期刊
STEROIDS
卷 152, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2019.108488
关键词
Furostanols; 22-Oxo-23-spiroketals; NMR; X-ray; Steroids
资金
- CONACYT [407518, 286638]
- CIC-UMSNH
The regioselective opening of the F ring of 22-oxo-23-spiroketals 7a-d using TiCl4 in acetic anhydride yielded the novel furostanols 11a-d along with cholestanic derivatives 8a-d with pyranone E ring. The structures of the new derivatives thus obtained were established using one- (DEPT) and two-dimensional H-1, C-13 NMR experiments (COSY, HSQC, HMBC, NOESY). The 22 alpha-hydroxyl orientation in compounds 11a-d was proposed by comparison of the C-13 chemical shifts with those of other aglycone members of this family, and confirmed by combined NOESY and X-ray diffraction analysis of compound 11a.
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