Article
Oncology
Chang Kyun Choi, Min-Ho Shin, Sang-Hee Cho, Hye-Yeon Kim, Wei Zheng, Jirong Long, Sun-Seog Kweon
Summary: This study found that the ALDH2 rs671 genotype related to alcohol consumption was associated with a reduced risk of colorectal cancer in men, especially among regular drinkers. However, the ADH1B rs1229984 genotype showed no significant association with colorectal cancer risk. The combined genotype with the highest genetically predicted alcohol consumption was associated with a higher risk for colorectal cancer.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Ting-Gang Chang, Ting-Ting Yen, Chia-Yi Wei, Tzu-Hung Hsiao, I-Chieh Chen
Summary: This study aimed to evaluate the associations of ADH1B rs1229984 and ALDH2 rs671 with the risks of alcohol-related disorder and cancer. The results showed significant additive and synergic risks of these genetic variants for alcohol-related disorders and cancer. It is recommended to advise high-risk individuals carrying these variants to reduce alcohol consumption as a preventive measure.
Article
Gastroenterology & Hepatology
Ayaka Tajiri, Ryu Ishihara, Hirohisa Sakurai, Takahiko Nakamura, Yasuhiro Tani, Takahiro Inoue, Katsunori Matsueda, Muneaki Miyake, Kotaro Waki, Hiromu Fukuda, Satoki Shichijo, Akira Maekawa, Takashi Kanesaka, Sachiko Yamamoto, Yoji Takeuchi, Koji Higashino, Noriya Uedo, Tomoki Michida, Takashi Matsunaga
Summary: The activation patterns of alcohol-metabolizing enzymes are associated with the age at onset of esophageal squamous cell carcinoma, lesion location, and metachronous esophageal squamous cell carcinoma and head and neck squamous cell carcinoma. Different approaches to the prophylaxis and treatment of esophageal cancer should be considered based on the enzyme activity pattern.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Ju Eun Seol, Jeongseon Kim, Bong-Hwa Lee, Dae-Yong Hwang, Jinyoung Jeong, Hun-Jae Lee, Yoon-Ok Ahn, Jung Eun Lee, Dong-Hyun Kim
Summary: This study found that alcohol intake increased the risk of colorectal cancer in East Asian populations, and there may be an interaction between ALDH2 gene and methyl diets, where a low methyl diet increased the risk of CRC among individuals with the ALDH2 A allele.
PUBLIC HEALTH NUTRITION
(2021)
Article
Pharmacology & Pharmacy
Yongxu Zhou, Liang Yu, Peng Huang, Xudong Zhao, Risheng He, Yunfu Cui, Bo Pan, Chang Liu
Summary: This study identified ADH1B as a key gene associated with afatinib in LIHC. It is negatively correlated with the immune microenvironment and can predict the prognosis of LIHC. ADH1B is also a potential target for candidate drugs, offering a promising approach for the development of novel LIHC treatments.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Vishal S. Patil, Darasaguppe R. Harish, Ganesh H. Sampat, Subarna Roy, Sunil S. Jalalpure, Pukar Khanal, Swarup S. Gujarathi, Harsha V. Hegde
Summary: Hepatitis B infection caused by the hepatitis B virus is a life-threatening disease that leads to liver fibrosis, cirrhosis, and hepatocellular carcinoma. Currently, there are no specific laboratory animal models available to study HBV pathogenesis or immune response. This study identifies a suitable chemically induced liver cirrhosis/HCC model that parallels HBV pathophysiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Ming-Chao Tsai, Sien-Sing Yang, Chih-Che Lin, Wen-Lun Wang, Yao-Chun Hsu, Yaw-Sen Chen, Jui-Ting Hu, James Yu Lin, Ming-Lung Yu, Chih-Wen Lin
Summary: The study demonstrates a significant association between heavy alcohol intake and ALDH2 rs671 polymorphism with an increased risk of HCC development and mortality in patients with HBV-related cirrhosis.
Article
Oncology
Biao Zhang, Yu-Hui Peng, Yun Luo, Chao-Qun Hong, Yi-Wei Lin, Yu-Ling Zhang, Yi-Wei Xu, Xue-Fen Su, Fang-Cai Wu
Summary: This meta-analysis study found that ADH1B rs1229984 is significantly associated with an increased risk of ESCC.
Article
Urology & Nephrology
Daniel R. Greenberg, Hriday P. Bhambhvani, Satvir S. Basran, Brett P. Salazar, Luis Carl Rios, Sin-Jin Li, Che-Hong Chen, Daria Mochly-Rosen, Michael L. Eisenberg
Summary: This study found an association between alcohol intake and semen parameters among East Asian men carrying the ALDH2*2 allele. Alcohol consumption was associated with significantly lower total and progressive sperm motility in ALDH2*2 carriers. Furthermore, ALDH2 expression in spermatozoa was significantly lower in ALDH2*2 carriers.
JOURNAL OF UROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Nicholas Noverati, Rukaiya Bashir-Hamidu, Dina Halegoua-DeMarzio, Hie-Won Hann
Summary: Hepatitis B virus is a significant cause of hepatocellular carcinoma globally. The complex mechanisms of this virus include interactions with the host's immune system. Factors such as stress can amplify these mechanisms. Chronic stress, harmful to health, can suppress or activate the host's defense system, leading to tumor initiation and progression in liver cancer. Chronic stress, often overlooked, should be recognized as a potential risk factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Satinder P. Kaur, Arslan Talat, Hamidreza Karimi-Sari, Andrew Grees, Hao Wei Chen, Daryl T. Y. Lau, Andreea M. Catana
Summary: Hepatitis B virus (HBV) infection is one of the main risk factors for hepatocellular carcinoma (HCC), and the risk of HCC is not completely eliminated even after viral suppression. Cirrhosis, HBV viral DNA levels, age, male gender, the immune response, and a combination of obesity and diabetes are among the main risk factors for HCC. Active viral replication and long-standing inflammation are associated with a higher risk of HCC. Treatment of HBV with nucleos(t)ide analogues can decrease the risk of HCC.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Meng Xue, Xiaona Lin, Qiu-Xiong Lin, Xiaoyong Pu, Jiumin Liu, Xing-Fang Li, Jun Hou, Xudong Liu, Ren Chen
Summary: This study found that HBV infection was associated with an increased risk of HCC compared to HEV infection, and that HEV infection may mitigate the promoting impact of HBV on HCC development.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Chang Kyun Choi, Jungho Yang, Sun-Seog Kweon, Sang-Hee Cho, Hye-Yeon Kim, Eun Myung, Min-Ho Shin
Summary: In Eastern Asians, ALDH2 rs671 polymorphisms are associated with esophageal cancer, which may be linked to acetaldehyde accumulation. The study found that in men, the risk of esophageal cancer was higher with GA and AA genotypes, while in women, the risk was higher with GA and AA genotypes as well. Additionally, in men, the association between ALDH2 polymorphisms and esophageal cancer was influenced by alcohol consumption.
Article
Immunology
Oscar C. Araujo, Vanessa S. de Paula, Kycia M. do O, Cristiane A. Villela-Nogueira, Natalia M. Araujo
Summary: The study revealed that GSTT1 gene polymorphisms have different distributions at different stages (chronic hepatitis, cirrhosis, and hepatocellular carcinoma) of HCV infection, which may impact liver disease progression. However, the distribution of GSTM1 gene polymorphisms or combined GSTM1/GSTT1 double-null genotypes did not significantly vary between the stages.
Article
Immunology
Zhiwei Liu, Chih-Jen Huang, Yu-Han Huang, Mei-Hung Pan, Mei-Hsuan Lee, Kelly J. Yu, Ruth M. Pfeiffer, Mathias Viard, Yuko Yuki, Xiaojiang Gao, Mary Carrington, Chien-Jen Chen, Allan Hildesheim, Hwai- Yang
Summary: The study found that an increase in the number of homozygous HLA class II loci is associated with an increased risk of chronic HBV infection and HBV-associated HCC. Specifically, HLA-DQB1 homozygosity is significantly associated with HCC risk.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Gastroenterology & Hepatology
Matt Liu, Tai-Chung Tseng, Dae Won Jun, Ming-Lun Yeh, Huy Trinh, Grace L. H. Wong, Chien-Hung Chen, Cheng-Yuan Peng, Sung Eun Kim, Hyunwoo Oh, Min-Sun Kwak, Michael Cheung, Hidenori Toyoda, Yao-Chun Hsu, Jae Yoon Jeong, Eileen L. Yoon, Teerapat Ungtrakul, Jian Zhang, Qing Xie, Sang Bong Ahn, Masaru Enomoto, Jae-Jun Shim, Chris Cunningham, Soung Won Jeong, Yong Kyun Cho, Eiichi Ogawa, Rui Huang, Dong-Hyun Lee, Hirokazu Takahashi, Pei-Chien Tsai, Chung-Feng Huang, Chia-Yen Dai, Cheng-Hao Tseng, Satoshi Yasuda, Ritsuzo Kozuka, Jiayi Li, Christopher Wong, Clifford C. Wong, Changqing Zhao, Joseph Hoang, Yuichiro Eguchi, Chao Wu, Yasuhito Tanaka, Ed Gane, Tawesak Tanwandee, Ramsey Cheung, Man-Fung Yuen, Hyo-Suk Lee, Ming-Lung Yu, Jia-Horng Kao, Hwai- Yang, Mindie H. Nguyen
Summary: This study analyzed data from 18,056 Asian chronic hepatitis B patients from various centers to provide detailed annual transition rates based on age, sex, disease activity, and treatment status. The findings can inform health economic modeling efforts and cost-effective public health interventions for hepatitis B elimination by 2030.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Jiyoon Park, An K. Le, Tai-Chung Tseng, Ming-Lun Yeh, Dae Won Jun, Huy Trinh, Grace L. H. Wong, Chien-Hung Chen, Cheng-Yuan Peng, Sung Eun Kim, Hyunwoo Oh, Min-Sun Kwak, Ka Shing Cheung, Hidenori Toyoda, Yao-Chun Hsu, Jae Yoon Jeong, Eileen L. Yoon, Teerapat Ungtrakul, Jian Zhang, Qing Xie, Sang Bong Ahn, Masaru Enomoto, Jae-Jun Shim, Chris Cunningham, Soung Won Jeong, Yong Kyun Cho, Eiichi Ogawa, Rui Huang, Dong-Hyun Lee, Hirokazu Takahashi, Pei-Chien Tsai, Chung-Feng Huang, Chia-Yen Dai, Cheng-Hao Tseng, Satoshi Yasuda, Ritsuzo Kozuka, Jiayi Li, Christopher Wong, Clifford C. Wong, Changqing Zhao, Joseph Hoang, Yuichiro Eguchi, Chao Wu, Yasuhito Tanaka, Ed Gane, Tawesak Tanwandee, Ramsey Cheung, Man-Fung Yuen, Hyo-Suk Lee, Ming-Lung Yu, Jia-Horng Kao, Hwai-I Yang, Mindie H. Nguyen
Summary: This study aimed to determine the rates of cirrhosis and hepatocellular carcinoma (HCC) development in patients with chronic hepatitis B (CHB), stratified by age, sex, treatment status, and disease activity. The results show that there is significant variability in CHB disease progression rates even among lower-risk populations.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Hui-Han Hu, Wen-Juei Jeng, Mei-Hung Pan, Wun-Sheng Luo, Chia-Ling Chang, Yen-Tsung Huang, Chien-Yu Su, Chen-Tse Chiang, Chin-Lan Jen, Yu-Chuan Chien, Shen-Nan Lu, Li-Yu Wang, Li-Rung Huang, Mei-Hsuan Lee, Jessica Liu, Mindie H. Nguyen, Chien-Jen Chen, Hwai- Yang
Summary: sPD-1 level is a novel marker that predicts spontaneous HBsAg seroclearance in patients with HBeAg-negative chronic hepatitis B with undetectable HBV DNA.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Public, Environmental & Occupational Health
An-Shun Tai, Yen-Tsung Huang, Hwai- Yang, Lauren V. Lan, Sheng-Hsuan Lin
Summary: Regression-based approaches are commonly used in causal mediation analysis, but they may not be efficient in cases with multiple mediators. Therefore, a flexible simulation-based approach was developed to address estimation issues and increase flexibility in model selection. The method was evaluated using a Taiwanese Cohort Study dataset and showed promising results in investigating the mediating role of HBV viral load in the effect of HCV infection on hepatocellular carcinoma.
FRONTIERS IN PUBLIC HEALTH
(2022)
Letter
Gastroenterology & Hepatology
Wen-Juei Jeng, Mei-Hung Pan, Hwai- Yang
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Yu-Ju Chu, Wen-Juei Jeng, Mei-Hung Pan, Hui-Han Hu, Wen-Sheng Luo, Chien-Yu Su, Chen-Tse Chiang, Chin-Lan Jen, Chien-Jen Chen, Hwai- Yang
Summary: Serum sPD-1 levels may serve as a novel immunological predictor for spontaneous HBeAg seroclearance in patients with chronic hepatitis B. Lower baseline sPD-1 levels and long-term decline in sPD-1 levels were independent predictors for HBeAg seroclearance, particularly significant in patients with genotype C infection.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Virology
Wen-Juei Jeng, Chien-Hung Chen, Yi-Wen Wang, Mei-Hung Pan, Chia-Wei Lin, Chun-Yen Lin, Hwai- Yang
Summary: There is no correlation between sPD-1 levels measured by MyBioSource (MB) and R&D (RD) kits. The sPD-1 measured by MB showed strong correlations with HBsAg, HBV DNA, and ALT levels, while an opposite trend was seen with the RD kit. Multivariate linear regression analysis indicated that HBsAg and ALT levels were the major factors associated with sPD-1 levels measured by MB and RD, respectively.
Article
Gastroenterology & Hepatology
Shanshan Wu, Jialing Zhou, Xiaoning Wu, Yameng Sun, Bingqiong Wang, Yuanyuan Kong, Siyan Zhan, Jidong Jia, Hwai- Yang, Hong You
Summary: This study assessed the comparative performance of 14 hepatocellular carcinoma prediction models in chronic hepatitis B patients and found that several models performed best when using on-treatment values within the first 2 years.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Yi-Chung Hsieh, Mei-Hung Pan, Wen-Juei Jeng, Hui-Han Hu, Jessica Liu, Masashi Mizokami, Chien-Jen Chen, Hwai- Yang
Summary: The study found an association between hepatitis B core-related antigen (HBcrAg) and hepatocellular carcinoma (HCC) in chronic hepatitis B patients. The relationship between HBcrAg and HCC was also investigated in individuals seronegative for hepatitis B surface antigen and anti-hepatitis C virus (NBNC) in Taiwan. The results showed that HBcrAg positivity was significantly associated with higher risk of HCC, indicating that it might serve as a marker for identifying individuals at a higher risk of HCC in hepatitis B virus endemic areas.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Chien-Wei Peng, Wen-Juei Jeng, Hwai- Yang, Yen-Chun Liu, Rong-Nan Chien, Yun-Fan Liaw
Summary: In HBeAg negative chronic hepatitis B (CHB) patients, stopping tenofovir and other nucleos(t)ide analogues (Nucs) is associated with more frequent and severe clinical relapse. This study found that switching to entecavir more than 12 weeks prior to stopping treatment can delay and reduce the occurrence of clinical relapse and flares.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Ilona Argirion, Jalen Brown, Sarah Jackson, Ruth M. Pfeiffer, Tram Kim Lam, Thomas R. O'Brien, Kelly J. Yu, Katherine A. McGlynn, Jessica L. Petrick, Ligia A. Pinto, Chien-Jen Chen, Allan Hildesheim, Hwai- Yang, Mei-Hsuan Lee, Jill Koshiol
Summary: This study investigated the role of circulating immunologic markers in predicting the progression of liver disease in individuals chronically infected with hepatitis C virus (HCV). The findings suggest that these markers play an important role in predicting HCV-related cirrhosis even 11 years after enrollment.
Meeting Abstract
Gastroenterology & Hepatology
Rachel Wen-Juei Jeng, Chien-Hung Chen, Hwai-I Yang, Yi-Cheng Chen, Yen-Chun Liu, Chia-Ying Wu, Rong-Nan Chien, Yun-Fan Liaw
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Rachel Wen-Juei Jeng, Yu-Ju Chu, Mei-Hung Pan, Hui-Han Hu, Wun-Sheng Luo, Chien-Yu Su, Chen-Tse Chiang, Chin-Lan Jen, Sheng-Nan Lu, Li-Yu Wang, Chien-Jen Chen, Hwai-I Yang
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Hui-Chen Wu, Wen-Juei Jeng, Mei-Hung Pan, Yi-Chung Hsieh, Sheng-Nan Lu, Chien-Jen Chen, Hwai- Yang
Summary: This study examined the cumulative risk of hepatocellular carcinoma (HCC) and mortality from liver-related disease among a non-hepatitis virus-infected population. It found that modifiable risk factors such as alcohol consumption, heart disease, diabetes, and abnormal liver function tests were strongly associated with an increased risk of HCC and mortality.
Meeting Abstract
Gastroenterology & Hepatology
Qingyao Daniel Huang, Xiaohe Li, Michael H. Le, An Le, Yee Hui Yeo, Huy N. Trinh, Jian Zhang, Jiayi Li, Christopher Wong, Clifford Wong, Ramsey Cheung, Hwai-I Yang, Mindie H. Nguyen
