Article
Chemistry, Analytical
Yu Liu, Fangfang Wang, Yawen Liu, Lu Cao, Haiming Hu, Xiaowei Yao, Junping Zheng, Hongtao Liu
Summary: This study proposed a novel label-free gold nanoparticles (AuNPs) plasmonic sensor for H2O2 sensing, based on the redox catalysis of 3, 3', 5, 5'-tetramethylbenzidine (TMB) induced by H2O2 and detected by combining an H2O2-generating oxidase. The optimized TreHOAuC platform allows for specific sensing of H2O2 within 2 minutes, with a detection limit of less than 0.5 mu M. In addition, a cholesterol oxidase-paired TreHOAuC system showed accurate detection of cholesterol in serum samples within a linear range of 2-40 mu M. Overall, this proposed method provides a novel and comprehensive application for biological sensing.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Optics
Yuhyun Ji, Yunsang Kwak, Sang Mok Park, Young L. Kim
Summary: This study discusses the mapping of spectral stimuli to RGB color values using spectral response functions of a three-color image sensor, highlighting the device-dependent differences between models. It introduces a compressive sensing framework in the frequency domain for accurately predicting RGB spectral response functions with several primary colors.
Article
Chemistry, Analytical
Jingjing Li, Yuxiang Zhao, Lin Sun, Aihui Liang, Zhiliang Jiang
Summary: A stable Fe-doped carbon dot nanosol with high catalytic activity was prepared and used for the catalytic amplification of H2O2, leading to the establishment of a new trimode molecular spectral method for the determination of trace H2O2. This method showed a linear range of 5.0 x 10(-10)-2.5 x 10(-8) mol/L and a detection limit of 2.52 x 10(-10) mol/L. The method was successfully applied to the analysis of H2O2 contents in food samples.
VIBRATIONAL SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
Ivo Safarik, Jitka Prochazkova
Summary: Solid phase extraction using color catcher sheets was used to preconcentrate food dyes in alcohol containing beverages. The photos of the adsorbed dyes on the sheets were analyzed using a Color Picker application on a smartphone, and values from various color spaces were collected. Proportional values in RGB, CMY, RYB, and LAB color spaces were found to correspond to the dye concentration in the samples. This inexpensive and simple method allows for analysis of dye concentration in diverse solutions without the need for elution.
Article
Chemistry, Analytical
Habeen Park, Young Gook Koh, Wonmok Lee
Summary: The study presents a smartphone-based colorimetric analysis method for an inverse opal photonic gel sensor, offering a simple, cost-effective, and rapid alternative to traditional UV-vis spectrometry. By using the HSV color space and the hue parameter, the smartphone analysis shows reasonable precision for pH determination under common illumination conditions, regardless of the smartphone brand used.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Engineering, Multidisciplinary
Yajun Fan, Jiawei Li, Yaping Guo, Lianwu Xie, Gui Zhang
Summary: Digital image colorimetry (DIC) on smartphone is a powerful, fast, and cost-effective analysis method for measuring target analytes through color changes in digital images. It is currently used in various fields with revealed advantages and disadvantages. In the future, DIC technology will become more robust and reliable with the continuous development of smartphone technology.
Review
Chemistry, Analytical
Sarah Di Nonno, Roland Ulber
Summary: In recent decades, there has been a growing trend towards the use of smartphone-based analysis systems, mainly due to the ubiquity of smartphones, their increasing computing capacity, their relatively low cost, and the ability to acquire and process data simultaneously. Smartphone integrated sensors, such as CMOS sensors, enable optical analysis methods like colorimeters, photometers, and spectrometers. This review explores the state-of-the-art smartphone-based optical analysis systems in various applications, organized into three sections focusing on colorimeters, photo- and spectrometers, and fluorimeters.
Article
Engineering, Civil
Yufeng Gong, Yu Qian
Summary: Evaluating railway ballast fouling is crucial for assessing track conditions and planning ballast maintenance. Various methods have been developed to estimate fouling conditions, but they often require special equipment or trained technicians. This study proposes a novel image analysis approach using statistical analysis of RGB color distributions to directly estimate ballast fouling conditions. The established prediction model shows promising performance in quantifying fouling conditions.
TRANSPORTATION RESEARCH RECORD
(2023)
Article
Nanoscience & Nanotechnology
Marta Guembe-Garcia, Lara Gonzalez-Ceballos, Ana Arnaiz, Miguel A. Fernandez-Muino, M. Teresa Sancho, Sandra M. Oses, Saturnino Ibeas, Jordi Rovira, Beatriz Melero, Cesar Represa, Jose M. Garcia, Saul Vallejos
Summary: We have developed a method for determining nitrite concentration in processed meats that can be used by unskilled personnel. It uses a colorimetric polymer sensor and a mobile app to analyze digital photographs and calculate the nitrite concentration.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Paulina K. Wells, Artem Melman, Evgeny Katz, Oleh Smutok
Summary: A new nano-structured platform using PQQ-dependent glucose dehydrogenase was developed for fluorescent analysis. The platform immobilized the enzyme on SiO2 nanoparticles and used a smartphone for signal quantification. This platform shows great potential for developing a variety of biosensors for different analytes.
Article
Engineering, Chemical
Ronald Wbeimar Pacheco Ortiz, Alline V. B. de Oliveira, Fabricio Venancio, Giuseppe Sampaio Almeida Cardoso, Vinicius Ottonio O. Goncalves, Joao Cajaiba, Vinicius Kartnaller
Summary: This work presents a novel apparatus for simultaneous monitoring of color and degrees Brix in fruit juices. The apparatus utilizes RGB image analysis as the juice flows through a transparent cell equipped with a webcam and a light source. By measuring the RGB color space of various fruit juice samples, the relationship between RGB and degrees Brix was established, enabling reliable monitoring of this parameter during concentration and dilution experiments. This apparatus has the potential to replace conventional instruments for online process monitoring, while reducing measurement errors and saving time.
JOURNAL OF FOOD PROCESS ENGINEERING
(2023)
Article
Computer Science, Information Systems
Rita Magdalena, Tariq Rahim, I. Putu Agus Eka Pratama, Ledya Novamizanti, I. Nyoman Apraz Ramatryana, Aamir Younas Raja, Soo Young Shin
Summary: The RGB-SARA method proposed for compressed medical imaging shows higher efficiency and visual quality in medical image processing compared to traditional methods, indicating its potential as a new compression method with high visual quality for medical images.
Article
Computer Science, Information Systems
Zixu Wang, Chenwei Nie, Hongwu Wang, Yong Ao, Xiuliang Jin, Xun Yu, Yi Bai, Yadong Liu, Mingchao Shao, Minghan Cheng, Shuaibing Liu, Siyu Wang, Nuremanguli Tuohuti
Summary: A method was developed to accurately determine the degree of crop lodging by fusing supervised and object-oriented classifications based on spectrum, texture, and canopy structure data. Factors affecting lodging degree were analyzed based on spatial distribution, enabling determination of optimal sowing date, density, and fertilization method.
ISPRS INTERNATIONAL JOURNAL OF GEO-INFORMATION
(2021)
Article
Biochemical Research Methods
Xuling Liu, Duanqin Zhang, Jie Liu, Liangwen Wang, Songjing Li
Summary: This article presents mixability experiments and RGB color model analysis of a simple structured micromixer based on pneumatic-driven membrane for multiple microreagent mixing applications. The RGB color model provides an easy and intuitive way to analyze mixing efficiency compared to conventional methods. Additionally, the designed micromixer requires less external laboratory infrastructure due to its simple structure.
Article
Multidisciplinary Sciences
Ali Al-Naji, Ahmed Bashar Fakhri, Sadik Kamel Gharghan, Javaan Chahl
Summary: The study introduces a smart irrigation system based on computer vision and neural networks to predict irrigation requirements by analyzing soil color differences, achieving high accuracy.
Article
Chemistry, Medicinal
Ziyu Li, Wei Yang, Yong Yang, Jianbo Wu, Pei Luo, Yong Liu
Summary: LS-102 effectively suppresses inflammatory responses in adipose stem cells, reduces body weight, improves fat tissue inflammation, and provides protective effects in an obesity-related nephropathy model, outperforming astragaloside IV at the same concentration.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Food Science & Technology
Haifeng Wang, Pingya Wang, Qing Shen, Huijuan Yang, Hujun Xie, Min Huang, Jin Zhang, Qiaoling Zhao, Pei Luo, Danping Jin, Jiahui Wu, Shikai Jian, Xi Chen
Summary: This was the first study to determine the relationships between tertiary structural and rheological properties of myofibrillar proteins under ultrasound treatment. The results showed that ultrasound treatment could improve the rheological properties of the proteins, but significantly change their tertiary structure.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Agriculture, Multidisciplinary
Yiwei Cui, Lijun Ge, Weibo Lu, Shitong Wang, Yunyan Li, Haifeng Wang, Min Huang, Hujun Xie, Jie Liao, Ye Tao, Pei Luo, Yin-Yi Ding, Qing Shen
Summary: This study successfully differentiated different animal species of milk using rapid evaporative ionization mass spectrometry (REIMS) combined with chemometric analysis. Chemometric algorithms were used to identify the specific molecules that constitute each type of milk. This method can be used to authenticate dairy products and address fraudulent practices in the market.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Qing Shen, Haixing Wang, Bin Quan, Xiuhua Sun, Guohua Wu, Darong Huang, Qingcheng Wang, Pei Luo
Summary: A polarity switching UPLC-MS/MS method was developed and optimized for the fast and accurate determination of bioactive compounds in Salvia miltiorrhiza Bunge and its derived products. The method showed high efficiency and precision, significantly shortening the analysis time compared to conventional methods.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Applied
Youjiao Wu, Lili He, Yi Yang, Zhigang Yan, Zhifeng Zhang, Xiaojun Yao, Pei Luo
Summary: Fresh Smilax glabra showed promising anti-inflammatory effect, with astilbin identified as the main bioactive compound responsible for its activity. However, heat processing led to isomerization of astilbin, resulting in decreased anti-inflammatory activity.
Review
Plant Sciences
Hua-Yi Yang, Mengnan Liu, Pei Luo, Xin-Sheng Yao, Hua Zhou
Summary: Network pharmacology has important applications in deciphering the mechanism of TCM in treating ischemic heart diseases. However, its current application in TCM research is still at a superficial level. By combining artificial intelligence technology and other advanced theories and technologies, and systematically studying the metabolic process and network relationships of TCM from a clinical perspective, network pharmacology may have great potential for development.
Article
Pharmacology & Pharmacy
You-Jiao Wu, Zhan-Hua Li, Jiu-Yan Li, Yan Zhou, Run-Yue Wang, Xiao-Yi Chen, Lin-Sen Qing, Pei Luo
Summary: LS-102 showed reversible and moderate binding affinity to human serum albumin (HSA), allowing easy diffusion from circulation to target tissues. It demonstrated cardioprotective effects and prevented thrombosis in a zebrafish model. These findings provide significant insights into the pharmacokinetic and pharmacodynamic properties of LS-102 and its potential clinical applications in the cardiovascular field.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Analytical
Lin-Sen Qing, Tian-Tian Wang, Han-Yue Luo, Jia-Lan Du, Run-Yue Wang, Pei Luo
Summary: Natural products are still the main source of drug candidates in new drug discovery. Microfluidic technology offers a rapid and efficient research system for natural products through miniaturizing the analytical process onto a single chip. This review comprehensively summarizes the design and applications of microfluidic devices in analyzing, evaluating, and studying natural products, as well as discussing limitations and future research directions.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Lancong Liu, Wenfeng Ding, Lili He, Yi Yang, Fuyi Guan, Xinlin Sun, Yan Peng, Xue Chen, Wenhao Zhao, Yu Xiao, Pei Luo
Summary: We synthesized a novel peptide, WK001, by modifying the RGD structure to combine with scutellarin. Experimental and docking evidence showed that WK001 provides immediate and potent platelet inhibition, surpassing the inhibition of eptifibatide and scutellarin in platelet aggregation. In vivo studies demonstrated that WK001 administered intravenously prevents thrombus formation and attenuates myocardial fibrosis progression. Therefore, WK001 has the potential to be developed as an antiplatelet drug for thrombosis-associated diseases, such as stroke and myocardial infarction.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Jin Xu, Chuankang Tang, Ahmad Ud Din, Yu Lu, Xiaoyu Ma, Tao Zhang, Jiaqi Wu, Zuoqin Du, Pei Luo, Jianbo Wu
Summary: Fructooligosaccharide isolated from Polygonatum Cyrtonema Hua (PFOS) shows anti-inflammatory effects and improves intestinal barrier function. It downregulates pro-inflammatory cytokines, upregulates antioxidant genes, and enhances the growth of probiotics, alleviating DSS-induced colitis in mice.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Aiting Liu, Pei Luo, Hui Huang
Summary: The complement system defends against pathogenic microbes and modulates immune homeostasis. Dysregulation or activation of the complement system contributes to autoimmune and cardiovascular diseases, particularly those related to vascular calcification. This review summarizes current evidence on the activation of the complement system in vascular calcification and discusses its complex interactions with various processes involved in the development of this condition. Understanding the relationship between the complement system and vascular calcification can provide insights for slowing its progression.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Qianlong Wang, Tiantian Wang, Chonkit Lio, Xina Yu, Xiaoyi Chen, Lancong Liu, Youjiao Wu, Hui Huang, Linsen Qing, Pei Luo
Summary: This study demonstrates the use of surface hydrolysis-designed AuNPs-zwitterionic-glucose to label and track macrophages infiltration into the MI sites using CT imaging. The study also addresses the concern of cell tracking or AuNP tracking and improves the accuracy and precision of imaging and target delivery using zwitterionic and glucose-functionalized AuNPs. This is the first study to noninvasively visualize the infiltration of macrophages into MI hearts using CT.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Nanoscience & Nanotechnology
Pan Liang, Tao Bi, Yanan Zhou, Yining Ma, Xinyue Liu, Wei Ren, Sijin Yang, Pei Luo
Summary: Astragalus membranaceus and Angelica sinensis are a classic herb pair used to treat myocardial fibrosis. This study reports the formation of supermolecules, called AA-NPs, from the codoping reactions of these herbs. The self-assembly mechanism of AA-NPs was investigated, and it was found that AA-NPs were effective in treating myocardial fibrosis by improving cardiac function, reducing collagen deposition, and inhibiting endothelial-to-mesenchymal transition.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
Shan-Shan Song, Run-Yue Wang, Zhan-Hua Li, Yi Yang, Tian-Tian Wang, Lin-Sen Qing, Pei Luo
Summary: Radix Astragali (RA) is a commonly used Asian herbal therapy or food supply with astragalosides and flavonoids as its major components. This study investigated the bioaccessibility of these compounds during the process of oral digestion and examined their effects on intracellular reactive oxygen species levels in a human arterial endothelial cells model. The results indicate that the acetyl biotransformation of RA in the small intestine directly affects the response to oxidative stress, providing insights into the multi-component action of oral RA in cardiovascular health care.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Medicine, Research & Experimental
Wenbin Xiao, Kerui He, Chong Yu, Zeming Zhou, Liye Xia, Shibao Xie, Hanqi Li, Ming Zhang, Zhifeng Zhang, Pei Luo, Lu Wen, Gang Chen
Summary: Composite nanoparticles are an ideal multi-drug delivery vehicle that can provide effective protection against drug-induced sensorineural hearing loss.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).