期刊
CANCER LETTERS
卷 379, 期 2, 页码 191-197出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2015.07.018
关键词
Hepatocellular carcinoma; Intrahepatic cholangiocarcinoma; Heterogeneity; Personalized therapy
类别
资金
- State Key Project For Liver Cancer [2012ZX10002-009]
- National Research Program of China [2012CB316503, 2012AA02A201]
- National Natural Science Foundation of China [81221061, 81422032, 81272212, 81300306, 81372674]
- Science Foundation of Shanghai [134119a3700]
Liver cancer is an extraordinarily heterogeneous malignant disease among the tumors that have so far been identified. Hepatocellular carcinoma (HCC) arises most frequently in the setting of chronic liver inflammation and fibrosis, and takes a variety of course in individual patients to process to tumor. The risk factors such as HBV and/or HCV infections, aflatoxin infection, abuse alcohol intake, metabolic syndrome, obesity and diabetes are closely related to the environmental and genetic susceptibilities to HCC. The consequent resulting genomic instability, molecular and signal transduction network disorders and microenvironmental discrepancies are characterized by the extraordinary heterogeneity of liver cancer. The histology-based definition of the morphological heterogeneity of liver cancer has been modified and refined to treat patients with targeted therapies, but this still cannot solve all the problems. Lack of consistent outcome for anticancer agents and conventional therapies in liver cancer treatment calls for assessing the benefits of new molecularly targeted drugs and combined therapy, under the heterogeneity condition of tumor. The present review article will provide the complex mechanism and phenotype of liver cancer heterogeneity, and help us to execute precision medicine in a really personalized manner. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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