Article
Immunology
Arman R. Badalyan, Marine Hovhannisyan, Gayane Ghavalyan, Mary M. Ter-Stepanyan, Rory Cave, Jennifer Cole, Andrew W. K. Farlow, Hermine Mkrtchyan
Summary: The study highlights low vaccine coverage and high vaccination hesitancy in Yerevan, Armenia. Physicians displayed varying levels of knowledge regarding the HPV vaccine, indicating a need for additional training and educational activities to improve understanding and trust in vaccination programs. The drivers of vaccine hesitancy are complex and may not be consistent for different vaccines, suggesting the importance of tailored approaches in addressing this issue.
Article
Multidisciplinary Sciences
Hengchen Dai, Silvia Saccardo, Maria A. Han, Lily Roh, Naveen Raja, Sitaram Vangala, Hardikkumar Modi, Shital Pandya, Michael Sloyan, Daniel M. Croymans
Summary: Enhancing vaccine uptake is crucial for public health, and effective communication strategies are necessary to overcome vaccine hesitancy. This study conducted two randomized controlled trials to test the impact of behavioral interventions on COVID-19 vaccine uptake, showing that text-based reminders can significantly increase vaccination rates, especially when designed to give participants ownership over the vaccine.
Article
Immunology
Sachiko Ozawa, Holly B. Schuh, Tomoka Nakamura, Tatenda T. Yemeke, Yi-Fang Ashley Lee, Noni E. Macdonald
Summary: Resilience in vaccination demand is crucial in the face of the COVID-19 pandemic, where there is timid demand for vaccines and reduced uptake of routine immunizations. The Vaccination Demand Resilience (VDR) framework highlights the complexity of vaccination demand and offers interventions to improve vaccination resilience. Interventions such as information, education, incentives, and provider communications can help address incongruences in individuals' attitudes, behaviors, and vaccination status.
Article
Public, Environmental & Occupational Health
Xiaomin Wang, Leesa Lin, Jiayao Xu, Weiyi Wang, Xudong Zhou
Summary: This study found that parents who had higher levels of trust towards crisis communication information and better critical understanding of crisis information were less likely to exhibit vaccine hesitancy. Additionally, parents with lower confidence in vaccine efficacy were more likely to be hesitant, but also more likely to maintain their vaccine intentions.
PREVENTIVE MEDICINE
(2021)
Review
Infectious Diseases
Jessica R. Cataldi, Sean T. O'Leary
Summary: Recent studies have expanded understanding of global parental vaccine hesitancy, identifying common concerns such as uncertainty, vaccine safety, and efficacy. Strategies to address hesitancy include presumptive or announcement vaccine recommendations, motivational interviewing, and the use of various immunization delivery strategies.
CURRENT OPINION IN INFECTIOUS DISEASES
(2021)
Article
Immunology
Sohela Moussaoui, Simon Combes, Gladys Ibanez, Arnaud Gautier, Bridget Relyea, Nicolas Vignier
Summary: Immigrants in France are less hesitant toward vaccinations than the host population, but vaccine hesitancy increases with time spent in France. Providing appropriate information and awareness to encourage critical thinking about anti-vaccine theories is necessary for immigrants.
Article
Immunology
Angela K. Shen, Safa Browne, Tuhina Srivastava, Melanie L. Kornides, Andy S. L. Tan
Summary: This study aimed to investigate trusted sources for vaccine information, describe persuasive characteristics of trusted messages promoting routine and COVID-19 vaccines, and explore how the pandemic has affected attitudes and beliefs about routine vaccinations. The results showed that primary care providers, family, and credible sources were the top sources of vaccine information. Neutrality, honesty, and having a trusted source to rely on were highly valued. Attitudes and beliefs about COVID-19 vaccines differed from routine vaccines due to the evolving nature of the pandemic. Vaccination messaging should be tailored to resonate with parents and adults to improve uptake.
Article
Immunology
Andrea Costantino, Marco Michelon, Daniele Noviello, Fabio Salvatore Macaluso, Salvo Leone, Nicole Bonaccorso, Claudio Costantino, Maurizio Vecchi, Flavio Caprioli, AMICI Sci Board
Summary: The vaccination rate against some vaccine-preventable diseases is low among Italian patients with inflammatory bowel disease (IBD), despite a generally positive attitude towards vaccinations.
Article
Psychology, Developmental
Sally H. Adams, Jason P. Schaub, Jason M. Nagata, M. Jane Park, Claire D. Brindis, Charles E. Irwin
Summary: Based on the March 2021 data, most unvaccinated young adults in the US express an intention to receive COVID-19 vaccines, but 24% remain hesitant. Common reasons for hesitancy include concerns about vaccine safety and side effects, as well as the belief that others are in greater need of the vaccine.
JOURNAL OF ADOLESCENT HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Mohamad-Hani Temsah, Abdullah N. Alhuzaimi, Fadi Aljamaan, Feras Bahkali, Ayman Al-Eyadhy, Abdulkarim Alrabiaah, Ali Alhaboob, Fahad A. Bashiri, Ahmad Alshaer, Omar Temsah, Rolan Bassrawi, Fatimah Alshahrani, Yazan Chaiah, Ali Alaraj, Rasha Assad Assiri, Amr Jamal, Mohammed A. Batais, Basema Saddik, Rabih Halwani, Fahad Alzamil, Ziad A. Memish, Mazin Barry, Sarah Al-Subaie, Jaffar A. Al-Tawfiq, Khalid Alhasan
Summary: The study found that many parents are hesitant towards the COVID-19 vaccine mainly due to lack of confidence in its effectiveness, safety, and necessity for their children. Parents who rely on official healthcare authority websites for information are more likely to accept childhood COVID-19 vaccination.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Naveen Siddique Sheikh, Mumtaz Touseef, Riddah Sultan, Kanwal Hassan Cheema, Sidra Shafiq Cheema, Afia Sarwar, Haniya Zainab Siddique
Summary: This study aimed to explore the determinants of vaccine hesitancy among the Pakistani population. A cross-sectional study was conducted with 421 participants. The results showed that non-healthcare workers were more likely to hesitate in getting vaccinated, and low practice of standard operating procedure was the strongest contributor to vaccine hesitancy. For healthcare workers, moderate confidence and convenience were the main factors influencing vaccine hesitancy. Increasing confidence, convenience, and educating the general population about the vaccine could help reduce vaccine hesitancy.
Article
Psychology, Developmental
Anne F. Rositch, Tanxin Liu, Christina Chao, Meghan Moran, Anna L. Beavis
Summary: Understanding parental vaccine hesitancy and reasons for lack of vaccination is crucial for tailoring public health interventions to achieve HPV vaccination goals.
JOURNAL OF ADOLESCENT HEALTH
(2022)
Article
Pediatrics
Salmah Alghamdi
Summary: Parental attitudes towards childhood COVID-19 vaccination have not been fully assessed, and a significant proportion of parents are hesitant to have their children receive the vaccine, primarily due to concerns about its side effects. Parents whose children received the COVID-19 vaccine showed more positive attitudes towards vaccination.
Article
Multidisciplinary Sciences
Shaikha Almheiri, Animesh Hazari, Praveen Kumar, Sampath Kumar, Srilatha Girish
Summary: This study aims to identify and compare the pre-post COVID-19 vaccination-related essential information among physical therapy university students. A cross-sectional survey conducted among physiotherapy university students in the UAE found that most students believed the vaccines to be safe, while some had doubts about their effectiveness. After vaccination, some students reported unusual symptoms, which were also observed in their family members. The findings of this study could help increase confidence and awareness among physiotherapy students and promote higher vaccination rates among healthcare professionals.
Article
Immunology
Tianxing Feng, Xiangshi Wang, Jingjing Li, Chuning Wang, Yue Qiu, Ying Zhang, Beihua Zhou, Jiali Wang, Aimei Xia, Xiaodong Sun, Zhuoying Huang, Zhongqiu Wei, Yi Wang, Mei Zeng
Summary: This study investigated common issues of immunization among 2,221 children with neurological conditions in China and the impact of specialists' recommendations on improving immunization practice. The results showed a high rate of delayed immunization among these children, but immunization was generally safe for children with neurological conditions.
Article
Immunology
Oskar Thofte, Serena Bettoni, Yu-Ching Su, John Thegerstrom, Sandra Jonsson, Emma Mattsson, Linda Sandblad, Sara Marti, Junkal Garmendia, Anna M. Blom, Kristian Riesbeck
Summary: The study identified P5 of NTHi as a novel ligand of C4BP, with P5-deficient mutants showing decreased serum resistance. Clinical isolates showed a positive correlation between P5 expression and C4BP binding, with higher P5 surface expression in isolates from the lower respiratory tract of COPD patients and tonsil specimens.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Infectious Diseases
Fabian Udden, Elisabeth Runow, Hans-Christian Slotved, Kurt Fuursted, Jonas Ahl, Kristian Riesbeck
Summary: This study investigated the serotype distribution and antimicrobial resistance of Streptococcus pneumoniae associated with mucosal infections in patients of all ages following the transition from PCV10 to PCV13. The results showed that 17% of isolates were covered by PCV13, with serotypes 3 and 19A being the most common. Nonvaccine serotypes such as 11A, 23B, 15A, and 35F were also identified, with certain serotypes showing multidrug resistance or penicillin nonsusceptibility.
JOURNAL OF INFECTION
(2021)
Article
Pediatrics
Kathy Falkenstein-Hagander, Emma Appelqvist, Ann-Sofie Frisk Cavefors, Henrik Kallberg, Lennart Jan Nilsson, Sven-Arne Silfverdal, Jann Storsaeter, Bernice Aronsson
Summary: Measures to reduce the spread of COVID-19 have been linked to reductions in other respiratory infections. A national Swedish cohort study found that the number of infant pertussis cases decreased significantly during the COVID-19 pandemic, indicating that strategies to mitigate the spread of COVID-19 may have impacted pertussis incidence in infants.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Urology & Nephrology
Oskar Ljungquist, Ale Persmark, Magnus Grabe, Ane Krag Jakobsen, Axel Gerdtsson, Gustav Torisson, Anders Bjartell, Kristian Riesbeck
Summary: This study reports an increasing trend of bloodstream infection (BSI) and urinary tract infection (UTI) after transrectal ultrasonography-guided prostate biopsy (TRUS PBx) over a 15-year period. The rise in infectious complications is not associated with quinolone-resistance. Further longitudinal studies are needed to explore the reasons for the increasing infection complications after TRUS PBx.
Review
Immunology
Martina Janouskova, Megan Laura Straw, Yu-Ching Su, Kristian Riesbeck
Summary: This review discusses the multifaceted gene regulation mechanisms employed by S. pneumoniae, H. influenzae, and M. catarrhalis during middle ear infection. Through phase variation- and quorum sensing-dependent gene regulation, these pathogens control their virulence phenotypes for survival and host adaptation. Understanding the gene expression regulation mechanisms during the onset of OM may lead to the development of new antimicrobial agents to combat antimicrobial resistance.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Michal Magda, Serena Bettoni, Maisem Laabei, Derek Fairley, Thomas A. Russo, Kristian Riesbeck, Anna M. Blom
Summary: This study investigated the resistance mechanisms of clinical Acinetobacter spp. isolates to the complement system. The results showed that most isolates were highly resistant to serum killing, yet efficiently recognized by the complement system. The production of a capsular polysaccharide was identified as a mechanism mediating resistance to complement-mediated bactericidal activity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Karlhans F. Che, Magnus Paulsson, Krzysztof Piersiala, Jakob Sax, Ibrahim Mboob, Mizanur Rahman, Rokeya S. Rekha, Jesper Safholm, Mikael Adner, Peter Bergman, Lars-Olaf Cardell, Kristian Riesbeck, Anders Linden
Summary: IL-26 plays a critical role in bacterial lung infection by modulating innate immune responses and promoting bacteria killing. IL-26 has both diagnostic and therapeutic potential in pneumonia and deserves further evaluation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
LindaYamba Yamba, Fabian Udden, Kurt Fuursted, Jonas Ahl, Hans-Christian Slotved, Kristian Riesbeck
Summary: This study characterized the molecular epidemiology, presence of resistance genes, and selected virulence genes of extensively drug-resistant (XDR) and multidrug-resistant (MDR) Streptococcus pneumoniae isolated from clinical respiratory tract samples in a southern Swedish county from 2016 to 2018. The study found a high correlation between the isolates and global multidrug-resistant pneumococci.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Farshid Jalalvand, Yu-Ching Su, Guillaume Manat, Alexey Chernobrovkin, Mahendar Kadari, Sandra Jonsson, Martina Janouskova, Dorothea Rutishauser, Szabolcs Semsey, Anders Lobner-Olesen, Linda Sandblad, Klas Flardh, Dominique Mengin-Lecreulx, Roman A. Zubarev, Kristian Riesbeck
Summary: This study used mass spectrometry to investigate vesiculation and the distribution of proteins in the outer membrane of Haemophilus influenzae. It found that the peptidoglycan synthase-activator Lipoprotein A (LpoA) was accumulated in outer membrane vesicles (OMVs) and played an important role in peptidoglycan biogenesis. Fluorescence microscopy also revealed the localization of LpoA in the cell envelope and during cell division.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Letter
Infectious Diseases
Oskar Ljungquist, Oleksandr Nazarchuk, Gunnar Kahlmeter, Vigith Andrews, Thalea Koithan, Lisa Wasserstrom, Dmytro Dmytriiev, Nadiia Fomina, Vira Bebyk, Erika Matuschek, Kristian Riesbeck
LANCET INFECTIOUS DISEASES
(2023)
Article
Immunology
Yu-Ching Su, Mahendar Kadari, Megan L. L. Straw, Martina Janouskova, Sandra Jonsson, Oskar Thofte, Farshid Jalalvand, Erika Matuschek, Linda Sandblad, Akos Vegvari, Roman A. A. Zubarev, Kristian Riesbeck
Summary: Non-typeable Haemophilus influenzae (NTHi) is a Gram-negative human pathogen that causes various airway diseases. The outer membrane protein P5 contributes to bacterial serum resistance and also plays a critical role in maintaining bacterial outer membrane integrity and protein composition.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Karin Hansen, Elisabeth Runow, Gustav Torisson, Christian Theilacker, Andreas Palmborg, Kaijie Pan, Qin Jiang, Jo Southern, Rohini Beavon, Bradford D. Gessner, Kristian Riesbeck, Jonas Ahl
Summary: The serotype distribution and potential coverage of pneumococcal conjugate vaccines (PCVs) in adults with community-acquired pneumonia (CAP) in Sweden were unknown. This study found that PCV20 expands the coverage of all-cause CAP compared to PCV13, indicating its potential effectiveness in preventing CAP caused by Streptococcus pneumoniae.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Emma Appelqvist, Madelene Danielsson, Asha Jama, Lina Schollin Ask, Christina Stenhammar, Ann Lindstrand, Kristian Riesbeck, Adam Roth
Summary: This study aimed to assess parental vaccine acceptance and explore factors contributing to the high vaccine acceptance in Sweden. Parents of children aged 1-2 years and 8-12 years were recruited through purposive sampling and participated in focus group discussions. The results showed that both individual and societal perspectives influenced the vaccination decision for childhood immunizations. Nurses play a key role in providing support and tools to help parents make informed decisions.
Article
Respiratory System
Magnus Paulsson, Louise Thelaus, Kristian Riesbeck, Ingemar Qvarfordt, Margaretha E. Smith, Anders Linden, Adam Linder
Summary: The study found that HBP concentrations were significantly higher in lower airway samples from patients with pneumonia compared to control subjects, indicating it may be a potentially useful biomarker for diagnosing VAP.
RESPIRATORY RESEARCH
(2021)