Article
Multidisciplinary Sciences
Pauline Bourigault, Michael Skwarski, Ruth E. Macpherson, Geoff S. Higgins, Daniel R. McGowan
Summary: This study investigated the correlation between 2-hour and 4-hour post-injection FMISO-PET imaging in NSCLC patients and found that imaging at 4 hours after injection provided better results. There was a strong correlation between the results of the 2-hour and 4-hour scans in overall tumors, but the correlation decreased from the center to the edge in tumor subregions.
SCIENTIFIC REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jasper Smit, Frank J. Borm, Anna-Larissa N. Niemeijer, Marc C. Huisman, Otto S. Hoekstra, Ronald Boellaard, Daniela E. Oprea-Lager, Danielle J. Vugts, Guus A. M. S. van Dongen, Berlinda J. de Wit-van der Veen, Erik Thunnissen, Egbert F. Smit, Adrianus J. de Langen
Summary: Zr-89-durvalumab is safe and may provide a better way to assess tumor PD-L1 expression in NSCLC patients treated with immunotherapy. However, further research is needed to validate its utility.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Letter
Medicine, General & Internal
Hollis Viray, Deepa Rangachari, Daniel B. Costa
Summary: The study reported initial data of trastuzumab deruxtecan in the treatment of lung cancers with ERBB2 mutations, including patients who had previously received ineffective ERBB2 tyrosine kinase inhibitors.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yong Han, Yuan Ma, Zhiyuan Wu, Feng Zhang, Deqiang Zheng, Xiangtong Liu, Lixin Tao, Zhigang Liang, Zhi Yang, Xia Li, Jian Huang, Xiuhua Guo
Summary: This study evaluated the capability of PET/CT images for differentiating histologic subtypes of NSCLC and identified the optimal model from radiomics-based machine learning/deep learning algorithms. Linear discriminant analysis and support vector machine coupled with feature selection method achieved optimal performance for the classification of ADC and SCC. The VGG16 deep learning algorithm outperformed conventional machine learning methods in combination with radiomics for the differential diagnosis of NSCLC subtypes.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Oncology
Giuseppe Giaccone, Yongfeng He
Summary: Lung cancer is the leading cause of cancer related death, with two major histological subtypes, NSCLC and SCLC. Transformation from NSCLC to SCLC can cause treatment resistance, potentially due to therapy-induced changes or clonal selection. This article discusses the potential mechanisms, cell of origin, and genomic alterations in both de novo and transformed SCLC, as well as treatment options including chemotherapy, radiotherapy, TKIs, immunotherapy, and antiangiogenic agents.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Engineering, Biomedical
Mathieu Gaudreault, James Korte, Nicholas Bucknell, Price Jackson, Pitchaya Sakyanun, Lachlan McIntosh, Beverley Woon, James P. Buteau, Michael S. Hofman, Tony Mulcahy, Tomas Kron, Shankar Siva, Nicholas Hardcastle
Summary: This study aims to determine the correlation between PBV determined from DECT and PET in the context of FLA radiotherapy. The results showed a strong correlation between DECT and PET determination of PBV, but there may be some factors that affect the correlation in the posterior region.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Oncology
Layla Mathieson, Richard A. O'Connor, Hazel Stewart, Paige Shaw, Kevin Dhaliwal, Gareth O. S. Williams, Alicia Megia-Fernandez, Ahsan R. Akram
Summary: Fibroblast activation protein (FAP) is upregulated in various solid organ malignancies and chronic inflammatory conditions. Optical imaging using a FAP-specific chemical probe can provide valuable information for disease monitoring and prognostication. This study describes the development of a FAP optical reporter sequence that retains FAP specificity and resistance to degradation.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Coline Le Meur, Luca Campedel, Dris Kharroubi, Karim Amrane
Summary: This study presents a rare case of relapsed non-small cell lung cancer with pituitary metastasis in a 75-year-old woman. Pituitary metastasis is uncommon, accounting for only approximately 2% of malignant metastases. F-18-FDG PET and cerebral MRI were used to guide the therapeutic strategy due to an atypical pituitary high FDG avidity.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Medicine, General & Internal
John V. Heymach, David Harpole, Tetsuya Mitsudomi, Janis M. Taube, Gabriella Galffy, Maximilian Hochmair, Thomas Winder, Ruslan Zukov, Gabriel Garbaos, Shugeng Gao, Hiroaki Kuroda, Gyula Ostoros, Tho V. Tran, Jian You, Kang-Yun Lee, Lorenzo Antonuzzo, Zsolt Papai-Szekely, Hiroaki Akamatsu, Bivas Biswas, Alexander Spira, Jeffrey Crawford, Ha T. Le, Mike Aperghis, Gary J. Doherty, Helen Mann, Tamer M. Fouad, Martin Reck, AEGEAN Invest
Summary: In resectable non-small-cell lung cancer patients, perioperative durvalumab plus neoadjuvant chemotherapy showed significantly improved event-free survival and pathological complete response compared to neoadjuvant chemotherapy alone, with a similar safety profile.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Isa Mambetsariev, Leonidas Arvanitis, Jeremy Fricke, Rebecca Pharaon, Angel R. Baroz, Michelle Afkhami, Marianna Koczywas, Erminia Massarelli, Ravi Salgia
Summary: EGFR-mutated lung adenocarcinoma patients can transform into SCLC after receiving TKI therapy. This study evaluated 9 patients who underwent such transformation and found that they had unique clinical, molecular, and histological characteristics at different time points. The findings are important for understanding the molecular heterogeneity and clinical outcomes of this EGFR TKI resistance subtype.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Qiao Hu, Wanjie Zhu, Jianjun Du, Saran Long, Wen Sun, Jiangli Fan, Xiaojun Peng
Summary: A near-infrared fluorescent probe ENBO-ML210 was developed for targeting and visualizing overexpressed glutathione peroxidase 4 (GPX4) in non-small cell lung cancer (H1299) cells. In vitro and in vivo imaging results demonstrated its potential for the diagnosis of non-small lung cancer.
CHEMICAL COMMUNICATIONS
(2023)
Review
Medicine, General & Internal
Yimin Wang, Chuling Li, Zimu Wang, Zhaofeng Wang, Ranpu Wu, Ying Wu, Yong Song, Hongbing Liu
Summary: This systematic review evaluated the efficacy and safety of immunotherapy in early and late lung cancer, finding that immunotherapy has better efficacy in early lung cancer compared to advanced lung cancer, especially when combined with chemotherapy. In terms of safety, immunotherapy, either alone or in combination with other therapies, was found to be safer in early lung cancer than in advanced lung cancer.
Article
Multidisciplinary Sciences
Nathan Farrokhian, Jeff Maltas, Mina Dinh, Arda Durmaz, Patrick Ellsworth, Masahiro Hitomi, Erin McClure, Andriy Marusyk, Artem Kaznatcheev, Jacob G. Scott
Summary: In this study, the frequency-dependent interactions between a gefitinib-resistant non-small cell lung cancer population and its sensitive ancestor were measured experimentally. The cost of resistance was found to be insufficient in predicting competitive exclusion, and frequency-dependent growth rate measurements were necessary. Simulations showed that ecological growth effects can influence the predicted extinction time.
Article
Radiology, Nuclear Medicine & Medical Imaging
Y. Yang, Z. Xie, H. Hu, G. Yang, X. Zhu, D. Yang, Z. Niu, G. Mao, M. Shao, J. Wang
Summary: This study aims to investigate the diagnostic performance of different models based on CT imaging features in differentiating the invasiveness of NSCLC with multiple pleural contact types. By analyzing the clinical and pathological data, as well as preoperative imaging features, it was found that surgical history, tumor marker, number of pleural tags, length of solid contact, and obstructive inflammation were independent risk predictors of pleural invasiveness. The image feature model showed great potential in predicting pleural invasiveness and had comparable diagnostic efficacy compared with the combined model containing clinical data.
CLINICAL RADIOLOGY
(2023)
Review
Oncology
Alisa N. Blumenthaler, Mara B. Antonoff
Summary: Around half of NSCLC patients have metastatic disease at diagnosis, some with limited metastatic sites termed oligometastasis. Aggressive treatment of oligometastasis has shown improved survival rates, but the lack of a universal definition hinders comparison between studies.
Review
Public, Environmental & Occupational Health
Anas Almatrafi, Owen Thomas, Matthew Callister, Rhian Gabe, Rebecca J. Beeken, Richard Neal
Summary: The burden of comorbidity in lung cancer screening populations is not fully understood. This review found that comorbidities were highly prevalent in lung cancer screening candidates, with higher prevalence compared to other cancer screening programs.
JOURNAL OF MEDICAL SCREENING
(2023)
Article
Critical Care Medicine
Jonathan R. Weir-McCall, Elise Debruyn, Scott Harris, Nagmi R. Qureshi, Robert C. Rintoul, Fergus Gleeson, Fiona J. Gilbert
Summary: A lung cancer prediction convolutional neural network (LCP-CNN) demonstrates diagnostic performance comparable to PET with CT imaging in the diagnosis of solitary pulmonary nodules. The LCP-CNN outperforms dynamic contrast-enhanced (DCE) CT imaging in accuracy, while being equal to PET with CT imaging.
Article
Respiratory System
Torsten Gerriet Blum, Rebecca L. Morgan, Valerie Durieux, Joanna Chorostowska-Wynimko, David R. Baldwin, Jeanette Boyd, Corinne Faivre-Finn, Francoise Galateau-Salle, Fernando Gamarra, Bogdan Grigoriu, Georgia Hardavella, Michael Hauptmann, Erik Jakobsen, Dragana Jovanovic, Paul Knaut, Gilbert Massard, John McPhelim, Anne-Pascale Meert, Robert Milroy, Riccardo Muhr, Luciano Mutti, Marianne Paesmans, Pippa Powell, Paul Martin Putora, Janette Rawlinson, Anna L. Rich, David Rigau, Dirk de Ruysscher, Jean-Paul Sculier, Arnaud Schepereel, Dragan Subotic, Paul Van Schil, Thomy Tonia, Clare Williams, Thierry Berghmans
Summary: This guideline provides good quality recommendations in lung cancer care, based on systematic reviews and evidence syntheses. The recommendations cover various quality improvement measures, such as avoiding delays in diagnosis and treatment, integrating multidisciplinary teams, adhering to guidelines, and using specific tools for decision-making. The recommendations should be periodically updated as new evidence becomes available.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Medicine, General & Internal
Scott J. Adams, Emily Stone, David R. Baldwin, Rozemarijn Vliegenthart, Pyng Lee, Florian J. Fintelmann
Summary: Randomised controlled trials have shown that low-dose CT lung cancer screening reduces mortality compared with chest radiography or no screening. However, uncertainties remain about optimizing clinical and cost effectiveness. This Review provides an international perspective on lung cancer screening, covering clinical trials, identification of individuals who benefit, management of screen-detected findings, smoking cessation interventions, cost-effectiveness, artificial intelligence and biomarkers, and challenges and opportunities in implementation.
Article
Respiratory System
Claire Bradley, Alison Boland, Louisa Clarke, Naomi Dallinson, Claire Eckert, Deborah Ellames, Jonathan Finn, Rhian Gabe, Neil Hancock, Martyn P. T. Kennedy, Jason Lindop, Ayad Mohamed, Gabriel Mullen, Rachael L. Murray, Suzanne Rogerson, Bethany Shinkins, Irene Simmonds, Sara Upperton, Anne Wilkinson, Philip A. Crosbie, Matthew E. J. Callister
Summary: Incorporating spirometry into LDCT screening for lung cancer may help identify individuals with undiagnosed COPD, but the downstream impacts are not well described.
Editorial Material
Critical Care Medicine
Philip A. J. Crosbie, Matthew E. J. Callister
LANCET RESPIRATORY MEDICINE
(2023)
Article
Critical Care Medicine
Weiqi Liao, Carol A. C. Coupland, Judith Burchardt, David R. Baldwin, Fergus Collaborators DART Initiat, Fergus Gleeson, Julia Hippisley-cox
Summary: This study aimed to develop and validate a risk prediction model (CanPredict (lung) model) for lung cancer screening in the UK and compare its performance with seven other risk prediction models. The model showed excellent discrimination, calibration, and net benefit, outperforming the other models. If implemented in primary care, the model has the potential to identify individuals at high risk of lung cancer for targeted screening.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Rebecca Landy, Vivian L. Wang, David R. Baldwin, Paul F. Pinsky, Li C. Cheung, Philip E. Castle, Martin Skarzynski, Hilary A. Robbins, Hormuzd A. Katki
Summary: By reusing LDCT images with deep learning algorithms or statistical models, the harms of low-dose computed tomographic (LDCT) screening can be reduced and the cost-effectiveness can be improved. This study aimed to identify low-risk individuals and estimate how many lung cancers would have been delayed by 1 year in diagnosis if they had been assigned a biennial screening.
Editorial Material
Oncology
Hannah Harrison, Angela Wood, Lisa Pennells, Sabrina H. Rossi, Matthew Callister, Jon Cartledge, Grant D. Stewart, Juliet A. Usher-Smith
Summary: The addition of kidney cancer screening to lung cancer screening can significantly improve early detection rates of kidney cancer. The study examined the performance of lung cancer screening eligibility criteria for selecting individuals for kidney cancer screening, and found that lung cancer models had moderate discrimination for kidney cancer. Approximately 25% of kidney cancer cases in the UK occur in individuals eligible for lung cancer screening, suggesting that a combined screening program could detect a significant number of kidney cancers.
EUROPEAN UROLOGY ONCOLOGY
(2023)
Article
Oncology
Bethany Wickramasinghe, Cristina Renzi, Matthew Barclay, Matthew E. J. Callister, Meena Rafiq, Georgios Lyratzopoulos
Summary: Patients with undiagnosed lung cancer often present with non-specific symptoms, such as dyspnoea, in primary care. Prescription patterns of relevant medications for dyspnoea management were examined in patients subsequently diagnosed with lung cancer. Results showed that there is a diagnostic window for potential earlier lung cancer diagnosis, and misattribution of symptoms to COPD or other benign conditions may delay diagnosis.
CANCER EPIDEMIOLOGY
(2023)
Article
Respiratory System
Minjoung Monica Koo, Luke T. A. Mounce, Meena Rafiq, Matthew E. J. Callister, Hardeep Singh, Gary A. Abel, Georgios Lyratzopoulos
Summary: Despite being eligible, a large proportion of patients presenting with dyspnoea and haemoptysis do not receive prompt chest imaging, indicating opportunities for earlier lung cancer diagnosis.
Editorial Material
Respiratory System
Helen Morgan, Savannah Gysling, Neal Navani, David Baldwin, Richard Hubbard, Emma O'Dowd
Summary: Early changes in lung cancer care have significant impact on survival, with decreased diagnosis during lockdown leading to lower survival rates. Decreased survival was observed from the first national lockdown onwards and within 90 days of diagnosis. People diagnosed at the end of 2020 had the highest hazard ratios for death within 90 days and between 91 and 270 days.
Article
Respiratory System
Sara Upperton, Paul Beirne, Bobby Bhartia, Alison Boland, Claire Bradley, Philip A. J. Crosbie, Mike Darby, Claire Eckert, Rhian Gabe, Neil Hancock, Martyn P. T. Kennedy, Jason Lindop, Suzanne Rogerson, Bethany Shinkins, Irene Simmonds, Tim J. T. Sutherland, Matthew E. J. Callister
Summary: Interstitial lung abnormalities (ILA) are commonly found in low-dose CT screening for lung cancer, some of which are benign while others are associated with interstitial lung disease (ILD). A study on the prevalence and outcomes of ILA in a screening trial is reported, providing valuable insights for the management of screen-detected ILD.
BMJ OPEN RESPIRATORY RESEARCH
(2023)
Article
Respiratory System
Claire Bradley, Panos Alexandris, David R. Baldwin, Richard Booton, Mike Darby, Claire J. Eckert, Rhian Gabe, Neil Hancock, Sam Janes, Martyn Kennedy, Jason Lindop, Richard D. Neal, Suzanne Rogerson, Bethany Shinkins, Irene Simmonds, Sara Upperton, Jorgen Vestbo, Philip A. J. Crosbie, Matthew E. J. Callister
Summary: Spirometry offered alongside LDCT screening can potentially identify cases of undiagnosed and misdiagnosed COPD. Future research should assess the downstream impact of these findings and determine the impact of co-delivering spirometry on other parameters of LDCT screening.
Review
Oncology
Emma L. O'Dowd, Richard W. Lee, Ahsan R. Akram, Emily C. Bartlett, Stephen H. Bradley, Kate Brain, Matthew E. J. Callister, Yan Chen, Anand Devaraj, Sinan R. Eccles, John K. Field, Jesme Fox, Seamus Grundy, Sam M. Janes, Martin Ledson, Melanie MacKean, Anne Mackie, Kieran G. McManus, Rachael L. Murray, Arjun Nair, Samantha L. Quaife, Robert Rintoul, Anne Stevenson, Yvonne Summers, Louise S. Wilkinson, Richard Booton, David R. Baldwint, Philip Crosbie
Summary: Lung cancer screening with low-dose CT has been recommended by the UK National Screening Committee based on trials showing a reduction in lung cancer mortality. The UK has made significant progress in addressing logistical issues and implementing targeted lung cancer screening through clinical trials and the NHS England Targeted Lung Health Check Programme. This Policy Review provides a summary of the consensus and key requirements for effective implementation of a screening programme, and can serve as a valuable resource for countries planning their own lung cancer screenings.