors apologize for any inconveniences or challenges caused by the publication and subsequent retraction of this article.
CANCER PREVENTION RESEARCH
(2022)
Retraction
Oncology
Kotha Subbaramaiah, Louise R. Howe, Priya Bhardwaj, Baoheng Du, Claudia Gravaghi, Rhonda K. Yantiss, Xi Kathy Zhou, Victoria A. Blaho, Timothy Hla, Peiying Yang, Levy Kopelovich, Clifford A. Hudis, Andrew J. Dannenberg
CANCER PREVENTION RESEARCH
(2022)
Meeting Abstract
Oncology
Priya Bhardwaj, Neil M. Iyengar, Sofya Oshchepkova, Phoebe Piloco, Rohan Bareja, Olivier Elemento, Dilip D. Giri, Michael Pollak, Monica Morrow, Jason A. Spector, Kristy A. Brown
Article
Hematology
Faezeh Darbaniyan, Hong Zheng, Rashmi Kanagal-Shamanna, Pamela Lockyer, Guillermo Montalban-Bravo, Marcos Estecio, Yue Lu, Kelly A. Soltysiak, Kelly S. Chien, Hui Yang, Koji Sasaki, Caleb Class, Irene Ganan-Gomez, Kim-Anh Do, Guillermo Garcia-Manero, Yue Wei
Summary: Research in CMML and MDS patients found that treatment failure with HMAs may be associated with changes in immunoglobulin genes and GABA receptor signaling, providing potential biological markers and therapeutic targets for further study.
EXPERIMENTAL HEMATOLOGY
(2022)
Article
Cell Biology
Priya Bhardwaj, Neil M. Iyengar, Heba Zahid, Katharine M. Carter, Dong Jun Byun, Man Ho Choi, Qi Sun, Oleksandr Savenkov, Charalambia Louka, Catherine Liu, Phoebe Piloco, Monica Acosta, Rohan Bareja, Olivier Elemento, Miguel Foronda, Lukas E. Dow, Sofya Oshchepkova, Dilip D. Giri, Michael Pollak, Xi Kathy Zhou, Benjamin D. Hopkins, Ashley M. Laughney, Melissa K. Frey, Lora Hedrick Ellenson, Monica Morrow, Jason A. Spector, Lewis C. Cantley, Kristy A. Brown
Summary: BMI is positively correlated with DNA damage and metabolic dysfunction biomarkers in BRCA mutation carriers. RNA sequencing revealed obesity-associated alterations in the breast adipose microenvironment, activating estrogen biosynthesis and affecting neighboring breast epithelial cells. Blocking estrogen biosynthesis or receptor activity decreased DNA damage, and inhibiting obesity-associated factors such as leptin and insulin also reduced DNA damage. Increased adiposity was associated with mammary gland DNA damage and increased breast tumor incidence in Brca1+/- mice.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Letter
Hematology
Mary Figueroa, Huaxian Ma, Mansour Alfayez, Daniel Enrique Morales-Mantilla, Fei Wang, Yue Lu, Marcos R. Estecio, Katherine Y. King, Eugenie Kleinerman, Seyed Javad Moghaddam, Naval Daver, Michael Andreeff, Marina Konopleva, Courtney Dinardo, Joya Chandra
Review
Oncology
Ramesh Butti, Ashwini Khaladkar, Priya Bhardwaj, Gopinath Prakasam
Summary: The interaction between cancer cells and surrounding fibroblasts is crucial for regulating various processes in tumor development and treatment. While cancer-associated fibroblasts have been targeted as potential therapeutics for cancer, recent studies have revealed their heterogeneity and highlighted a subset of these cells with tumor-restricting functions. Understanding this heterogeneity and the signaling processes involved is important for developing effective cancer treatments. In this review, we discuss the role of heterogeneity and heterotypic signaling of cancer-associated fibroblasts in shaping drug resistance and list potential therapies targeting these cells.
CANCER DRUG RESISTANCE
(2023)