Article
Medicine, General & Internal
Xiaoyan Gao, Aigui Jiang, Yahui Shen, Huiyu Lu, Rong Chen
Summary: This study demonstrated that increased expression of AURKB in lung adenocarcinoma is associated with poor prognosis, suggesting its potential as a promising prognostic biomarker and novel therapeutic target for LUAD.
Article
Oncology
Sho Sekiya, Junki Fukuda, Ryodai Yamamura, Takako Ooshio, Yusuke Satoh, Shinya Kosuge, Reo Sato, Kanako C. Hatanaka, Yutaka Hatanaka, Tomoko Mitsuhashi, Toru Nakamura, Yoshihiro Matsuno, Satoshi Hirano, Masahiro Sonoshita
Summary: Significant progress has been made in understanding pancreatic ductal adenocarcinoma (PDAC) through the use of murine models. In this study, a Drosophila model was generated to mimic alterations in PDAC and identify therapeutic targets. Genetic screening revealed kinases such as MEK and AURKB, which could be potential targets for treatment.
Article
Oncology
Xintong Guo, Min Liang
Summary: Metformin alleviates glucocorticoid-induced osteoblast apoptosis by inducing autophagy through the AMPK/mTOR/p70S6K pathway.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Oncology
Ismail Ayberk Kirbiyik, Ahmet Ata Ozcimen
Summary: The study investigated the effects of danusertib, an Aurora kinase inhibitor, on cytotoxicity, apoptosis, and cell cycle arrest in human pancreatic carcinoma CFPAC-1 cells. The results showed that danusertib at a concentration of approximately 400 nM induced significant apoptosis and cell cycle arrest in the cells, suggesting its potential as an alternative treatment for pancreatic cancers.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Bin Huang, Meng Hao, Chuwen Li, Kathy Qian Luo
Summary: In this study, we found that acetyltanshinone IIA (ATA) showed stronger potency than erlotinib in inhibiting the growth of drug-resistant NSCLC cells. ATA achieved this effect by inhibiting phosphorylation and promoting degradation of p70S6K. ATA also reduced protein synthesis of cell cycle-related proteins and regulated the levels of p53 and p21 to block cell cycle progression. Therefore, ATA has potential to be developed as a multi-target anti-cancer agent for treating TKI-resistant NSCLC.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Mashima Naksawat, Chosita Norkaew, Kantorn Charoensedtasin, Sittiruk Roytrakul, Dalina Tanyong
Summary: This study revealed the anti-leukemic effects and underlying mechanisms of menthol in NB4 and Molt-4 leukemic cell lines, including induction of apoptosis and autophagy through activating the caspase cascade, regulating BAX and p53/MDM2, and modulating autophagy via the ATG3/mTOR signaling pathway.
Article
Pharmacology & Pharmacy
Haile Zhao, Peijun Jia, Kathleen Nanding, Man Wu, Xiaozhou Bai, Morigen Morigen, Lifei Fan
Summary: This study revealed the significant impact of geminin protein on autophagy and reactive oxygen species production in HGSOC cells, while LPA activation of geminin expression further affects growth and proliferation of HGSOC cells. These findings provide potential therapeutic targets for enhancing the clinical benefit of HGSOC precision medicine.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhongqiu Zhou, Qingqing Ye, Hui Ren, Yuan Zhang, Bing Han, Honghong Yao, Ying Bai
Summary: This study found that circDYM inhibits microglial apoptosis induced by LPS via the CEBPB/ZC3H4 axis. CircDYM prevents CEBPB from translocating into the nucleus by binding with it. In addition, LPS-induced CEBPB nuclear entry downregulates the expression of ZC3H4, which promotes autophagy and apoptosis in microglia. These findings provide new insights into the relationship between circDYM and microglial apoptosis, as well as shed new light on the complex changes in the brain associated with depression.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Oncology
Jin Soo Kim, Dae Young Hur
Summary: This study identified the increased expression of aurora kinase A and B in EBV-infected B-cells and EBV-positive lymphoma cells. Danusertib, a pan-aurora kinase inhibitor, significantly suppressed the proliferation of EBV-transformed B-cells. It induced apoptosis and cell cycle arrest through disruption of mitochondrial membrane potential and activated ER stress-associated molecules in EBV-transformed B-cells. These findings suggest that aurora kinases may be potential therapeutic targets against EBV-associated carcinoma.
ANTICANCER RESEARCH
(2022)
Article
Oncology
Giuseppa Augello, Maria Rita Emma, Antonina Azzolina, Roberto Puleio, Lucia Condorelli, Antonella Cusimano, Lydia Giannitrapani, James A. McCubrey, Juan Lucio Iovanna, Melchiorre Cervello
Summary: The study revealed that NUPR1 knock-down impaired autophagic flux, increasing cell sensitivity to sorafenib, and activated the p73 signaling pathway, enhancing the anti-tumor effects of the drug. Combined therapy with the p73 activator NSC59984 and sorafenib showed synergistic suppression of tumor growth, suggesting a novel approach for HCC treatment.
Article
Multidisciplinary Sciences
Paweena Subkorn, Chosita Norkaew, Kamolchanok Deesrisak, Dalina Tanyong
Summary: Punicalagin showed dose-dependent reduction in cell viability of NB4 and MOLT-4 leukemic cell lines, exhibiting synergistic cytotoxic effects when combined with daunorubicin. It induced apoptosis by upregulating caspase cascade and Bax, while promoting autophagy by downregulating mTOR and upregulating ULK1. Cyclooxygenase-2 and toll-like receptor 4 were found to be involved in punicalagin-induced cell death through protein interactions.
Review
Oncology
Wonhyoung Seo, Prashanta Silwal, Ik-Chan Song, Eun-Kyeong Jo
Summary: In this review, the multifaceted functions of autophagy in AML were discussed, including its link to genetic alterations, potential prognostic predictors, and drivers of AML tumorigenesis. The crosstalk between autophagy and tumor cell metabolism and its impact on AML progression and treatment were also examined. Additionally, the potential therapeutics for AML, such as autophagy regulators, were described, along with their translation into clinical practice.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Cell Biology
Xiufeng Chu, Xiang Xiao, Guangchuan Wang, Ahmed Uosef, Xiaohua Lou, Preston Arnold, Yixuan Wang, Gangcheng Kong, Mou Wen, Laurie J. Minze, Xian C. C. Li
Summary: This study shows that the cytolytic activity of Gasdermin D N-terminal pore-forming domain (GD-NT) is negatively regulated by AMP-activated protein kinase (AMPK). AMPK phosphorylates GD-NT at serine 46, which alters its oligomerization and inhibits its pore-forming ability. The negative regulation of GD-NT by AMPK impacts its anti-tumor activity and promotes aggressive tumor growth.
CELL DEATH & DISEASE
(2023)
Article
Evolutionary Biology
Jingchuan Xiao, Yingai Zhang
Summary: The study investigated the prognostic role of Aurora kinases in hepatocellular carcinoma (HCC) by analyzing their expression, overall survival data, promoter methylation level, and relationship with immunoinhibitors in patients from multiple databases. The results showed significant differences in mRNA expression, HCC stages, and overall survival of AURKA and AURKB in HCC tissues compared to control tissues. A hub module including AURKA, AURKB, and AURKC was identified within the protein-protein interaction network, and AURKB was suggested as a potential biomarker for HCC prognosis.
EVOLUTIONARY BIOINFORMATICS
(2021)
Article
Medicine, Research & Experimental
Mengliang Luo, Zexin Su, Haotian Gao, Jianye Tan, Rongdong Liao, Jiancheng Yang, Lijun Lin
Summary: Cirsiliol inhibits the growth of osteosarcoma cells and induces cell apoptosis by reducing AKT phosphorylation and promoting FOXO1 expression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Analytical
Junji Li, Zi-Xuan Liu, Yi-Xuan Li, Guofang Shu, Xue-Ji Zhang, Robert S. Marks, Dan Shan
Summary: In this study, a tailored metal-organic framework transducer material Cu BDC(NH2)@2-MI was synthesized using 2-methylimidazole as a competitive ligand, which allowed for the modulation of its morphology and catalytic activity. The 2-MI-doped MOF exhibited well-tuned morphology and showed efficient performance in electrochemical H2O2 reduction. This novel design could potentially enable the utilization of proprietary MOFs materials beyond the laboratory.
Article
Chemistry, Analytical
Xiangfang Lin, Meng Tian, Chengcheng Cao, Tong Shu, Yongqiang Wen, Lei Su, Xueji Zhang
Summary: A novel label-free sensing platform based on the inner filter effect is reported for the sensitive and specific determination of the prostate cancer biomarker sarcosine. The platform utilizes photoluminescent bimetallic nanoplatelets to construct a highly efficient sensor for sarcosine detection. The platform exhibits two linear regions for sarcosine concentration in the ranges of 0.5-5 mu M and 5-100 mu M, with a detection limit of 0.12 mu M.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Li-Ping Zong, Junji Li, Guofang Shu, Xinye Liu, Robert S. Marks, Xue-Ji Zhang, Serge Cosnier, Dan Shan
Summary: A novel ECL amplification strategy was established by designing Fe-N-C nanosheets with exceptional catalytic activity for O-2 activation. The material was successfully applied for antibiotic detection, indicating promising prospects for biological analysis and environmental monitoring.
ANALYTICAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Zhiwei Lei, Xuantong Sun, Shifeng Zhu, Kai Dong, Xuqing Liu, Lili Wang, Xiansheng Zhang, Lijun Qu, Xueji Zhang
Summary: This research presents a solar evaporator with enhanced light absorption, minimal thermal loss, and efficient salt harvesting. The evaporator demonstrates high solar efficiency and evaporation rate, and enables complete separation of water/solute and efficient salt harvesting even under high salinity conditions.
NANO-MICRO LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Xiaojun Cheng, Tong Shu, Yanping Sun, Xiang Zhou, Jialu An, Qiong Dai, Xin Du, Lei Su, Xueji Zhang
Summary: Fluorescent metal nanomaterials, gold nanoclusters, are embedded inside hair through a fast protein-assisted biomineralization approach under heating and alkaline conditions, providing new photophysical properties and enhancing comfort and cosmetic performance of hair.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Chemistry, Analytical
Xiaonan Zheng, Yucheng Sun, Haifang Li, Nan Li, Xueji Zhang, Jin-Ming Lin
Summary: During tumorigenesis and development, cancer cells need to adapt to complex and dynamic signals in the tumor microenvironment. To study synergistic effects, researchers have proposed a biomimetic multi-factor stimulation platform that creates a controllable two-dimensional matrix environment with adjustable stiffness as a biomechanical factor and can introduce biochemical cues.
Article
Chemistry, Multidisciplinary
Yi-Xuan Li, Jing Li, Dunru Zhu, Ju-Zheng Wang, Guo-Fang Shu, Junji Li, Sheng-Li Zhang, Xue-Ji Zhang, Serge Cosnier, Hai-Bo Zeng, Dan Shan
Summary: In this study, a porphyrin-based heterobimetallic 2D metal organic framework (MOF) with high electrocatalytic activity and tunable luminescence was successfully self-assembled. The MOF can serve as an ECL probe for rapid detection of the RdRp gene of SARS-CoV-2 with a very low limit of detection.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Analytical
Yan Huang, Yiyi Zhang, Wenbin Hao, Huiting Lu, Haifeng Dong, Xueji Zhang
Summary: To achieve fast, convenient, and highly sensitive detection of microRNA (miRNA), palladium-gold (Pd-Au) bimetallic nanoplates with high photothermal effect were synthesized and combined with locked nucleic acid (LNA) detection probe to develop a photothermal lateral flow locked nucleic acid biosensor (P-LFLNAB) for miRNA detection. The P-LFLNAB enables sensitive and selective miRNA-21 detection with detection limit down to 0.094 pM using a smartphone with external thermal imager, which is 639.5 times lower than that of the conventional gold nanoparticles based colorimetric lateral flow biosensor and the most sensitive enzyme-free lateral flow biosensor for miRNA detection. Besides, the P-LFLNAB achieved single-base mismatch discrimination and can quantify signals in various cell lysates. This highly sensitive, selective and portable P-LFLNAB with smartphone readout has great potential in point-of-care test of miRNAs-related biomedical application.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Xiangdan Meng, Sirong Sun, Chenchen Gong, Junyan Yang, Zhou Yang, Xueji Zhang, Haifeng Dong
Summary: In this study, we report the design of a Ti-based metal-organic framework (MIL) and silver nanoparticles (Ag NPs) heterostructure, MIL@Ag. It is found that the introduction of Ag NPs significantly improves the electron transfer efficiency and O2 adsorption capacity of MIL, leading to enhanced reactive oxygen species (ROS) generation for sonodynamic therapy (SDT). Under ultrasound irradiation, the activated electrons and holes from MIL and Ag NPs produce superoxide radicals and hydroxyl radicals, respectively, improving the therapeutic efficiency of SDT. MIL@Ag-PEG-mediated SDT demonstrates effective cancer cell killing and bacterial infection eradication. Thus, MIL@Ag-PEG provides a promising strategy for enhancing SDT performance through rational heterostructure design of sonosensitizers.
Article
Chemistry, Analytical
Shuangshuang Yang, Jinya Du, Menglian Wei, Yan Huang, Yufan Zhang, Yeyu Wang, Jinze Li, Wei Wei, Yuchun Qiao, Haifeng Dong, Xueji Zhang
Summary: Rapid, simple, sensitive and reliable approaches for quantifying biogenic amines in food samples are essential for food safety. Here, the authors reported a Fe3O4@Au nanoparticles based multimodal readout LFIA for rapid quantification of putrescine and histamine. The assay showed high sensitivity and could be easily expanded to detect other biogenic amines.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biophysics
Mengyun Zhou, Yong Luo, Lirong Wang, Chuan Fan, Tailin Xu, Xueji Zhang
Summary: The outbreak of COVID-19 has posed a great challenge to global health systems. A rapid and sensitive POCT diagnostic platform for SARS-CoV-2 that can be deployed on-site is crucial in containing the epidemic. A portable microdroplet detection platform with temperature control and micro-stirring has been developed, enabling high-throughput and ultrafast COVID-19 diagnosis. The platform, utilizing a PN junction as the temperature controller and incorporating an ultrasonic micro-stirring unit, shows good linearity and low LOD, providing results in a short time. This integrated platform offers a promising tool for point-of-care diagnosis of COVID-19 in resource-limited settings.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Environmental
Kun Yu, Mengjie Li, Huining Chai, Qian Liu, Xin Hai, Mingwei Tian, Lijun Qu, Tailin Xu, Guangyao Zhang, Xueji Zhang
Summary: This study presents a portable colorimetric and electrochemical dual-mode sensor based on MOF-818 nanozyme for the detection of cellular secreted H2O2 and H2S. The sensor enables accurate detection of H2O2 and H2S through colorimetric and electrochemical methods. By combining with a smartphone and miniature electrochemical analyzer, it allows for in situ detection of H2O2 and H2S released from live cells, showcasing potential applications in various fields.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Tingyi Yan, Guangyao Zhang, Kun Yu, Huining Chai, Mingwei Tian, Lijun Qu, Haifeng Dong, Xueji Zhang
Summary: Maintaining normal levels of vitamin C is crucial for a healthy immune system. The development of real-time non-invasive wearable sensors for monitoring vitamin C in sweat shows promise in personalized health management. In this study, a smartphone light-driven enzyme-free wearable photoelectrochemical sensor was presented for precise monitoring of sweat vitamin C.
CHEMICAL ENGINEERING JOURNAL
(2023)
Correction
Biotechnology & Applied Microbiology
Mengjie Li, Guangyao Zhang, Andrews Boakye, Huining Chai, Lijun Qu, Xueji Zhang
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Analytical
Yaodong Hu, Shuaibing Yu, Nan Ma, Jinming Kong, Xueji Zhang
Summary: In this study, a Rose Bengal-Mediated photoinduced atom transfer radical polymerization (photo-ATRP) method was used to achieve highly sensitive detection of target DNA (tDNA), which is of great significance in the field of early disease screening.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
