Article
Biochemistry & Molecular Biology
Linda Droessler, Valeria Cornelius, Alexander G. Markov, Salah Amasheh
Summary: The study demonstrates the detrimental effects of TNFα on non-transformed intestinal epithelial cells, leading to barrier dysfunction. This is achieved through modulation of tight junction proteins and TNF receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Yuansen Li, Deshenyue Kong, Ke Bi, Huayou Luo
Summary: Methamphetamine abuse can impair the intestinal barrier and lead to severe digestive diseases. The gut microbiota play a role in this process through the gut-brain axis.
FRONTIERS IN MEDICINE
(2022)
Article
Food Science & Technology
Yunika Mayangsari, Mayu Okudaira, Chinatsu Mano, Yuki Tanaka, Osamu Ueda, Tomohiro Sakuta, Yoshiharu Suzuki, Yoshinari Yamamoto, Takuya Suzuki
Summary: Research showed that DMF can enhance intestinal TJ barrier integrity by increasing the expression of occludin and claudin-1, while reducing the expression of claudin-2. This regulation involves the induction of occludin protein translation via mTOR and silencing Cldn2 mRNA via miR-16-5p.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Environmental Sciences
Andong Zha, Ruiqi Tu, Ming Qi, Jing Wang, Bie Tan, Peng Liao, Chenchen Wu, Yulong Yin
Summary: The study showed that dietary supplementation of MOSS had beneficial effects on ETEC-induced diarrhea in weaned piglets, increasing growth performance, reducing diarrhea incidence, and regulating intestinal microbiota composition. MOSS also decreased inflammation and oxidative stress, and improved intestinal barrier function.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Immunology
Yingman Liu, Wenxuan Huang, Jiaqi Wang, Jiaojiao Ma, Manman Zhang, Xiaoying Lu, Jie Liu, Yurong Kou
Summary: Periodontal disease, considered a common inflammatory disease, is believed to contribute to the development of gastrointestinal diseases and other systemic diseases by affecting the intestinal barrier through periodontal pathogens. This review summarizes studies on the effects of periodontal pathogens on the intestinal barrier, potentially shedding light on the link between periodontitis and gastrointestinal diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Susrutha Puthanmadhom Narayanan, Daniel R. O'Brien, Mayank Sharma, Thomas C. Smyrk, Rondell P. Graham, Madhusudan Grover, Adil E. Bharucha
Summary: In patients with functional dyspepsia (FD), there is a modest reduction in the expression of several duodenal epithelial barrier proteins, possibly due to the up-regulation of regulatory miRNAs, along with increased small intestinal permeability measured in vivo.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Veterinary Sciences
Ruibiao Wang, Yuheng Zhang, Jingbo Zhen, Jinpeng Zhang, Zixuan Pang, Xuewei Song, Lihao Lin, Feng Sun, Yixin Lu
Summary: This study explored the effect of exosomes derived from Trichinella spiralis infective larvae (TsExos) on the barrier function of porcine small intestinal epithelial cells (IPEC-J2). The results showed that TsExos ingestion decreased cell viability, increased FITC-dextran content, lactate dehydrogenase and reactive oxygen species levels. TsExos also induced apoptosis, nuclear pyknosis, and nuclear rupture. In addition, TsExos disrupted tight junctions and altered gene expression.
VETERINARY RESEARCH
(2022)
Article
Food Science & Technology
Sefat E. Khuda, Ann V. Nguyen, Girdhari M. Sharma, Mohammad S. Alam, Kannan V. Balan, Kristina M. Williams
Summary: This study found that polysorbate-80 may enhance the absorption of allergens in a size-dependent manner by modulating paracellular permeability.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Medicine, Research & Experimental
Haishan Wu, Rong Huang, Jinjin Fan, Ning Luo, Xiao Yang
Summary: Low potassium diet may increase intestinal permeability, leading to bacterial translocation, suspected to be due to impaired intestinal epithelial barrier and biological barrier.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Jingru Guo, Jing Xu, Leichong Chen, Zhuo Chen, Huijie Hu, Junshu Nie, Jianbin Yuan, Li Ma, Jingjing Lu, Hong Ji, Bin Xu
Summary: This study revealed that chronic cold exposure damages the ileal epithelial barrier and induces endoplasmic reticulum stress. Knockout of SIRT2 alleviates ileal injury via enhanced autophagy. Autophagy can restore the expression of ZO-1 under stress.
Article
Biochemistry & Molecular Biology
Ya-Nan Gao, Song-Li Li, Xue Yang, Jia-Qi Wang, Nan Zheng
Summary: The study found that lactoferrin (LF) can reduce the increased intestinal permeability caused by aflatoxin M1 (AFM1) and repair the damaged intestinal barrier. In addition, the research revealed that LF acts through regulating multiple pathways related to intestinal cell survival and intestinal integrity. These findings suggest that LF may be a potential option for treating compromised intestinal barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Luz del Carmen Martinez-Sanchez, Phuong Anh Ngo, Rashmita Pradhan, Lukas-Sebastian Becker, David Boehringer, Despina Soteriou, Marketa Kubankova, Christine Schweitzer, Tatyana Koch, Veronika Thonn, Lena Erkert, Iris Stolzer, Claudia Guenther, Christoph Becker, Benno Weigmann, Monika Klewer, Christoph Daniel, Kerstin Amann, Stefan Tenzer, Raja Atreya, Martin Bergo, Cord Brakebusch, Alastair J. M. Watson, Jochen Guck, Ben Fabry, Imke Atreya, Markus F. Neurath, Rocio Lopez-Posadas
Summary: Abnormal cell shedding is associated with intestinal barrier dysfunction and inflammatory bowel diseases. Deletion of PGGTase and RAC1 in intestinal epithelial cells leads to cell overcrowding and epithelial leakage, resulting in chronic intestinal inflammation. RAC1 plays a crucial role in regulating cytoskeletal dynamics, cell mechanics, and intestinal cell shedding.
Article
Engineering, Environmental
Yuan Cui, Qianqian Xiao, Zhenyu Wang, Qiong Zhang, Yuetong Liu, Weidong Hao, Jianjun Jiang, Qinghe Meng, Xuetao Wei
Summary: The study found that the novel brominated flame retardant BTBPE causes damage to the intestine by activating the IRX3/NOS2 axis, leading to necroptosis and disruption of tight junctions. Blocking the IRX3/NOS2 axis can inhibit necroptosis and restore tight junctions. Additionally, BTBPE exposure also induces inflammation and loss of the mucous layer in the intestine.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Review
Gastroenterology & Hepatology
Sweta Ghosh, Caleb Samuel Whitley, Bodduluri Haribabu, Venkatakrishna Rao Jala
Summary: This review discusses the recent advances in understanding the role of gut microbial metabolites in regulating intestinal barrier function. While the mechanisms of action of these metabolites are still being explored, they likely impact gut barrier function through shared pathways. Utilizing beneficial microbiota and their metabolites to restore pathophysiological balance may prove to be a valuable therapeutic tool amidst advancing technology and expanding knowledge.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Plant Sciences
Lujia Yang, Qian Zhang, Jieyao Huang, Danning Liu, Yunfei Lan, Lujiang Yuan, Qianfeng Chen
Summary: The study demonstrated the therapeutic effect of Xianglian Pill on antibiotic-associated diarrhea, improving the condition by promoting the recovery of intestinal microbiota and attenuating mucosal damage.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Psychiatry
Qingyang Li, Lingli Zhang, Haidi Shan, Juehua Yu, Yuan Dai, Hua He, Wei-Guang Li, Christelle Langley, Barbara J. Sahakian, Yin Yao, Qiang Luo, Fei Li
Summary: This study found that cytokine measurements can help identify possible responders to bumetanide in children with ASD, suggesting that immune responses may interact with the mechanism of action of bumetanide to enhance GABA function in ASD.
TRANSLATIONAL PSYCHIATRY
(2022)