Article
Microbiology
Ning Chen, Qin Wang, Yulong Hu, Yanyong Sun, Junping Li, Huawei Wu, Lu Xu, Huanhuan Liu, Chenghuai Yang, Xiaochun Chen, Yong Deng, Yingju Xia, Qianyi Zhang, Shi Cheng, Aihua Fan, Guanghua Chen
Summary: This study evaluated the efficacy of different classical swine fever (CSF) vaccines in the presence of maternally derived antibodies (MDAs) and assessed different vaccination schemes. The results demonstrated that a single dose of C-strain-PK vaccine provided effective protection against CSF and reduced viremia, with negligible interference from MDAs. However, MDAs significantly impacted the efficacy of the subunit E2 vaccine in a one-dose vaccination scheme. In field studies, a single dose of C-strain-PK vaccine was more effective than the routine prime and boost vaccination scheme, with improved clinical protection and immunity.
VETERINARY MICROBIOLOGY
(2022)
Article
Immunology
Ntungufhadzeni M. Rathogwa, Katherine A. Scott, Pamela Opperman, Jacques Theron, Francois F. Maree
Summary: This study compared the efficacy of two adjuvant formulations combined with a structurally stabilized SAT2 vaccine antigen and found that the Montanide ISA 206B-adjuvanted vaccine elicited a higher SAT2 neutralizing antibody response and three times higher systemic IFN-gamma responses compared to the Quil-A Saponin-adjuvanted vaccine group at 14- and 28-days post-vaccination. Serum antibodies from the immunized animals reacted similarly to both the parental vaccine virus and mutated viruses simulating antigenic drift in nature.
Article
Immunology
W. A. Gayan Chathuranga, Chamith Hewawaduge, N. A. Nadeeka Nethmini, Tae-Hwan Kim, Ju Hun Kim, Young-Hoon Ahn, In-Joong Yoon, Sung-Sik Yoo, Jong-Hyeon Park, Jong-Soo Lee
Summary: This study developed two multiepitope recombinant proteins as potential vaccine candidates for foot-and-mouth disease. The results showed that these proteins effectively induced immune responses and protected animals from the virus. By using appropriate adjuvants, the protective efficacy of the vaccine candidates can be enhanced, providing a method for developing effective and safe vaccines for the prevention and control of foot-and-mouth disease.
Article
Microbiology
Mi-Kyeong Ko, Jong-Hyeon Park, Hye-Eun Jo, Joo-Hyung Choi, Su-Hwa You, Sung Ho Shin, Seong Yun Hwang, Hyundong Jo, Hyun Mi Kim, Min Ja Lee, Su-Mi Kim, Byounghan Kim
Summary: The study developed two vaccine strains to prevent Asia1 type foot-and-mouth disease virus effectively. Immunogenicity tests in mice, cattle, and pigs showed that these vaccines can generate sufficient antibodies to protect animals against viral challenges, especially showing significant protection in pigs.
VETERINARY MICROBIOLOGY
(2021)
Article
Immunology
Haozhou Li, Aldo Dekker, Shiqi Sun, Alison Burman, Jeroen Kortekaas, Michiel M. Harmsen
Summary: The efficacy of foot-and-mouth disease (FMD) vaccine depends on the content of intact and empty viral particles. Capsid-specific VHH antibodies can be used to quantify intact capsids in the vaccine, improving efficacy and stability. These antibodies serve as excellent tools for monitoring the quantity and stability of intact capsids during the vaccine manufacturing process.
Article
Immunology
Ploypailin Semkum, Nattarat Thangthamniyom, Penpitcha Chankeeree, Challika Keawborisuth, Sirin Theerawatanasirikul, Porntippa Lekcharoensuk
Summary: In this study, infectious clones of foot-and-mouth disease virus (FMDV) types O and A were successfully constructed using Gibson Assembly (GA) technology. These clones were generated by joining each FMDV coding region with a 4.3-kb FMDV minigenome vector. The assembled DNA was transfected into BHK-21 cells to produce the infectious FMDVs, which showed similar growth kinetics and antigenicity to the parental viruses. This method and the FMDV minigenome will facilitate the construction of FMDV infectious clones and enable genetic manipulation for FMDV research and vaccine production.
Article
Infectious Diseases
Carolina Stenfeldt, Miranda R. Bertram, Haillie C. Meek, Ethan J. Hartwig, George R. Smoliga, Megan C. Niederwerder, Diego G. Diel, Scott A. Dee, Jonathan Arzt
Summary: The study investigated the infectivity of foot-and-mouth disease virus (FMDV) in commercial pig feed and feed ingredients, determining the minimum infectious dose required for pigs to develop the disease. The results indicated that FMDV can remain infectious in pig feed ingredients for durations compatible with transoceanic transport, with variations in feeding conditions and virus strains affecting the probability of infection. This information can be used to model the risk of FMDV incursions and regulate feed importation to minimize the risk of unintentional importation.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Immunology
Eun-Ju Sohn, Hyangju Kang, Kyungmin Min, Minhee Park, Ju-Hun Kim, Hwi-Won Seo, Sang-Joon Lee, Heeyeon Kim, Dongseob Tark, Ho-Seong Cho, Bo-Hwa Choi, Yeonsu Oh
Summary: There is an urgent need for a rapid, safe, and cost-effective vaccine to protect newborn piglets from a highly contagious enteritis caused by the porcine epidemic diarrhea virus (PEDV). Plant-based vaccines have advantages over conventional vaccines in terms of cost, scalability, thermostability, and shelf life. By using a plant-based vaccine platform, a recombinant S1 protein was developed and shown to induce humoral immunity specific to S1 in suckling piglets, resulting in significant viral neutralization and reduced mortality rates when challenged with PEDV.
Article
Immunology
Sehee Shin, So Hui Park, Jong-Hyeon Park, Su-Mi Kim, Min Ja Lee
Summary: This study aimed to determine the optimal timing of vaccination for young animals against foot-and-mouth disease (FMD) and investigate the impact of maternally derived antibodies (MDAs) on vaccine-mediated active immunity. Through analyzing antibody levels and immunoglobulin subtypes, the study provided insights into the age-dependent characteristics of MDAs and their interference with vaccine responses. Additionally, the correlation between MDA-mediated passive immunity and vaccine-mediated active immunity was explored, shedding light on potential novel strategies and vaccine development.
Article
Virology
Mei Liu, Xinyue Shen, Yan Yu, Jianmei Li, Jianhua Fan, Xuebo Jia, Yabin Dai
Summary: Newcastle disease is an acute and highly contagious avian disease that has significant economic impact worldwide. Vaccination is the most effective method for control. This study evaluated the correlation between hemagglutination inhibition (HI) antibody levels in chicks and hens and the decaying pattern of maternally derived HI antibodies, as well as the protective efficacy of different levels of maternally derived HI antibodies against a virulent NDV strain of genotype VII. The results showed that high levels of maternally derived HI antibodies can protect chicks from mortality, but not from virus shedding or infection.
Article
Biotechnology & Applied Microbiology
Kun Li, Guoqiang Zhu, Shasha Zhou, Pu Sun, Hengmei Wang, Huifang Bao, Yuanfang Fu, Pinghua Li, Xingwen Bai, Xueqing Ma, Jing Zhang, Dong Li, Yingli Chen, Zaixin Liu, Yimei Cao, Zengjun Lu
Summary: Pigs are susceptible to foot-and-mouth disease virus (FMDV), and the humoral immune response plays a crucial role in protection. Antibodies from pigs recognize conserved antigen epitopes on capsid protein VP2 and exhibit broad reactivity against both FMDV serotypes A and O. The study reveals a novel method for analyzing the antibody response against FMDV in pigs at the clonal level.
JOURNAL OF GENERAL VIROLOGY
(2021)
Article
Immunology
Kay Childs, Yongjie Harvey, Ryan Waters, Timothy Woma, Ginette Wilsden, Hualu Sun, Peng Sun, Julian Seago
Summary: Foot-and-mouth disease is a highly contagious viral disease of livestock that has a severe economic impact on the agriculture industry in many regions. Current vaccines are not effective against the contemporary strains of the disease, particularly in East Africa. Researchers have identified stable strains of the virus and developed a quadrivalent vaccine that generates high neutralizing antibody titers and provides good cross-protection against regional strains.
Article
Immunology
Ah-Young Kim, Hyejin Kim, Sun Young Park, Sang Hyun Park, Jae-Seok Kim, Jung-Won Park, Jong-Hyeon Park, Young-Joon Ko
Summary: The optimal stabilizer composition for long-term storage of FMD vaccine antigens, especially the O JC strain, was determined, extending shelf-life at both 4 degrees C and -70 degrees C.
Article
Medicine, General & Internal
S. A. Madhi, A. S. Anderson, J. Absalon, D. Radley, R. Simon, B. Jongihlati, R. Strehlau, A. M. van Niekerk, A. Izu, N. Naidoo, G. Kwatra, Y. Ramsamy, M. Said, S. Jones, L. Jose, L. Fairlie, S. L. Barnabas, R. Newton, S. Munson, Z. Jefferies, D. Pavliakova, N. C. Silmon de Monerri, E. Gomme, J. L. Perez, D. A. Scott, W. C. Gruber, K. U. Jansen
Summary: This study evaluated the safety and immunogenicity of a hexavalent vaccine in pregnant women and found that it reduced the risk of group B streptococcal disease in newborns. The study also identified specific antibody concentrations associated with a reduced risk of disease.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Immunology
Michael Puckette, Benjamin A. A. Clark, Jose Barrera, John G. G. Neilan, Max V. V. Rasmussen
Summary: We evaluated four DNA vaccine candidates for their ability to produce virus-like particles (VLPs) and elicit a protective immune response against Foot-and-mouth disease virus (FMDV) in cattle. However, none of the DNA vaccine candidates elicited protection from clinical disease when administered independently. Administration of pTarget O1P1-3C plasmid enhanced neutralizing antibody titers when used as a priming dose prior to administration of a conditionally licensed adenovirus-vectored FMD vaccine.
Article
Immunology
Taeseong Kim, Jang-Kwan Hong, Jae-Ku Oem, Kwang-Nyeong Lee, Hyang-Sim Lee, Yong Joo Kim, Soyoon Ryoo, Young-Joon Ko, Jong-Hyeon Park, Jida Choi, Seung Heon Lee, Hye Jun Jo, Myoung-Heon Lee, Byounghan Kim, Jaejo Kim
Article
Immunology
Jieun Choi, Hye Jun Jo, Sung Suk Jung, Jida Choi, Seung Heon Lee, Ha-Hyun Kim, Yong-Joo Kim, Byounghan Kim, Jong-Hyeon Park, Jaejo Kim
Summary: The study evaluated the in vivo efficacy of two type O commercial vaccines against a heterologous virus challenge in pigs. The optimal age for primary vaccination with these vaccines was found to be 8 weeks, demonstrating a significant protective effect.
Article
Agriculture, Dairy & Animal Science
Seung Heon Lee, Ha-Hyun Kim, Seo Young Moon, Min Young Kim, Seon Woo Kim, Jong-Hyeon Park, Jaejo Kim
Summary: This study developed a liquid-phase blocking ELISA (LPBE) method for sero-monitoring, which showed better analytical performance and higher consistency with virus neutralization test compared to the commercial solid-phase competition ELISA commonly used in South Korea.
JOURNAL OF APPLIED ANIMAL RESEARCH
(2022)
