Review
Biochemistry & Molecular Biology
Chiara Lembo, Giuseppe Buonocore, Serafina Perrone
Summary: Preterm babies are vulnerable to oxidative stress due to an imbalance between oxidant and antioxidant systems, leading to oxidative damage and various diseases. Biomarkers can help identify newborns at risk of free radical-mediated diseases early on, leading to the development of new antioxidant strategies for prevention and treatment.
Article
Medicine, General & Internal
Melinda Matyas, Monica Hasmasanu, Ciprian N. Silaghi, Gabriel Samasca, Iulia Lupan, Kovacs Orsolya, Gabriela Zaharie
Summary: The study reveals that early preeclampsia increases the risk of complications in preterm neonates and is correlated with hematological changes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Anna S. Swierzko, Dariusz Jarych, Gabriela Gajek, Karolina Chojnacka, Paulina Kobiela, Maja Kufelnicka-Babout, Mateusz Michalski, Katarzyna Sobczuk, Agnieszka Szala-Pozdziej, Misao Matsushita, Jan Mazela, Iwona Domzalska-Popadiuk, David C. Kilpatrick, Jaroslaw Kalinka, Hideharu Sekine, Maciej Cedzynski
Summary: The study identified FCN2 gene 3'UTR polymorphisms associated with ficolin-2 expression and perinatal complications in preterm neonates, with some polymorphisms showing linkage disequilibrium and influence on serum ficolin-2 concentration. These findings indicate a potential genetic basis for susceptibility to infections and birthweight in preterm neonates.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pediatrics
Vineet Lamba, Oscar Winners, Prem Fort
Summary: The study found that early high-dose caffeine (HD) therapy can reduce the duration of mechanical ventilation in premature infants and decrease the risk of bronchopulmonary dysplasia (BPD).
Article
Pediatrics
Olivia Falconer, Savannah Ivy, Dana Le Carpentier, Johanna Gavlak, Natasha Liddle, Emily Senior, Paula Lowe, Philippa Crowley, Aneurin Young, Mark J. Johnson, Robert Mark Beattie, Hazel J. Evans
Summary: This study aimed to determine the patterns of nocturnal pulse oximetry indices in moderate to late preterm infants and investigate the relationship between oxygen desaturations, the apnoea hypopnoea index, and both corrected gestational and postnatal age.
PEDIATRIC RESEARCH
(2023)
Article
Nutrition & Dietetics
Lila S. Nolan, Angela N. Lewis, Qingqing Gong, James J. Sollome, Olivia N. DeWitt, Robert D. Williams, Misty Good
Summary: Metabolomics analysis of breast milk from mothers of preterm infants revealed significant differences in metabolites related to fatty acid metabolism, oligosaccharides, amino sugars, amino acids, vitamins, and oxidative stress between mothers of infants with different birth weights. Understanding these differences may provide insights into tailored nutrition and care for preterm newborns in the future.
Article
Multidisciplinary Sciences
Gul Ambreen, Manoj Kumar, Amin Ali, Syed Akbar Ali Shah, Syed Muzafar Saleem, Ayesha Tahir, Muhammad Sohail Salat, Muhammad Shahzad Aslam, Kashif Hussain
Summary: The study aimed to evaluate the impact of orally administered caffeine on medication adherence and hospital readmission frequency in preterm neonates. The results showed that oral caffeine significantly reduced the cost of therapy, increased medication refill rates, and decreased parental complaints. Furthermore, the implementation of oral caffeine was found to significantly reduce the risk of hospital readmission.
Article
Immunology
Gabriela Gajek, Anna S. Swierzko, Dariusz Jarych, Damian Mikulski, Paulina Kobiela, Karolina Chojnacka, Maja Kufelnicka-Babout, Agnieszka Szala-Pozdziej, Jedrzej Chrzanowski, Katarzyna Sobczuk, Wojciech Fendler, Misao Matsushita, Iwona Domzalska-Popadiuk, Jan Mazela, Jaroslaw Kalinka, Hideharu Sekine, Maciej Cedzynski
Summary: This study found that low concentration of Ficolin-2 in cord blood serum is associated with complications related to premature birth, especially an increased risk of respiratory distress syndrome (RDS).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Elida Duenas-Meza, Maria Isabel Escamilla-Gil, Maria Angelica Bazurto-Zapata, Elizabeth Caparo, Miguel Suarez Cuartas, Laura Rincon Martinez, Lizbeth Pernett Buenaver, Ariana Rojas Ortega, Jorge Torres, Sonia Restrepo-Gualteros, Andrea Parra Buitrago, Mauricio Gonzalez-Garcia
Summary: This study found that preterm infants born at high altitudes have a greater impact on oxygen saturation and intermittent hypoxia during sleep compared to full-term infants. These preterm infants have a higher rate of respiratory events and lower oxygen saturation, indicating the need for timely diagnosis and treatment of respiratory disturbances during sleep.
Article
Physiology
Daniele De Luca, Raquel Arroyo, Silvia Foligno, Chiara Autilio, Lhousseine Touqui, Paul S. Kingma
Summary: This study aimed to investigate the association between surfactant protein-D (SP-D) expression and clinical outcomes in extremely preterm neonates. The results showed that SP-D levels increased with gestational age and were inversely associated with the development of bronchopulmonary dysplasia (BPD). SP-D was also correlated with the duration of hospital stay, invasive ventilation, and total sPLA2 activity.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Pediatrics
Manoj Kumar, Amin Ali, Muhammad Azeem Khan, Sadia Sohail, Syed Muzafar Saleem, Midhat Khan, Fizzah Naz, Wasif Ahmed Khan, Muhammad Sohail Salat, Kashif Hussain, Gul Ambreen
Summary: Caffeine therapy for apnea of prematurity may contribute to the development of osteopenia of prematurity, and the dosage of caffeine and gestational age of preterm neonates are associated with the development of osteopenia.
Article
Biochemistry & Molecular Biology
Agnieszka Szala-Pozdziej, Anna S. S. Swierzko, Gabriela Gajek, Maja Kufelnicka-Babout, Karolina Chojnacka, Paulina Kobiela, Dariusz Jarych, Katarzyna Sobczuk, Jan Mazela, Iwona Domzalska-Popadiuk, Jaroslaw Kalinka, Hideharu Sekine, Misao Matsushita, Maciej Cedzynski
Summary: This study explored the relationship between single nucleotide polymorphisms (SNPs) in the promoter region of the FCN2 gene and clinical complications in preterm babies. The results showed that certain SNPs were associated with very low birthweight (VLBW) and gestational age, suggesting that ficolin-2 is an important factor in fetal development and intrauterine growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Robert B. Flint, Sinno H. P. Simons, Peter Andriessen, Kian D. Liem, Pieter L. J. Degraeuwe, Irwin K. M. Reiss, Rob Ter Heine, Aline G. J. Engbers, Birgit C. P. Koch, Ronald de Groot, David M. Burger, Catherijne A. J. Knibbe, Swantje Voller
Summary: The study described the pharmacokinetics of doxapram in preterm infants, finding that dosing based solely on bodyweight may result in the highest exposure in infants with the lowest postnatal age and gestational age, suggesting the need to adjust doxapram dosing based on gestational age and postnatal age.
PEDIATRIC RESEARCH
(2021)
Article
Pediatrics
Liron Borenstein-Levin, Jarinda A. Poppe, Willem van Weteringen, H. Rob Taal, Ori Hochwald, Amir Kugelman, Irwin K. M. Reiss, Sinno H. P. Simons
Summary: The study showed that the SpO(2) histogram classification system provides an objective measure of response to doxapram therapy in preterm infants. Infants who responded to treatment within 24 hours were less likely to require invasive mechanical ventilation. The classification system allows for bedside assessment of oxygenation status changes in response to respiratory interventions within a few hours.
PEDIATRIC RESEARCH
(2023)
Review
Pediatrics
Laura Chavez, Eduardo Bancalari
Summary: Apnea of prematurity is a developmental disorder that affects preterm infants. The use of caffeine is a common treatment for this condition, as it has been shown to reduce apnea episodes and potentially have beneficial effects on neurodevelopmental outcomes. However, there is still uncertainty regarding its efficacy and safety, and further research is needed to provide stronger evidence.