期刊
CANCER LETTERS
卷 380, 期 2, 页码 485-493出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2016.07.018
关键词
Breast cancer stem cells; Chemotherapy; Radiotherapy; Chemoresistance; Radioresistance; Bioinformatics
类别
资金
- EU grant [MC-CIG-303514]
- COST Action 'Biomimetic Radical Chemistry' [CM1201]
- European Union (European Social Fund-ESF)
- Greek National funds through Operational Program 'Educational and Lifelong Learning of the National Strategic Reference Framework (NSRF)-Research Funding Program: THALES-UOA- [MIS 377177]
- TUBITAIK grant [214S097]
Breast cancer cells are suggested to be organized in a hierarchical manner with a subpopulation of stem cells, termed as breast cancer stem cells (BCSCs), which contribute significantly to tumorigenesis, cancer recurrence and metastasis. BCSCs haye been demonstrated to exhibit significant resistance to conventional chemo- and radiotherapy. Recent evidence suggests that treatment of breast cancers with radiation or chemotherapy agents induces stem cell-like properties in non-stem cells. Herein, we provide an overview of the key determinants of resistance to chemotherapy and radiation in BCSCs. To this end and by the use of bioinformatics, the molecular pathways, the defining markers, as well as the microenvironmental and genetic factors, which are implicated in the maintenance of sternness, chemo- and radioresistance in BCSCs, are identified and presented. Our findings could provide the foundation for the design of targeted chemo- or radiotherapeutic regimens in order to eliminate or sensitize BCSCs to cytotoxic therapies and prevent tumor relapse and metastasis. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据