Article
Oncology
Kara A. Michels, Ashley M. Geczik, Doug C. Bauer, Louise A. Brinton, Diana S. M. Buist, Jane A. Cauley, Cher M. Dallal, Roni T. Falk, Trisha F. Hue, James V. Lacey, Andrea Z. LaCroix, Jeffrey A. Tice, Xia Xu, Britton Trabert
Summary: The study found that progestogens are generally not associated with colorectal cancer risk in postmenopausal women. These findings are consistent with prior research on circulating endogenous sex hormones, suggesting that sex hormones may not be major drivers of colorectal carcinogenesis in postmenopausal women.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Oncology
M. Constanza Camargo, Minkyo Song, Xia Xu, Isaac Zhao, Joshua N. Sampson, Arash Etemadi, Hermann Brenner, Hwi-Won Lee, Britton Trabert, Bernd Holleczek, Ben Schoettker, Kathleen Spaid, Sanford M. Dawsey, Sangjun Lee, Takaya Shimura, Sue K. Park, Reza Malekzadeh, Daehee Kang, Charles S. Rabkin
Summary: The study evaluated the associations of gastric cancer with estrogen metabolites in postmenopausal women, finding that urinary levels of estrogen-related molecules were not associated with gastric cancer.
Review
Biochemistry & Molecular Biology
Swati Sucharita Mohanty, Prafulla Kumar Mohanty
Summary: Breast cancer is the second most prevalent cancer globally, with a significant relationship between obesity and increased risk of developing the disease. Premature menopause and premenopausal obesity decrease the risk, while postmenopausal obesity amplifies it due to adipose tissue being a major reservoir for estrogen biosynthesis. High estrogen levels in overweight postmenopausal women are seen as a major factor in breast cancer development.
Review
Pharmacology & Pharmacy
Andrea M. P. Romani
Summary: Phytoestrogens have been identified as a natural alternative to synthetic estrogens for post-menopausal women, and have shown beneficial effects in attenuating severe complications in diseases such as type 2 diabetes, metabolic syndrome, NAFLD, and obesity. However, uncertainties regarding their effectiveness, conversion to active principles in the gut microbiome, and synergistic effects of different phytoestrogens remain, highlighting the need for further research in the field.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Ryoko Katagiri, Motoki Iwasaki, Sarah Krull Abe, Md. Rashedul Islam, Md. Shafiur Rahman, Eiko Saito, Melissa A. Merritt, Ji-Yeob Choi, Aesun Shin, Norie Sawada, Akiko Tamakoshi, Woon-Puay Koh, Ritsu Sakata, Ichiro Tsuji, Jeongseon Kim, Chisato Nagata, Sue K. Park, Sun-Seog Kweon, Xiao-Ou Shu, Yu-Tang Gao, Shoichiro Tsugane, Takashi Kimura, Jian-Min Yuan, Seiki Kanemura, Yukai Lu, Yumi Sugawara, Keiko Wada, Min-Ho Shin, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang
Summary: This study found that late menarche, early menopause, and a higher number of deliveries were significantly associated with a lower risk of endometrial cancer. These findings from a large pooled study of Asian women add to the growing body of evidence on the association between reproductive factors and endometrial cancer risk.
Article
Geriatrics & Gerontology
Ohad Rotenberg, Georgios Doulaveris, Dmitry Fridman, Malte Renz, Julie Kaplan, Xianhong Xie, Gary L. Goldberg, Pe'er Dar
Summary: Postmenopausal women with proliferative endometrium are at higher risk of developing endometrial polyps, uterine fibroids, and requiring surgical intervention. They also have a higher risk of future endometrial biopsy for recurrent vaginal bleeding and future hysterectomy or hysteroscopy. Medical management to reduce estrogenic activity and associated risks may be considered in these cases.
Article
Oncology
Britton Trabert, Ashley M. Geczik, Doug C. Bauer, Diana S. M. Buist, Jane A. Cauley, Roni T. Falk, Gretchen L. Gierach, Trisha F. Hue, James V. Lacey, Andrea Z. LaCroix, Kara A. Michels, Jeffrey A. Tice, Xia Xu, Louise A. Brinton, Cher M. Dallal
Summary: This study found that prediagnostic levels of progesterone are not strongly associated with endometrial or ovarian cancer risks, while an increasing progesterone-to-estradiol ratio is inversely associated with endometrial cancer risk. Additionally, 17-hydroxypregnenolone levels are positively associated with ovarian cancer risk and inversely associated with endometrial cancer risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Oncology
Etienne X. Holder, Serena C. Houghton, Sylvia S. Sanchez, A. Heather Eliassen, Jing Qian, Elizabeth R. Bertone-Johnson, Zhenhua Liu, Shelley S. Tworoger, Martyn T. Smith, Susan E. Hankinson
Summary: This study found a positive association between EA and breast cancer risk using a breast cancer cell line-based EA assay. However, the association weakened after accounting for other estrogen levels.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Kristen D. Brantley, Oana A. Zeleznik, Bernard Rosner, Rulla M. Tamimi, Julian Avila-Pacheco, Clary B. Clish, A. Heather Eliassen
Summary: This study explored the association between metabolites and breast cancer risk and found that cholesteryl esters measured earlier in disease etiology were inversely associated with breast cancer, while triacylglycerols with many double bonds measured closer to diagnosis were inversely associated with breast cancer risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Chuner Jiang, Peng Wu, Xiangming He, Jianfen Ni, Xiaowen Ding, Xiaohong Xu, Fangzheng Wang, Dehong Zou
Summary: This study investigated the relationship between serum reproductive hormone concentrations and patient characteristics and hormone receptor status among postmenopausal Chinese women with breast cancer. The results showed that decreased serum LH and FSH levels were associated with increased ER and PR expressions and decreased HER2 expression in postmenopausal patients with breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Environmental Sciences
Danielle N. Medgyesi, Britton Trabert, Joshua Sampson, Peter J. Weyer, Anna Prizment, Jared A. Fisher, Laura E. Beane Freeman, Mary H. Ward, Rena R. Jones
Summary: This study investigated the relationship between disinfection byproducts and N-nitroso compounds with endometrial cancer risk. The results showed that high levels of disinfection byproducts were associated with an increased risk of endometrial cancer.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Oncology
S. Ghazaleh Dashti, Julie A. Simpson, Vivian Viallon, Amalia Karahalios, Margarita Moreno-Betancur, Theodore Brasky, Kathy Pan, Thomas E. Rohan, Aladdin H. Shadyab, Cynthia A. Thomson, Robert A. Wild, Sylvia Wassertheil-Smoller, Gloria Y. F. Ho, Howard D. Strickler, Dallas R. English, Marc J. Gunter
Summary: This study quantified the mediating roles of CRP, leptin, fasting insulin, and estradiol in the effect of adiposity on breast, endometrial, and colorectal cancer risk. The results suggest that these mediators play different roles in the association between high BMI and cancer risk in postmenopausal women, with possibly varying levels of importance between cancer types.
Article
Endocrinology & Metabolism
Wen-Yu Chen, Yan-Peng Fu, Wen Zhong, Min Zhou
Summary: Our study found that E-DII was positively associated with androgens and estrogens in postmenopausal women, with some indicators showing non-linear associations, particularly among women who experienced natural menopause. Further research is needed to explore the underlying mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Mickey V. Patel, Zheng Shen, Marta Rodriguez-Garcia, Edward J. Usherwood, Laura J. Tafe, Charles R. Wira
Summary: Endometrial cancer suppresses host immune function by regulating the cytotoxic capacity of CD8+ T cells. CD103-CD8+ T cells are primarily responsible for killing of allogeneic target cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
S. Ghazaleh Dashti, Dallas R. English, Julie A. Simpson, Amalia Karahalios, Margarita Moreno-Betancur, Carine Biessy, Sabina Rinaldi, Pietro Ferrari, Anne Tjonneland, Jytte Halkjaer, Christina C. Dahm, Helene Tilma Vistisen, Florence Menegaux, Vittorio Perduca, Gianluca Severi, Krasimira Aleksandrova, Matthias B. Schulze, Giovanna Masala, Sabina Sieri, Rosario Tumino, Alessandra Macciotta, Salvatore Panico, Anouk E. Hiensch, Anne M. May, J. Ramon Quiros, Antonio Agudo, Maria-Jose Sanchez, Pilar Amiano, Sandra Colorado-Yohar, Eva Ardanaz, Naomi E. Allen, Elisabete Weiderpass, Renee Turzanski Fortner, Sofia Christakoudi, Konstantinos K. Tsilidis, Elio Riboli, Rudolf Kaaks, Marc J. Gunter, Vivian Viallon, Laure Dossus
Summary: Based on a case-control study within the EPIC, the research aimed to quantify the mediating effects of various biomarkers in the link between adiposity and endometrial cancer risk in postmenopausal women. Results showed that reduced adiponectin and increased inflammatory biomarkers, C-peptide, and estrogens mediated approximately 70% of the increased odds of endometrial cancer in women with obesity versus normal weight. These findings could have implications for intervention strategies to reduce endometrial cancer risk in women with obesity.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Oncology
Katharine K. Brieger, Minh Tung Phung, Bhramar Mukherjee, Kelly M. Bakulski, Hoda Anton-Culver, Elisa Bandera, David D. L. Bowtell, Daniel W. Cramer, Anna DeFazio, Jennifer A. Doherty, Sian Fereday, Renee Turzanski Fortner, Aleksandra Gentry-Maharaj, Ellen L. Goode, Marc T. Goodman, Holly R. Harris, Keitaro Matsuo, Usha Menon, Francesmary Modugno, Kirsten B. Moysich, Bo Qin, Susan J. Ramus, Harvey A. Risch, Mary Anne Rossing, Joellen M. Schildkraut, Britton Trabert, Robert A. Vierkant, Stacey J. Winham, Nicolas Wentzensen, Anna H. Wu, Argyrios Ziogas, Lilah Khoja, Kathleen R. Cho, Karen McLean, Jean Richardson, Bronwyn Grout, Anne Chase, Cindy McKinnon Deurloo, Kunle Odunsi, Brad H. Nelson, James D. Brenton, Kathryn L. Terry, Paul D. P. Pharoah, Andrew Berchuck, Gillian E. Hanley, Penelope M. Webb, Malcolm C. Pike, Celeste Leigh Pearce
Summary: Inflammation is associated with ovarian cancer survival, and a higher prediagnosis inflammation-related risk score is associated with increased mortality risk after an ovarian cancer diagnosis.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Lauren M. Hurwitz, Aladdin H. Shadyab, Fred K. Tabung, Garnet L. Anderson, Nazmus Saquib, Robert B. Wallace, Robert A. Wild, Ruth M. Pfeiffer, Xia Xu, Britton Trabert
Summary: This study investigated the relationship between analgesic use and endogenous hormone levels in postmenopausal women. It found a positive association between low-dose aspirin use and estrogen concentrations. These findings provide insights into the potential mechanisms by which aspirin may prevent hormone-related cancers.
CANCER PREVENTION RESEARCH
(2022)
Article
Environmental Sciences
Ashley M. Geczik, Roni T. Falk, Xia Xu, Beatrice Wiafe-Addai, Joel Yarney, Baffour Awuah, Richard Biritwum, Verna Vanderpuye, Florence Dedey, Ernest Adjei, Francis Aitpillah, Ernest Osei-Bonsu, Joseph Oppong, Nicholas Titiloye, Lawrence Edusei, Kofi Nyarko, Joe-Nat Clegg-Lamptey, Seth Wiafe, Daniel Ansong, Thomas U. Ahearn, Jonine Figueroa, Montserrat Garcia-Closas, Louise A. Brinton, Britton Trabert
Summary: This study provides evidence that the use of lye-based hair relaxer products may increase circulating levels of 16-pathway estrogens, particularly estriol and 16-epiestriol. Additionally, scalp burns among hair relaxer users were associated with elevated levels of unconjugated estrogens. However, no association was found between the use of skin lighteners and estrogen metabolism.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Correction
Environmental Sciences
Ashley M. Geczik, Roni T. Falk, Xia Xu, Beatrice Wiafe-Addai, Joel Yarney, Baffour Awuah, Richard Biritwum, Verna Vanderpuye, Florence Dedey, Ernest Adjei, Francis Aitpillah, Ernest Osei-Bonsu, Joseph Oppong, Nicholas Titiloye, Lawrence Edusei, Kofi Nyarko, Joe-Nat Clegg-Lamptey, Seth Wiafe, Daniel Ansong, Thomas U. Ahearn, Jonine Figueroa, Montserrat Garcia-Closas, Louise A. Brinton, Britton Trabert
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Article
Oncology
Danielle N. Medgyesi, Britton Trabert, Jared A. Fisher, Qian Xiao, Peter James, Alexandra J. White, Jessica M. Madrigal, Rena R. Jones
Summary: This study is the first to evaluate the association between outdoor light at night (LAN) and the risk of endometrial cancer. The study found no association between LAN and endometrial cancer risk based on the analysis of postmenopausal women's enrollment addresses and satellite imagery of nighttime radiance.
CANCER CAUSES & CONTROL
(2023)
Article
Oncology
Theodore M. Brasky, Erinn M. Hade, David E. Cohn, Alison M. Newton, Stacey Petruzella, Kelli O'Connell, Kimberly A. Bertrand, Linda S. Cook, Immaculata De Vivo, Mengmeng Du, Jo L. Freudenheim, Christine M. Friedenreich, Marc T. Goodman, Jessica Gorzelitz, Torukiri I. Ibiebele, Vittorio Krogh, Linda M. Liao, Loren Lipworth, Lingeng Lu, Susan McCann, Tracy A. O'Mara, Julie R. Palmer, Jeanette Ponte, Anna Prizment, Harvey Risch, Sven Sandin, Leo J. Schouten, Veronica Wendy Setiawan, Xiao-ou Shu, Britton Trabert, Piet A. van den Brandt, Penelope M. Webb, Nicolas Wentzensen, Lynne R. Wilkens, Alicja Wolk, Herbert Yu, Marian L. Neuhouser
Summary: This study analyzed data from 12 prospective cohort studies and found that higher dietary intake of long-chain omega-3 polyunsaturated fatty acids (LCn3PUFA) may increase the risk of endometrial cancer, especially among specific subgroups characterized by body weight and tumor pathology.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Andrology
Andreas Stang, Pietro Trocchi, Hiltraud Kajuter, Britton Trabert, J. Wolter Oosterhuis, Katherine A. McGlynn
Summary: This study compares the incidence rates of gonadal germ cell tumors between males and females, revealing lower rates among females and an earlier age peak. This may be attributed to the absence of the Y-chromosome and a younger age at puberty.
Article
Oncology
Todd R. Sponholtz, Julie R. Palmer, Lynn Rosenberg, Chu Chen, Yu Chen, Megan A. Clarke, Tess Clendenen, Mengmeng Du, Lisa Johnson, Linda M. Liao, Kara A. Michels, Kelli O'Connell, Sara H. Olson, Stacey Petruzella, Timothy R. Rebbeck, Veronica Wendy Setiawan, Britton Trabert, Noel S. Weiss, Nicholas Wentzensen, Lynne Wilkens, Lauren A. Wise
Summary: The incidence of endometrial cancer (EC) is increasing faster among Black women in the US. There is limited research on the risk factors for EC among Black women, especially regarding menopausal hormone use and severe obesity. This study found that established risk factors for EC are similar between Black and White women, suggesting that other factors may contribute to the recent increase in EC incidence among Black women.
CANCER CAUSES & CONTROL
(2023)
Article
Oncology
Andrea Romanos-Nanclares, Fred K. Tabung, Jennifer A. Sinnott, Britton Trabert, Immaculata De Vivo, Mary C. Playdon, A. Heather Eliassen
Summary: This study found that diets with inflammatory and insulinemic potential were associated with increased risk of endometrial cancer, and obesity may mediate this association.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Joy Shi, Peter Kraft, Bernard A. Rosner, Yolanda Benavente, Amanda Black, Louise A. Brinton, Chu Chen, Megan A. Clarke, Linda S. Cook, Laura Costas, Luigino Dal Maso, Jo L. Freudenheim, Jon Frias-Gomez, Christine M. Friedenreich, Montserrat Garcia-Closas, Marc T. Goodman, Lisa Johnson, Carlo La Vecchia, Fabio Levi, Jolanta Lissowska, Lingeng Lu, Susan E. McCann, Kirsten B. Moysich, Eva Negri, Kelli O'Connell, Fabio Parazzini, Stacey Petruzella, Jerry Polesel, Jeanette Ponte, Timothy R. Rebbeck, Peggy Reynolds, Fulvio Ricceri, Harvey A. Risch, Carlotta Sacerdote, Veronica W. Setiawan, Xiao-Ou Shu, Amanda B. Spurdle, Britton Trabert, Penelope M. Webb, Nicolas Wentzensen, Lynne R. Wilkens, Wang Hong Xu, Hannah P. Yang, Herbert Yu, Mengmeng Du, Immaculata De Vivo
Summary: To mitigate the burden of endometrial cancer, risk stratification can help target interventions. The study developed risk prediction models using data from postmenopausal White women aged 45-85 years. The models based on epidemiologic factors alone successfully identified women at high risk of endometrial cancer, with limited improvements from genetic factors.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Oana A. Zeleznik, Sarah R. Irvin, Goli Samimi, Britton Trabert
Summary: Ovarian and endometrial cancers are commonly seen gynecologic malignancies, and recent evidence suggests that lipid metabolism and subsequent inflammation play significant roles in the development of these tumors. Statins, the most commonly prescribed lipid-lowering drugs in the United States, have been shown to have anti-inflammatory, antiproliferative, and apoptotic effects in cancer cell lines, indicating a potential role in cancer prevention.
CANCER PREVENTION RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Summer Harvey, Nicolas Wentzensen, Kimberly Bertrand, Amanda Black, Louise A. Brinton, Chu Chen, Laura Costas, Luigino Dal Maso, Immaculata De Vivo, Mengmeng Du, Montserrat Garcia-Closas, Marc T. Goodman, Jessica Gorzelitz, Lisa Johnson, James Lacey, Linda Liao, Loren Lipworth, Jolanta Lissowska, Anthony B. Miller, Kelli O'Connell, Tracy A. O'Mara, Xiao Ou, Julie R. Palmer, Alpa Patel, Sonia Paytubi, Beatriz Pelegrina, Stacey Petruzella, Anna Prizment, Thomas Rohan, Sven Sandin, Veronica Wendy Setiawan, Rashmi Sinha, Britton Trabert, Penelope M. Webb, Lynne R. Wilkens, Wanghong Xu, Hannah P. Yang, Wei Zheng, Megan A. Clarke
Summary: This study evaluated the associations between obesity in young adulthood and adulthood with endometrial cancer risk. The results showed that obesity in both periods was positively associated with endometrial cancer risk, and weight gain was also positively associated with this risk while weight loss was inversely associated.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Microbiology
Zeni Wu, Ruth M. Pfeiffer, Doratha A. Byrd, Yunhu Wan, Daniel Ansong, Joe-Nat Clegg-Lamptey, Beatrice Wiafe-Addai, Lawrence Edusei, Ernest Adjei, Nicholas Titiloye, Florence Dedey, Francis Aitpillah, Joseph Oppong, Verna Vanderpuye, Ernest Osei-Bonsu, Casey L. Dagnall, Kristine Jones, Amy Hutchinson, Belynda D. Hicks, Thomas U. Ahearn, Rob Knight, Richard Biritwum, Joel Yarney, Seth Wiafe, Baffour Awuah, Kofi Nyarko, Montserrat Garcia-Closas, Rashmi Sinha, Jonine D. Figueroa, Louise A. Brinton, Britton Trabert, Emily Vogtmann
Summary: The study aimed to investigate the associations between the fecal and oral microbiome and circulating estrogens and estrogen metabolites. The results showed several associations between specific estrogens and estrogen metabolites and the microbial communities in the gut and oral cavity.
MICROBIOLOGY SPECTRUM
(2023)
Article
Medicine, General & Internal
Lauren M. Hurwitz, Penelope M. Webb, Susan J. Jordan, Jennifer A. Doherty, Holly R. Harris, Marc T. Goodman, Yurii B. Shvetsov, Francesmary Modugno, Kirsten B. Moysich, Joellen M. Schildkraut, Andrew Berchuck, Hoda Anton-Culver, Argyrios Ziogas, Usha Menon, Susan J. Ramus, Anna H. Wu, Celeste Leigh Pearce, Nicolas Wentzensen, Shelley S. Tworoger, Paul D. P. Pharoah, Britton Trabert
Summary: Frequent aspirin use is associated with reduced ovarian cancer risk, and genetic factors do not appear to modify this association according to a study. The findings suggest that aspirin use may be effective in preventing ovarian cancer regardless of genetic susceptibility.
Article
Oncology
Cassandra A. Hathaway, Mary K. Townsend, Elliot M. Sklar, Kamilah B. Thomas-Purcell, Kathryn L. Terry, Britton Trabert, Shelley S. Tworoger
Summary: This study evaluated the relationship between markers of kidney function and ovarian cancer risk, and found no clear association. However, there was a suggestive trend for increased ovarian cancer risk in women with poor kidney function and high CRP.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)