期刊
THERIOGENOLOGY
卷 150, 期 -, 页码 106-112出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.theriogenology.2020.01.083
关键词
Extracellular vesicle; Uterus; Conceptus; Pregnancy
资金
- AFRI competitive grants from the United States Department of Agriculture National Institute of Food and Agriculture [2015-67015-23678, 2016-67015-24741]
- National Institutes of Health [T32 HD087166]
- NIFA [810809, 2016-67015-24741] Funding Source: Federal RePORTER
This review focuses on extracellular vesicles (EV) in the uterus and their potential biological roles as mediators of conceptus-uterine interactions essential for implantation and pregnancy establishment. Growing evidence supports the idea that EV are produced by both the endometrium and conceptus during pregnancy. Exosomes and microvesicles, collectively termed EV, mediate cell-cell communication in other tissues and organs. EV have distinct cargo, including lipids, proteins, RNAs, and DNA, that vary depending on the cell of origin and regulate processes including angiogenesis, adhesion, proliferation, cell survival, inflammation, and immune response in recipient cells. Molecular crosstalk between the endometrial epithelium and the blastocyst/conceptus, particularly the trophectoderm, regulates early pregnancy events and is a prerequisite for successful implantation. Trafficking of EV between the conceptus and endometrium may represent a key form of communication important for pregnancy establishment. Increased understanding of EV in the uterine environment and their physiological roles in endometrial-conceptus interactions is expected to provide opportunities to improve pregnancy success. (C) 2020 Elsevier Inc. All rights reserved.
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