Evaluation of artemisinins for the treatment of acute myeloid leukemia

Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia

(2015) A Eriksson et al.   Blood Cancer Journal

Abstract 818: Repurposing Artemisinins for treatment of acute leukemias

(2015) Jennifer M. Fox et al.   CANCER RESEARCH

Advances in treatment of de-novo pediatric acute myeloid leukemia

(2014) Raul C. Ribeiro   CURRENT OPINION IN ONCOLOGY

Crenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemia

(2013) E. I. Zimmerman et al.   BLOOD

Population Pharmacokinetics of Intramuscular Artesunate in African Children With Severe Malaria: Implications for a Practical Dosing Regimen

(2013) ICE Hendriksen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

LC–MS/MS method for the simultaneous quantitation of three active components derived from a novel prodrug against schistosome infection

(2013) Guangzhao He et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Acute myeloid leukaemia in adults

(2013) Felicetto Ferrara et al.   LANCET

Pharmacokinetics and Pharmacodynamics of Oral Artesunate Monotherapy in Patients with Uncomplicated Plasmodium falciparum Malaria in Western Cambodia

(2012) David Saunders et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors

(2012) Mahadeo A. Sukhai et al.   JOURNAL OF CLINICAL INVESTIGATION

Dihydroartemisinin induces autophagy and inhibits the growth of iron-loaded human myeloid leukemia K562 cells via ROS toxicity

(2012) Zeng Wang et al.   FEBS Open Bio

Interruption of the MEK/ERK signaling cascade promotes dihydroartemisinin-induced apoptosis in vitro and in vivo

(2011) Ning Gao et al.   APOPTOSIS

An Integrated In Vitro and In Vivo High-Throughput Screen Identifies Treatment Leads for Ependymoma

(2011) Jennifer M. Atkinson et al.   CANCER CELL

Activity of the Multikinase Inhibitor Sorafenib in Combination With Cytarabine in Acute Myeloid Leukemia

(2011) Shuiying Hu et al.   JNCI-Journal of the National Cancer Institute

Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species

(2010) Jin-Jian Lu et al.   CANCER BIOLOGY & THERAPY

Heme synthesis increases artemisinin-induced radical formation and cytotoxicity that can be suppressed by superoxide scavengers

(2010) Shiming Zhang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Artesunate Activates Mitochondrial Apoptosis in Breast Cancer Cells via Iron-catalyzed Lysosomal Reactive Oxygen Species Production

(2010) Anne Hamacher-Brady et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance

(2009) A. V. Kurtova et al.   BLOOD

Bone marrow mesenchymal stem cells from leukemia patients inhibit growth and apoptosis in serum-deprived K562 cells

(2009) Zhaohui Wei et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Transferrin receptor-dependent cytotoxicity of artemisinin–transferrin conjugates on prostate cancer cells and induction of apoptosis

(2008) Ikuhiko Nakase et al.   CANCER LETTERS

Anticancer properties of artemisinin derivatives and their targeted delivery by transferrin conjugation

(2007) Ikuhiko Nakase et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS