Article
Chemistry, Multidisciplinary
Yildiz Bal, Yusuf Surmeli, Gulsah Sanli-Mohamed
Summary: Alginate microcapsules loaded with olive leaf extract (OLE) were immobilized using calcium alginate (CA) and chitosan-coated CA (CCA) in this study. The loading capacity of OLE-CA and OLE-CCA was found to be 80% and 99%, respectively. Cytotoxicity analysis showed that OLE-CA and OLE-CCA exhibited higher cytotoxic effects against A549 and MCF-7 cells compared to free OLE. Optical microscopy images confirmed the greater effectiveness of OLE microcapsules against these cancer cells.
Article
Pharmacology & Pharmacy
Alexander Chota, Blassan P. George, Heidi Abrahamse
Summary: This study investigated the effects of Dicoma anomala methanol root extract on breast cancer cells and found that it decreased cell viability and increased apoptosis. When combined with photodynamic therapy, the effects were more significant.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Katherine Junkins, Margaret Rodgers, Shelley A. Phelan
Summary: This study found that oleuropein showed cytotoxicity in MCF-7 human breast cancer cells but had no effect on MCF-10A breast epithelial cells. Furthermore, oleuropein significantly increased the expression of peroxiredoxins in MCF-7 cells. These results suggest that oleuropein has cancer-specific cytotoxicity and may exert its effects through the regulation of peroxiredoxins.
ANTICANCER RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Eric Chekwube Aniogo, Blassan P. George, Heidi Abrahamse
Summary: Breast cancer is a severe global threat to health, and chemotherapy often faces the setback of tumor relapse and resistance. Photodynamic therapy shows promise as a treatment modality, but the emergence of resistant cell populations in breast cancer patients is a challenge. Studying resistant cells can provide insights into designing more effective treatment strategies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Balaji Babu, John Mack, Tebello Nyokong
Summary: A new Sn(IV) tetraarylchlorin with thien-2-yl substituents (SnC) has been synthesized and characterized, showing high Phi(Delta) value and promising photodynamic activity against MCF-7 breast cancer cells. These results suggest that Sn(IV) tetraarylchlorins like SnC are suitable candidates for further photodynamic therapy studies.
DALTON TRANSACTIONS
(2021)
Article
Multidisciplinary Sciences
Ola E. E. Abdel-Sattar, Rasha Mosa Allam, Ahmed M. M. Al-Abd, Bharathi Avula, Kumar Katragunta, Ikhlas A. A. Khan, Ahmed M. M. El-Desoky, Shanaz O. O. Mohamed, Ali El-Halawany, Essam Abdel-Sattar, Meselhy R. R. Meselhy
Summary: The genus Phyllanthus has potential in the treatment of various diseases, and its extracts showed cytotoxicity against breast cancer cells. The methylene chloride fraction exhibited the strongest cytotoxic activity among all tested fractions.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Naushad Ahmad, Suliman Yousef Alomar, Fadwa Albalawi, Mohammad Rizwan Khan, Nida Nayyar Farshori, Rizwan Wahab, Mohammed Rafi Shaik
Summary: In this study, magnetic nanoparticles of cobalt ferrite (CF-NPs) and magnesium-cobalt ferrite (MCF-NPs) were synthesized and characterized. The CF-NPs showed higher cytotoxicity and reactive oxygen species generation compared to MCF-NPs in breast cancer cells. These findings suggest that ferrites may be a promising model for cancer treatments.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Aml I. Mekkawy, Nermin E. Eleraky, Ghareb M. Soliman, Mohamed G. Elnaggar, Marwa G. Elnaggar
Summary: Breast cancer, the most common cancer in women in developed regions, can be controlled by estrogen inhibition. However, drug resistance limits the effectiveness of this treatment. In this study, a novel drug delivery system for combination therapy was developed, which showed superior cytotoxicity and ROS production compared to individual treatments.
Article
Biochemistry & Molecular Biology
Carolina Alonso-Gonzalez, Cristina Gonzalez-Abalde, Javier Menendez-Menendez, Alicia Gonzalez-Gonzalez, Virginia Alvarez-Garcia, Alicia Gonzalez-Cabeza, Carlos Martinez-Campa, Samuel Cos
Summary: Radiation therapy is a crucial part of cancer treatment, but it has adverse effects. Melatonin, as an adjuvant molecule, can limit damage to normal tissues and enhance the efficacy of radiation therapy in breast cancer. This study revealed that melatonin can potentiate the anti-proliferative effect of radiation, modulate gene and microRNA expression, and enhance the inhibition of cancer growth. Melatonin shows promise as both a radiosensitizer and radioprotector in breast cancer treatment.
Article
Pharmacology & Pharmacy
Dimakatso Mokoena, Blassan P. George, Heidi Abrahamse
Summary: Breast cancer, a common and treatment-resistant cancer, can be effectively treated using photodynamic therapy with the aid of gold nanoparticles. This study demonstrates the successful adsorption of a photosensitizer onto gold nanoparticles and its application in inducing apoptosis in MCF-7 breast cancer cells in vitro.
Article
Polymer Science
Nabil A. Alhakamy, Usama A. Fahmy, Shaimaa M. Badr Eldin, Osama A. A. Ahmed, Hibah M. Aldawsari, Solomon Z. Okbazghi, Mohamed A. Alfaleh, Wesam H. Abdulaal, Abdulmohsin J. Alamoudi, Fatma M. Mady
Summary: This study demonstrates that incorporating quercetin, scorpion venom peptides, and Phospholipon(R) 90H into a nano-based delivery platform improves the cellular uptake and antiproliferative efficacy of quercetin, showing potential as a therapeutic approach for the treatment of breast cancer.
Article
Medicine, Research & Experimental
Hosny A. Ibrahim, Abd El-Alim F. Abd El-Alim, Mai Abd El-Hafeez, Mohamed M. M. Metwally, Tarek Khamis, Azza A. A. Galal
Summary: This study investigated the effects of baicalein (BAI) on enhancing the anticancer potential of capecitabine (CAP) in MCF-7 cells and its protective effect against CAP-induced cardiotoxicity in female Wistar rats. In vitro experiments showed that co-treatment of BAI with CAP significantly reduced cell viability, improved cytotoxicity, altered cell cycle progression, and affected the expression of BAX and Bcl2 genes. In vivo experiments revealed that CAP administration elevated cardiac markers and inflammatory cytokines, while reducing antioxidant capacity and causing cardiac tissue alterations. Simultaneous administration of BAI and CAP improved these alterations and modulated related pathways.
Article
Chemistry, Medicinal
Katarzyna Biezunska-Kusiak, Julita Kulbacka, Anna Choromanska, Nina Rembialkowska, Olga Michel, Jolanta Saczko
Summary: Breast cancer is one of the most common malignant neoplasms in Poland. The use of calcium ion-assisted electroporation has been proven effective in recent studies. This research aimed to investigate the antitumor effects of electroporation and calcium ion-assisted electroporation on human mammary adenocarcinoma cells. The obtained results confirmed the effectiveness of the investigated therapeutic method, providing a basis for further in vivo research and the development of a more effective and safer treatment for breast cancer patients.
Article
Multidisciplinary Sciences
Ovgu Isbilen, Ender Volkan
Summary: Ethanolic extracts of Allium willeanum Holmboe showed significant cytotoxic and apoptotic activities on both MCF-7 and MDA-MB-231 breast cancer cell lines in vitro, with a more pronounced effect on highly metastatic breast cancer cells.
Article
Biochemistry & Molecular Biology
Wenqian Yang, Yuan Jiang, Qulian Guo, Zhixin Tian, Zhigang Cheng
Summary: Neu5Gc is an aberrant molecule in humans due to the lack of a converting enzyme. It has been observed in human cancer cells and tissues and can cause obstacles in clinical treatments. Therefore, studying Neu5Gc in humans is important for pathology and clinical relevance.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Editorial Material
Chemistry, Multidisciplinary
Magdalena Gorska-Ponikowska, Francesco Cappello
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Tomasz Kostrzewa, Jakub Jonczyk, Joanna Drzezdzon, Dagmara Jacewicz, Magdalena Gorska-Ponikowska, Marcin Kolaczkowski, Alicja Kuban-Jankowska
Summary: One of the main goals of recent bioinorganic chemistry studies is to develop new substances for treating human diseases. This study focuses on the potential anticancer activity of vanadium-based compounds, specifically their inhibitory effect on PTP1B. The researchers synthesized five complexes and observed that they effectively inhibited PTP1B and exhibited anticancer activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Milena Kotewicz, Miroslawa Krauze-Baranowska, Agnieszka Daca, Agata Ploska, Sylwia Godlewska, Leszek Kalinowski, Barbara Lewko
Summary: Urolithins are bioactive compounds generated in human and animal intestines through bacterial metabolism. They have various effects and potential therapeutic applications. This study evaluated the effects of urolithins on mouse podocytes, with a focus on their potential use in improving podocyte function in diabetes. The results showed that urolithin A (UA) improved podocyte viability and reduced reactive oxygen species levels more effectively than urolithin B (UB), particularly in high glucose conditions. UA also upregulated nephrin expression and enhanced nephrin internalization. These findings suggest that UA could be a promising therapeutic candidate for diabetic podocytopathy.
Article
Computer Science, Software Engineering
Domenico Amato, Giosue Lo Bosco, Raffaele Giancarlo
Summary: Learned Indexes use a model to restrict the search range of a sorted table, and using the SOSD benchmarking software, this study demonstrates that k-ary search is more efficient in certain computer architectures. This research provides guidelines for selecting the search routine within the learned indexing framework.
SOFTWARE-PRACTICE & EXPERIENCE
(2023)
Article
Biochemistry & Molecular Biology
Claudia Musial, Narcyz Knap, Renata Zaucha, Paulina Bastian, Giampaolo Barone, Giosue Lo Bosco, Fabrizio Lo-Celso, Lucyna Konieczna, Mariusz Belka, Tomasz Baczek, Antonella Marino Gammazza, Alicja Kuban-Jankowska, Francesco Cappello, Stephan Nussberger, Magdalena Gorska-Ponikowska
Summary: Research shows that 2-ME can inhibit the growth of lung cancer cells and increase protein palmitoylation and oxidative stress phenomena. Through metabolomics analysis of blood serum, 2-ME can be used as a selective tumor biomarker in specific types of lung cancer. In addition, computational analysis suggests that 2-ME has relatively safe bioactivity in healthy human cells.
Article
Biochemistry & Molecular Biology
Paulina Emilia Bastian, Agnieszka Daca, Agata Ploska, Alicja Kuban-Jankowska, Leszek Kalinowski, Magdalena Gorska-Ponikowska
Summary: Gliomas are the most common primary tumors of the central nervous system, and glioblastoma is the most prevalent form of malignant glioma. 2-ME has been found to induce nitro-oxidative stress and modulate heat shock proteins, making it a potential candidate for GBM therapy.
Article
Biochemistry & Molecular Biology
Federica Scalia, Giosue Lo Bosco, Letizia Paladino, Alessandra Maria Vitale, Leila Noori, Everly Conway de Macario, Alberto J. L. Macario, Fabio Bucchieri, Francesco Cappello, Fabrizio Lo Celso
Summary: Mutations in genes encoding molecular chaperones, such as the CCT genes, have been linked to rare neurodegenerative disorders. This study investigated the impact of two specific mutations in the CCT5 gene on conformational changes and physicochemical properties. The findings suggest that these mutations alter the protein-binding capacity of the CCT5 variants, potentially affecting both hetero- and/or homo-oligomeric complexes. Further research is needed to understand the molecular mechanisms underlying the distinct phenotypes caused by these mutations, and to explore the prevalence of CCT chaperonopathies in patients with neuropathies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Alicja Kuban-Jankowska, Tomasz Kostrzewa, Magdalena Gorska-Ponikowska
Summary: This review focuses on the role of bacterial protein tyrosine phosphatases (PTPs) as virulence factors and explores the potential of inhibiting these enzymes to combat bacterial infections. This has important implications for the design of antimicrobial adjuvant therapy.
Article
Nanoscience & Nanotechnology
Tomasz Kostrzewa, Izabela Nowak, Agnieszka Feliczak-Guzik, Joanna Drzezdzon, Dagmara Jacewicz, Magdalena Gorska-Ponikowska, Alicja Kuban-Jankowska
Summary: Solid lipid nanoparticles (SLN) have shown promising potential as a drug delivery system for the treatment of various human diseases, including cancers. Encapsulation of two compounds into SLNs increased their cytotoxicity against MDA-MB-231 breast cancer cell line and enhanced the effect of vincristine.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Klaudia Ciesielska-Figlon, Karolina Wojciechowicz, Agnieszka Daca, Adam Kokotkiewicz, Maria Luczkiewicz, Jacek Maciej Witkowski, Katarzyna Aleksandra Lisowska
Summary: The study examines the effects of black seed oil on T cells in patients with Hashimoto's thyroiditis (HT). The results show that black seed oil can inhibit the proliferation of CD4(+) and CD8(+) T cells and induce cell death in HT patients and healthy women. It also reduces the concentration of certain cytokines.
Article
Biochemistry & Molecular Biology
Agnieszka Daca, Hanna Storoniak, Alicja Debska-Slizien, Mariusz Andrzej Kusztal, Magdalena Krajewska, Katarzyna Aleksandra Lisowska
Summary: Levels of IL-6, IL-8, IL-10, TNF, and MIG were significantly higher in the serum of AAV patients compared to healthy controls, while IL-1 beta levels were higher in healthy volunteers. Levels of IL-6, IL-10, IP-10, and MIG negatively correlated with eGFR levels, while IFN-alpha levels positively correlated with PR3-ANCA titre. Studying the association between these cytokines/chemokines levels and clinical symptoms of AAV may aid in diagnosis and predicting disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Paulina Bastian, Lucyna Konieczna, Jaroslaw Dulski, Agnieszka Daca, Dagmara Jacewicz, Agata Ploska, Narcyz Knap, Jaroslaw Slawek, Tomasz Baczek, Leszek Kalinowski, Joanna Drzezdzon, Anna Roszmann, Mariusz Belka, Magdalena Gorska-Ponikowska
Summary: 2-ME2, a metabolite of 17-β-estradiol, has anticancer effects, but may promote neurodegenerative diseases like Parkinson's disease in the central nervous system. It generates nitro-oxidative stress, controls heat shock proteins, and leads to DNA strand breakage and apoptosis. Plasma levels of methoxyestrogens and hydrogen peroxide may serve as novel biomarkers for Parkinson's disease.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Tomasz Jarzembowski, Agnieszka Daca, Wieslaw J. Cubala, Marek Bronk, Lukasz Naumiuk
Summary: This study evaluated the in vitro effects of low concentration ketamine on enterococci proliferation and their interactions with monocytes. The results showed that in the early stage of culture, 57.7% of enterococci strains had enhanced proliferation rate and metabolic activity when exposed to ketamine. These strains were also less susceptible to phagocytosis compared to cultures without ketamine. The response of isolates to ketamine was also evident in changes of protein profiles determined by MALDI-TOF.
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ
(2022)
Article
Biochemistry & Molecular Biology
Claudia Musial, Narcyz Knap, Renata Zaucha, Paulina Bastian, Giampaolo Barone, Giosue Lo Bosco, Fabrizio Lo-Celso, Lucyna Konieczna, Mariusz Belka, Tomasz Baczek, Antonella Marino Gammazza, Alicja Kuban-Jankowska, Francesco Cappello, Stephan Nussberger, Magdalena Gorska-Ponikowska
Summary: 2-Methoxyestradiol (2-ME) as an inhibitor for non-small cell lung cancer cells may serve as a potential therapeutic approach, reducing cell viability, promoting protein palmitoylation and oxidative stress, and showing relative safety in healthy human cells compared to other estrogen metabolism intermediates.
Article
Toxicology
Kathryn Page, Walter Westerink, Kristie Sullivan, Thomas McDonald, Clive Roper
Summary: This study developed a new method to assess the skin irritation of antimicrobial cleaning products. The method utilized a more human-like model and demonstrated its effectiveness through comparison with in vivo rabbit skin irritation data.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Arupam Patra, Thirukumaran Kandasamy, Siddhartha Sankar Ghosh, Gurvinder Kaur Saini
Summary: This study successfully produced recombinant anisoplin and demonstrated its significant anti-cancer effect and ability to induce apoptosis in breast cancer cells. The activation of related signaling pathways may be the key to cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Thomas Haller, Alexander Jesacher, Alberto Hidalgo, Christina Schmidt
Summary: This study used live cell imaging to observe the accumulation of amiodarone in primary rat alveolar type II cells, and found that it specifically accumulates in lamellar bodies. The uptake is rapid, while storage is persistent. The main mechanisms for intracellular bioaccumulation of amiodarone are proposed to be passive diffusion, ion-trapping, and lipophilic interactions.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Filiz Bakar-Ates, Erva Ozkan
Summary: This study investigated the ferroptotic effect of CuB in breast cancer cells and evaluated its combination with erastin, a ferroptosis inducer. The results showed that the combination treatment significantly activated the ferroptotic pathways and altered the expression of iron-related proteins in breast cancer cells.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Rachel Z. Bennie, Ian C. Shaw
Summary: Estrogen mimics are synthetic and naturally occurring compounds that can interact with estrogen receptors in animals. In vitro transactivation reporter gene assay and in silico molecular modelling can be used to predict the mimicry of these compounds, reducing reliance on animal studies.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Sevda Isik, Semra Cicek
Summary: This study found that high doses of riboflavin can cause cytotoxicity in rainbow trout gonad cells and affect the transcriptional expressions of antioxidant enzymes and growth and reproductive genes, potentially leading to DNA damage and cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Ying Wang, Jie Wu, Mengqi Wan, Dou Yang, Fasheng Liu, Kehao Li, Manxin Hu, Yuanyuan Tang, Huiqiang Lu, Shouhua Zhang, Yuanzhen Xiong
Summary: m-Cresol is commonly used as an intermediate for pesticides and other industrial applications. This study investigated the hepatotoxicity of m-cresol using zebrafish larvae and explored its molecular mechanisms. The results suggest that m-cresol may induce liver damage in zebrafish larvae through oxidative stress and cell apoptosis pathways.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Vincent J. Manna, Shannon Dwyer, Vanessa Pizutelli, Salvatore J. Caradonna
Summary: The widespread use of electronic cigarettes and the emergence of a new illness have raised concerns about the effects of e-cigarette vapor on respiratory tissues. Researchers have developed a simple device to mimic the response of human airway tissue after long-term exposure to e-cigarette vapor, and have identified differences in the effects of different vapor compositions on airway tissue.
TOXICOLOGY IN VITRO
(2024)
