Article
Cell Biology
Mustafa Karabicici, Yagmur Azbazdar, Gunes Ozhan, Serif Senturk, Zeynep Firtina Karagonlar, Esra Erdal
Summary: In this study, it was found that regorafenib treatment activated Wnt/beta-catenin signaling only in hepatoblast-like HCC cell lines and induced enrichment of markers associated with hepatic stem/progenitor cells. On the other hand, regorafenib resistant cells demonstrated diminished Wnt/beta-catenin signaling activity and enhanced TGF-beta signaling activity. The inhibition of TGF-beta pathway in combination with regorafenib administration might increase regorafenib-induced cell death in HCC tumors with aberrant activation in the Wnt/beta-catenin pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Tong-tong Li, Jie Mou, Yao-jie Pan, Fu-chun Huo, Wen-qi Du, Jia Liang, Yang Wang, Lan-sheng Zhang, Dong-sheng Pei
Summary: Our study revealed that the downregulation of miR-138-1-3p and upregulation of PAK5 were associated with sorafenib resistance in HCC cells. Mechanistic studies showed that miR-138-1-3p targeted PAK5 mRNA to reduce PAK5 protein expression. Additionally, PAK5 promoted the activation of a multidrug resistance protein ABCB1 via the beta-catenin signaling pathway, contributing to sorafenib resistance in HCC.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Fei-fei Pan, Yan-Biao Zheng, Chuan-Jian Shi, Feng-wei Zhang, Jin-fang Zhang, Wei-ming Fu
Summary: The research demonstrates that apigenin (API) can suppress tumor growth of hepatocellular carcinoma (HCC) by down-regulating the H19-mediated Wnt/beta-catenin signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Lili Zhu, Xiaobei Yang, Jingyu Feng, Jian Mao, Qidong Zhang, Mengru He, Yang Mi, Yingwu Mei, Ge Jin, Haifeng Zhang
Summary: The study reveals that CYP2E1 plays a role in hepatocarcinogenesis by manipulating the Wnt/Dvl2/beta-catenin pathway through inducing ROS accumulation, which leads to the inhibition of tumor growth and metastasis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yuan Guo, Yan-Rong Zhao, Huan Liu, Yang Xin, Jian-Zhi Yu, Yun-Jin Zang, Qing-guo Xu
Summary: The study identified EHMT2 as a critical factor in the development of hepatocellular carcinoma, showing that elevated EHMT2 expression promotes tumorigenesis and activates the Wnt-beta-catenin signaling pathway. EHMT2 was found to epigenetically silence the APC promoter through methylation, and the specific inhibitor UNC0642 demonstrated anti-tumorigenesis effects in HCC, suggesting it as a potential candidate for targeted drug therapy.
CELL AND BIOSCIENCE
(2021)
Article
Cell Biology
Sang Hyun Seo, Kyung Joo Cho, Hye Jung Park, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Jae Hee Cheon, Jong In Yook, Man-Deuk Kim, Dong Jin Joo, Seung Up Kim
Summary: This study found that DKK1 is overexpressed in patients with hepatocellular carcinoma (HCC), and inhibiting DKK1 can enhance the anti-tumor efficacy of sorafenib in HCC. By regulating the activity of GSK3 beta and inhibiting the PI3K/Akt and Wnt/β-catenin pathways, a new therapeutic strategy for HCC has been identified.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Environmental Sciences
Rong Li, Runze Shang, Shunle Li, Yifan Ren, Lin Shen, Longbao Yang, Shuo Chen, Xi Chen, Junhui Li, Meng Xu
Summary: The study found that high expression of LOXL3 in HCC was significantly correlated with tumor size and clinical stage, predicting a poor prognosis. Experimental results demonstrated that LOXL3 promoted HCC EMT process through the Snail1/USP4-mediated circulation loop and Wnt/β-catenin signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Oncology
Yan Huang, Hailong Sheng, Yazhi Xiao, Wei Hu, Zhihong Zhang, Yiyao Chen, Zhenru Zhu, Dehua Wu, Chuanhui Cao, Jingyuan Sun
Summary: The Wnt/β-catenin inhibitor ICG-001 combined with radiotherapy shows enhanced anti-tumor effects in hepatocellular carcinoma by improving T cell infiltration and immune response, increasing the sensitivity of HCC cells to radiation, and promoting the activation of the cGAS/STING pathway.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Dan Fang, Mu-Ru Wang, Jia-Lun Guan, Ying-Ying Han, Jia-Qi Sheng, De-An Tian, Pei-Yuan Li
Summary: The study found that in HCC, high expression of BRD9 was closely related to malignancy, tumor stage, tumor size, and prognosis. BRD9 promoted cell proliferation and tumor growth, and mediated its effects by activating the Wnt/beta-catenin signaling pathway.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Rongcai Yue, Haiping Liu, Yaxin Huang, Jing Wang, Dongmei Shi, Yanping Su, Yufei Luo, Ping Cai, Guilin Jin, Changxi Yu
Summary: Gelsemium elegans, a toxic plant used in traditional Chinese medicine, showed anti-tumor effects in hepatocellular carcinoma (HCC) through the alkaloid compound sempervirine which induced apoptosis, cell cycle arrest in G(1) phase, and inactivation of the Wnt/beta-catenin pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Osman Oecal, Daniel Roessler, Antonio Gasbarrini, Thomas Berg, Heinz-Josef Klumpen, Irene Bargellini, Bora Peynircioglu, Otto van Delden, Christian Schulz, Kerstin Schuette, Roberto Iezzi, Maciej Pech, Peter Malfertheiner, Bruno Sangro, Jens Ricke, Max Seidensticker
Summary: This study evaluated the prognostic value of gadoxetic acid uptake on hepatobiliary phase MRI in advanced HCC patients receiving sorafenib. High gadoxetic acid uptake was associated with shorter survival, highlighting its potential role in treatment decision-making.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Cell Biology
I-Lun Hsin, Pei-Ju Wu, Sheau-Chung Tang, Chu-Chyn Ou, Hui-Yi Chang, Huang-Pin Shen, Jiunn-Liang Ko, Po-Hui Wang
Summary: ICG-001 inhibits endometrial cancer by reducing cell viability, cancer stem cell sphere formation, and cell cycle progression, while activating autophagy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Fan Sheng, Yinli Luo, Di Wu, Jiachen Yuan, Ge Zheng, Yuhao Zheng, Zhehu Jin
Summary: This study investigates the effects of ICG-001 on the proliferation, invasion, and apoptosis of keloid fibroblasts, as well as the excessive deposition of collagen. It also explores the inhibitory effect of ICG-001 on tumor growth in a keloid mouse model. The results show that ICG-001 is effective in inhibiting keloid fibroblast proliferation and promoting apoptosis.
MATERIALS & DESIGN
(2022)
Article
Biotechnology & Applied Microbiology
Hui Xu, Bin Li
Summary: In this study, the researchers investigated the role of miR-582-3p in hepatocellular carcinoma (HCC) and found that its upregulation inhibited the proliferation and migration of HCC cells and suppressed tumor growth. They also discovered that miR-582-3p regulates the Wnt/β-catenin signaling pathway by targeting RRM2, thereby blocking the progression of HCC.
Article
Multidisciplinary Sciences
German Belenguer, Gianmarco Mastrogiovanni, Clare Pacini, Zoe Hall, Anna M. Dowbaj, Robert Arnes-Benito, Aleksandra Sljukic, Nicole Prior, Sofia Kakava, Charles R. Bradshaw, Susan Davies, Michele Vacca, Kourosh Saeb-Parsy, Bon-Kyoung Koo, Meritxell Huch
Summary: RNF43/ZNRF3 alterations contribute to liver disease and liver cancer by affecting differentiation and lipid metabolism of hepatocytes. The loss of these genes leads to steatohepatitis and an increase in unsaturated lipids. Deletion of Rnf43/Znrf3 results in defective hepatocyte regeneration and liver cancer, causing an imbalance between differentiation and proliferation. Interestingly, ZNRF3 mutant liver cancer patients have a poorer prognosis and exhibit altered hepatic lipid metabolism and steatohepatitis/NASH signatures.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Hung-Yang Kuo, Jhe-Cyuan Guo, Chih-Hung Hsu
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Oncology
Kuo-Hsing Chen, Chia-Lang Hsu, Yu-Li Su, Chang-Tsu Yuan, Liang-In Lin, Jia-Huei Tsai, Yi-Hsin Liang, Ann-Lii Cheng, Kun-Huei Yeh
Summary: This study found that the immune contexture in the tumor microenvironment is closely associated with prognosis in patients with metastatic BRAF V600E mutant colorectal cancer. High expression of immune genes and complement activation are correlated with poor prognosis, and the complement score is strongly correlated with tumor-associated macrophage M2 signatures.
BRITISH JOURNAL OF CANCER
(2023)
Article
Gastroenterology & Hepatology
Masatoshi Kudo, Richard S. Finn, Shukui Qin, Kwang-Hyub Han, Kenji Ikeda, Ann-Lii Cheng, Arndt Vogel, Francesco Tovoli, Kazuomi Ueshima, Hiroshi Aikata, Carlos Lopez Lopez, Marc Pracht, Zhiqiang Meng, Bruno Daniele, Joong-Won Park, Daniel Palmer, Toshiyuki Tamai, Kenichi Saito, Corina E. Dutcus, Riccardo Lencioni
Summary: The study aimed to validate objective response as an independent predictor of overall survival (OS) in individuals with unresectable hepatocellular carcinoma (HCC) receiving systemic anti-angiogenic therapy. The results showed that objective response assessed by investigator-assessed mRECIST could predict the survival of patients. Further studies are needed to confirm this finding.
JOURNAL OF HEPATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Satoru Matsuda, Takahiro Tsushima, Ken Kato, Chih-Hung Hsu, Jang Ming Lee, Ian Yu-Hong Wong, Hu-Lin Christina Wang, Chang Hyun Kang, Xufeng Guo, Shun Yamamoto, Takayuki Tsuji, Hirofumi Kawakubo, Hiroya Takeuchi, Simon Law, Yuko Kitagawa
Summary: A multimodality treatment conference was held with experts from East Asia to establish a consensus on conversion therapy. It was agreed that conversion therapy refers to surgery or chemoradiotherapy aimed at curing initially unresectable tumors.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Article
Gastroenterology & Hepatology
Chiao-Ling Tsai, Po-Sheng Yang, Feng-Ming Hsu, Ann-Lii Cheng, Wan-Ni Yu, Jason Chia-Hsien Cheng
Summary: This study investigated the effect of TOP1 inhibition and DNA-PKcs/RNF144A mechanism on radiosensitization mediated by natural killer (NK) cells in radiation therapy (RT). The results showed that TOP1 inhibitors and RT had a synergistic effect on hepatocellular carcinoma (HCC) cells, enhancing the anti-HCC effect of RT through increased DNA damage and DNA-PKcs signaling. RNF144A mediated DNA-PKcs ubiquitination and provided a reason for the difference in radiosensitization effect between HCC cells.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Oncology
Yu-Chieh Tsai, Tzu-Yin Wang, Chia-Lang Hsu, Wei-Chou Lin, Jyun-Yu Chen, Jia-Hua Li, Yeong-Shiau Pu, Ann-Lii Cheng, Jason Chia-Hsien Cheng, Sheng-Fang Su
Summary: This study found that inhibiting HDAC6 can enhance the radiosensitivity of bladder cancer and reduce the expression of genes related to cell migration, angiogenesis, and metastasis induced by radiotherapy, thereby improving therapeutic efficacy.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Jhe-Cyuan Guo, Chia-Lang Hsu, Min-Shu Hsieh, Chia-Chi Lin, Ta-Chen Huang, Hung-Yang Kuo, Yu-Yun Shao, Chih-Hung Hsu
Summary: This study describes a patient with advanced esophageal squamous cell carcinoma who exhibited a response to durvalumab plus tremelimumab for more than 6 months, except for primary resistant esophageal tumor. The esophageal tumor showed higher levels of regulatory T cells, neutrophils, and mast cells compared to the hepatic tumor. Immunohistochemistry confirmed higher expression levels of Foxp3 and myeloperoxidase (MPO) in the esophageal tumor. The heterogeneous responses to ICI combination may be related to the different immune contextures in this ESCC patient.
Article
Oncology
Masatoshi Kudo, Richard S. Finn, Ann-Lii Cheng, Andrew X. Zhu, Michel Ducreux, Peter R. Galle, Naoya Sakamoto, Naoya Kato, Michitaka Nakano, Jing Jia, Arndt Vogel
Summary: This exploratory analysis examined the prognostic impact of baseline albumin-bilirubin (ALBI) score in patients with unresectable hepatocellular carcinoma (HCC) treated with atezolizumab + bevacizumab or sorafenib. The study found that atezolizumab + bevacizumab improved overall survival and progression-free survival compared to sorafenib in patients with ALBI score of 1, but not in patients with ALBI score of 2. ALBI grade appeared to be prognostic for outcomes in both treatment groups.
Article
Oncology
Philippe Merle, Masatoshi Kudo, Julien Edeline, Mohamed Bouattour, Ann-Lii Cheng, Stephen Lam Chan, Thomas Yau, Marcelo Garrido, Jennifer Knox, Bruno Daniele, Valeriy Breder, Ho Yeong Lim, Sadahisa Ogasawara, Stephane Cattan, Yee Chao, Abby B. Siegel, Ivan Martinez-Forero, Ziwen Wei, Chih-Chin Liu, Richard S. Finn
Summary: With extended follow-up, pembrolizumab demonstrated continued improvement in overall survival (OS) and progression-free survival (PFS) compared to placebo in advanced hepatocellular carcinoma (HCC) patients previously treated with sorafenib. The adverse event profile of pembrolizumab remained consistent with placebo.
Meeting Abstract
Oncology
Li-Chun Lu, Yi-Hsuan Lee, Yu Yun Shao, Tsung-Hao Liu, Ann-Lii Cheng, Chih-Hung Hsu
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Li Du, Yichun Ji, Bing Xin, Jiemeng Zhang, Li-Chun Lu, Christopher K. Glass, Gen-Sheng Feng
Summary: The study aimed to clarify the interactions between hepatocytes and Kupffer cells and investigate the unique functions of Kupffer cells and non-Kupffer macrophages in liver tumorigenesis. It found that deleting the Shp2 gene in Kupffer cells generated a tumor-promoting environment, which was exacerbated by concurrent removal of Shp2 in hepatocytes.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Yu-Yun Shao, Ching-Liang Ho, Cheng-Shyong Chang, Chia-Lun Chang, Jen-Kuang Lee, Hung-Ju Lin, Hui-Hua Hsiao, Ta-Chung Chao, Ching-Yeh Lin, Chuang -Chi Liaw
Summary: Cancer-associated thrombosis is a common complication of malignancies. Taiwanese patients may have a lower incidence of CAT, leading to false reassurance. Oncologists and cardiologists from multiple medical institutions in Taiwan have collaborated to provide clinical consensus guidelines on the management of CAT, based on local clinical practices and international guidelines.
ACTA CARDIOLOGICA SINICA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bang-Bin Chen, Po-Chin Liang, Tiffany Ting-Fang Shih, Tsung-Hao Liu, Ying-Chun Shen, Li-Chun Lu, Zhong-Zhe Lin, Chiun Hsu, Chih-Hung Hsu, Ann-Lii Cheng, Yu-Yun Shao
Summary: Sarcopenia and myosteatosis are independent prognostic factors in patients who received immunotherapy for advanced HCC.
EUROPEAN RADIOLOGY
(2023)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
